DANIEL JOSEPH CONKLIN

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial progenitor cells from the bone marrow
    Petra Haberzettl
    Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky 40202, USA
    Environ Health Perspect 120:848-56. 2012
  2. pmc Acrolein-induced dyslipidemia and acute-phase response are independent of HMG-CoA reductase
    DANIEL J CONKLIN
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40292, USA
    Mol Nutr Food Res 55:1411-22. 2011
  3. pmc Acrolein consumption induces systemic dyslipidemia and lipoprotein modification
    DANIEL J CONKLIN
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 243:1-12. 2010
  4. pmc Increased sensitivity of glutathione S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity
    DANIEL J CONKLIN
    Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky, USA
    J Pharmacol Exp Ther 331:456-69. 2009
  5. pmc Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke
    DANIEL J CONKLIN
    Institute of Molecular Cardiology, Div of Cardiovascular Medicine, Dept of Medicine, Univ of Louisville, Delia Baxter Bldg, 580 S Preston St, Rm 421C, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 296:H1586-97. 2009
  6. pmc Acrolein generation stimulates hypercontraction in isolated human blood vessels
    D J Conklin
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 217:277-88. 2006
  7. ncbi request reprint Vasoactive effects of methylamine in isolated human blood vessels: role of semicarbazide-sensitive amine oxidase, formaldehyde, and hydrogen peroxide
    D J Conklin
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 286:H667-76. 2004
  8. pmc Acrolein induces vasodilatation of rodent mesenteric bed via an EDHF-dependent mechanism
    S O Awe
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 217:266-76. 2006
  9. pmc Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice
    Laura A Wheat
    Diabetes and Obesity Center, Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
    Arterioscler Thromb Vasc Biol 31:1598-606. 2011
  10. pmc Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived aldehyde-4-hydroxy trans-2-nonenal in vascular smooth muscle cells
    S Srivastava
    Experimental Research Laboratories, Division of Cardiology, University of Louisville, and Jewish Hospital Heart and Lung Institute, Louisville, KY 40202, USA
    Atherosclerosis 158:339-50. 2001

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial progenitor cells from the bone marrow
    Petra Haberzettl
    Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky 40202, USA
    Environ Health Perspect 120:848-56. 2012
    ..Endothelial progenitor cells (EPCs) contribute to postnatal endothelial repair and regeneration. In humans and mice, EPC levels are decreased upon exposure to elevated levels of PM(2.5)...
  2. pmc Acrolein-induced dyslipidemia and acute-phase response are independent of HMG-CoA reductase
    DANIEL J CONKLIN
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40292, USA
    Mol Nutr Food Res 55:1411-22. 2011
    ..Because lipid synthesis and trafficking are largely under hepatic control, we examined hepatic genes in murine models of acute and chronic oral acrolein exposure...
  3. pmc Acrolein consumption induces systemic dyslipidemia and lipoprotein modification
    DANIEL J CONKLIN
    Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 243:1-12. 2010
    ..These observations suggest that oral exposure to acrolein could induce or exacerbate systemic dyslipidemia and thereby contribute to cardiovascular disease risk...
  4. pmc Increased sensitivity of glutathione S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity
    DANIEL J CONKLIN
    Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky, USA
    J Pharmacol Exp Ther 331:456-69. 2009
    ..In addition, pretreatment with dietary or nutrient inducers of GSTP may be of use in minimizing bladder injury in patients undergoing CY therapy...
  5. pmc Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke
    DANIEL J CONKLIN
    Institute of Molecular Cardiology, Div of Cardiovascular Medicine, Dept of Medicine, Univ of Louisville, Delia Baxter Bldg, 580 S Preston St, Rm 421C, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 296:H1586-97. 2009
    ..These results indicate that GSTP protects against the endothelial dysfunction induced by tobacco smoke exposure and that this protection may be related to the detoxification of acrolein or other related cigarette smoke constituents...
  6. pmc Acrolein generation stimulates hypercontraction in isolated human blood vessels
    D J Conklin
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 217:277-88. 2006
    ..We conclude that acrolein generation in the blood vessel wall increases human susceptibility to vasospasm, an event that is enhanced in hypertension...
  7. ncbi request reprint Vasoactive effects of methylamine in isolated human blood vessels: role of semicarbazide-sensitive amine oxidase, formaldehyde, and hydrogen peroxide
    D J Conklin
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 286:H667-76. 2004
    ..MA-induced relaxation in LIMA was nitric oxide, prostaglandin, and possibly cGMP independent and blocked by hyperpolarization. We conclude that vascular SSAO activity may convert endogenous amines, like MA, to vasoactive metabolites...
  8. pmc Acrolein induces vasodilatation of rodent mesenteric bed via an EDHF-dependent mechanism
    S O Awe
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Toxicol Appl Pharmacol 217:266-76. 2006
    ..These data indicate that low level acrolein exposure associated with vascular oxidative stress or inflammation stimulates vasodilatation via EDHF release in medium-sized arteries--a novel function...
  9. pmc Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice
    Laura A Wheat
    Diabetes and Obesity Center, Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
    Arterioscler Thromb Vasc Biol 31:1598-606. 2011
    ..Because exposure to these pollutants is associated with an increase in cardiovascular disease risk, we studied the effects of acrolein on Flk-1(+)/Sca-1(+) cells that are involved in vascular repair...
  10. pmc Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived aldehyde-4-hydroxy trans-2-nonenal in vascular smooth muscle cells
    S Srivastava
    Experimental Research Laboratories, Division of Cardiology, University of Louisville, and Jewish Hospital Heart and Lung Institute, Louisville, KY 40202, USA
    Atherosclerosis 158:339-50. 2001
    ..These metabolic pathways may be the key regulators of the vascular effects of HNE and oxidized LDL...
  11. ncbi request reprint Amine metabolism: a novel path to coronary artery vasospasm
    D J Conklin
    Biology Department, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin 54702-4004, USA
    Toxicol Appl Pharmacol 175:149-59. 2001
    ....
  12. ncbi request reprint Culture medium enhances semicarbazide-sensitive amine oxidase activity
    M B Trent
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    In Vitro Cell Dev Biol Anim 38:523-8. 2002
    ..This study identifies an important enhancement effect of culture media on the FCS enzyme, SSAO, although the media components responsible for the enhancement are yet to be identified...

Research Grants3

  1. Cardioprotective Mechanisms of Glutathione S-transferase P
    Daniel Conklin; Fiscal Year: 2009
    ....
  2. Cardioprotective Mechanisms of Glutathione S-transferase P
    DANIEL JOSEPH CONKLIN; Fiscal Year: 2010
    ....
  3. Cardioprotective Mechanisms of Glutathione S-transferase P
    Daniel Conklin; Fiscal Year: 2009
    ....