Research Topics
Species | Harold R CollardSummaryAffiliation: University of California Country: USA Publications
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Publications
Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosisJ S Lee
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Eur Respir J 39:352-8. 2012..Pepsin level was not an independent predictor of survival time. These results suggest occult aspiration may play a role in some cases of acute exacerbation of idiopathic pulmonary fibrosis...- Dyspnea in interstitial lung diseaseHarold R Collard
Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
Curr Opin Support Palliat Care 2:100-4. 2008..Dyspnea is a common complication of interstitial lung disease, yet little is known about its cause and effective management. This review attempts to summarize the current state of the art in this area... - Depression is a common and chronic comorbidity in patients with interstitial lung diseaseChristopher J Ryerson
Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California, USA
Respirology 17:525-32. 2012..The aim of this study was to determine the prevalence of depression, characterize the association of depression with clinical variables and describe the natural history of depression in patients with ILD... - A multidimensional index and staging system for idiopathic pulmonary fibrosisBrett Ley
Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, Box 0111, San Francisco, CA 94143, USA
Ann Intern Med 156:684-91. 2012..Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an overall poor prognosis. A simple-to-use staging system for IPF may improve prognostication, help guide management, and facilitate research... - Cough predicts prognosis in idiopathic pulmonary fibrosisChristopher J Ryerson
Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
Respirology 16:969-75. 2011..The clinical associations and prognostic value of cough in IPF have not been adequately described. The objective of this study was to describe the characteristics and prognostic value of cough in IPF... 
Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosisSeung Ick Cha
Department of Medicine, University of California, San Francisco School of Medicine, CA 94143 0111, USA
Histopathology 61:98-106. 2012..This study was performed to characterize the relationship of mast cells to fibrotic lung diseases...- Current diagnosis and management of idiopathic pulmonary fibrosis: a survey of academic physiciansHarold R Collard
Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, 5K1, San Francisco, CA 94110, USA
Respir Med 101:2011-6. 2007..These results suggest there is general consensus regarding the approach to diagnosis, but that there is no consensus about medical management in IPF... - Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosisJoyce S Lee
Department of Medicine, University of California San Francisco, USA
Am J Respir Crit Care Med 184:1390-4. 2011..Gastroesophageal reflux (GER) is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF). Chronic microaspiration secondary to GER may play a role in the pathogenesis and natural history of IPF... 
Combined corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary fibrosisHarold R Collard
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
Chest 125:2169-74. 2004....- Current perspectives on the treatment of idiopathic pulmonary fibrosisNicholas Walter
San Francisco General Hospital, 1001 Potrero Avenue, Room 5H22, San Francisco, CA 94110, USA
Proc Am Thorac Soc 3:330-8. 2006..g., IFN-gamma1b, pirfenidone, N-acetylcysteine, coumadin, bosentan, or etanercept). This article examines the body of evidence supporting the current therapies and reviews the newer agents being tested in patients with IPF... - Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosisHarold R Collard
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 1400 Jackson Street, Room F107, Denver, CO 80206, USA
Am J Respir Crit Care Med 168:538-42. 2003..Evaluation of changes in clinical and physiological variables over 6 and 12 months may provide clinicians with more accurate prognostic information than baseline values alone... - Depression and functional status are strongly associated with dyspnea in interstitial lung diseaseChristopher J Ryerson
Department of Medicine, School of Medicine, University of California San Francisco, 505 Parnassus Ave, Box 0111, San Francisco, CA 94143, USA
Chest 139:609-16. 2011..The aim of this study was to determine the relationship of dyspnea with clinical parameters, including depression and functional status, in patients with ILD... - Acute exacerbations of idiopathic pulmonary fibrosisHarold R Collard
Department of Medicine, San Francisco General Hospital, University of California, USA
Am J Respir Crit Care Med 176:636-43. 2007..The potential pathobiological roles of infection, disordered cell biology, coagulation, and genetics are discussed, and future research directions are proposed... - Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung functionBrent W Kinder
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0564, USA
Lung 188:143-9. 2010..These findings demonstrate the clinical importance of identifying UCTD in patients presenting with an "idiopathic" interstitial pneumonia... - Clinical problem-solving. A perfect stormWilliam J Janssen
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
N Engl J Med 353:1956-61. 2005 - Clinical problem-solving. Anatomy of a diagnosisHarold R Collard
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
N Engl J Med 349:987-92. 2003 - Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease?Brent W Kinder
Department of Medicine, University of California School of Medicine, San Francisco, California, USA
Am J Respir Crit Care Med 176:691-7. 2007.... - Management of dyspnea in interstitial lung diseaseChristopher J Ryerson
Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California, USA
Curr Opin Support Palliat Care 4:69-75. 2010..Dyspnea is the most common symptom in interstitial lung disease, yet little is known about its management. This review summarizes the available evidence for the treatment of dyspnea in interstitial lung disease... - A practical guide for clinicians who treat patients with amiodarone: 2007Nora Goldschlager
University of California, San Francisco, California, USA
Heart Rhythm 4:1250-9. 2007..The recommendations included herein are based on the best available data and the collective experience of the member of the writing committee... - Clinical problem-solving. Diagnosis still in questionAshish K Jha
General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
N Engl J Med 346:1813-6. 2002 - Dyspnea in idiopathic pulmonary fibrosis: a systematic reviewChristopher J Ryerson
Department of Medicine, School of Medicine, University of California at San Francisco, San Francisco, CA, USA
J Pain Symptom Manage 43:771-82. 2012..Little is known about the treatment and correlates of dyspnea in idiopathic pulmonary fibrosis (IPF)... - Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosisJoyce S Lee
Department of Medicine at University of California, San Francisco, 505 Parnassus Avenue, Box 0111, San Francisco, CA 94143, USA Electronic address
Respir Med 107:249-55. 2013..The objective of this study was to determine the frequency and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis... - Diffuse alveolar hemorrhageHarold R Collard
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, C272, Denver, CO 80262, USA
Clin Chest Med 25:583-92, vii. 2004..In patients with evidence of diffuse alveolar hemorrhage and renal involvement, kidney biopsy should be considered to identify the underlying cause and help direct therapy... - Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosisHarold R Collard
Department of Medicine, University of California San Francisco, San Francisco, California, USA
Am J Physiol Lung Cell Mol Physiol 299:L3-7. 2010..Furthermore, they suggest that acute exacerbation of IPF has a distinct plasma biomarker profile from that of acute lung injury... - Pulmonary rehabilitation in interstitial lung disease: benefits and predictors of responseAlicia Ferreira
Department of Medicine, University of California San Francisco, San Francisco, CA 94610, USA
Chest 135:442-7. 2009..We tested the hypothesis that PR can improve functional status and dyspnea in a large group of patients with ILD, and that certain baseline patient variables can predict this improvement... - Clinical problem-solving. Why "why" mattersWilliam J Janssen
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
N Engl J Med 351:2429-34. 2004 - Reduced lung diffusion capacity in type 2 diabetes is independent of heart failureOana L Klein
Department of Medicine, University of California, San Francisco, CA 94143 0131, USA
Diabetes Res Clin Pract 96:e73-5. 2012..5±0.9 vs. 16.4 ±0.9, p=0.01)... - Patient experiences with pulmonary fibrosisHarold R Collard
Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Respir Med 101:1350-4. 2007..These results suggest there is a substantial need for improved patient education regarding the diagnosis and management of pulmonary fibrosis... - Does chronic microaspiration cause idiopathic pulmonary fibrosis?Joyce S Lee
Department of Medicine, University of California, San Francisco, CA, USA
Am J Med 123:304-11. 2010..Defining the role of chronic microaspiration in idiopathic pulmonary fibrosis is essential as it has potential clinical, pathobiological, and treatment implications for this deadly disease... - Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathologic and radiographic patternEunice J Kim
Division of Pulmonary and Critical CareMedicine, Department of Medicine, University of California at San Francisco, CA, USA
Chest 136:1397-405. 2009..In patients in whom the underlying pattern cannot be determined by HRCT scanning, surgical lung biopsy should be considered... - Clinical course and prediction of survival in idiopathic pulmonary fibrosisBrett Ley
Department of Medicine, University of California San Francisco, San Francisco, California, USA
Am J Respir Crit Care Med 183:431-40. 2011..Finally, we will discuss challenges and future directions related to predicting survival in IPF... - Demystifying idiopathic interstitial pneumoniaHarold R Collard
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, USA
Arch Intern Med 163:17-29. 2003.... - Clinical and economic consequences of ventilator-associated pneumonia: a systematic reviewNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
Crit Care Med 33:2184-93. 2005..Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in critically ill patients. The clinical and economic consequences of VAP are unclear, with a broad range of values reported in the literature.. - Comprehensive care of the patient with idiopathic pulmonary fibrosisJoyce S Lee
Department of Medicine, University of California, San Francisco, San Francisco, California, USA
Curr Opin Pulm Med 17:348-54. 2011..In the current document, we summarize and supplement this recent expert document and propose a comprehensive approach to the care and management of patients with IPF... - Prevention of ventilator-associated pneumonia: an evidence-based systematic reviewHarold R Collard
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Campus Box C272, Denver, Colorado 80262, USA
Ann Intern Med 138:494-501. 2003..Interventions beneficial to the prevention of ventilator-associated pneumonia would therefore have a significant impact on the care of these patients... - Classification and natural history of the idiopathic interstitial pneumoniasDong Soon Kim
Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan, 388 1 Poongnap dong, Songpa Ku, Seoul, Korea, 138 736
Proc Am Thorac Soc 3:285-92. 2006..However, there is still confusion and controversy over the relationship between idiopathic pulmonary fibrosis and fibrotic nonspecific interstitial pneumonia... - Prognosis in idiopathic pulmonary fibrosisGabriel Thabut
Am J Respir Crit Care Med 169:1075-6; author reply 1076. 2004 - On beyond zebra: understanding rare diseasesHarold R Collard
Chest 131:644-6. 2007 - Anticoagulant therapy and idiopathic pulmonary fibrosisBrent W Kinder
Chest 130:302-3. 2006 - Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung diseaseAna C Zamora
Hospital Universitario Dr José Eleuterio González, Monterrey, NL, Mexico
Respir Med 102:150-5. 2008..Treatment of patients with scleroderma ILD for up to 24 months with MMF was generally associated with stable pulmonary function. These data argue for a prospective trial using MMF to treat scleroderma ILD... - Sildenafil improves walk distance in idiopathic pulmonary fibrosisHarold R Collard
David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, Los Angeles, CA 90095, USA
Chest 131:897-9. 2007..Sildenafil is a promising and well-tolerated therapeutic agent for use in patients with IPF and pulmonary hypertension, and should be studied in a large, well-controlled trial...