Lucio Comai

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells
    Baomin Li
    Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Aging (Albany NY) 3:395-406. 2011
  2. pmc A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction
    JOSE CANDELARIO
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Aging (Albany NY) 4:567-77. 2012
  3. pmc CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction
    Chih Yin Lin
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Nucleic Acids Res 34:4752-66. 2006
  4. pmc Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity
    Baomin Li
    Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Aging (Albany NY) 1:289-302. 2009
  5. ncbi The Werner syndrome protein at the crossroads of DNA repair and apoptosis
    Lucio Comai
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Mech Ageing Dev 125:521-8. 2004
  6. pmc RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP
    Warunee Dansithong
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, 2250 Alcazar Street, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    EMBO Rep 12:735-42. 2011
  7. pmc Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing
    Sharan Paul
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    EMBO J 25:4271-83. 2006
  8. pmc WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening
    Baomin Li
    Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, 2250 Alcazar St, CSC 264, Los Angeles, CA 90033, USA
    Mol Cell Biol 28:1892-904. 2008
  9. pmc Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex
    Sharan Paul
    Department of Biochemistry, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 286:38427-38. 2011
  10. ncbi Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1
    Baomin Li
    Departments of Molecular Microbiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 279:13659-67. 2004

Collaborators

Detail Information

Publications27

  1. pmc Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells
    Baomin Li
    Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Aging (Albany NY) 3:395-406. 2011
    ..These findings demonstrate that non homology-based processes contribute to the maintenance of t-circles and proliferation of ALT cells...
  2. pmc A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction
    JOSE CANDELARIO
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Aging (Albany NY) 4:567-77. 2012
    ..These findings suggest a potential link between this transcription factor and cell dysfunction induced by altered prelamin A metabolism...
  3. pmc CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction
    Chih Yin Lin
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Nucleic Acids Res 34:4752-66. 2006
    ..These data demonstrate that CK2 is recruited to the rRNA gene promoter and directly regulates Pol I transcription re-initiation by stabilizing the association between UBF and SL1...
  4. pmc Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity
    Baomin Li
    Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Aging (Albany NY) 1:289-302. 2009
    ....
  5. ncbi The Werner syndrome protein at the crossroads of DNA repair and apoptosis
    Lucio Comai
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Mech Ageing Dev 125:521-8. 2004
    ....
  6. pmc RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP
    Warunee Dansithong
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, 2250 Alcazar Street, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    EMBO Rep 12:735-42. 2011
    ..These results demonstrate a role for the inactivation of SHARP transcription in DM1 biology...
  7. pmc Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing
    Sharan Paul
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    EMBO J 25:4271-83. 2006
    ..These data demonstrate that coordinated physical and functional interactions between hnRNP H, CUG-BP1 and MBNL1 dictate IR splicing in normal and DM1 myoblasts...
  8. pmc WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening
    Baomin Li
    Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, 2250 Alcazar St, CSC 264, Los Angeles, CA 90033, USA
    Mol Cell Biol 28:1892-904. 2008
    ..Thus, WRN has a key protective function at telomeres which influences telomere topology and inhibits accelerated attrition of telomeres...
  9. pmc Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex
    Sharan Paul
    Department of Biochemistry, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 286:38427-38. 2011
    ..Thus expression of expanded CUG repeats alters the stoichiometry of MBNL1(CUG) complexes to allow both the reinforcement and expansion of RNA processing defects...
  10. ncbi Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1
    Baomin Li
    Departments of Molecular Microbiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 279:13659-67. 2004
    ....
  11. pmc RNA splicing is responsive to MBNL1 dose
    Sonali P Jog
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, University of Southern California, Los Angeles, California, USA
    PLoS ONE 7:e48825. 2012
    ....
  12. doi Altered nuclear functions in progeroid syndromes: a paradigm for aging research
    Baomin Li
    Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
    ScientificWorldJournal 9:1449-62. 2009
    ....
  13. pmc A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in Arabidopsis
    Baomin Li
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, LA, USA
    Nucleic Acids Res 33:6861-7. 2005
    ....
  14. doi Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis
    JOSE CANDELARIO
    Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Exp Cell Res 317:319-29. 2011
    ....
  15. ncbi Modifications of both selectivity factor and upstream binding factor contribute to poliovirus-mediated inhibition of RNA polymerase I transcription
    Rajeev Banerjee
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Gen Virol 86:2315-22. 2005
    ..These results suggested that both SL-1 and UBF are transcriptionally inactivated in PV-infected HeLa cells...
  16. pmc Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features
    Warunee Dansithong
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, University of Southern California, Los Angeles, CA, USA
    PLoS ONE 3:e3968. 2008
    ....
  17. pmc Perturbation of wild-type lamin A metabolism results in a progeroid phenotype
    JOSE CANDELARIO
    Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Aging Cell 7:355-67. 2008
    ....
  18. pmc PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex
    Cheng Zhang
    Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, Los Angeles, 90033, USA
    Mol Cell Biol 25:6899-911. 2005
    ..Furthermore, PTEN induces dissociation of the SL1 subunits. Together, these results demonstrate that PTEN represses RNA Pol I transcription through a novel mechanism that involves disruption of the SL1 complex...
  19. ncbi The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF
    Chih Yin Lin
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Curr Biol 12:2142-6. 2002
    ..Thus, TAF1 may be involved in the coordinate expression of Pol I- and Pol II-transcribed genes required for protein biosynthesis and cell cycle progression...
  20. doi Lamin A, farnesylation and aging
    Sita Reddy
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Exp Cell Res 318:1-7. 2012
    ....
  21. pmc Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes
    Keigo Machida
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 185:6985-98. 2010
    ..These effects may explain the oncogenicity and immunological perturbation of HCV infection...
  22. ncbi Mechanism of RNA polymerase I transcription
    Lucio Comai
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Adv Protein Chem 67:123-55. 2004
  23. pmc Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein
    Baomin Li
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, HMR 509, Los Angeles, CA 90089, USA
    Nucleic Acids Res 30:3653-61. 2002
    ..Moreover, exonuclease assays indicate that DNA-PKcs does not protect DNA from the nucleolytic action of WRN. These results suggest that WRN may influence the mechanism by which DNA ends are processed...
  24. pmc Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system
    Federica Madia
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    J Cell Biol 180:67-81. 2008
    ..The conserved function of Akt/S6k homologues in lifespan regulation raises the possibility that modulation of the IGF-I-Akt-56K pathway can protect against premature aging syndromes in mammals...
  25. ncbi Coimmunoprecipitation assay for the detection of kinase-substrate interactions
    Lucio Comai
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 218:277-84. 2003
    ....
  26. ncbi MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1
    Warunee Dansithong
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Biol Chem 280:5773-80. 2005
    ..The data therefore support MBNL1-mediated therapy for DM1...
  27. pmc Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain
    Yingge Liu
    Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Biochemistry 48:7525-32. 2009
    ..We show that the activity of LYP is inhibited by an intramolecular mechanism, whereby the proximal portion of the interdomain directly interacts with the catalytic domain and reduces its activity...

Research Grants16

  1. Role of the Werner syndrome protein complex in the metabolism of chromosome ends
    Lucio Comai; Fiscal Year: 2010
    ....
  2. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2004
    ..These studies will provide important insights into the mechanistic basis of cell transformation by viral oncogenes. ..
  3. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2002
    ..These studies will provide new insights on the molecular mechanisms of mammalian gene regulation and will unravel some of the strategies adopted by small DNA viruses such as SV40 to alter the regulation of key cellular processes. ..
  4. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2001
    ..These studies will provide new insights on the molecular mechanisms of mammalian gene regulation and will unravel some of the strategies adopted by small DNA viruses such as SV40 to alter the regulation of key cellular processes. ..
  5. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2007
    ..These studies will provide important insights into the mechanistic basis of cell transformation by viral oncogenes. ..
  6. The Werner syndrome protein in CPT-induced DNA damage
    Lucio Comai; Fiscal Year: 2007
    ..Taken together, these experiments should provide important mechanistic insights into the process of human aging. ..
  7. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2006
    ..These studies will provide important insights into the mechanistic basis of cell transformation by viral oncogenes. ..
  8. The Werner syndrome protein in CPT-induced DNA damage
    Lucio Comai; Fiscal Year: 2006
    ..Taken together, these experiments should provide important mechanistic insights into the process of human aging. ..
  9. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 1999
    ..These studies will provide new insights on the molecular mechanisms of mammalian gene regulation and will unravel some of the strategies adopted by small DNA viruses such as SV40 to alter the regulation of key cellular processes. ..
  10. The Werner syndrome protein in CPT-induced DNA damage
    Lucio Comai; Fiscal Year: 2005
    ..Taken together, these experiments should provide important mechanistic insights into the process of human aging. ..
  11. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2000
    ..These studies will provide new insights on the molecular mechanisms of mammalian gene regulation and will unravel some of the strategies adopted by small DNA viruses such as SV40 to alter the regulation of key cellular processes. ..
  12. The Werner syndrome protein in CPT-induced DNA damage
    Lucio Comai; Fiscal Year: 2004
    ..Taken together, these experiments should provide important mechanistic insights into the process of human aging. ..
  13. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2005
    ..These studies will provide important insights into the mechanistic basis of cell transformation by viral oncogenes. ..