Sarah A Compton

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy
    Sarah A Compton
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 285:13349-56. 2010
  2. pmc Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain
    Anthony J Cesare
    Corresonding author Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell Biol 28:20-9. 2008
  3. pmc The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer
    Sarah A Compton
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 283:24478-83. 2008
  4. ncbi Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells
    Sarah A Compton
    Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Mason Farm Road, Chapel Hill, NC 27599, USA
    Cancer Res 67:1513-9. 2007
  5. ncbi The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats
    Nicole Fouché
    Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 281:37486-95. 2006

Research Grants

Collaborators

Detail Information

Publications5

  1. pmc Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy
    Sarah A Compton
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 285:13349-56. 2010
    ..This work provides the first EM visualization of BCDX2 and CX3 binding to Holliday junctions and forked DNAs and suggests the complexes form ring-shaped structures...
  2. pmc Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain
    Anthony J Cesare
    Corresonding author Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell Biol 28:20-9. 2008
    ..These results suggest that disruption of Rap1 results in elevated recombination at telomeres, leading to increased strand invasion of the 3' overhang within t-loop junctions and resolution of the t-loop junctions into free t-circles...
  3. pmc The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer
    Sarah A Compton
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 283:24478-83. 2008
    ..Calculations of the molecular weight of full-length WRN revealed that, in solution, WRN exists predominantly as a dimer. However, WRN bound to DNA is larger; the mass is consistent with that of a tetramer...
  4. ncbi Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells
    Sarah A Compton
    Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Mason Farm Road, Chapel Hill, NC 27599, USA
    Cancer Res 67:1513-9. 2007
    ..We show that Xrcc3 and Nbs1 are indeed required for the production of t circles in human ALT. However, these cells continue to proliferate in the absence of t circles, suggesting that they are not required for the survival of ALT cells...
  5. ncbi The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats
    Nicole Fouché
    Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 281:37486-95. 2006
    ..Junction-specific binding would also allow TRF2 to stabilize a strand invasion structure that is thought to exist at the strand invasion site of the t-loop...

Research Grants1