CHRISTOPHER SCOTT COLWELL

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The Q175 mouse model of Huntington's disease shows gene dosage- and age-related decline in circadian rhythms of activity and sleep
    Dawn H Loh
    Laboratory of Circadian and Sleep Medicine, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 8:e69993. 2013
  2. pmc Voluntary scheduled exercise alters diurnal rhythms of behaviour, physiology and gene expression in wild-type and vasoactive intestinal peptide-deficient mice
    ANALYNE M SCHROEDER
    Department of Psychiatry and Biobehavioral Sciences, Laboratory of Circadian and Sleep Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
    J Physiol 590:6213-26. 2012
  3. pmc Select cognitive deficits in vasoactive intestinal peptide deficient mice
    Dipesh Chaudhury
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, California 90024 1759, USA
    BMC Neurosci 9:63. 2008
  4. pmc Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus
    Stephan Michel
    Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Neurosci 7:15. 2006
  5. ncbi request reprint Disrupted circadian rhythms in VIP- and PHI-deficient mice
    Christopher S Colwell
    Mental Retardation Res Ctr, Univ of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Am J Physiol Regul Integr Comp Physiol 285:R939-49. 2003
  6. ncbi request reprint Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: role of calcium channels
    C S Colwell
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Brain Res 833:234-41. 1999
  7. doi request reprint Linking neural activity and molecular oscillations in the SCN
    Christopher S Colwell
    Laboratory of Circadian and Sleep Medicine, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, California 90024, USA
    Nat Rev Neurosci 12:553-69. 2011
  8. ncbi request reprint Circadian modulation of calcium levels in cells in the suprachiasmatic nucleus
    C S Colwell
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioural Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Eur J Neurosci 12:571-6. 2000
  9. pmc Rhythmic coupling among cells in the suprachiasmatic nucleus
    C S Colwell
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, California 90024 1759, USA
    J Neurobiol 43:379-88. 2000
  10. ncbi request reprint Postnatal development of glutamate receptor-mediated responses in the neostriatum
    C S Colwell
    Mental Retardation Research Center, University of California, Los Angeles, CA 90024 1759, USA
    Dev Neurosci 20:154-63. 1998

Research Grants

  1. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 1999
  2. A role for circadian clock genes in hippocampal function?
    Christopher Colwell; Fiscal Year: 2007
  3. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2007
  4. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2006
  5. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2005
  6. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2004
  7. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2003
  8. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2002
  9. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2001
  10. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2000

Collaborators

Detail Information

Publications28

  1. pmc The Q175 mouse model of Huntington's disease shows gene dosage- and age-related decline in circadian rhythms of activity and sleep
    Dawn H Loh
    Laboratory of Circadian and Sleep Medicine, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 8:e69993. 2013
    ....
  2. pmc Voluntary scheduled exercise alters diurnal rhythms of behaviour, physiology and gene expression in wild-type and vasoactive intestinal peptide-deficient mice
    ANALYNE M SCHROEDER
    Department of Psychiatry and Biobehavioral Sciences, Laboratory of Circadian and Sleep Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
    J Physiol 590:6213-26. 2012
    ..Our results raise the possibility that scheduled exercise could be used as a tool to modulate daily rhythms and, when applied, may counteract some of the negative impacts of ageing and disease on the circadian system...
  3. pmc Select cognitive deficits in vasoactive intestinal peptide deficient mice
    Dipesh Chaudhury
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, California 90024 1759, USA
    BMC Neurosci 9:63. 2008
    ..Among other actions, the loss of VIP has a profound effect on circadian timing and may specifically influence the temporal regulation of learning and memory functions...
  4. pmc Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus
    Stephan Michel
    Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Neurosci 7:15. 2006
    ....
  5. ncbi request reprint Disrupted circadian rhythms in VIP- and PHI-deficient mice
    Christopher S Colwell
    Mental Retardation Res Ctr, Univ of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Am J Physiol Regul Integr Comp Physiol 285:R939-49. 2003
    ..Together, the observations suggest that VIP/PHI peptides are critically involved in both the generation of circadian oscillations as well as the normal synchronization of these rhythms to light...
  6. ncbi request reprint Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: role of calcium channels
    C S Colwell
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Brain Res 833:234-41. 1999
    ..Again this effect was blocked by omega-conotoxin GVIA. Overall the results suggest that mGluR regulation of voltage-gated calcium channels can limit NMDA toxicity in the neostriatum...
  7. doi request reprint Linking neural activity and molecular oscillations in the SCN
    Christopher S Colwell
    Laboratory of Circadian and Sleep Medicine, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, California 90024, USA
    Nat Rev Neurosci 12:553-69. 2011
    ..This article reviews our current understanding of the ionic and molecular mechanisms that drive the rhythmic firing patterns in the SCN...
  8. ncbi request reprint Circadian modulation of calcium levels in cells in the suprachiasmatic nucleus
    C S Colwell
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioural Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Eur J Neurosci 12:571-6. 2000
    ..Because [Ca2+]i is known to play a critical role in many cellular processes, the presence of this rhythm is likely to have many implications for the cell biology of SCN neurons...
  9. pmc Rhythmic coupling among cells in the suprachiasmatic nucleus
    C S Colwell
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, California 90024 1759, USA
    J Neurobiol 43:379-88. 2000
    ..Together the results are consistent with a model in which gap junctions provide a means to couple SCN neurons on a circadian basis...
  10. ncbi request reprint Postnatal development of glutamate receptor-mediated responses in the neostriatum
    C S Colwell
    Mental Retardation Research Center, University of California, Los Angeles, CA 90024 1759, USA
    Dev Neurosci 20:154-63. 1998
    ..The NMDA receptor subtype displays minimal functional development until PND 14. In contrast, neostriatal AMPA/KA receptor function appears to precede NMDA receptor function...
  11. ncbi request reprint Selective deficits in the circadian light response in mice lacking PACAP
    C S Colwell
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024 1759, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1194-201. 2004
    ..The results reported here show that the loss of PACAP produced selective deficits in the light response of the circadian system...
  12. pmc Circadian rhythm in inhibitory synaptic transmission in the mouse suprachiasmatic nucleus
    Jason Itri
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Science, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    J Neurophysiol 92:311-9. 2004
    ..Overall, these data demonstrate that there is a circadian rhythm in GABAergic transmission in the dorsal region of the mouse SCN and that the VIP is required for expression of this rhythm...
  13. doi request reprint The role of the neuropeptides PACAP and VIP in the photic regulation of gene expression in the suprachiasmatic nucleus
    Joanna M Dragich
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Eur J Neurosci 31:864-75. 2010
    ..Furthermore, VIP, but not PACAP, is required for the appropriate temporal gating of light-induced gene expression within the SCN...
  14. ncbi request reprint Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene
    Erin C Jacobs
    Neuropsychiatric Institute, University of California Los Angeles School of Medicine, Los Angeles, California 90024, USA
    J Neurosci 25:7004-13. 2005
    ..Together, all these findings suggest a role for golli proteins in oligodendrocyte differentiation, migration, and/or myelin elaboration in the brain...
  15. pmc Fast delayed rectifier potassium current is required for circadian neural activity
    Jason N Itri
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, California 90024 1759, USA
    Nat Neurosci 8:650-6. 2005
    ..We conclude that the FDR is necessary for the circadian modulation of electrical activity in SCN neurons and represents an important part of the ionic basis for the generation of rhythmic output...
  16. ncbi request reprint Regulation of inhibitory synaptic transmission by vasoactive intestinal peptide (VIP) in the mouse suprachiasmatic nucleus
    Jason Itri
    Mental Retardation Research Center, Department of Psychiatry, University of California, Los Angeles, California 90024 1759, USA
    J Neurophysiol 90:1589-97. 2003
    ..Our data suggest that VIP activates presynaptic VPAC2 receptors to regulate inhibitory synaptic transmission within the SCN and that this effect varies from day to night...
  17. pmc Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels
    Takahiro J Nakamura
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90024, USA
    Steroids 75:203-12. 2010
    ....
  18. pmc Vasoactive intestinal peptide is critical for circadian regulation of glucocorticoids
    Dawn H Loh
    Semel Institute for Neuroscience, Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Calif 90024 1759, USA
    Neuroendocrinology 88:246-55. 2008
    ..The aim of our study was to examine the possible role of VIP in driving circadian rhythms in the hypothalamic-pituitary-adrenal axis...
  19. ncbi request reprint Circadian modulation of learning and memory in fear-conditioned mice
    Dipesh Chaudhury
    Department of Psychiatry and Biobehavioral Sciences, Mental Retardation Research Center, University of California Los Angeles, 760 Westwood Plaza, 90024 1759, USA
    Behav Brain Res 133:95-108. 2002
    ..When we reversed the phase of the LD cycle, the phase of the rhythm also reversed. Importantly, all three of the rhythms also continued in constant darkness demonstrating the endogenous, and presumably circadian nature, of the rhythms...
  20. ncbi request reprint Golli protein negatively regulates store depletion-induced calcium influx in T cells
    Ji Ming Feng
    Semel Institute of Neuroscience and Human Behavior, UCLA Geffen School of Medicine, 635 Charles Young Drive, Los Angeles, California 90095, USA
    Immunity 24:717-27. 2006
    ..These results indicate that golli functions in a unique way to regulate T cell activation through a mechanism involving the modulation of the calcium homeostasis...
  21. pmc Circadian regulation of hippocampal long-term potentiation
    Dipesh Chaudhury
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024 1759, USA
    J Biol Rhythms 20:225-36. 2005
    ..These results provide the 1st evidence that an endogenous circadian oscillator modulates synaptic plasticity in the hippocampus...
  22. pmc Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors
    Stephan Michel
    Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024 1759, USA
    J Neurophysiol 88:817-28. 2002
    ..Overall, our data suggest that glutamatergic synaptic transmission mediated by AMPA/KA GluRs play an important role throughout the SCN synaptic circuitry...
  23. pmc Vasoactive intestinal peptide and the mammalian circadian system
    Andrew M Vosko
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Gen Comp Endocrinol 152:165-75. 2007
    ....
  24. pmc Circadian regulation of a-type potassium currents in the suprachiasmatic nucleus
    Jason N Itri
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    J Neurophysiol 103:632-40. 2010
    ..Additionally, these data suggest a role for IA in the regulation of spontaneous action potential firing during the transitions between day/night and in the integration of synaptic inputs to SCN neurons throughout the daily cycle...
  25. pmc Melatonin inhibits hippocampal long-term potentiation
    Louisa M Wang
    Department of Psychiatry and Biobehavioural Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, California 90024 1759, USA
    Eur J Neurosci 22:2231-7. 2005
    ..These results suggest that hippocampal synaptic plasticity may be constrained by melatonin through a mechanism involving MT2-receptor-mediated regulation of the adenylyl cyclase-protein kinase A pathway...
  26. doi request reprint Circadian regulation of cardiovascular function: a role for vasoactive intestinal peptide
    Analyne Schroeder
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024, USA
    Am J Physiol Heart Circ Physiol 300:H241-50. 2011
    ..These results demonstrate that VIP is an important regulator of physiological circadian rhythmicity in the heart...

Research Grants11

  1. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 1999
    ..Finally, the proposed work will determine whether a model developed to explain synchronization of molluscan circadian oscillators can be applied to the mammalian SCN. ..
  2. A role for circadian clock genes in hippocampal function?
    Christopher Colwell; Fiscal Year: 2007
    ..This line of research has not been previously funded, is exploratory in nature, and thus qualifies under the R21 format. ..
  3. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2007
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..
  4. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2006
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..
  5. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2005
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..
  6. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2004
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..
  7. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2003
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..
  8. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2002
    ..Finally, the proposed work will determine whether a model developed to explain synchronization of molluscan circadian oscillators can be applied to the mammalian SCN. ..
  9. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2001
    ..Finally, the proposed work will determine whether a model developed to explain synchronization of molluscan circadian oscillators can be applied to the mammalian SCN. ..
  10. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2000
    ..Finally, the proposed work will determine whether a model developed to explain synchronization of molluscan circadian oscillators can be applied to the mammalian SCN. ..