Timothy J Collier

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 442:320-30. 2002
  2. pmc Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism
    Timothy J Collier
    Department of Neurology, University of Cincinnati, PO Box 670525, 265 Albert Sabin Way, Cincinnati, OH 45267, USA
    Neurobiol Dis 26:56-65. 2007
  3. pmc Subthalamic nucleus stimulation increases brain derived neurotrophic factor in the nigrostriatal system and primary motor cortex
    Anne L Spieles-Engemann
    Department of Neurology, University of Cincinnati, OH, USA
    J Parkinsons Dis 1:123-36. 2011
  4. pmc Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model
    Sara E Gombash
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
    Mol Ther 20:544-54. 2012
  5. pmc 3,4-Methylenedioxy-N-methamphetamine (ecstasy) promotes the survival of fetal dopamine neurons in culture
    Jack W Lipton
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267, USA
    Neuropharmacology 55:851-9. 2008
  6. pmc Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian rats
    Kathy Steece-Collier
    Department of Neurology, Movement Disorders Division, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Comp Neurol 515:15-30. 2009
  7. pmc Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neurons
    Brian T Terpstra
    Department of Neurology, University of Cincinnati, PO Box 670525, Cincinnati, OH 45267 0525, United States
    J Neurosci Methods 166:13-9. 2007
  8. pmc Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease
    Lalitha Madhavan
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Comp Neurol 515:102-15. 2009
  9. pmc Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian rat
    Lalitha Madhavan
    Department of Neurology, University of Cincinnati, Cincinnati, OH, USA
    Eur J Neurosci 35:883-95. 2012
  10. doi request reprint A synergistic approach for neural repair: cell transplantation and induction of endogenous precursor cell activity
    Lalitha Madhavan
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA
    Neuropharmacology 58:835-44. 2010

Research Grants

  1. AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYS
    Timothy Collier; Fiscal Year: 2000
  2. An Approach to Dopamine Graft Augmentation
    Timothy Collier; Fiscal Year: 2007
  3. Cell Grafts for Parkinson's Disease
    Timothy Collier; Fiscal Year: 2004
  4. AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYS
    Timothy Collier; Fiscal Year: 2003
  5. Cell Grafts for Parkinson's Disease
    Timothy Collier; Fiscal Year: 2003
  6. AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYS
    Timothy Collier; Fiscal Year: 2003
  7. Cell Grafts for Parkinson's Disease
    Timothy Collier; Fiscal Year: 2002
  8. AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYS
    Timothy Collier; Fiscal Year: 2002
  9. AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYS
    Timothy Collier; Fiscal Year: 2001
  10. Cell Grafts for Parkinson's Disease
    Timothy Collier; Fiscal Year: 2001

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 442:320-30. 2002
    ..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease...
  2. pmc Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism
    Timothy J Collier
    Department of Neurology, University of Cincinnati, PO Box 670525, 265 Albert Sabin Way, Cincinnati, OH 45267, USA
    Neurobiol Dis 26:56-65. 2007
    ....
  3. pmc Subthalamic nucleus stimulation increases brain derived neurotrophic factor in the nigrostriatal system and primary motor cortex
    Anne L Spieles-Engemann
    Department of Neurology, University of Cincinnati, OH, USA
    J Parkinsons Dis 1:123-36. 2011
    ....
  4. pmc Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model
    Sara E Gombash
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
    Mol Ther 20:544-54. 2012
    ....
  5. pmc 3,4-Methylenedioxy-N-methamphetamine (ecstasy) promotes the survival of fetal dopamine neurons in culture
    Jack W Lipton
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267, USA
    Neuropharmacology 55:851-9. 2008
    ..Understanding how MDMA increases DA neuron survival may provide insight into normal DA neuron loss during development...
  6. pmc Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian rats
    Kathy Steece-Collier
    Department of Neurology, Movement Disorders Division, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Comp Neurol 515:15-30. 2009
    ..Furthermore, dopamine terminal replacement prior to introduction of chronic levodopa is highly effective at preventing development of levodopa-induced dyskinesias, and GID-like behaviors occur regardless of pregraft levodopa status...
  7. pmc Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neurons
    Brian T Terpstra
    Department of Neurology, University of Cincinnati, PO Box 670525, Cincinnati, OH 45267 0525, United States
    J Neurosci Methods 166:13-9. 2007
    ..These data have the potential to identify optimal transplantation parameters that can be applied to procedures utilizing stem cells, neural progenitors, and primary mesencephalic cells...
  8. pmc Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease
    Lalitha Madhavan
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Comp Neurol 515:102-15. 2009
    ....
  9. pmc Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian rat
    Lalitha Madhavan
    Department of Neurology, University of Cincinnati, Cincinnati, OH, USA
    Eur J Neurosci 35:883-95. 2012
    ..Thus, both endogenous and transplanted NPCs are important in creating an environment suitable for neural protection and rescue, and harnessing their synergistic interaction may lead to the optimization of cell-based therapies for PD...
  10. doi request reprint A synergistic approach for neural repair: cell transplantation and induction of endogenous precursor cell activity
    Lalitha Madhavan
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA
    Neuropharmacology 58:835-44. 2010
    ..Elucidating mechanisms underlying this exogenous-endogenous stem cell synergism may lead to the development of optimal cell therapies for neural disorders...
  11. doi request reprint Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease
    Katrina L Paumier
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
    Mov Disord 27:880-7. 2012
    ..Tricyclic antidepressants are associated with a delay in reaching the end point of need to start dopaminergic therapy. The lack of change in overall UPDRS scores suggests the delay was not attributable to symptomatic effects...
  12. pmc Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival
    Caryl E Sortwell
    Department of Neurology University of Cincinnati, PO Box 670537, ML0537, Cincinnati, OH 45267 0537, USA
    Brain Res 1134:33-44. 2007
    ..Even with highly efficient viral vector-mediated transduction, our results demonstrate that ex vivo gene transfer of bcl-2 to mesencephalic reaggregates is ineffective in increasing grafted DA neuron survival...
  13. ncbi request reprint Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability
    Nicholas M Kanaan
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 502:683-700. 2007
    ..Furthermore, the results begin to characterize the nature of the link between aging and PD, and they support the concept that aged monkeys represent a valuable model for studying specific events preceding PD...
  14. ncbi request reprint Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease
    Deanna M Marchionini
    Dept Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Brain Res 1147:77-88. 2007
    ..Thus, PTN was identified as a factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the DA system...
  15. ncbi request reprint Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons
    Susan O McGuire
    Department of Pathology, Loyola University Medical School, Loyola University Chicago, Maywood, IL 60153, USA
    Nutr Neurosci 9:251-8. 2006
    ..These findings provide support for the potential of dietary phytochemicals as an easily administered and well-tolerated therapy that can be used to improve the effectiveness of DA neuron replacement...
  16. ncbi request reprint Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    Ann Neurol 60:264-8. 2006
    ..Furthermore, administration of PSI or epoxomicin to monkeys in an attempt to extend the model to a primate species failed. Currently, systemic proteasome inhibition is not a reliable model for Parkinson's disease...
  17. ncbi request reprint Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's disease
    Nicholas M Kanaan
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Brain Res 1068:221-9. 2006
    ..As direct neurotrophic effects of Epo were not observed in vitro, the mechanism of Epo neuroprotection remains to be elucidated...
  18. ncbi request reprint Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons
    Scott E Counts
    Department of Neurological Sciences and Pharmacology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Neurochem 83:442-51. 2002
    ..GAL inhibition of midbrain DA activity may involve a GALR1- mediated reduction of TH in midbrain dopaminergic neurons...
  19. ncbi request reprint Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): studies of grafted and cultured embryonic ventral mesencephalic cells
    Mark R Pitzer
    Department of Neurological Sciences and Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 182:435-45. 2003
    ..We conclude that with the proper method of delivery, VEGF165 may prove to be one of several strategies necessary to significantly improve the survival and function of fetal VM tissue grafts...
  20. ncbi request reprint Interference with anoikis-induced cell death of dopamine neurons: implications for augmenting embryonic graft survival in a rat model of Parkinson's disease
    Deanna M Marchionini
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, 2422 West Harrison St, Chicago, Illinois 60612, USA
    J Comp Neurol 464:172-9. 2003
    ....
  21. ncbi request reprint Embryonic mesencephalic grafts increase levodopa-induced forelimb hyperkinesia in parkinsonian rats
    Kathy Steece-Collier
    Department of Neurological Science, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 18:1442-54. 2003
    ....
  22. ncbi request reprint Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged rats
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Tech 2000, Suite 200, 2242 W Harrison St, Chicago, IL 60612, USA
    Neurobiol Aging 25:209-21. 2004
    ..The results suggest that an aging-related reduction in cortical NE neurotransmission is associated with the expression of increased neophobia and deficits in spatial learning and memory performance occurring with advanced age in rats...
  23. ncbi request reprint An in vitro interval before transplantation of mesencephalic reaggregates does not compromise survival or functionality
    Caryl E Sortwell
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 187:58-64. 2004
    ..This ex vivo reaggregate system allows for extended pretreatment (3 days) of mesencephalic cells with survival-promoting agents and immunological screening of tissue before transplantation...
  24. ncbi request reprint Reassessment of caspase inhibition to augment grafted dopamine neuron survival
    Deanna M Marchionini
    Department of Neurological Sciences, Research Center for Brain Repair, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Transplant 13:273-82. 2004
    ..Furthermore, we suggest that cell culture paradigms used to model grafting paradigms must more closely approximate the cell densities of mesencephalic grafts to effectively screen potential augmentative treatments...
  25. ncbi request reprint Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism
    Timothy J Collier
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 191:S60-7. 2005
    ..Third, the aging-related chronic increase in combined striatal trophic activity was not attributable to BDNF or GDNF as these molecules either decreased or did not change with aging...
  26. ncbi request reprint Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats
    Eleonora Maries
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, N Chicago, IL 60064, USA
    Neurobiol Dis 21:165-80. 2006
    ..The onset of forelimb-facial stereotypy correlated with measures of increased graft function...
  27. ncbi request reprint Partial dopamine loss enhances activated caspase-3 activity: differential outcomes in striatal projection systems
    Marjorie A Ariano
    Department of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurosci Res 82:387-96. 2005
    ..These observations could be capitalized upon to develop therapeutic interventions in the preclinical phases of the disorder...
  28. ncbi request reprint Primate models of Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Exp Neurol 183:258-62. 2003
  29. ncbi request reprint Cellular models to study dopaminergic injury responses
    Timothy J Collier
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Ann N Y Acad Sci 991:140-51. 2003
    ..Thus, cell culture models provide an important bidirectional link between mechanistic studies and clinically relevant observations...

Research Grants12

  1. AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYS
    Timothy Collier; Fiscal Year: 2000
    ....
  2. An Approach to Dopamine Graft Augmentation
    Timothy Collier; Fiscal Year: 2007
    ..With optimization, cell replacement therapy could become a practical therapeutic option for late stage PD. ..
  3. Cell Grafts for Parkinson's Disease
    Timothy Collier; Fiscal Year: 2004
    ..If successful, cytokine-converted mesencephalic progenitor cells could potentially replace embryonic tissue as the primary source of cells for grafting in PD. ..
  4. AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYS
    Timothy Collier; Fiscal Year: 2003
    ....
  5. Cell Grafts for Parkinson's Disease
    Timothy Collier; Fiscal Year: 2003
    ..If successful, cytokine-converted mesencephalic progenitor cells could potentially replace embryonic tissue as the primary source of cells for grafting in PD. ..
  6. AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYS
    Timothy Collier; Fiscal Year: 2003
    ....
  7. Cell Grafts for Parkinson's Disease
    Timothy Collier; Fiscal Year: 2002
    ..If successful, cytokine-converted mesencephalic progenitor cells could potentially replace embryonic tissue as the primary source of cells for grafting in PD. ..
  8. AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYS
    Timothy Collier; Fiscal Year: 2002
    ....
  9. AGING AND DOPAMINE GRAFTS IN PARKINSONIAN MONKEYS
    Timothy Collier; Fiscal Year: 2001
    ....
  10. Cell Grafts for Parkinson's Disease
    Timothy Collier; Fiscal Year: 2001
    ..If successful, cytokine-converted mesencephalic progenitor cells could potentially replace embryonic tissue as the primary source of cells for grafting in PD. ..
  11. An Approach to Dopamine Graft Augmentation
    Timothy Collier; Fiscal Year: 2009
    ..With optimization, cell replacement therapy could become a practical therapeutic option for late stage PD. ..