Research Topics
Species | Irina ConboySummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesisIrina M Conboy
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Cell 3:397-409. 2002....
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cellsMorgan E Carlson
Department of Bioengineering, University of California, Berkeley, California 94720, USA
Nature 454:528-32. 2008..Thus a balance between endogenous pSmad3 and active Notch controls the regenerative competence of muscle stem cells, and deregulation of this balance in the old muscle microniche interferes with regeneration...
Aging of signal transduction pathways, and pathologyMorgan E Carlson
Department of Bioengineering, University of California, Berkeley, Berkeley, California 94720 1762, USA
Exp Cell Res 314:1951-61. 2008....- Geometric control of myogenic cell fateElena M de Juan-Pardo
Department of Bioengineering, University of California at Berkeley, Berkley, CA, USA
Int J Nanomedicine 1:203-12. 2006..Additionally, this work may also serve as a general model to engineer synthetic cellular niches to harness the regenerative potential of organ stem cells... - Notch signaling pathway and tissue engineeringMorgan E Carlson
Department of Bioengineering, University of California at Berkeley, Berkeley, California
Front Biosci 12:5143-56. 2007..Such methods will likely facilitate the engineering and dynamic remodeling of tissues composed of stem, progenitor and differentiated cells derived from an initially equivalent cell population... - Heterochronic parabiosis for the study of the effects of aging on stem cells and their nichesIrina M Conboy
Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA
Cell Cycle 11:2260-7. 2012..Here we review current literature on the relationship between the vigor of tissue stem cells and the process of aging, with an emphasis on the rejuvenation of old tissues by the extrinsic modifications of stem cell niches... - Aging, stem cells and tissue regeneration: lessons from muscleIrina M Conboy
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305 5235, USA
Cell Cycle 4:407-10. 2005..Therefore, it may be that even very old stem cells may be capable of maintaining and repairing aged tissues if provided with optimal environmental cues... - Embryonic anti-aging nicheIrina M Conboy
Department of Bioengineering, QB3 Institute, UC Berkeley, CA 94720 3220, USA
Aging (Albany NY) 3:555-63. 2011.... - Molecular aging and rejuvenation of human muscle stem cellsMorgan E Carlson
Department of Bioengineering, University of California, Berkeley, Berkeley CA, USA
EMBO Mol Med 1:381-91. 2009..These findings strongly suggest that aging of human muscle maintenance and repair can be reversed by 'youthful' calibration of specific molecular pathways... - Loss of stem cell regenerative capacity within aged nichesMorgan E Carlson
Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94702, USA
Aging Cell 6:371-82. 2007..Comprehensively, this work points toward novel venues for in situ restoration of tissue repair in the old and identifies critical determinants of successful cell-replacement therapies for aged degenerating organs... - Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscleRichard I Sherwood
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 119:543-54. 2004..Together, these studies describe the clonal isolation of functional adult myogenic progenitors and demonstrate that these cells do not arise from hematopoietic or other bone marrow or circulating precursors... - Rejuvenation of aged progenitor cells by exposure to a young systemic environmentIrina M Conboy
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 433:760-4. 2005..These results suggest that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age... - Notch-mediated restoration of regenerative potential to aged muscleIrina M Conboy
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
Science 302:1575-7. 2003..Thus, Notch signaling is a key determinant of muscle regenerative potential that declines with age... - Differentiation rather than aging of muscle stem cells abolishes their telomerase activityMatthew S O'Connor
Department of Bioengineering, University of California, Berkeley, CA 94720, USA
Biotechnol Prog 25:1130-7. 2009.... - Immuno-analysis and FACS sorting of adult muscle fiber-associated stem/precursor cellsMichael J Conboy
Department of Bioengineering, University of California, Berkeley, CA, USA
Methods Mol Biol 621:165-73. 2010.... - Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responsesMorgan E Carlson
Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
Aging Cell 8:676-89. 2009.... - Embryonic vs. adult myogenesis: challenging the 'regeneration recapitulates development' paradigmJohn Wang
Department of Bioengineering, University of California, Berkeley, 174 Stanley Hall, Berkeley, CA 94720 1762, USA
J Mol Cell Biol 2:1-4. 2010..In a recent Nature article, Lepper et al. questioned this approach, highlighting the differences in requirements for Pax7 during myogenesis for embryonic, juvenile and adult muscle... - Preparation of adult muscle fiber-associated stem/precursor cellsMichael J Conboy
Department of Bioengineering, University of California, Berkeley, CA, USA
Methods Mol Biol 621:149-63. 2010..The protocol is applicable to any age and condition of muscle and may be adapted for other tissues... - Regulating the Notch pathway in embryonic, adult and old stem cellsMorgan E Carlson
Department of Bioengineering, UC Berkeley, Berkeley, CA 94720 1762, USA
Curr Opin Pharmacol 7:303-9. 2007..g. Alzheimer's, Alagille Syndrome, various cancers and other disease states)... - A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesisAndrew S Brack
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305 5235 USA
Cell Stem Cell 2:50-9. 2008.... - Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesisAmy J Wagers
Joslin Diabetes Center and Department of Pathology Harvard Medical School, Boston, Massachusetts 02215, USA
Cell 122:659-67. 2005....
Research Grants
- Myogenic potential of human embryonic stem cells in heterochronic environmentsIrina Conboy; Fiscal Year: 2007....
- Genetic & Epi-Genetic Regulation of Muscle RegenerationIrina Conboy; Fiscal Year: 2006..This work will help to understand postnatal myogenesis and is likely to have therapeutic value for the enhancement of regeneration in adult tissues. ..
- Effects of the systemic environment on muscle agingIrina Conboy; Fiscal Year: 2009..These goals will be approached here in the proposed Specific Aims. ..
- Effects of the systemic environment on muscle agingIrina Conboy; Fiscal Year: 2009..These goals will be approached here in the proposed Specific Aims. ..