Robert L Conhaim
Affiliation: University of Wisconsin
- Acute hypoxia does not alter inter-alveolar perfusion distribution in unanesthetized ratsRobert L Conhaim
Department of Surgery, University of Wisconsin Madison and The William S Middleton Memorial Veterans Hospital, United States
Respir Physiol Neurobiol 160:277-83. 2008..s.) and 0.48+/-0.25 in air-breathing controls (n.s.). Our results suggest that acute hypoxia did not cause significant changes in inter-alveolar perfusion distribution in unanesthetized, spontaneously breathing rats...
- Bacteremia does not affect cellular uptake of ultrafine particles in the lungs of ratsRobert L Conhaim
Department of Surgery, The William S Middleton Memorial Veterans Hospital, 600 Highland Avenue, Madison, WI 53792, USA
Anat Rec (Hoboken) 294:550-7. 2011..Our results suggest that these 6 nm particles were able to freely cross cell and organelle membranes, and further suggest that this ability was not altered by bacteremia...
- Microthrombus formation may trigger lung injury after acute blood lossRobert L Conhaim
Dpartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Shock 34:601-7. 2010..The development of lung injury after blood loss may be a consequence of leukocyte chemoattraction to fibrin microthrombi that seem to form within minutes after blood loss...
- Hemorrhage causes interalveolar perfusion maldistribution in the lungs of anesthetized ratsRobert L Conhaim
Department of Surgery, Medical School, University of Wisconsin Madison, BX 3236, 600 Highland Avenue, Madison, WI 53792 7375, USA
J Trauma 60:158-63. 2006..To test this, we measured interalveolar perfusion distribution in anesthetized, spontaneously breathing rats subjected to blood losses of 0%, 10%, 20%, or 30% of calculated blood volume...
- Hemorrhage progressively disturbs interalveolar perfusion in the lungs of ratsRobert L Conhaim
Department of Surgery, University of Wisconsin School of Medicine and Public Health and The William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA
Shock 29:410-6. 2008..Our particle distance measurements led us to further conclude that this maldistribution occurred in areas that were perfused at 15 min rather than in previously unperfused areas ...
- Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of ratsRobert L Conhaim
Department of Surgery, University of Wisconsin Medical School, Madison, WI, USA
Crit Care Med 36:511-7. 2008..One preinjury phenomenon that has not been explored previously is the effect of bacterial (nonlipopolysaccharide) sepsis on the distribution of alveolar perfusion. The goals of our studies were to measure this...
- Thromboxane receptor analog, U-46619, redistributes pulmonary microvascular perfusion in isolated rat lungsRobert L Conhaim
Department of Surgery, University of Wisconsin Madison, Madison, WI 53792 7375, USA
J Appl Physiol 96:245-52. 2004..These results suggest that vasoconstriction occurred in the microvessels themselves, which are much smaller vessels than those previously thought to be capable of vasoconstriction...
- Perfusion heterogeneity in rat lungs assessed from the distribution of 4-microm-diameter latex particlesRobert L Conhaim
Department of Surgery, University of Wisconsin Madison, 53792 7375, USA
J Appl Physiol 94:420-8. 2003..We conclude that perfusion distribution is random at tissue volumes less than that of an alveolus and nonrandom at tissue volumes greater than that of an alveolus...
- Evidence for active control of perfusion within lung microvesselsKal E Watson
The William S Middleton Memorial Veterans Hospital, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
J Appl Physiol 112:48-53. 2012..Our results suggest that these agents did not produce vasoconstriction by a common mechanism and support the idea that pulmonary microvessels possess a level of active control and are not simply passive exchange vessels...
- Hypoxia recruits intrapulmonary arteriovenous pathways in intact rats but not isolated rat lungsMelissa L Bates
Department of Pediatrics and the John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
J Appl Physiol 112:1915-20. 2012..These data provide evidence that large-diameter, direct arteriovenous connections exist in the lung and are recruitable by hypoxia in the intact animal...
- Motexafin-gadolinium taken up in vitro by at least 90% of glioblastoma cell nucleiGelsomina De Stasio
Department of Physics and Synchrotron Radiation Center, University of Wisconsin Madison, Stoughton, Winconsin 53589, USA
Clin Cancer Res 12:206-13. 2006....
- Interstitial albumin concentration measured during growth of perivascular cuffs in liquid-filled rabbit lungSonja M Moe
Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506-0070, USA
J Appl Physiol 96:283-92. 2004..The initial cuff growth occurred against an albumin colloid osmotic pressure gradient because a high interstitial resistance reduced the overall epithelial-interstitial reflection coefficient to the low value of the interstitium...