Michael D Collins

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Retinoid-induced limb malformations
    Grace S Lee
    Molecular Toxicology Interdepartmental Program, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
    Curr Pharm Des 10:2657-99. 2004
  2. ncbi request reprint Differential teratogenesis of all-trans-retinoic acid administered on gestational day 9.5 to SWV and C57BL/6N mice: emphasis on limb dysmorphology
    M D Collins
    Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Birth Defects Res A Clin Mol Teratol 76:96-106. 2006
  3. ncbi request reprint Teratology of retinoids
    M D Collins
    Department of Environmental Health Sciences, University of California at Los Angeles, School of Public Health 90095 1735, USA
    Annu Rev Pharmacol Toxicol 39:399-430. 1999
  4. ncbi request reprint Comparative molecular pathology of cadmium- and all-trans-retinoic acid-induced postaxial forelimb ectrodactyly
    Xiaoyan Liao
    Department of Environmental Health Sciences, UCLA School of Public Health, Los Angeles, CA 90095, USA
    Toxicol Appl Pharmacol 225:47-60. 2007
  5. doi request reprint Genetic and pathologic aspects of retinoic acid-induced limb malformations in the mouse
    Grace S Lee
    Molecular Toxicology Interdepartmental Program, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    Birth Defects Res A Clin Mol Teratol 88:863-82. 2010
  6. doi request reprint Sensitivity to cadmium-chloride-induced forelimb ectrodactyly is independent of the p53 gene-dosage in the C57BL/6J mouse
    Ahmed F Elsaid
    Molecular Toxicology Interdepartmental Program, University of California at Los Angeles, Los Angeles, California, USA
    Birth Defects Res A Clin Mol Teratol 88:223-7. 2010
  7. doi request reprint All-trans retinoic acid-induced ectopic limb and caudal structures: murine strain sensitivities and pathogenesis
    Xiaoyan Liao
    Department of Environmental Health Sciences, University of California, Los Angeles, California 90095, USA
    Dev Dyn 237:1553-64. 2008
  8. doi request reprint Proteomic analysis to characterize differential mouse strain sensitivity to cadmium-induced forelimb teratogenesis
    Haiyan Chen
    Department of Environmental Health Sciences, University of California, Los Angeles, California, USA
    Birth Defects Res A Clin Mol Teratol 82:187-99. 2008
  9. ncbi request reprint Altered localization of gene expression in both ectoderm and mesoderm is associated with a murine strain difference in retinoic acid-induced forelimb ectrodactyly
    Hirohito Shimizu
    Department of Environmental Health Sciences, UCLA School of Public Health, Los Angeles, California 90095, USA
    Birth Defects Res A Clin Mol Teratol 79:465-82. 2007
  10. pmc A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11
    Grace S Lee
    Molecular Toxicology Interdepartmental Program, UCLA School of Public Health, Los Angeles, California 90095, USA
    Genetics 170:345-53. 2005

Research Grants

Collaborators

  • Rita M Cantor
  • Jon M Fukuto
  • Lisa J Martin
  • H Nau
  • Conrad Wagner
  • Emmanuèle C Délot
  • Thomas Arnhold
  • A G Hendrickx
  • Grace S Lee
  • Xiaoyan Liao
  • Ahmed F Elsaid
  • Hirohito Shimizu
  • A F Machado
  • Gloria E Mao
  • Haiyan Chen
  • D N Hovland
  • Jesús Santos-Guzmán
  • Khaled M M Koriem
  • Pinmanee Boontheung
  • Jian Yu Rao
  • Rachel R Ogorzalek Loo
  • Yongming Xie
  • Joseph A Loo
  • Sudheer R Beedanagari
  • Arin Abnoosian
  • Mitsuko L Yamamoto
  • Euisun Park
  • David N Hovland
  • Devendra M Kochhar
  • Susanne M Henning
  • Jennie C Wang
  • Sharon H Fahr
  • Marie A Caudill
  • Marian E Swendseid
  • W J Scott
  • E F Zimmerman
  • R Weiss
  • G S Lee
  • T L Brown
  • S S Potter
  • W C Fischer
  • D M Supp
  • A N Ernst
  • B K De

Detail Information

Publications24

  1. ncbi request reprint Retinoid-induced limb malformations
    Grace S Lee
    Molecular Toxicology Interdepartmental Program, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
    Curr Pharm Des 10:2657-99. 2004
    ..In this review, phenotypic features, pathogenesis and the molecular basis of retinoid-induced limb malformations are discussed with a description of normal limb development and endogenous retinoid pathways...
  2. ncbi request reprint Differential teratogenesis of all-trans-retinoic acid administered on gestational day 9.5 to SWV and C57BL/6N mice: emphasis on limb dysmorphology
    M D Collins
    Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Birth Defects Res A Clin Mol Teratol 76:96-106. 2006
    ....
  3. ncbi request reprint Teratology of retinoids
    M D Collins
    Department of Environmental Health Sciences, University of California at Los Angeles, School of Public Health 90095 1735, USA
    Annu Rev Pharmacol Toxicol 39:399-430. 1999
    ..The teratogenic activity of various retinoid compounds, the role of the retinoid receptors, and important toxicokinetic parameters in teratogenesis are reviewed...
  4. ncbi request reprint Comparative molecular pathology of cadmium- and all-trans-retinoic acid-induced postaxial forelimb ectrodactyly
    Xiaoyan Liao
    Department of Environmental Health Sciences, UCLA School of Public Health, Los Angeles, CA 90095, USA
    Toxicol Appl Pharmacol 225:47-60. 2007
    ..Collectively, a model is hypothesized where limb patterning can be perturbed by insults to both ectoderm and mesoderm...
  5. doi request reprint Genetic and pathologic aspects of retinoic acid-induced limb malformations in the mouse
    Grace S Lee
    Molecular Toxicology Interdepartmental Program, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    Birth Defects Res A Clin Mol Teratol 88:863-82. 2010
    ..The hypothesis is that these agents have separate molecular pathologic pathways that converge to perturb a common anatomic structure...
  6. doi request reprint Sensitivity to cadmium-chloride-induced forelimb ectrodactyly is independent of the p53 gene-dosage in the C57BL/6J mouse
    Ahmed F Elsaid
    Molecular Toxicology Interdepartmental Program, University of California at Los Angeles, Los Angeles, California, USA
    Birth Defects Res A Clin Mol Teratol 88:223-7. 2010
    ..In this study, the hypothesis that the p53 gene dosage might affect the incidence or severity of CdCl(2)-induced forelimb ectrodactyly was examined...
  7. doi request reprint All-trans retinoic acid-induced ectopic limb and caudal structures: murine strain sensitivities and pathogenesis
    Xiaoyan Liao
    Department of Environmental Health Sciences, University of California, Los Angeles, California 90095, USA
    Dev Dyn 237:1553-64. 2008
    ..We propose that all extra hindlimbs were derived from ectopic axis formation, perturbation of which is genetic background dependent...
  8. doi request reprint Proteomic analysis to characterize differential mouse strain sensitivity to cadmium-induced forelimb teratogenesis
    Haiyan Chen
    Department of Environmental Health Sciences, University of California, Los Angeles, California, USA
    Birth Defects Res A Clin Mol Teratol 82:187-99. 2008
    ....
  9. ncbi request reprint Altered localization of gene expression in both ectoderm and mesoderm is associated with a murine strain difference in retinoic acid-induced forelimb ectrodactyly
    Hirohito Shimizu
    Department of Environmental Health Sciences, UCLA School of Public Health, Los Angeles, California 90095, USA
    Birth Defects Res A Clin Mol Teratol 79:465-82. 2007
    ..Maternal exposure to excess levels of all-trans-retinoic acid (RA) at gestational day 9.5 induces postaxial ectrodactyly (digit loss) in the murine C57BL/6N strain but not in the SWV/Fnn strain...
  10. pmc A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11
    Grace S Lee
    Molecular Toxicology Interdepartmental Program, UCLA School of Public Health, Los Angeles, California 90095, USA
    Genetics 170:345-53. 2005
    ..The human syntenic region of this locus has been previously linked to Meckel syndrome; the phenotype includes postaxial polydactyly, an ectopic digital defect hypothesized to be induced by a common molecular pathway with ectrodactyly...
  11. ncbi request reprint Interactive effects of cadmium and all-trans-retinoic acid on the induction of forelimb ectrodactyly in C57BL/6 mice
    Grace S Lee
    Molecular Toxicology Interdepartmental Program, University of California, Los Angeles School of Public Health, Los Angeles, California 90095, USA
    Birth Defects Res A Clin Mol Teratol 76:19-28. 2006
    ..In the present study, the interactive effects of coadministration of cadmium and RA on developing limbs were investigated...
  12. ncbi request reprint Effect of arsenite, maternal age, and embryonic sex on spina bifida, exencephaly, and resorption rates in the splotch mouse
    Lisa J Martin
    Department of Environmental Health Sciences, Interdepartmental Program in Molecular Toxicology, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
    Birth Defects Res A Clin Mol Teratol 67:231-9. 2003
    ....
  13. ncbi request reprint Differential perturbation of the Fgf/Erk1/2 and Shh pathways in the C57BL/6N and SWV embryonic limb buds after mid-gestational cadmium chloride administration
    Ahmed F Elsaid
    Molecular Toxicology Interdepartmental Program, University of California, Los Angeles School of Public Health, Los Angeles, CA, USA
    Mol Genet Metab 92:258-70. 2007
    ..The data of the present study indicate that a differential strain response to CdCl(2)-induced forelimb digital loss may be due to a polymorphic interference with the Fgf/Shh positive feedback loop and Erk1/2 phosphorylation...
  14. ncbi request reprint Enhanced expression of limb malformations and axial skeleton alterations in legless mutants by transplacental exposure to retinoic acid
    W J Scott
    Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio
    Dev Biol 164:277-89. 1994
    ....
  15. ncbi request reprint Antagonism of hypervitaminosis A-induced anterior neural tube closure defects with a methyl-donor deficiency in murine whole-embryo culture
    Jesús Santos-Guzmán
    UCLA School of Public Health, Los Angeles, CA 90095, USA
    J Nutr 133:3561-70. 2003
    ..Biochemical measurements of metabolites in relevant pathways were performed. We propose that the amelioration of these malformations may be used to determine biochemical pathways critical for retinoid teratogenesis...
  16. ncbi request reprint Interactive endogenous small molecule (gaseous) signaling: implications for teratogenesis
    Jon M Fukuto
    Molecular Toxicology Interdepartmental Program, University of California at Los Angeles, USA
    Curr Pharm Des 13:2952-78. 2007
    ..Consequently, these small (gaseous) signaling molecules have been demonstrated to interact with respect to signaling pathways, but whether this indicates a similar result for teratogenesis remains unevaluated...
  17. ncbi request reprint Quantification and localization of expression of the retinoic acid receptor-beta and -gamma mRNA isoforms during neurulation in mouse embryos with or without spina bifida
    Gloria E Mao
    Department of Environmental Health Sciences, School of Public Health, University of California, Los Angeles, California 90095, USA
    Teratology 66:331-43. 2002
    ....
  18. ncbi request reprint The effect of administration time on malformations induced by three anticonvulsant agents in C57BL/6J mice with emphasis on forelimb ectrodactyly
    M D Collins
    Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Ohio 45229
    Teratology 44:617-27. 1991
    ..The overall syndrome of malformations induced by the three anticonvulsant agents was relatively similar in the two mouse strains and differed between each of the anticonvulsant agents...
  19. ncbi request reprint Pax3 and the splotch mutations: structure, function, and relationship to teratogenesis, including gene-chemical interactions
    A F Machado
    Department of Environmental Health Sciences, UCLA School of Public Health, Los Angeles, CA 90095-1772, USA
    Curr Pharm Des 7:751-85. 2001
    ..The primary goal of this review is to examine the role of a single important developmental gene in the interaction of genetics and abnormal development...
  20. ncbi request reprint Identification of a murine locus conveying susceptibility to cadmium-induced forelimb malformations
    D N Hovland
    Department of Environmental Health Sciences, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
    Genomics 63:193-201. 2000
    ..One QTL demonstrating significant linkage to expression of the defect, designated Cadfar (cadmium-induced forelimb autopod reduction), was mapped to the distal end of chromosome 6 with a lod score of 3.1...
  21. ncbi request reprint Induction of postaxial forelimb ectrodactyly with anticonvulsant agents in A/J mice
    M D Collins
    Children s Hospital Research Foundation, Cincinnati, Ohio
    Teratology 41:61-70. 1990
    ..This finding suggests that these agents are capable of acting via different mechanisms or by the differential spatial and temporal dynamics of a common mechanism...
  22. ncbi request reprint Identification of a 100-kDa phosphoprotein in developing murine embryos as elongation factor 2
    T L Brown
    Developmental Biology Program, University of Cincinnati College of Medicine, Ohio
    Arch Biochem Biophys 309:105-10. 1994
    ....
  23. ncbi request reprint Diabetic embryopathy in C57BL/6J mice. Altered fetal sex ratio and impact of the splotch allele
    A F Machado
    Department of Environmental Health Sciences, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
    Diabetes 50:1193-9. 2001
    ..Thus, Pax3 haploinsufficiency in this murine model of diabetic embryopathy is associated with caudal but not cranial NTDs...
  24. ncbi request reprint Intracellular pH monkey embryos at various stages of organogenesis estimated by dimethadione distribution
    M D Collins
    Department of Pediatrics, Children s Hospital Research Foundation, Cincinnati, OH 45229 2899, USA
    Reprod Fertil Dev 8:911-20. 1996
    ..The difference in the pH gradient between the two species may lead to differential transplacental distribution of exogenous and endogenous substances...

Research Grants11

  1. Teratology Society 47th Annual Meeting: Student and Postdoctoral Travel Awards
    Michael Collins; Fiscal Year: 2007
    ....
  2. Student and Postdoctoral Travel Awards for the 2006 Meeting
    Michael Collins; Fiscal Year: 2006
    ..this proposal, the investigators are requesting funds to defray part of the cost of travel awards, which will be granted to students and postdoctoral fellows presenting their research finding at the 2006 Teratology Society Annual Meeting ..
  3. 2005 Teratology Society Meeting
    Michael Collins; Fiscal Year: 2005
    ..Funds to help support and encourage student-fellow attendance at the Teratology Society 2005 Annual Meeting will enhance the quality of the meeting and the experience of the student and postdoctoral fellow attendees. ..
  4. Murine strain sensitivity to cadmium teratogenesis
    Michael Collins; Fiscal Year: 2005
    ..An additive oligogenic model involving nine genes for the induction of the forelimb defect has been proposed. ..
  5. Cadmium Teratogenesis to murine strains proteomics
    Michael Collins; Fiscal Year: 2003
    ..abstract_text> ..