Research Topics
Genomes and Genes
| Lucio ComaiSummaryAffiliation: University of Southern California Country: USA Publications
Research Grants
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Detail Information
Publications
The Werner syndrome protein at the crossroads of DNA repair and apoptosisLucio Comai
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Mech Ageing Dev 125:521-8. 2004....
RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARPWarunee Dansithong
Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, 2250 Alcazar Street, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
EMBO Rep 12:735-42. 2011..These results demonstrate a role for the inactivation of SHARP transcription in DM1 biology...
Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complexSharan Paul
Department of Biochemistry, University of Southern California, Los Angeles, California 90033, USA
J Biol Chem 286:38427-38. 2011..Thus expression of expanded CUG repeats alters the stoichiometry of MBNL1(CUG) complexes to allow both the reinforcement and expansion of RNA processing defects...
CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interactionChih-Yin Lin
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
Nucleic Acids Res 34:4752-66. 2006..These data demonstrate that CK2 is recruited to the rRNA gene promoter and directly regulates Pol I transcription re-initiation by stabilizing the association between UBF and SL1...- Altered nuclear functions in progeroid syndromes: a paradigm for aging researchBaomin Li
Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
ScientificWorldJournal 9:1449-62. 2009.... - Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasisJOSE CANDELARIO
Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Exp Cell Res 317:319-29. 2011.... - Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 featuresWarunee Dansithong
Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, University of Southern California, Los Angeles, CA, USA
PLoS ONE 3:e3968. 2008.... - WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shorteningBaomin Li
Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, 2250 Alcazar St, CSC 264, Los Angeles, CA 90033, USA
Mol Cell Biol 28:1892-904. 2008..Thus, WRN has a key protective function at telomeres which influences telomere topology and inhibits accelerated attrition of telomeres... - Modifications of both selectivity factor and upstream binding factor contribute to poliovirus-mediated inhibition of RNA polymerase I transcriptionRajeev Banerjee
Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
J Gen Virol 86:2315-22. 2005..These results suggested that both SL-1 and UBF are transcriptionally inactivated in PV-infected HeLa cells... - Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activityBaomin Li
Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, University of Southern California, Los Angeles, CA 90033, USA
Aging (Albany NY) 1:289-302. 2009.... - Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cellsBaomin Li
Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Aging (Albany NY) 3:395-406. 2011..These findings demonstrate that non homology-based processes contribute to the maintenance of t-circles and proliferation of ALT cells... - A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in ArabidopsisBaomin Li
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, LA, USA
Nucleic Acids Res 33:6861-7. 2005.... - Lamin A, farnesylation and agingSita Reddy
Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Exp Cell Res 318:1-7. 2012.... - Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1Baomin Li
Departments of Molecular Microbiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Biol Chem 279:13659-67. 2004.... - RNA Splicing Is Responsive to MBNL1 DoseSonali P Jog
Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, University of Southern California, Los Angeles, California, United States of America
PLoS ONE 7:e48825. 2012.... - PTEN represses RNA Polymerase I transcription by disrupting the SL1 complexCheng Zhang
Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, Los Angeles, 90033, USA
Mol Cell Biol 25:6899-911. 2005..Furthermore, PTEN induces dissociation of the SL1 subunits. Together, these results demonstrate that PTEN represses RNA Pol I transcription through a novel mechanism that involves disruption of the SL1 complex... - Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytesKeigo Machida
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Immunol 185:6985-98. 2010..These effects may explain the oncogenicity and immunological perturbation of HCV infection... - Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicingSharan Paul
Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
EMBO J 25:4271-83. 2006..These data demonstrate that coordinated physical and functional interactions between hnRNP H, CUG-BP1 and MBNL1 dictate IR splicing in normal and DM1 myoblasts... - Mechanism of RNA polymerase I transcriptionLucio Comai
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Adv Protein Chem 67:123-55. 2004 - A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunctionJOSE CANDELARIO
Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
Aging (Albany NY) 4:567-77. 2012..These findings suggest a potential link between this transcription factor and cell dysfunction induced by altered prelamin A metabolism... - Perturbation of wild-type lamin A metabolism results in a progeroid phenotypeJOSE CANDELARIO
Department of Molecular Microbiology and Immunology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Aging Cell 7:355-67. 2008.... - Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model systemFederica Madia
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
J Cell Biol 180:67-81. 2008..The conserved function of Akt/S6k homologues in lifespan regulation raises the possibility that modulation of the IGF-I-Akt-56K pathway can protect against premature aging syndromes in mammals... - Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomainYingge Liu
Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
Biochemistry 48:7525-32. 2009..We show that the activity of LYP is inhibited by an intramolecular mechanism, whereby the proximal portion of the interdomain directly interacts with the catalytic domain and reduces its activity... - The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBFChih Yin Lin
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Curr Biol 12:2142-6. 2002..Thus, TAF1 may be involved in the coordinate expression of Pol I- and Pol II-transcribed genes required for protein biosynthesis and cell cycle progression... - Displacement of DNA-PKcs from DNA ends by the Werner syndrome proteinBaomin Li
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, HMR 509, Los Angeles, CA 90089, USA
Nucleic Acids Res 30:3653-61. 2002..Moreover, exonuclease assays indicate that DNA-PKcs does not protect DNA from the nucleolytic action of WRN. These results suggest that WRN may influence the mechanism by which DNA ends are processed...
Research Grants
- VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTIONLucio Comai; Fiscal Year: 2007..These studies will provide important insights into the mechanistic basis of cell transformation by viral oncogenes. ..
- The Werner syndrome protein in CPT-induced DNA damageLucio Comai; Fiscal Year: 2007..Taken together, these experiments should provide important mechanistic insights into the process of human aging. ..
- VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTIONLucio Comai; Fiscal Year: 2002..These studies will provide new insights on the molecular mechanisms of mammalian gene regulation and will unravel some of the strategies adopted by small DNA viruses such as SV40 to alter the regulation of key cellular processes. ..
- Role of the Werner syndrome protein complex in the metabolism of chromosome endsLucio Comai; Fiscal Year: 2010....