James F Collins

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Gene chip analyses reveal differential genetic responses to iron deficiency in rat duodenum and jejunum
    James F Collins
    Department of Pediatrics and Nutritional Sciences, Steele Children s Research Center, University of Arizona, Tucson, Arizona, USA
    Biol Res 39:25-37. 2006
  2. ncbi request reprint 1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport
    Olga I Kolek
    Dept of Pediatrics, Steele Children s Research Center, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 289:G1036-42. 2005
  3. ncbi request reprint Effects of angiotensin II on NaPi-IIa co-transporter expression and activity in rat renal cortex
    Liping Xu
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Biochim Biophys Acta 1667:114-21. 2004
  4. pmc Menkes Copper ATPase (Atp7a) is a novel metal-responsive gene in rat duodenum, and immunoreactive protein is present on brush-border and basolateral membrane domains
    Jennifer J Ravia
    Department of Pediatrics, Steele Children s Research Center, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    J Biol Chem 280:36221-7. 2005
  5. ncbi request reprint NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene
    Hua Xu
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 288:G175-81. 2005
  6. ncbi request reprint Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum
    James F Collins
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona, 1501 N Campbell Ave, Tucson, Arizona 85724, USA
    Am J Physiol Gastrointest Liver Physiol 288:G964-71. 2005
  7. ncbi request reprint Effect of angiotensin-II on renal Na+/H+ exchanger-NHE3 and NHE2
    Mehul P Dixit
    Department of Pediatrics and Physiology, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Biochim Biophys Acta 1664:38-44. 2004
  8. pmc Promoter analysis of intestinal genes induced during iron-deprivation reveals enrichment of conserved SP1-like binding sites
    James F Collins
    Department of Exercise and Nutrition Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA
    BMC Genomics 8:420. 2007
  9. pmc Prediction of synergistic transcription factors by function conservation
    Zihua Hu
    New York State Center of Excellence in Bioinformatics and Life Sciences, Department of Biostatistics, Department of Medicine, University at Buffalo, State University of New York SUNY, Buffalo, NY 14260, USA
    Genome Biol 8:R257. 2007
  10. ncbi request reprint Novel insights into intestinal and renal folate transport. Focus on "Apical membrane targeting and trafficking of the human proton-coupled folate transporter in polarized epithelia"
    James F Collins
    Department of Exercise and Nutrition Sciences, University at Buffalo, The State University of New York, 3435 Main St, G10 Farber Hall, Buffalo, NY 14214 8001, USA
    Am J Physiol Cell Physiol 294:C381-2. 2008

Collaborators

Detail Information

Publications18

  1. pmc Gene chip analyses reveal differential genetic responses to iron deficiency in rat duodenum and jejunum
    James F Collins
    Department of Pediatrics and Nutritional Sciences, Steele Children s Research Center, University of Arizona, Tucson, Arizona, USA
    Biol Res 39:25-37. 2006
    ....
  2. ncbi request reprint 1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport
    Olga I Kolek
    Dept of Pediatrics, Steele Children s Research Center, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 289:G1036-42. 2005
    ..Our data also establish FGF23 induction by 1,25(OH)(2)D(3) in osteoblasts as a feedback loop between these two hormones that completes a kidney-intestine-bone axis that mediates phosphate homeostasis...
  3. ncbi request reprint Effects of angiotensin II on NaPi-IIa co-transporter expression and activity in rat renal cortex
    Liping Xu
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Biochim Biophys Acta 1667:114-21. 2004
    ..A-II stimulation of Na/Pi co-transport activity is a result of increases in the expression of BBM NaPi-IIa protein level and that stimulation is most likely mediated by posttranscriptional mechanisms...
  4. pmc Menkes Copper ATPase (Atp7a) is a novel metal-responsive gene in rat duodenum, and immunoreactive protein is present on brush-border and basolateral membrane domains
    Jennifer J Ravia
    Department of Pediatrics, Steele Children s Research Center, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    J Biol Chem 280:36221-7. 2005
    ..We conclude that ATP7A is involved in copper loading observed during iron deficiency and that increased intestinal copper transport is of physiological relevance, as copper plays important roles in overall body iron homeostasis...
  5. ncbi request reprint NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene
    Hua Xu
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 288:G175-81. 2005
    ..This study has thus identified a new target gene in the small intestinal epithelium that is directly regulated by NF1 transcriptional factor(s)...
  6. ncbi request reprint Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum
    James F Collins
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona, 1501 N Campbell Ave, Tucson, Arizona 85724, USA
    Am J Physiol Gastrointest Liver Physiol 288:G964-71. 2005
    ..These findings may thus explain copper loading in the iron-deficient state. We also demonstrate that many other novel genes may be differentially regulated in the setting of iron deprivation...
  7. ncbi request reprint Effect of angiotensin-II on renal Na+/H+ exchanger-NHE3 and NHE2
    Mehul P Dixit
    Department of Pediatrics and Physiology, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Biochim Biophys Acta 1664:38-44. 2004
    ..A-II treatment did not alter brush border NHE2 protein abundance in the renal proximal tubules. In conclusion, chronic A-II treatment increases NHE3-mediated Na+ uptake by stimulating NHE3 mRNA and protein content...
  8. pmc Promoter analysis of intestinal genes induced during iron-deprivation reveals enrichment of conserved SP1-like binding sites
    James F Collins
    Department of Exercise and Nutrition Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA
    BMC Genomics 8:420. 2007
    ..We thus identified promoters from the up-regulated gene cluster from rat, mouse and human, and performed enrichment analyses with the Clover program and the TRANSFAC database...
  9. pmc Prediction of synergistic transcription factors by function conservation
    Zihua Hu
    New York State Center of Excellence in Bioinformatics and Life Sciences, Department of Biostatistics, Department of Medicine, University at Buffalo, State University of New York SUNY, Buffalo, NY 14260, USA
    Genome Biol 8:R257. 2007
    ..Previous methods employed for the identification of synergistic transcription factors (TFs) are based on either TF enrichment from co-regulated genes or phylogenetic footprinting. Despite the success of these methods, both have limitations...
  10. ncbi request reprint Novel insights into intestinal and renal folate transport. Focus on "Apical membrane targeting and trafficking of the human proton-coupled folate transporter in polarized epithelia"
    James F Collins
    Department of Exercise and Nutrition Sciences, University at Buffalo, The State University of New York, 3435 Main St, G10 Farber Hall, Buffalo, NY 14214 8001, USA
    Am J Physiol Cell Physiol 294:C381-2. 2008
  11. doi request reprint Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators
    James F Collins
    Dept of Exercise and Nutrition Sciences, G10 Farber Hall, 3435 Main St, Univ at Buffalo, Buffalo, NY 14214, USA
    Am J Physiol Gastrointest Liver Physiol 294:G948-62. 2008
    ..The resulting lipid mediators may be related to documented alterations in villus structure and cell proliferation rates in iron deficiency, or to structural alterations in membrane lipid composition...
  12. ncbi request reprint 1,25-dihydroxyvitamin D3 down-regulation of PHEX gene expression is mediated by apparent repression of a 110 kDa transfactor that binds to a polyadenine element in the promoter
    Eric R Hines
    Department of Pediatrics, College of Medicine, Steele Memorial Children s Research Center, University of Arizona, Tucson, Arizona 85724, USA
    J Biol Chem 279:46406-14. 2004
    ..Thus, we have identified a cis-element required for PHEX gene transcription that participates in negative feedback control of PHEX expression and thereby modulates the actions of phosphatonin...
  13. ncbi request reprint Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen
    Hua Xu
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Am J Physiol Gastrointest Liver Physiol 285:G1317-24. 2003
    ..This stimulation is associated with increased NaPi-IIb mRNA and protein expression. Thus the effect of estrogen on intestinal Pi absorption may be partially due to activation of NaPi-IIb gene transcription...
  14. ncbi request reprint Transcriptional regulation of the rat NHE3 gene. Functional interactions between GATA-5 and Sp family transcription factors
    Pawel R Kiela
    Departmentf Pediatrics and Physiology, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    J Biol Chem 278:5659-68. 2003
    ..This interaction represents a novel regulatory mechanism, which is likely to participate in a gradient of intestinal gene expression along the crypt-villus axis...
  15. ncbi request reprint Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH)(2) vitamin D(3)
    Hua Xu
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Am J Physiol Cell Physiol 282:C487-93. 2002
    ..Our data also suggest that the effect of 1,25-(OH)(2) vitamin D(3) on NaP(i)-IIb expression is at least partially mediated by gene transcription in suckling rats...
  16. ncbi request reprint Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb
    Hua Xu
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Am J Physiol Cell Physiol 284:C1262-71. 2003
    ..We further conclude that this downregulation of promoter function is mediated by EGF-activated PKC/PKA and MAPK pathways. This is the first study that demonstrates involvement of c-myb in the regulation of intestinal nutrient absorption...
  17. ncbi request reprint Functional characterization of the human intestinal NaPi-IIb cotransporter in hamster fibroblasts and Xenopus oocytes
    Hua Xu
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, 1501 N Campbell Avenue, Tucson, AZ 85274, USA
    Biochim Biophys Acta 1567:97-105. 2002
    ....
  18. ncbi request reprint Glucocorticoid regulation and glycosylation of mouse intestinal type IIb Na-P(i) cotransporter during ontogeny
    Kayo Arima
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, Tucson 85724, USA
    Am J Physiol Gastrointest Liver Physiol 283:G426-34. 2002
    ..We also demonstrate that Na-P(i)-IIb is an N-linked glycoprotein and that glycosylation is age dependent...