Research Topics
| Timothy J CollierSummaryAffiliation: University of Cincinnati Country: USA Publications
Research Grants
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Detail Information
Publications
Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's diseaseTimothy J Collier
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Comp Neurol 442:320-30. 2002..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease...
Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonismTimothy J Collier
Department of Neurology, University of Cincinnati, PO Box 670525, 265 Albert Sabin Way, Cincinnati, OH 45267, USA
Neurobiol Dis 26:56-65. 2007....- Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine modelSara E Gombash
Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
Mol Ther 20:544-54. 2012.... - Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neuronsBrian T Terpstra
Department of Neurology, University of Cincinnati, PO Box 670525, Cincinnati, OH 45267 0525, United States
J Neurosci Methods 166:13-9. 2007..These data have the potential to identify optimal transplantation parameters that can be applied to procedures utilizing stem cells, neural progenitors, and primary mesencephalic cells... - Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian ratsKathy Steece-Collier
Department of Neurology, Movement Disorders Division, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Comp Neurol 515:15-30. 2009..Furthermore, dopamine terminal replacement prior to introduction of chronic levodopa is highly effective at preventing development of levodopa-induced dyskinesias, and GID-like behaviors occur regardless of pregraft levodopa status... - 3,4-Methylenedioxy-N-methamphetamine (ecstasy) promotes the survival of fetal dopamine neurons in cultureJack W Lipton
Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267, USA
Neuropharmacology 55:851-9. 2008..Understanding how MDMA increases DA neuron survival may provide insight into normal DA neuron loss during development... - Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's diseaseLalitha Madhavan
Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Comp Neurol 515:102-15. 2009.... 
Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian ratLalitha Madhavan
Department of Neurology, University of Cincinnati, Cincinnati, OH, USA
Eur J Neurosci 35:883-95. 2012..Thus, both endogenous and transplanted NPCs are important in creating an environment suitable for neural protection and rescue, and harnessing their synergistic interaction may lead to the optimization of cell-based therapies for PD...- A synergistic approach for neural repair: cell transplantation and induction of endogenous precursor cell activityLalitha Madhavan
Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA
Neuropharmacology 58:835-44. 2010..Elucidating mechanisms underlying this exogenous-endogenous stem cell synergism may lead to the development of optimal cell therapies for neural disorders... - Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's diseaseKatrina L Paumier
Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
Mov Disord 27:880-7. 2012..Tricyclic antidepressants are associated with a delay in reaching the end point of need to start dopaminergic therapy. The lack of change in overall UPDRS scores suggests the delay was not attributable to symptomatic effects... - Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survivalCaryl E Sortwell
Department of Neurology University of Cincinnati, PO Box 670537, ML0537, Cincinnati, OH 45267 0537, USA
Brain Res 1134:33-44. 2007..Even with highly efficient viral vector-mediated transduction, our results demonstrate that ex vivo gene transfer of bcl-2 to mesencephalic reaggregates is ineffective in increasing grafted DA neuron survival... - Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerabilityNicholas M Kanaan
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
J Comp Neurol 502:683-700. 2007..Furthermore, the results begin to characterize the nature of the link between aging and PD, and they support the concept that aged monkeys represent a valuable model for studying specific events preceding PD... - Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's diseaseDeanna M Marchionini
Dept Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Brain Res 1147:77-88. 2007..Thus, PTN was identified as a factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the DA system... - Dietary supplementation with blueberry extract improves survival of transplanted dopamine neuronsSusan O McGuire
Department of Pathology, Loyola University Medical School, Loyola University Chicago, Maywood, IL 60153, USA
Nutr Neurosci 9:251-8. 2006..These findings provide support for the potential of dietary phytochemicals as an easily administered and well-tolerated therapy that can be used to improve the effectiveness of DA neuron replacement... - Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeysJeffrey H Kordower
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Ann Neurol 60:264-8. 2006..Furthermore, administration of PSI or epoxomicin to monkeys in an attempt to extend the model to a primate species failed. Currently, systemic proteasome inhibition is not a reliable model for Parkinson's disease... - Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's diseaseNicholas M Kanaan
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Brain Res 1068:221-9. 2006..As direct neurotrophic effects of Epo were not observed in vitro, the mechanism of Epo neuroprotection remains to be elucidated... - Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neuronsScott E Counts
Department of Neurological Sciences and Pharmacology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Neurochem 83:442-51. 2002..GAL inhibition of midbrain DA activity may involve a GALR1- mediated reduction of TH in midbrain dopaminergic neurons... - Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): studies of grafted and cultured embryonic ventral mesencephalic cellsMark R Pitzer
Department of Neurological Sciences and Research Center for Brain Repair, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA
Exp Neurol 182:435-45. 2003..We conclude that with the proper method of delivery, VEGF165 may prove to be one of several strategies necessary to significantly improve the survival and function of fetal VM tissue grafts... - Interference with anoikis-induced cell death of dopamine neurons: implications for augmenting embryonic graft survival in a rat model of Parkinson's diseaseDeanna M Marchionini
Department of Neurological Sciences, Research Center for Brain Repair, Rush-Presbyterian-St. Luke's Medical Center, 2422 West Harrison St, Chicago, Illinois 60612, USA
J Comp Neurol 464:172-9. 2003.... - Embryonic mesencephalic grafts increase levodopa-induced forelimb hyperkinesia in parkinsonian ratsKathy Steece-Collier
Department of Neurological Science, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
Mov Disord 18:1442-54. 2003.... - Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged ratsTimothy J Collier
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Tech 2000, Suite 200, 2242 W Harrison St, Chicago, IL 60612, USA
Neurobiol Aging 25:209-21. 2004..The results suggest that an aging-related reduction in cortical NE neurotransmission is associated with the expression of increased neophobia and deficits in spatial learning and memory performance occurring with advanced age in rats... - An in vitro interval before transplantation of mesencephalic reaggregates does not compromise survival or functionalityCaryl E Sortwell
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Exp Neurol 187:58-64. 2004..This ex vivo reaggregate system allows for extended pretreatment (3 days) of mesencephalic cells with survival-promoting agents and immunological screening of tissue before transplantation... - Reassessment of caspase inhibition to augment grafted dopamine neuron survivalDeanna M Marchionini
Department of Neurological Sciences, Research Center for Brain Repair, Rush University Medical Center, Chicago, IL 60612, USA
Cell Transplant 13:273-82. 2004..Furthermore, we suggest that cell culture paradigms used to model grafting paradigms must more closely approximate the cell densities of mesencephalic grafts to effectively screen potential augmentative treatments... - Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonismTimothy J Collier
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Exp Neurol 191:S60-7. 2005..Third, the aging-related chronic increase in combined striatal trophic activity was not attributable to BDNF or GDNF as these molecules either decreased or did not change with aging... - Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian ratsEleonora Maries
Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, N. Chicago, IL 60064, USA
Neurobiol Dis 21:165-80. 2006..The onset of forelimb-facial stereotypy correlated with measures of increased graft function... - Partial dopamine loss enhances activated caspase-3 activity: differential outcomes in striatal projection systemsMarjorie A Ariano
Department of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
J Neurosci Res 82:387-96. 2005..These observations could be capitalized upon to develop therapeutic interventions in the preclinical phases of the disorder... - Primate models of Parkinson's diseaseTimothy J Collier
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA
Exp Neurol 183:258-62. 2003 - Cellular models to study dopaminergic injury responsesTimothy J Collier
Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
Ann N Y Acad Sci 991:140-51. 2003..Thus, cell culture models provide an important bidirectional link between mechanistic studies and clinically relevant observations...
Research Grants
- An Approach to Dopamine Graft AugmentationTimothy Collier; Fiscal Year: 2007..With optimization, cell replacement therapy could become a practical therapeutic option for late stage PD. ..
- Cell Grafts for Parkinson's DiseaseTimothy Collier; Fiscal Year: 2004..If successful, cytokine-converted mesencephalic progenitor cells could potentially replace embryonic tissue as the primary source of cells for grafting in PD. ..
- AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYSTimothy Collier; Fiscal Year: 2003....
- An Approach to Dopamine Graft AugmentationTimothy Collier; Fiscal Year: 2009..With optimization, cell replacement therapy could become a practical therapeutic option for late stage PD. ..