Genomes and Genes
Affiliation: University of Alabama at Birmingham
- Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cellsYingzi Cong
Division of Gastroenterology and Hepatology, Department of Medicine, Birmingham, AL 35294 0007, USA
Eur J Immunol 39:3134-46. 2009..More importantly, these Treg inhibited antigen-specific T-cell activation in vitro and inhibited colitis due to antigen-specific pathogenic T cells in vivo...
- Probiotics and immune regulation of inflammatory bowel diseasesYingzi Cong
Division of Gastroenterology and Hepatology, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
Curr Drug Targets Inflamm Allergy 2:145-54. 2003....
- A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiotaYingzi Cong
Departments of Medicine and Microbiology, Pediatric Dentistry, and Genetics, University of Alabama at Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 106:19256-61. 2009..We propose that the major role of this coordinated Treg-IgA response is to maintain commensalism with the microbiota...
- Early upregulation of T cell IL-10 production plays an important role in oral tolerance inductionY Cong
Division of Gastroenterology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Ann N Y Acad Sci 1029:319-20. 2004..Early in oral tolerance induction, IL-10-producing CD4(+) T cells were increased, and adoptive transfer of IL-10-deficient CD4(+) T cells failed induction of oral tolerance, suggesting a key role of IL-10 production in such a process...
- Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric floraYingzi Cong
Division of Gastroenterology and Hepatology, University of Alabama, Birmingham 35294, USA
J Immunol 169:6112-9. 2002..We conclude that CD4(+) T cells with the properties of Tr1 cells are present in the intestinal lamina propria and hypothesize that these cells maintain intestinal immune homeostasis to the enteric flora...
- Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitisTing Feng
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Exp Med 207:1321-32. 2010..Collectively, our data demonstrate that induction of colitis requires both spontaneous proliferation of T cells driven by microbiota-derived innate signals and antigen-specific T cell proliferation...
- Immuno-bacterial homeostasis in the gut: new insights into an old enigmaC O Elson
Department of Medicine, The University of Alabama at Birmingham, 35233, USA
Semin Immunol 13:187-94. 2001..NK cells, and B cells may also have a role in mucosal immune regulation. A model for T cell-immune homeostasis in the intestinal mucosa is presented...
- Isolation of flagellated bacteria implicated in Crohn's diseaseL Wayne Duck
Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Inflamm Bowel Dis 13:1191-201. 2007..The present study was done to identify the microbial source of such flagellins...
- Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiotaAstrid Konrad
Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Gastroenterology 130:2050-9. 2006..The normal host immune response to antigens of the enteric microbiota is poorly defined. In this study, we isolated recombinant microbial antigens from commensal bacteria and used them to probe the normal murine immune response...
- Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acidTing Feng
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 185:5915-25. 2010..These data indicate that RA plays a critical role in the generation of mucosal DCs from bone marrow and in their functional activity...
- TGF-beta promotes Th17 cell development through inhibition of SOCS3Hongwei Qin
Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
J Immunol 183:97-105. 2009..Our data indicate that inhibition of SOCS3 and, thus, enhancement of STAT3 activation is at least one of the mechanisms of TGF-beta promotion of Th17 cell development...
- Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in miceCharles O Elson
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Gastroenterology 132:2359-70. 2007..Interleukin (IL)-23 supports a distinct lineage of T cells producing IL-17 (Th17) that can mediate chronic inflammation. This study was performed to define the role of IL-23 and Th17 cells in chronic colitis in mice...
- Tumor exosomes inhibit differentiation of bone marrow dendritic cellsShaohua Yu
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Immunol 178:6867-75. 2007..These data suggest that tumor exosome-mediated induction of IL-6 plays a role in blocking BM DC differentiation...
- Molecular approaches to the role of the microbiota in inflammatory bowel diseaseCharles O Elson
Division of Gastroenterology and Hepatology, The University of Alabama Birmingham, 633 Zeigler Research Building, 703 S 19th Street, Birmingham, AL 35294 0007, USA
Ann N Y Acad Sci 1072:39-51. 2006..Previously unknown microbial flagellins were the dominant cluster of antigens identified. About half of the sera from patients with Crohn's disease have IgG antibodies to these flagellins...
- Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiotaCharles O Elson
Division of Gastroenterology and Hepatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
Immunol Rev 206:260-76. 2005..The same is true for both spontaneous models of IBD, C3H/HeJBir and SAMPI/Yit mice. The thesis is advanced that 'multiple hits' or defects in these interacting components is required for IBD to occur in both mouse and human...
- Understanding immune-microbial homeostasis in intestineCharles O Elson
Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, 35294 0007, USA
Immunol Res 26:87-94. 2002..Manyquestions remain to be answered, including, How do the enteric bacterial-host interactions shape the immune system for abnormal responses such as inflammatory bowel disease, autoimmunity, and allergy?..
- Gene disruption and immunity in experimental colitisCharles O Elson
Division of Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Inflamm Bowel Dis 10:S25-8. 2004
- Experimental models to study molecular mechanisms underlying intestinal inflammationC O Elson
Division of Gastroenterology and Hepatology, University of Alabama at Birmingham 35294, USA
Ann N Y Acad Sci 859:85-95. 1998..The antigens driving disease seem to be a selective subset of immunodominant proteins, likely derived from a subset of organisms. Multiple genes contribute to colitis susceptibility and a number of these genes are being localized...
- Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome functionYingzi Cong
Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
J Immunol 174:2787-95. 2005..We conclude that NF-kappaB-blocked, immature APC are able to induce the differentiation of Treg cells that can function in vitro and in vivo in an Ag-specific manner...
- Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activationH Takedatsu
Division of Gastroenterology, Inflammatory Bowel Disease Center, Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Gut 58:60-7. 2009..Our aim was to conduct a linkage study using expression of anti-CBir1, anti-I2, anti-OmpC and ASCA as quantitative traits...
- Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microgliaHongwei Qin
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 179:5966-76. 2007....
- CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-) mice, which can be abrogated by anti-CXCL10 antibody inhibitionUdai P Singh
Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
J Interferon Cytokine Res 28:31-43. 2008..Our data also support the premise that CXCL10 blockade can attenuate chronic colitis by preventing the activation and recruitment of CXCR3+ leukocytes during IBD...
- Bacterial flagellin is a dominant antigen in Crohn diseaseMichael J Lodes
Corixa Corp, Seattle, Washington, USA
J Clin Invest 113:1296-306. 2004....
- Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient miceJimmy W Lee
Biomedical Sciences Division, University of California, Riverside, California 92521 0121, USA
Gastroenterology 133:108-23. 2007....
- Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigensJason Beckwith
The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
Gastroenterology 129:1473-84. 2005..We developed reciprocal Cdcs1 congenic stocks on both interleukin 10-deficient backgrounds to identify the susceptibility gene and its function...
- Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's diseaseStephan R Targan
Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, California 90048, USA
Gastroenterology 128:2020-8. 2005....