Robert L Conhaim

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats
    Robert L Conhaim
    Department of Surgery, University of Wisconsin Medical School, Madison, WI, USA
    Crit Care Med 36:511-7. 2008
  2. doi request reprint Bacteremia does not affect cellular uptake of ultrafine particles in the lungs of rats
    Robert L Conhaim
    Department of Surgery, The William S Middleton Memorial Veterans Hospital, 600 Highland Avenue, Madison, WI 53792, USA
    Anat Rec (Hoboken) 294:550-7. 2011
  3. doi request reprint Microthrombus formation may trigger lung injury after acute blood loss
    Robert L Conhaim
    Dpartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Shock 34:601-7. 2010
  4. ncbi request reprint Hemorrhage causes interalveolar perfusion maldistribution in the lungs of anesthetized rats
    Robert L Conhaim
    Department of Surgery, Medical School, University of Wisconsin Madison, BX 3236, 600 Highland Avenue, Madison, WI 53792 7375, USA
    J Trauma 60:158-63. 2006
  5. ncbi request reprint Hemorrhage progressively disturbs interalveolar perfusion in the lungs of rats
    Robert L Conhaim
    Department of Surgery, University of Wisconsin School of Medicine and Public Health and The William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA
    Shock 29:410-6. 2008
  6. ncbi request reprint Acute hypoxia does not alter inter-alveolar perfusion distribution in unanesthetized rats
    Robert L Conhaim
    Department of Surgery, University of Wisconsin Madison and The William S Middleton Memorial Veterans Hospital, United States
    Respir Physiol Neurobiol 160:277-83. 2008
  7. ncbi request reprint Thromboxane receptor analog, U-46619, redistributes pulmonary microvascular perfusion in isolated rat lungs
    Robert L Conhaim
    Department of Surgery, University of Wisconsin Madison, Madison, WI 53792 7375, USA
    J Appl Physiol (1985) 96:245-52. 2004
  8. ncbi request reprint Perfusion heterogeneity in rat lungs assessed from the distribution of 4-microm-diameter latex particles
    Robert L Conhaim
    Department of Surgery, University of Wisconsin Madison, 53792 7375, USA
    J Appl Physiol (1985) 94:420-8. 2003
  9. doi request reprint Evidence for active control of perfusion within lung microvessels
    Kal E Watson
    The William S Middleton Memorial Veterans Hospital, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    J Appl Physiol (1985) 112:48-53. 2012
  10. doi request reprint A method for quantifying blood flow distribution among the alveoli of the lung
    Robert L Conhaim
    Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Methods Mol Biol 1075:297-304. 2014

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats
    Robert L Conhaim
    Department of Surgery, University of Wisconsin Medical School, Madison, WI, USA
    Crit Care Med 36:511-7. 2008
    ..One preinjury phenomenon that has not been explored previously is the effect of bacterial (nonlipopolysaccharide) sepsis on the distribution of alveolar perfusion. The goals of our studies were to measure this...
  2. doi request reprint Bacteremia does not affect cellular uptake of ultrafine particles in the lungs of rats
    Robert L Conhaim
    Department of Surgery, The William S Middleton Memorial Veterans Hospital, 600 Highland Avenue, Madison, WI 53792, USA
    Anat Rec (Hoboken) 294:550-7. 2011
    ..Our results suggest that these 6 nm particles were able to freely cross cell and organelle membranes, and further suggest that this ability was not altered by bacteremia...
  3. doi request reprint Microthrombus formation may trigger lung injury after acute blood loss
    Robert L Conhaim
    Dpartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Shock 34:601-7. 2010
    ..The development of lung injury after blood loss may be a consequence of leukocyte chemoattraction to fibrin microthrombi that seem to form within minutes after blood loss...
  4. ncbi request reprint Hemorrhage causes interalveolar perfusion maldistribution in the lungs of anesthetized rats
    Robert L Conhaim
    Department of Surgery, Medical School, University of Wisconsin Madison, BX 3236, 600 Highland Avenue, Madison, WI 53792 7375, USA
    J Trauma 60:158-63. 2006
    ..To test this, we measured interalveolar perfusion distribution in anesthetized, spontaneously breathing rats subjected to blood losses of 0%, 10%, 20%, or 30% of calculated blood volume...
  5. ncbi request reprint Hemorrhage progressively disturbs interalveolar perfusion in the lungs of rats
    Robert L Conhaim
    Department of Surgery, University of Wisconsin School of Medicine and Public Health and The William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA
    Shock 29:410-6. 2008
    ..Our particle distance measurements led us to further conclude that this maldistribution occurred in areas that were perfused at 15 min rather than in previously unperfused areas ...
  6. ncbi request reprint Acute hypoxia does not alter inter-alveolar perfusion distribution in unanesthetized rats
    Robert L Conhaim
    Department of Surgery, University of Wisconsin Madison and The William S Middleton Memorial Veterans Hospital, United States
    Respir Physiol Neurobiol 160:277-83. 2008
    ..s.) and 0.48+/-0.25 in air-breathing controls (n.s.). Our results suggest that acute hypoxia did not cause significant changes in inter-alveolar perfusion distribution in unanesthetized, spontaneously breathing rats...
  7. ncbi request reprint Thromboxane receptor analog, U-46619, redistributes pulmonary microvascular perfusion in isolated rat lungs
    Robert L Conhaim
    Department of Surgery, University of Wisconsin Madison, Madison, WI 53792 7375, USA
    J Appl Physiol (1985) 96:245-52. 2004
    ..These results suggest that vasoconstriction occurred in the microvessels themselves, which are much smaller vessels than those previously thought to be capable of vasoconstriction...
  8. ncbi request reprint Perfusion heterogeneity in rat lungs assessed from the distribution of 4-microm-diameter latex particles
    Robert L Conhaim
    Department of Surgery, University of Wisconsin Madison, 53792 7375, USA
    J Appl Physiol (1985) 94:420-8. 2003
    ..We conclude that perfusion distribution is random at tissue volumes less than that of an alveolus and nonrandom at tissue volumes greater than that of an alveolus...
  9. doi request reprint Evidence for active control of perfusion within lung microvessels
    Kal E Watson
    The William S Middleton Memorial Veterans Hospital, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    J Appl Physiol (1985) 112:48-53. 2012
    ..Our results suggest that these agents did not produce vasoconstriction by a common mechanism and support the idea that pulmonary microvessels possess a level of active control and are not simply passive exchange vessels...
  10. doi request reprint A method for quantifying blood flow distribution among the alveoli of the lung
    Robert L Conhaim
    Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Methods Mol Biol 1075:297-304. 2014
    ..Methods for using this technique are described, and the SAS routines are included. This technique can be an important tool for learning how this critical vascular bed performs in health and disease. ..
  11. pmc Hypoxia recruits intrapulmonary arteriovenous pathways in intact rats but not isolated rat lungs
    Melissa L Bates
    Department of Pediatrics and the John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Appl Physiol (1985) 112:1915-20. 2012
    ..These data provide evidence that large-diameter, direct arteriovenous connections exist in the lung and are recruitable by hypoxia in the intact animal...
  12. ncbi request reprint Inhaled thrombolytics reduce lung microclot and leukocyte infiltration after acute blood loss
    Robert L Conhaim
    Department of Surgery, University of Wisconsin School of Medicine and Public Heath William S Middleton Memorial Veterans Hospital and Department of Pediatrics, University of Wisconsin School of Medicine and Public Heath, Madison, Wisconsin
    Shock 41:528-36. 2014
    ..We confirmed this using an in vitro assay. Our results demonstrate that lyses of microthrombi that accumulate in the lung after acute blood loss prevent subsequent leukocyte sequestration...
  13. ncbi request reprint Motexafin-gadolinium taken up in vitro by at least 90% of glioblastoma cell nuclei
    Gelsomina De Stasio
    Department of Physics and Synchrotron Radiation Center, University of Wisconsin Madison, Stoughton, Winconsin 53589, USA
    Clin Cancer Res 12:206-13. 2006
    ....
  14. ncbi request reprint Interstitial albumin concentration measured during growth of perivascular cuffs in liquid-filled rabbit lung
    Sonja M Moe
    Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506 0070, USA
    J Appl Physiol 96:283-92. 2004
    ..The initial cuff growth occurred against an albumin colloid osmotic pressure gradient because a high interstitial resistance reduced the overall epithelial-interstitial reflection coefficient to the low value of the interstitium...