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Genomes and GenesSpecies | Ricki J ColmanSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Skeletal effects of long-term caloric restriction in rhesus monkeysRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
Age (Dordr) 34:1133-43. 2012..Circulating serum markers of bone turnover were not different between C and R with nonsignficant diet-by-time interactions. We believe the lower bone mass in R animals reflects the smaller body size and not pathological osteopenia...- Nonhuman primate calorie restrictionRicki J Colman
Wisconsin National Primate Research Center, SMPH, University of Wisconsin, Madison, Wisconsin 53715, USA
Antioxid Redox Signal 14:229-39. 2011..Finally, we highlight the importance of primate studies in the context of aging research and its potential to advance our understanding of human aging and health... - Caloric restriction delays disease onset and mortality in rhesus monkeysRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
Science 325:201-4. 2009..Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species... - Attenuation of sarcopenia by dietary restriction in rhesus monkeysRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin Madison, 1220 Capitol Ct, Madison, WI 53715, USA
J Gerontol A Biol Sci Med Sci 63:556-9. 2008..Body weight-adjusted skeletal muscle mass declined somewhat in both groups but was far more rapid in the control group. We have shown that moderate, adult-onset DR can attenuate sarcopenia in a nonhuman primate model... 
Muscle mass loss in Rhesus monkeys: age of onsetRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin, Madison, 53715, USA
Exp Gerontol 40:573-81. 2005..5 years of age. Furthermore, our data indicate percentage declines in ESM similar to those seen in humans with advancing age. These data support the suitability of the Rhesus monkey as a primate sarcopenia model...- A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeysErik K Kastman
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
J Neurosci 32:11897-904. 2012..Our observations suggest that the CR-induced benefit of reduced iron deposition and preserved motor function may indicate neural protection similar to effects described previously in aging rodent and primate species... - Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeysAuriel A Willette
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Psychoneuroendocrinology 37:903-16. 2012..Dietary interventions, such as calorie restriction (CR), affect stress biology and may moderate the pathogenic relationship between stress reactivity and brain in limbic and prefrontal regions... - Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeysAuriel A Willette
Harlow Primate Laboratory, Department of Psychology, University of Wisconsin Madison, Madison, WI, USA
Neurobiol Aging 33:670-80. 2012..The data suggest that CR may ameliorate the influence of Hcy on several important age-related parameters of parenchymal health... - Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeysAuriel A Willette
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA
Diabetes 61:1036-42. 2012..These results suggest that CR improves glucose regulation and may positively influence specific brain regions and at least motor task performance. Additional studies are warranted to validate these relationships... - Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeysSusan H McKiernan
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States
Exp Gerontol 47:229-36. 2012..We suggest that muscle fibers from CR animals are better poised to endure and adapt to changes in muscle mass than those of Control animals... - Influences of calorie restriction and age on energy expenditure in the rhesus monkeyAarthi Raman
Nutritional Sciences, Univ of Wisconsin Madison, 1415 Linden Dr, Madison, WI 53607, USA
Am J Physiol Endocrinol Metab 292:E101-6. 2007..077). Night EE did not differ between calorie-restricted and C younger monkeys after adjusting for FFM and FM. In conclusion, CR did not alter the age-related decrease in EE with CR... - Dietary restriction and beta-cell sensitivity to glucose in adult male rhesus monkeysTheresa A Gresl
Wisconsin National Primate Research Center and Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, 53715, USA
J Gerontol A Biol Sci Med Sci 58:598-610. 2003..Enhanced peripheral insulin sensitivity among R monkeys was strongly correlated with lower Ø(b)... - Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeysCristin M Bruns
Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
J Clin Endocrinol Metab 89:6218-23. 2004..52, 711.89); P < 0.02]. PA males do not exhibit elevated androgens during adulthood, suggesting that insulin resistance and impaired pancreatic beta-cell function may result from fetal reprogramming of key metabolic tissues... - Metabolizable energy intake during long-term calorie restriction in rhesus monkeysAarthi Raman
Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
Exp Gerontol 42:988-94. 2007..Use of diet weight is a reasonable estimate of the level of CR when food waste is assessed... - Effects of caloric restriction on cardiovascular aging in non-human primates and humansChristina Cruzen
Wisconsin National Primate Research Center, University of Wisconsin Madison, 1220 Capitol Court, Madison, WI 53715, USA
Clin Geriatr Med 25:733-43, ix-x. 2009..This article reviews evidence that CR in nonhuman primates and people has a positive effect on risk factors for CVD... - Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscleSusan H McKiernan
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States
Exp Gerontol 46:23-9. 2011..CR did not prevent stochastic mitochondrial deletion mutations in muscle fibers but CR may have contributed to the maintenance of affected fibers... - Reference body composition in adult rhesus monkeys: glucoregulatory and anthropometric indicesAarthi Raman
Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA
J Gerontol A Biol Sci Med Sci 60:1518-24. 2005..The estimated reference range for %BF was 9%-23% in male and 8%-18% in female monkeys, corresponding to body mass indices of 32-44 kg/m(2) for male and 27-35 kg/m(2) for female monkeys... - Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeysAadhavi Sridharan
Neuroscience Training Program, University of Wisconsin Madison Madison, WI, USA Medical Scientist Training Program, University of Wisconsin Madison Madison, WI, USA
Front Aging Neurosci 4:31. 2012..Finally, these brain-behavior correlations for the motor task were attenuated in CR animals compared to controls, indicating a potential protective effect of the dietary intervention... 
Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: A preliminary quantitative imaging studyAadhavi Sridharan
Medical Scientist Training Program, University of Wisconsin Madison, 750 Highland Ave, Madison, WI 53705, USA Neuroscience Training Program, University of Wisconsin Madison, 1300 University Ave, Madison, WI 53706, USA
Brain Res 1508:1-8. 2013..The present study is a preliminary post-mortem histological analysis of the effects of CR on brain health, and further studies using molecular and biochemical techniques are warranted to elucidate underlying mechanisms...- Early-to-mid gestation fetal testosterone increases right hand 2D:4D finger length ratio in polycystic ovary syndrome-like monkeysAndrew D Abbott
Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, United States of America
PLoS ONE 7:e42372. 2012..As variation in timing and duration of gestational T exposure alter male-like dimensions of RH2D independently of RH4D, postnatal RH2D:4D provides a complex biomarker for fetal T exposure... - Insulin sensitivity and glucose effectiveness from three minimal models: effects of energy restriction and body fat in adult male rhesus monkeysTheresa A Gresl
Wisconsin Primate Research Center, 1220 Capitol Court, Madison, WI 53715, USA
Am J Physiol Regul Integr Comp Physiol 285:R1340-54. 2003..The observed insulin sensitivity indexes from all models, elevated among R vs. C monkeys, may be explained, at least in part, by the difference in body fat content between these groups after chronic DR... - Energy restriction-induced changes in body composition are age specific in miceRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
J Nutr 137:2247-51. 2007..Our data refute the hypothesis that ER causes a unique change in body composition that is conserved across age and suggest that fat loss may not be an essential component of the anti-aging effects of ER... - Increased adiposity in female rhesus monkeys exposed to androgen excess during early gestationJoel R Eisner
Wisconsin Primate Research Center, Department of Obstetrics and Gynecology, Endocrinology-Reproductive Physiology Program, University of Wisconsin, Madison, Wisconsin, USA
Obes Res 11:279-86. 2003..This study establishes alterations in abdominal adiposity as another consequence of prenatal androgen excess in female rhesus monkeys that may contribute to the impaired insulin secretion observed in these animals during adulthood... - Glucoregulatory function in adult rhesus macaques (Macaca mulatta) undergoing treatment with medroxyprogesterone acetate for endometriosisChristina L Cruzen
Wisconsin National Primate Research Center, University of Wisconsin Madison, WI, USA
J Am Assoc Lab Anim Sci 50:921-5. 2011..These data suggest that glucoregulatory function should be considered when endometriosis treatment is planned for rhesus macaques... - Body weight impact on puberty: effects of high-calorie diet on puberty onset in female rhesus monkeysEi Terasawa
Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
Endocrinology 153:1696-705. 2012..The findings of this study suggest the importance of close monitoring of juvenile feeding behaviors as an important intervention to reduce the prevalence of precocious development and metabolic diseases in adulthood... - α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissuesGuorui Huang
Department of Cell and Regenerative Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
J Clin Invest 121:769-83. 2011..Our results underscore the emerging view of the importance of ECM to the microenvironments that inform proper development/functioning of specialized cells, such as adipocytes, β cells, and skeletal muscle... - A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeysErik K Kastman
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
J Neurosci 30:7940-7. 2010..Our observations suggest that the CR-induced benefit of reduced iron deposition and preserved motor function may indicate neural protection similar to effects described previously in aging rodent and primate species... - Aspects of common marmoset basic biology and life history important for biomedical researchDavid H Abbott
Wisconsin Primate Research Center, Department of OB/GYN, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715, USA
Comp Med 53:339-50. 2003..These differences, however, permit the use of common marmosets in unconventional research strategies targeted on human pathology... - Sex differences in spinal osteoarthritis in humans and rhesus monkeys (Macaca mulatta)Andrea E Duncan
Department of Anthropology, University of Washington, Seattle, WA 98195, USA
Spine (Phila Pa 1976) 37:915-22. 2012..Retrospective study of male and female spinal osteoarthritis, characterized by lateral spine thoracolumbar radiographs, in humans and nonhuman primates... - Prospects and perspectives in primate aging researchRozalyn M Anderson
Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
Antioxid Redox Signal 14:203-5. 2011.... - Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locusMaureen K Bunger
McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
Genesis 41:122-32. 2005..This pathology appears to explain the decreased activity of Mop3 null mice and suggests that MOP3 is an inhibitor of ligament and tendon ossification... - The influence of sex hormones on circulating nitric oxide (NOx) levels in rhesus monkeys (Macaca Mulatta)Omid Khorram
Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI, USA
Med Sci Monit 8:BR489-95. 2002..Circulating NOx was higher during the luteal phase. In both ERT treated and cycling monkeys estradiol correlated negatively with NOx suggesting the existence of a negative feedback of NO on either NOS activity or expression...