Patrick J Concannon

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    Cancer Res 68:6486-91. 2008
  2. pmc Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    Jeffrey C Barrett
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:703-7. 2009
  3. pmc Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    Diabetes 58:1018-22. 2009
  4. pmc A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    Diabetes 57:2858-61. 2008
  5. doi request reprint Recent progress in the genetics of diabetes
    Stephen S Rich
    Department of Public Health Sciences and Medicine, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    Horm Res 71:17-23. 2009

Research Grants

Detail Information

Publications5

  1. pmc Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    Cancer Res 68:6486-91. 2008
    ..1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53...
  2. pmc Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    Jeffrey C Barrett
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:703-7. 2009
    ..01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27...
  3. pmc Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    Diabetes 58:1018-22. 2009
    ..However, such studies have limited power to detect genes containing multiple rare variants that contribute significantly to disease risk...
  4. pmc A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    Diabetes 57:2858-61. 2008
    ..In the current study, we tested for evidence of loci associated with type 1 diabetes utilizing genome-wide linkage scan data and family-based association methods...
  5. doi request reprint Recent progress in the genetics of diabetes
    Stephen S Rich
    Department of Public Health Sciences and Medicine, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    Horm Res 71:17-23. 2009
    ..Nonetheless, detection of diabetes susceptibility genes may facilitate identification of novel pathways that can serve as therapeutic targets and lead to disease prevention...

Research Grants3

  1. ATM mutations in breast cancer - a functional approach
    Patrick Concannon; Fiscal Year: 2007
    ..abstract_text> ..
  2. Expression and proteomic characterization of risk loci in type 1 diabetes
    Patrick Concannon; Fiscal Year: 2009
    ..The proposed studies in this application will characterize newly discovered genetic risk loci for T1D which may serve as useful biomarkers for prediction of disease or as targets for therapy. ..
  3. Isolation of Genes for Radiation Sensitivity
    Patrick Concannon; Fiscal Year: 2010
    ....