Irina Conboy

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 3:397-409. 2002
  2. doi request reprint Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells
    Morgan E Carlson
    Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Nature 454:528-32. 2008
  3. pmc Aging of signal transduction pathways, and pathology
    Morgan E Carlson
    Department of Bioengineering, University of California, Berkeley, Berkeley, California 94720 1762, USA
    Exp Cell Res 314:1951-61. 2008
  4. pmc Geometric control of myogenic cell fate
    Elena M de Juan-Pardo
    Department of Bioengineering, University of California at Berkeley, Berkley, CA, USA
    Int J Nanomedicine 1:203-12. 2006
  5. ncbi request reprint Notch signaling pathway and tissue engineering
    Morgan E Carlson
    Department of Bioengineering, University of California at Berkeley, Berkeley, California
    Front Biosci 12:5143-56. 2007
  6. pmc Molecular aging and rejuvenation of human muscle stem cells
    Morgan E Carlson
    Department of Bioengineering, University of California, Berkeley, Berkeley CA, USA
    EMBO Mol Med 1:381-91. 2009
  7. pmc Loss of stem cell regenerative capacity within aged niches
    Morgan E Carlson
    Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94702, USA
    Aging Cell 6:371-82. 2007
  8. pmc hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding
    Hanadie Yousef
    Department of Bioengineering and California Institute for Quantitative Biosciences QB3, UC Berkeley, Berkeley, CA 94720, USA
    Aging (Albany NY) 5:357-72. 2013
  9. pmc Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches
    Irina M Conboy
    Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA
    Cell Cycle 11:2260-7. 2012
  10. pmc Embryonic anti-aging niche
    Irina M Conboy
    Department of Bioengineering, QB3 Institute, UC Berkeley, CA 94720 3220, USA
    Aging (Albany NY) 3:555-63. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 3:397-409. 2002
    ....
  2. doi request reprint Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells
    Morgan E Carlson
    Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Nature 454:528-32. 2008
    ..Thus a balance between endogenous pSmad3 and active Notch controls the regenerative competence of muscle stem cells, and deregulation of this balance in the old muscle microniche interferes with regeneration...
  3. pmc Aging of signal transduction pathways, and pathology
    Morgan E Carlson
    Department of Bioengineering, University of California, Berkeley, Berkeley, California 94720 1762, USA
    Exp Cell Res 314:1951-61. 2008
    ....
  4. pmc Geometric control of myogenic cell fate
    Elena M de Juan-Pardo
    Department of Bioengineering, University of California at Berkeley, Berkley, CA, USA
    Int J Nanomedicine 1:203-12. 2006
    ..Additionally, this work may also serve as a general model to engineer synthetic cellular niches to harness the regenerative potential of organ stem cells...
  5. ncbi request reprint Notch signaling pathway and tissue engineering
    Morgan E Carlson
    Department of Bioengineering, University of California at Berkeley, Berkeley, California
    Front Biosci 12:5143-56. 2007
    ..Such methods will likely facilitate the engineering and dynamic remodeling of tissues composed of stem, progenitor and differentiated cells derived from an initially equivalent cell population...
  6. pmc Molecular aging and rejuvenation of human muscle stem cells
    Morgan E Carlson
    Department of Bioengineering, University of California, Berkeley, Berkeley CA, USA
    EMBO Mol Med 1:381-91. 2009
    ..These findings strongly suggest that aging of human muscle maintenance and repair can be reversed by 'youthful' calibration of specific molecular pathways...
  7. pmc Loss of stem cell regenerative capacity within aged niches
    Morgan E Carlson
    Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94702, USA
    Aging Cell 6:371-82. 2007
    ..Comprehensively, this work points toward novel venues for in situ restoration of tissue repair in the old and identifies critical determinants of successful cell-replacement therapies for aged degenerating organs...
  8. pmc hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding
    Hanadie Yousef
    Department of Bioengineering and California Institute for Quantitative Biosciences QB3, UC Berkeley, Berkeley, CA 94720, USA
    Aging (Albany NY) 5:357-72. 2013
    ..Moreover, hESC-secreted factors improve the viability of human cortical neurons in an Alzheimer's disease (AD) model, suggesting that these factors can enhance the maintenance and regeneration of multiple tissues in the aging body. ..
  9. pmc Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches
    Irina M Conboy
    Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA
    Cell Cycle 11:2260-7. 2012
    ..Here we review current literature on the relationship between the vigor of tissue stem cells and the process of aging, with an emphasis on the rejuvenation of old tissues by the extrinsic modifications of stem cell niches...
  10. pmc Embryonic anti-aging niche
    Irina M Conboy
    Department of Bioengineering, QB3 Institute, UC Berkeley, CA 94720 3220, USA
    Aging (Albany NY) 3:555-63. 2011
    ....
  11. ncbi request reprint Aging, stem cells and tissue regeneration: lessons from muscle
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5235, USA
    Cell Cycle 4:407-10. 2005
    ..Therefore, it may be that even very old stem cells may be capable of maintaining and repairing aged tissues if provided with optimal environmental cues...
  12. ncbi request reprint Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle
    Richard I Sherwood
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 119:543-54. 2004
    ..Together, these studies describe the clonal isolation of functional adult myogenic progenitors and demonstrate that these cells do not arise from hematopoietic or other bone marrow or circulating precursors...
  13. ncbi request reprint Notch-mediated restoration of regenerative potential to aged muscle
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Science 302:1575-7. 2003
    ..Thus, Notch signaling is a key determinant of muscle regenerative potential that declines with age...
  14. ncbi request reprint Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 433:760-4. 2005
    ..These results suggest that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age...
  15. pmc Differentiation rather than aging of muscle stem cells abolishes their telomerase activity
    Matthew S O'Connor
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Biotechnol Prog 25:1130-7. 2009
    ....
  16. pmc Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses
    Morgan E Carlson
    Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    Aging Cell 8:676-89. 2009
    ....
  17. doi request reprint Immuno-analysis and FACS sorting of adult muscle fiber-associated stem/precursor cells
    Michael J Conboy
    Department of Bioengineering, University of California, Berkeley, CA, USA
    Methods Mol Biol 621:165-73. 2010
    ....
  18. doi request reprint Embryonic vs. adult myogenesis: challenging the 'regeneration recapitulates development' paradigm
    John Wang
    Department of Bioengineering, University of California, Berkeley, 174 Stanley Hall, Berkeley, CA 94720 1762, USA
    J Mol Cell Biol 2:1-4. 2010
    ..In a recent Nature article, Lepper et al. questioned this approach, highlighting the differences in requirements for Pax7 during myogenesis for embryonic, juvenile and adult muscle...
  19. doi request reprint Preparation of adult muscle fiber-associated stem/precursor cells
    Michael J Conboy
    Department of Bioengineering, University of California, Berkeley, CA, USA
    Methods Mol Biol 621:149-63. 2010
    ..The protocol is applicable to any age and condition of muscle and may be adapted for other tissues...
  20. doi request reprint A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis
    Andrew S Brack
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305 5235 USA
    Cell Stem Cell 2:50-9. 2008
    ....
  21. ncbi request reprint Regulating the Notch pathway in embryonic, adult and old stem cells
    Morgan E Carlson
    Department of Bioengineering, UC Berkeley, Berkeley, CA 94720 1762, USA
    Curr Opin Pharmacol 7:303-9. 2007
    ..g. Alzheimer's, Alagille Syndrome, various cancers and other disease states)...
  22. ncbi request reprint Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis
    Amy J Wagers
    Joslin Diabetes Center and Department of Pathology Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 122:659-67. 2005
    ....

Research Grants6

  1. Myogenic potential of human embryonic stem cells in heterochronic environments
    Irina Conboy; Fiscal Year: 2007
    ....
  2. Genetic & Epi-Genetic Regulation of Muscle Regeneration
    Irina Conboy; Fiscal Year: 2006
    ..This work will help to understand postnatal myogenesis and is likely to have therapeutic value for the enhancement of regeneration in adult tissues. ..
  3. Effects of the systemic environment on muscle aging
    Irina Conboy; Fiscal Year: 2007
    ..These goals will be approached here in the proposed Specific Aims. ..
  4. Effects of the systemic environment on muscle aging
    Irina Conboy; Fiscal Year: 2009
    ..These goals will be approached here in the proposed Specific Aims. ..
  5. Effects of the systemic environment on muscle aging
    Irina Conboy; Fiscal Year: 2009
    ..These goals will be approached here in the proposed Specific Aims. ..