Harold R Collard

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials
    Harold R Collard
    University of California San Francisco, San Francisco, CA, USA
    Respir Res 14:73. 2013
  2. doi request reprint Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis
    J S Lee
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Eur Respir J 39:352-8. 2012
  3. doi request reprint Dyspnea in interstitial lung disease
    Harold R Collard
    Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Curr Opin Support Palliat Care 2:100-4. 2008
  4. doi request reprint Depression is a common and chronic comorbidity in patients with interstitial lung disease
    Christopher J Ryerson
    Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California, USA
    Respirology 17:525-32. 2012
  5. doi request reprint A multidimensional index and staging system for idiopathic pulmonary fibrosis
    Brett Ley
    Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, Box 0111, San Francisco, CA 94143, USA
    Ann Intern Med 156:684-91. 2012
  6. doi request reprint Cough predicts prognosis in idiopathic pulmonary fibrosis
    Christopher J Ryerson
    Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Respirology 16:969-75. 2011
  7. pmc Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function
    Brent W Kinder
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0564, USA
    Lung 188:143-9. 2010
  8. doi request reprint Pulmonary rehabilitation in interstitial lung disease: benefits and predictors of response
    Alicia Ferreira
    Department of Medicine, University of California San Francisco, San Francisco, CA 94610, USA
    Chest 135:442-7. 2009
  9. pmc Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis
    Joyce S Lee
    Department of Medicine, University of California San Francisco, USA
    Am J Respir Crit Care Med 184:1390-4. 2011
  10. pmc Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis
    Seung Ick Cha
    Department of Medicine, University of California, San Francisco School of Medicine, CA 94143 0111, USA
    Histopathology 61:98-106. 2012

Detail Information

Publications50

  1. pmc Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials
    Harold R Collard
    University of California San Francisco, San Francisco, CA, USA
    Respir Res 14:73. 2013
    ..Acute exacerbation of idiopathic pulmonary fibrosis has become an important outcome measure in clinical trials. This study aimed to explore the concept of suspected acute exacerbation as an outcome measure...
  2. doi request reprint Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis
    J S Lee
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Eur Respir J 39:352-8. 2012
    ..Pepsin level was not an independent predictor of survival time. These results suggest occult aspiration may play a role in some cases of acute exacerbation of idiopathic pulmonary fibrosis...
  3. doi request reprint Dyspnea in interstitial lung disease
    Harold R Collard
    Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Curr Opin Support Palliat Care 2:100-4. 2008
    ..Dyspnea is a common complication of interstitial lung disease, yet little is known about its cause and effective management. This review attempts to summarize the current state of the art in this area...
  4. doi request reprint Depression is a common and chronic comorbidity in patients with interstitial lung disease
    Christopher J Ryerson
    Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California, USA
    Respirology 17:525-32. 2012
    ..The aim of this study was to determine the prevalence of depression, characterize the association of depression with clinical variables and describe the natural history of depression in patients with ILD...
  5. doi request reprint A multidimensional index and staging system for idiopathic pulmonary fibrosis
    Brett Ley
    Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, Box 0111, San Francisco, CA 94143, USA
    Ann Intern Med 156:684-91. 2012
    ..Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an overall poor prognosis. A simple-to-use staging system for IPF may improve prognostication, help guide management, and facilitate research...
  6. doi request reprint Cough predicts prognosis in idiopathic pulmonary fibrosis
    Christopher J Ryerson
    Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Respirology 16:969-75. 2011
    ..The clinical associations and prognostic value of cough in IPF have not been adequately described. The objective of this study was to describe the characteristics and prognostic value of cough in IPF...
  7. pmc Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function
    Brent W Kinder
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0564, USA
    Lung 188:143-9. 2010
    ..These findings demonstrate the clinical importance of identifying UCTD in patients presenting with an "idiopathic" interstitial pneumonia...
  8. doi request reprint Pulmonary rehabilitation in interstitial lung disease: benefits and predictors of response
    Alicia Ferreira
    Department of Medicine, University of California San Francisco, San Francisco, CA 94610, USA
    Chest 135:442-7. 2009
    ..We tested the hypothesis that PR can improve functional status and dyspnea in a large group of patients with ILD, and that certain baseline patient variables can predict this improvement...
  9. pmc Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis
    Joyce S Lee
    Department of Medicine, University of California San Francisco, USA
    Am J Respir Crit Care Med 184:1390-4. 2011
    ..Gastroesophageal reflux (GER) is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF). Chronic microaspiration secondary to GER may play a role in the pathogenesis and natural history of IPF...
  10. pmc Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis
    Seung Ick Cha
    Department of Medicine, University of California, San Francisco School of Medicine, CA 94143 0111, USA
    Histopathology 61:98-106. 2012
    ..This study was performed to characterize the relationship of mast cells to fibrotic lung diseases...
  11. pmc Current diagnosis and management of idiopathic pulmonary fibrosis: a survey of academic physicians
    Harold R Collard
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, 5K1, San Francisco, CA 94110, USA
    Respir Med 101:2011-6. 2007
    ..These results suggest there is general consensus regarding the approach to diagnosis, but that there is no consensus about medical management in IPF...
  12. pmc Outcomes in systemic sclerosis-related lung disease after lung transplantation
    Peter D Sottile
    Department of Internal Medicine, University of California San Francisco, San Francisco, CA, USA
    Transplantation 95:975-80. 2013
    ..We sought to evaluate posttransplantation outcomes in persons with SSc-LD with esophageal involvement compared with persons with nonconnective tissue disease-related interstitial lung disease (nCTD-ILD)...
  13. doi request reprint Depression and functional status are strongly associated with dyspnea in interstitial lung disease
    Christopher J Ryerson
    Department of Medicine, School of Medicine, University of California San Francisco, 505 Parnassus Ave, Box 0111, San Francisco, CA 94143, USA
    Chest 139:609-16. 2011
    ..The aim of this study was to determine the relationship of dyspnea with clinical parameters, including depression and functional status, in patients with ILD...
  14. pmc Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis
    Seung Ick Cha
    Department of Medicine, University of California, San Francisco School of Medicine, San Francisco, CA 94143 0111, USA
    Respir Res 13:105. 2012
    ....
  15. ncbi request reprint Current perspectives on the treatment of idiopathic pulmonary fibrosis
    Nicholas Walter
    San Francisco General Hospital, 1001 Potrero Avenue, Room 5H22, San Francisco, CA 94110, USA
    Proc Am Thorac Soc 3:330-8. 2006
    ..g., IFN-gamma1b, pirfenidone, N-acetylcysteine, coumadin, bosentan, or etanercept). This article examines the body of evidence supporting the current therapies and reviews the newer agents being tested in patients with IPF...
  16. ncbi request reprint Combined corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary fibrosis
    Harold R Collard
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Chest 125:2169-74. 2004
    ..This study retrospectively compared combination corticosteroid and cyclophosphamide therapy in a large population of patients who meet the current consensus definition of IPF...
  17. pmc Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis
    Joyce S Lee
    Department of Medicine at University of California, San Francisco, 505 Parnassus Avenue, Box 0111, San Francisco, CA 94143, USA
    Respir Med 107:249-55. 2013
    ..The objective of this study was to determine the frequency and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis...
  18. pmc Acute exacerbations of idiopathic pulmonary fibrosis
    Harold R Collard
    Department of Medicine, San Francisco General Hospital, University of California, USA
    Am J Respir Crit Care Med 176:636-43. 2007
    ..The potential pathobiological roles of infection, disordered cell biology, coagulation, and genetics are discussed, and future research directions are proposed...
  19. doi request reprint Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials
    Joyce S Lee
    Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Lancet Respir Med 1:369-76. 2013
    ..Retrospective studies have shown improved outcomes in patients given anti-acid treatment. The aim of this study was to investigate the association between anti-acid treatment and disease progression in IPF...
  20. ncbi request reprint Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis
    Harold R Collard
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 1400 Jackson Street, Room F107, Denver, CO 80206, USA
    Am J Respir Crit Care Med 168:538-42. 2003
    ..Evaluation of changes in clinical and physiological variables over 6 and 12 months may provide clinicians with more accurate prognostic information than baseline values alone...
  21. doi request reprint Pathogenesis of idiopathic pulmonary fibrosis
    Paul J Wolters
    Department of Medicine, School of Medicine, University of California, San Francisco, California 94143 email
    Annu Rev Pathol 9:157-79. 2014
    ..We then discuss the pathologic changes within IPF fibroblasts and the extracellular matrix, and we conclude with a summary of how these profibrotic pathways may be interrelated. ..
  22. doi request reprint Clinical course and prediction of survival in idiopathic pulmonary fibrosis
    Brett Ley
    Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Am J Respir Crit Care Med 183:431-40. 2011
    ..Finally, we will discuss challenges and future directions related to predicting survival in IPF...
  23. doi request reprint Dyspnea in idiopathic pulmonary fibrosis: a systematic review
    Christopher J Ryerson
    Department of Medicine, School of Medicine, University of California at San Francisco, San Francisco, CA, USA
    J Pain Symptom Manage 43:771-82. 2012
    ..Little is known about the treatment and correlates of dyspnea in idiopathic pulmonary fibrosis (IPF)...
  24. pmc Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis
    Harold R Collard
    Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Am J Physiol Lung Cell Mol Physiol 299:L3-7. 2010
    ..Furthermore, they suggest that acute exacerbation of IPF has a distinct plasma biomarker profile from that of acute lung injury...
  25. ncbi request reprint Clinical problem-solving. Anatomy of a diagnosis
    Harold R Collard
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 349:987-92. 2003
  26. ncbi request reprint Clinical problem-solving. A perfect storm
    William J Janssen
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 353:1956-61. 2005
  27. pmc Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease?
    Brent W Kinder
    Department of Medicine, University of California School of Medicine, San Francisco, California, USA
    Am J Respir Crit Care Med 176:691-7. 2007
    ....
  28. doi request reprint Management of dyspnea in interstitial lung disease
    Christopher J Ryerson
    Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California, USA
    Curr Opin Support Palliat Care 4:69-75. 2010
    ..Dyspnea is the most common symptom in interstitial lung disease, yet little is known about its management. This review summarizes the available evidence for the treatment of dyspnea in interstitial lung disease...
  29. ncbi request reprint Clinical problem-solving. Diagnosis still in question
    Ashish K Jha
    General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    N Engl J Med 346:1813-6. 2002
  30. ncbi request reprint A practical guide for clinicians who treat patients with amiodarone: 2007
    Nora Goldschlager
    University of California, San Francisco, California, USA
    Heart Rhythm 4:1250-9. 2007
    ..The recommendations included herein are based on the best available data and the collective experience of the member of the writing committee...
  31. doi request reprint Burden of illness in idiopathic pulmonary fibrosis
    Harold R Collard
    University of California San Francisco, San Francisco, CA, USA
    J Med Econ 15:829-35. 2012
    ..The objective of this study was to describe the burden of illness (comorbidity, healthcare resource utilization, and associated costs) in patients with idiopathic pulmonary fibrosis...
  32. pmc Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathologic and radiographic pattern
    Eunice J Kim
    Division of Pulmonary and Critical CareMedicine, Department of Medicine, University of California at San Francisco, CA, USA
    Chest 136:1397-405. 2009
    ..In patients in whom the underlying pattern cannot be determined by HRCT scanning, surgical lung biopsy should be considered...
  33. ncbi request reprint Idiopathic pulmonary fibrosis
    Jessica M Adkins
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Semin Respir Crit Care Med 33:433-9. 2012
    ..For now, clinicians should practice comprehensive management, including symptom-based management, aggressive management of comorbidities, and patient education and support...
  34. ncbi request reprint Diffuse alveolar hemorrhage
    Harold R Collard
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, C272, Denver, CO 80262, USA
    Clin Chest Med 25:583-92, vii. 2004
    ..In patients with evidence of diffuse alveolar hemorrhage and renal involvement, kidney biopsy should be considered to identify the underlying cause and help direct therapy...
  35. doi request reprint Acute exacerbation of idiopathic pulmonary fibrosis associated with air pollution exposure
    Kerri A Johannson
    University of California San Francisco, San Francisco, CA
    Eur Respir J 43:1124-31. 2014
    ....
  36. pmc Does chronic microaspiration cause idiopathic pulmonary fibrosis?
    Joyce S Lee
    Department of Medicine, University of California, San Francisco, CA, USA
    Am J Med 123:304-11. 2010
    ..Defining the role of chronic microaspiration in idiopathic pulmonary fibrosis is essential as it has potential clinical, pathobiological, and treatment implications for this deadly disease...
  37. ncbi request reprint Clinical problem-solving. Why "why" matters
    William J Janssen
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 351:2429-34. 2004
  38. doi request reprint Reduced lung diffusion capacity in type 2 diabetes is independent of heart failure
    Oana L Klein
    Department of Medicine, University of California, San Francisco, CA 94143 0131, USA
    Diabetes Res Clin Pract 96:e73-5. 2012
    ..5±0.9 vs. 16.4 ±0.9, p=0.01)...
  39. ncbi request reprint Patient experiences with pulmonary fibrosis
    Harold R Collard
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Respir Med 101:1350-4. 2007
    ..These results suggest there is a substantial need for improved patient education regarding the diagnosis and management of pulmonary fibrosis...
  40. doi request reprint Update on the diagnosis and classification of ILD
    Christopher J Ryerson
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Curr Opin Pulm Med 19:453-9. 2013
    ..In addition, the strengths and limitations of the current approach to ILD diagnosis and management are discussed...
  41. ncbi request reprint Clinical and economic consequences of ventilator-associated pneumonia: a systematic review
    Nasia Safdar
    Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Crit Care Med 33:2184-93. 2005
    ..Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in critically ill patients. The clinical and economic consequences of VAP are unclear, with a broad range of values reported in the literature..
  42. ncbi request reprint Demystifying idiopathic interstitial pneumonia
    Harold R Collard
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, USA
    Arch Intern Med 163:17-29. 2003
    ....
  43. doi request reprint Comprehensive care of the patient with idiopathic pulmonary fibrosis
    Joyce S Lee
    Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Curr Opin Pulm Med 17:348-54. 2011
    ..In the current document, we summarize and supplement this recent expert document and propose a comprehensive approach to the care and management of patients with IPF...
  44. ncbi request reprint Prevention of ventilator-associated pneumonia: an evidence-based systematic review
    Harold R Collard
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Campus Box C272, Denver, Colorado 80262, USA
    Ann Intern Med 138:494-501. 2003
    ..Interventions beneficial to the prevention of ventilator-associated pneumonia would therefore have a significant impact on the care of these patients...
  45. pmc Classification and natural history of the idiopathic interstitial pneumonias
    Dong Soon Kim
    Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan, 388 1 Poongnap dong, Songpa Ku, Seoul, Korea, 138 736
    Proc Am Thorac Soc 3:285-92. 2006
    ..However, there is still confusion and controversy over the relationship between idiopathic pulmonary fibrosis and fibrotic nonspecific interstitial pneumonia...
  46. ncbi request reprint Prognosis in idiopathic pulmonary fibrosis
    Gabriel Thabut
    Am J Respir Crit Care Med 169:1075-6; author reply 1076. 2004
  47. ncbi request reprint Anticoagulant therapy and idiopathic pulmonary fibrosis
    Brent W Kinder
    Chest 130:302-3. 2006
  48. ncbi request reprint Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung disease
    Ana C Zamora
    Hospital Universitario Dr José Eleuterio González, Monterrey, NL, Mexico
    Respir Med 102:150-5. 2008
    ..Treatment of patients with scleroderma ILD for up to 24 months with MMF was generally associated with stable pulmonary function. These data argue for a prospective trial using MMF to treat scleroderma ILD...
  49. ncbi request reprint On beyond zebra: understanding rare diseases
    Harold R Collard
    Chest 131:644-6. 2007
  50. pmc Sildenafil improves walk distance in idiopathic pulmonary fibrosis
    Harold R Collard
    David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, Los Angeles, CA 90095, USA
    Chest 131:897-9. 2007
    ..Sildenafil is a promising and well-tolerated therapeutic agent for use in patients with IPF and pulmonary hypertension, and should be studied in a large, well-controlled trial...