A Conley

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Adrenarche in nonhuman primates: the evidence for it and the need to redefine it
    A J Conley
    Department of Population Health and Reproduction, VM PHR, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA
    J Endocrinol 214:121-31. 2012
  2. doi request reprint Costs and consequences of cellular compartmentalization and substrate competition among human enzymes involved in androgen and estrogen synthesis
    Alan J Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, USA
    Biol Reprod 86:1-8. 2012
  3. pmc Adaptive evolution of mammalian aromatases: lessons from Suiformes
    A J Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Exp Zool A Ecol Genet Physiol 311:346-57. 2009
  4. ncbi request reprint Placental expression and molecular characterization of aromatase cytochrome P450 in the spotted hyena (Crocuta crocuta)
    A J Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA 95616, USA
    Placenta 28:668-75. 2007
  5. doi request reprint The ontogeny of fetal adrenal steroidogenesis as a prerequisite for the initiation of parturition
    A J Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Exp Clin Endocrinol Diabetes 116:385-92. 2008
  6. doi request reprint Defining adrenarche in the rhesus macaque (Macaca mulatta), a non-human primate model for adrenal androgen secretion
    A J Conley
    School of Veterinary Medicine, University of California Davis, 1 Shields Ave, Davis, CA 95618, USA
    Mol Cell Endocrinol 336:110-6. 2011
  7. ncbi request reprint Variations in adrenal androgen production among (nonhuman) primates
    Alan J Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Semin Reprod Med 22:311-26. 2004
  8. pmc Adrenal androgen concentrations increase during infancy in male rhesus macaques (Macaca mulatta)
    A J Conley
    School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    Am J Physiol Endocrinol Metab 301:E1229-35. 2011
  9. ncbi request reprint Structural determinants of aromatase cytochrome p450 inhibition in substrate recognition site-1
    Alan Conley
    Department of Population Health and Reproduction, University of California School of Veterinary Medicine, Davis, California 95616, USA
    Mol Endocrinol 16:1456-68. 2002
  10. ncbi request reprint Mammalian aromatases
    A Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Reproduction 121:685-95. 2001

Research Grants

Collaborators

Detail Information

Publications35

  1. doi request reprint Adrenarche in nonhuman primates: the evidence for it and the need to redefine it
    A J Conley
    Department of Population Health and Reproduction, VM PHR, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA
    J Endocrinol 214:121-31. 2012
    ....
  2. doi request reprint Costs and consequences of cellular compartmentalization and substrate competition among human enzymes involved in androgen and estrogen synthesis
    Alan J Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, USA
    Biol Reprod 86:1-8. 2012
    ....
  3. pmc Adaptive evolution of mammalian aromatases: lessons from Suiformes
    A J Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Exp Zool A Ecol Genet Physiol 311:346-57. 2009
    ....
  4. ncbi request reprint Placental expression and molecular characterization of aromatase cytochrome P450 in the spotted hyena (Crocuta crocuta)
    A J Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA 95616, USA
    Placenta 28:668-75. 2007
    ..Other hyaenids and carnivores must be investigated to determine the morphological and functional ancestral state of their placentas, as it relates to evolutionary relationships among species in this important taxonomic group...
  5. doi request reprint The ontogeny of fetal adrenal steroidogenesis as a prerequisite for the initiation of parturition
    A J Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Exp Clin Endocrinol Diabetes 116:385-92. 2008
  6. doi request reprint Defining adrenarche in the rhesus macaque (Macaca mulatta), a non-human primate model for adrenal androgen secretion
    A J Conley
    School of Veterinary Medicine, University of California Davis, 1 Shields Ave, Davis, CA 95618, USA
    Mol Cell Endocrinol 336:110-6. 2011
    ..Adrenarche in any species should be defined only after careful longitudinal hormone analysis have been conducted in stages of development that are suggested by morphological and biochemical evidence of ZR maturation...
  7. ncbi request reprint Variations in adrenal androgen production among (nonhuman) primates
    Alan J Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Semin Reprod Med 22:311-26. 2004
    ..Based on the very limited available data, the most promising nonhuman primate models are marmosets for the human FZ, chimpanzees for human adrenarche, and macaques and baboons for mature ZR function that declines with senescence...
  8. pmc Adrenal androgen concentrations increase during infancy in male rhesus macaques (Macaca mulatta)
    A J Conley
    School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    Am J Physiol Endocrinol Metab 301:E1229-35. 2011
    ..The rhesus is a promising model for androgen secretion from the human adrenal cortex...
  9. ncbi request reprint Structural determinants of aromatase cytochrome p450 inhibition in substrate recognition site-1
    Alan Conley
    Department of Population Health and Reproduction, University of California School of Veterinary Medicine, Davis, California 95616, USA
    Mol Endocrinol 16:1456-68. 2002
    ....
  10. ncbi request reprint Mammalian aromatases
    A Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Reproduction 121:685-95. 2001
    ....
  11. ncbi request reprint A comparative approach to structure-function studies of mammalian aromatases
    A Conley
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Steroid Biochem Mol Biol 79:289-97. 2001
    ..These studies are currently in progress...
  12. ncbi request reprint Cytochrome b5 (b5) in the developing rhesus adrenal
    S Mapes
    University of California, Davis, California, USA
    Endocr Res 28:623. 2002
  13. ncbi request reprint Porcine aromatases: studies on tissue-specific, functionally distinct isozymes from a single gene?
    A Conley
    School of Veterinary Medicine, University of California, Davis 95616, U S A
    J Steroid Biochem Mol Biol 61:407-13. 1997
    ..Clearly, the regulation of P450arom expression is more complex in the pig than in other vertebrates investigated to date...
  14. ncbi request reprint Structure of the midterm placenta of the spotted hyena, Crocuta crocuta, with emphasis on the diverse hemophagous regions
    Allen C Enders
    Department of Cell Biology and Human Anatomy, University of California, Davis, CA 95616, USA
    Cells Tissues Organs 183:141-55. 2006
    ..The widespread distribution of the hemophagous regions suggests a nutritive function in addition to an iron transfer function of the columnar cytotrophoblast...
  15. doi request reprint Serum 17alpha-hydroxyprogesterone concentrations during the reproductive cycle in healthy dogs and dogs with hyperadrenocorticism
    Catharina Brömel
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    J Am Vet Med Assoc 236:1208-14. 2010
    ....
  16. ncbi request reprint Sex steroid concentrations and localization of steroidogenic enzyme expression in free-ranging female northern fur seals (Callorhinus ursinus)
    Patience Browne
    Population, Health and Reproduction, University of California, Davis, 1114 Tupper Hall, 95616, USA
    Gen Comp Endocrinol 147:175-83. 2006
    ..These data suggest androgens may play a substantial regulatory role in the embryonic delay of northern fur seals...
  17. pmc Effects of triclocarban on intact immature male rat: augmentation of androgen action
    Antoni J Duleba
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, CA 95817, USA
    Reprod Sci 18:119-27. 2011
    ..In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in prostate cancer cells...
  18. doi request reprint Morphological adrenarche in rhesus macaques: development of the zona reticularis is concurrent with fetal zone regression in the early neonatal period
    Ann D Nguyen
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Endocrinol 199:367-78. 2008
    ....
  19. ncbi request reprint Adrenocortical cytochrome b5 expression during fetal development of the rhesus macaque
    Samantha Mapes
    Department of Population Health and Reproduction, University of California, Davis, California 95616, USA
    Endocrinology 143:1451-8. 2002
    ..However, the lack of cytochrome b5 and P450c17 expression in the FZ of the developing macaque adrenal cortex for much of the second and third trimesters distinguishes it from the mature zona reticularis seen in adult animals...
  20. ncbi request reprint Structural and functional differences among purified recombinant mammalian aromatases: glycosylation, N-terminal sequence and kinetic analysis of human, bovine and the porcine placental and gonadal isozymes
    C Jo Corbin
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Mol Cell Endocrinol 206:147-57. 2003
    ..These data emphasize the structural and functional variability of even the most conserved of proteins among diverse species wherein such differences have previously remained unexpected...
  21. doi request reprint Adrenal androgens in humans and nonhuman primates: production, zonation and regulation
    Ann D Nguyen
    Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Endocr Dev 13:33-54. 2008
    ..It is hoped that recent studies demonstrating adrenarche in the rhesus will put in proper context the significance of adrenal zonation in nonhuman primates as valid models for human adrenal development and function...
  22. ncbi request reprint Allopregnanolone infusion induced neurobehavioural alterations in a neonatal foal: is this a clue to the pathogenesis of neonatal maladjustment syndrome?
    J E Madigan
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, USA
    Equine Vet J Suppl 44:109-12. 2012
    ..Increased plasma progestagen concentrations have been reported in foals with neonatal maladjustment syndrome (NMS). These steroids may cross the blood-brain barrier and have dampening effects in the central nervous system...
  23. ncbi request reprint Mammalian sexual differentiation: lessons from the spotted hyena
    Stephen E Glickman
    Departments of Psychology and Integrative Biology, University of California, Berkeley, CA 94720, USA
    Trends Endocrinol Metab 17:349-56. 2006
    ..Naturally circulating androgens, acting prenatally, reduce reproductive success in adult female spotted hyenas. Effects on aggression and dominance might offset these reproductive 'costs' of female androgenization in utero...
  24. pmc The developmental increase in adrenocortical 17,20-lyase activity (biochemical adrenarche) is driven primarily by increasing cytochrome b5 in neonatal rhesus macaques
    Ann D Nguyen
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Endocrinology 150:1748-56. 2009
    ..The rhesus macaque is a relevant and accessible model for human ZR development and adrenal function...
  25. ncbi request reprint In vitro exposure to environmental tobacco smoke induces CYP1B1 expression in human luteinized granulosa cells
    Justin D Vidal
    Population Health and Reproduction, University of California at Davis, Davis, CA 95616, USA
    Reprod Toxicol 22:731-7. 2006
    ..CYP1B1 metabolizes both endogenous estrogens and polyaromatic hydrocarbons in ETS to a variety of reactive species and may contribute to the complex effects of ETS on ovarian function...
  26. ncbi request reprint Reducing estrogen synthesis in developing boars increases testis size and total sperm production
    Eeman E At-Taras
    Department of Animal Science, School of Veterinary Medicine, University of California, One Shields Ave, Davis, CA 95616, USA
    J Androl 27:552-9. 2006
    ....
  27. ncbi request reprint Suppression of endogenous estrogen during development affects porcine epididymal sperm maturation
    Megan J McCarthy
    Department of Animal Science, College of Agricultural and Environmental Sciences, University of California, Davis, 95616 8521, USA
    Mol Reprod Dev 73:1122-8. 2006
    ..These transient effects suggest that the pig, with its high endogenous estrogen, may respond differently than other species to reduced estrogen synthesis...
  28. pmc Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome
    David H Abbott
    Department of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Endocr Dev 13:145-58. 2008
    ..As adult prenatally androgenized female rhesus monkeys closely emulate PCOS-like symptoms, excess fetal androgen programming may contribute to adult adrenal androgen excess in women with PCOS...
  29. pmc Gender and gonadal status differences in zona reticularis expression in marmoset monkey adrenals: Cytochrome b5 localization with respect to cytochrome P450 17,20-lyase activity
    J Christina Pattison
    Perinatal Research Laboratories, University of Wisconsin Madison, Madison, WI 53715, USA
    Mol Cell Endocrinol 265:93-101. 2007
    ....
  30. ncbi request reprint Effects of aging on cytochrome b5 expression in the human adrenal gland
    Sejal Dharia
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 618 South 20th Street, 360 Old Hillman Building, Birmingham, Alabama 35294 7333, USA
    J Clin Endocrinol Metab 90:4357-61. 2005
    ..Aging in humans is characterized by a selective decline in circulating levels of adrenal androgens. The results of in vivo studies are suggestive of reduced adrenal 17,20-lyase activity in aging men and women...
  31. ncbi request reprint Male marmoset monkeys express an adrenal fetal zone at birth, but not a zona reticularis in adulthood
    J Christina Pattison
    Perinatal Research Laboratories, University of Wisconsin Madison, Madison, Wisconsin 53715, USA
    Endocrinology 146:365-74. 2005
    ..We conclude that neonatal marmosets exhibit a C19 steroid-secreting FZ similar to humans, but adult males fail to acquire a functional ZR...
  32. ncbi request reprint Colocalization of P450c17 and cytochrome b5 in androgen-synthesizing tissues of the human
    Sejal Dharia
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biol Reprod 71:83-8. 2004
    ..Our findings of colocalization of CytB5 and P450c17 are strongly supportive of the view that CytB5 plays an important role in the regulation of the androgen biosynthetic pathway in the fetal and adult human...
  33. ncbi request reprint Does alligator testis produce estradiol? A comparison of ovarian and testicular aromatase
    Valentine A Lance
    Center for Reproduction of Endangered Species, San Diego, California 92112, USA
    Biol Reprod 69:1201-7. 2003
    ..Circulating estradiol in male alligators is probably of extragonadal origin, and the testis produces little if any of this steroid...
  34. ncbi request reprint Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase
    Manjunath S Shet
    Purdue Pharma LP, Department of Pharmocokinetics and Drug Metabolism, Stamford, Connecticut, USA
    Drug Metab Rev 39:289-307. 2007
    ..Alignment did not permit the assignment of specific amino acids or domains to the observed differences in enzymatic activities...
  35. ncbi request reprint Isolation of marmoset P450c17 cDNA and gene regulation in vitro
    J Christina Pattison
    Perinatal Research Laboratories, Department of Obstetrics and Gynaecology, University of Wisconsin, Madison, Wisconsin 53715, USA
    Endocr Res 30:737-43. 2004
    ..Since marmoset adrenocortical cells exhibit similar endocrine function to rhesus, impaired 17,20-lyase activity in the adult marmoset adrenal may in part be due to differences in the primary sequence...

Research Grants4

  1. REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIES
    Alan Conley; Fiscal Year: 2001
    ..abstract_text> ..
  2. New Paradigms of P450-mediated Steroids Metabolism
    Alan Conley; Fiscal Year: 2006
    ..abstract_text> ..