Y Cong

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. doi request reprint Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells
    Yingzi Cong
    Division of Gastroenterology and Hepatology, Department of Medicine, Birmingham, AL 35294 0007, USA
    Eur J Immunol 39:3134-46. 2009
  2. ncbi request reprint Probiotics and immune regulation of inflammatory bowel diseases
    Yingzi Cong
    Division of Gastroenterology and Hepatology, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Curr Drug Targets Inflamm Allergy 2:145-54. 2003
  3. pmc A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota
    Yingzi Cong
    Departments of Medicine and Microbiology, Pediatric Dentistry, and Genetics, University of Alabama at Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 106:19256-61. 2009
  4. ncbi request reprint Early upregulation of T cell IL-10 production plays an important role in oral tolerance induction
    Y Cong
    Division of Gastroenterology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Ann N Y Acad Sci 1029:319-20. 2004
  5. ncbi request reprint Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora
    Yingzi Cong
    Division of Gastroenterology and Hepatology, University of Alabama, Birmingham 35294, USA
    J Immunol 169:6112-9. 2002
  6. pmc Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis
    Ting Feng
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:1321-32. 2010
  7. ncbi request reprint Immuno-bacterial homeostasis in the gut: new insights into an old enigma
    C O Elson
    Department of Medicine, The University of Alabama at Birmingham, 35233, USA
    Semin Immunol 13:187-94. 2001
  8. ncbi request reprint Isolation of flagellated bacteria implicated in Crohn's disease
    L Wayne Duck
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Inflamm Bowel Dis 13:1191-201. 2007
  9. ncbi request reprint Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota
    Astrid Konrad
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Gastroenterology 130:2050-9. 2006
  10. doi request reprint Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid
    Ting Feng
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:5915-25. 2010

Collaborators

Detail Information

Publications26

  1. doi request reprint Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells
    Yingzi Cong
    Division of Gastroenterology and Hepatology, Department of Medicine, Birmingham, AL 35294 0007, USA
    Eur J Immunol 39:3134-46. 2009
    ..More importantly, these Treg inhibited antigen-specific T-cell activation in vitro and inhibited colitis due to antigen-specific pathogenic T cells in vivo...
  2. ncbi request reprint Probiotics and immune regulation of inflammatory bowel diseases
    Yingzi Cong
    Division of Gastroenterology and Hepatology, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Curr Drug Targets Inflamm Allergy 2:145-54. 2003
    ....
  3. pmc A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota
    Yingzi Cong
    Departments of Medicine and Microbiology, Pediatric Dentistry, and Genetics, University of Alabama at Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 106:19256-61. 2009
    ..We propose that the major role of this coordinated Treg-IgA response is to maintain commensalism with the microbiota...
  4. ncbi request reprint Early upregulation of T cell IL-10 production plays an important role in oral tolerance induction
    Y Cong
    Division of Gastroenterology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Ann N Y Acad Sci 1029:319-20. 2004
    ..Early in oral tolerance induction, IL-10-producing CD4(+) T cells were increased, and adoptive transfer of IL-10-deficient CD4(+) T cells failed induction of oral tolerance, suggesting a key role of IL-10 production in such a process...
  5. ncbi request reprint Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora
    Yingzi Cong
    Division of Gastroenterology and Hepatology, University of Alabama, Birmingham 35294, USA
    J Immunol 169:6112-9. 2002
    ..We conclude that CD4(+) T cells with the properties of Tr1 cells are present in the intestinal lamina propria and hypothesize that these cells maintain intestinal immune homeostasis to the enteric flora...
  6. pmc Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis
    Ting Feng
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:1321-32. 2010
    ..Collectively, our data demonstrate that induction of colitis requires both spontaneous proliferation of T cells driven by microbiota-derived innate signals and antigen-specific T cell proliferation...
  7. ncbi request reprint Immuno-bacterial homeostasis in the gut: new insights into an old enigma
    C O Elson
    Department of Medicine, The University of Alabama at Birmingham, 35233, USA
    Semin Immunol 13:187-94. 2001
    ..NK cells, and B cells may also have a role in mucosal immune regulation. A model for T cell-immune homeostasis in the intestinal mucosa is presented...
  8. ncbi request reprint Isolation of flagellated bacteria implicated in Crohn's disease
    L Wayne Duck
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Inflamm Bowel Dis 13:1191-201. 2007
    ..The present study was done to identify the microbial source of such flagellins...
  9. ncbi request reprint Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota
    Astrid Konrad
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Gastroenterology 130:2050-9. 2006
    ..The normal host immune response to antigens of the enteric microbiota is poorly defined. In this study, we isolated recombinant microbial antigens from commensal bacteria and used them to probe the normal murine immune response...
  10. doi request reprint Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid
    Ting Feng
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:5915-25. 2010
    ..These data indicate that RA plays a critical role in the generation of mucosal DCs from bone marrow and in their functional activity...
  11. pmc TGF-beta promotes Th17 cell development through inhibition of SOCS3
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    J Immunol 183:97-105. 2009
    ..Our data indicate that inhibition of SOCS3 and, thus, enhancement of STAT3 activation is at least one of the mechanisms of TGF-beta promotion of Th17 cell development...
  12. ncbi request reprint Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
    Charles O Elson
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Gastroenterology 132:2359-70. 2007
    ..Interleukin (IL)-23 supports a distinct lineage of T cells producing IL-17 (Th17) that can mediate chronic inflammation. This study was performed to define the role of IL-23 and Th17 cells in chronic colitis in mice...
  13. ncbi request reprint Tumor exosomes inhibit differentiation of bone marrow dendritic cells
    Shaohua Yu
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Immunol 178:6867-75. 2007
    ..These data suggest that tumor exosome-mediated induction of IL-6 plays a role in blocking BM DC differentiation...
  14. ncbi request reprint Molecular approaches to the role of the microbiota in inflammatory bowel disease
    Charles O Elson
    Division of Gastroenterology and Hepatology, The University of Alabama Birmingham, 633 Zeigler Research Building, 703 S 19th Street, Birmingham, AL 35294 0007, USA
    Ann N Y Acad Sci 1072:39-51. 2006
    ..Previously unknown microbial flagellins were the dominant cluster of antigens identified. About half of the sera from patients with Crohn's disease have IgG antibodies to these flagellins...
  15. ncbi request reprint Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
    Charles O Elson
    Division of Gastroenterology and Hepatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Immunol Rev 206:260-76. 2005
    ..The same is true for both spontaneous models of IBD, C3H/HeJBir and SAMPI/Yit mice. The thesis is advanced that 'multiple hits' or defects in these interacting components is required for IBD to occur in both mouse and human...
  16. ncbi request reprint Understanding immune-microbial homeostasis in intestine
    Charles O Elson
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, 35294 0007, USA
    Immunol Res 26:87-94. 2002
    ..Manyquestions remain to be answered, including, How do the enteric bacterial-host interactions shape the immune system for abnormal responses such as inflammatory bowel disease, autoimmunity, and allergy?..
  17. ncbi request reprint Gene disruption and immunity in experimental colitis
    Charles O Elson
    Division of Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Inflamm Bowel Dis 10:S25-8. 2004
  18. ncbi request reprint Experimental models to study molecular mechanisms underlying intestinal inflammation
    C O Elson
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham 35294, USA
    Ann N Y Acad Sci 859:85-95. 1998
    ..The antigens driving disease seem to be a selective subset of immunodominant proteins, likely derived from a subset of organisms. Multiple genes contribute to colitis susceptibility and a number of these genes are being localized...
  19. ncbi request reprint Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function
    Yingzi Cong
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 174:2787-95. 2005
    ..We conclude that NF-kappaB-blocked, immature APC are able to induce the differentiation of Treg cells that can function in vitro and in vivo in an Ag-specific manner...
  20. pmc Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation
    H Takedatsu
    Division of Gastroenterology, Inflammatory Bowel Disease Center, Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gut 58:60-7. 2009
    ..Our aim was to conduct a linkage study using expression of anti-CBir1, anti-I2, anti-OmpC and ASCA as quantitative traits...
  21. ncbi request reprint Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 179:5966-76. 2007
    ....
  22. pmc CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-) mice, which can be abrogated by anti-CXCL10 antibody inhibition
    Udai P Singh
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Interferon Cytokine Res 28:31-43. 2008
    ..Our data also support the premise that CXCL10 blockade can attenuate chronic colitis by preventing the activation and recruitment of CXCR3+ leukocytes during IBD...
  23. pmc Bacterial flagellin is a dominant antigen in Crohn disease
    Michael J Lodes
    Corixa Corp, Seattle, Washington, USA
    J Clin Invest 113:1296-306. 2004
    ....
  24. ncbi request reprint Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice
    Jimmy W Lee
    Biomedical Sciences Division, University of California, Riverside, California 92521 0121, USA
    Gastroenterology 133:108-23. 2007
    ....
  25. ncbi request reprint Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens
    Jason Beckwith
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Gastroenterology 129:1473-84. 2005
    ..We developed reciprocal Cdcs1 congenic stocks on both interleukin 10-deficient backgrounds to identify the susceptibility gene and its function...
  26. ncbi request reprint Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    Stephan R Targan
    Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, California 90048, USA
    Gastroenterology 128:2020-8. 2005
    ....