JOHN J COLICELLI

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc ABL tyrosine kinases: evolution of function, regulation, and specificity
    John Colicelli
    Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Sci Signal 3:re6. 2010
  2. pmc ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1
    M Thai
    Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Leukemia 25:290-300. 2011
  3. pmc RIN3 is a negative regulator of mast cell responses to SCF
    Christine Janson
    Molecular Biology Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e49615. 2012
  4. pmc Human RAS superfamily proteins and related GTPases
    John Colicelli
    Department of Biological Chemistry and Molecular Biology Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Sci STKE 2004:RE13. 2004
  5. pmc Signal transduction: RABGEF1 fingers RAS for ubiquitination
    John Colicelli
    Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Biol 20:R630-2. 2010
  6. pmc Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration
    Hailiang Hu
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Cell Biol 28:1573-83. 2008
  7. pmc The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins
    Ying Wang
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
    Mol Cell Biol 22:916-26. 2002
  8. ncbi The RAS effector RIN1 modulates the formation of aversive memories
    Ajay Dhaka
    Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
    J Neurosci 23:748-57. 2003

Research Grants

Collaborators

  • Hailiang Hu
  • Christine Janson
  • M Thai
  • Ajay Dhaka
  • Apoor Patel
  • Ying Wang
  • Noriyuki Kasahara
  • George C Prendergast
  • M MUSCHEN
  • J McLaughlin
  • P Y Ting
  • O N Witte
  • D Cheng
  • Lucia C Huynh
  • Minh Thai
  • Marc Milstein
  • Gautam Malhotra
  • Joanne M Bliss
  • Harley I Kornblum
  • Alcino J Silva
  • Rui M Costa
  • THOMAS J O'DELL
  • Dwain K Irvin
  • Richard T Waldron
  • Maggie M Riley
  • Enrique Rozengurt

Detail Information

Publications9

  1. pmc ABL tyrosine kinases: evolution of function, regulation, and specificity
    John Colicelli
    Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Sci Signal 3:re6. 2010
    ..Information on ABL regulatory mechanisms is being mined to provide new therapeutic strategies against hematopoietic malignancies caused by BCR-ABL1 and related leukemogenic proteins...
  2. pmc ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1
    M Thai
    Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Leukemia 25:290-300. 2011
    ..The findings suggest that RIN1 targeting could be efficacious for imatinib-resistant disease and might complement ABL kinase inhibitors in first-line therapy...
  3. pmc RIN3 is a negative regulator of mast cell responses to SCF
    Christine Janson
    Molecular Biology Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e49615. 2012
    ..These findings directly connect KIT activation with a mast cell-specific RAS effector that regulates the cellular response to SCF and provide new insight for the development of more effective mastocytosis treatments...
  4. pmc Human RAS superfamily proteins and related GTPases
    John Colicelli
    Department of Biological Chemistry and Molecular Biology Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Sci STKE 2004:RE13. 2004
    ..These related proteins employ GTP binding and GTPase domains in diverse structural contexts, expanding the scope of their function in humans...
  5. pmc Signal transduction: RABGEF1 fingers RAS for ubiquitination
    John Colicelli
    Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Biol 20:R630-2. 2010
    ..A new mechanism for RAS signal attenuation with implications for receptor trafficking has been uncovered...
  6. pmc Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration
    Hailiang Hu
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Cell Biol 28:1573-83. 2008
    ..These findings shed new light on the basis for distinct interpretations of TGF-beta signaling by normal versus transformed cells...
  7. pmc The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins
    Ying Wang
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
    Mol Cell Biol 22:916-26. 2002
    ..These data suggest that the normal localization and function of RIN1, as well as its ability to compete with RAF, are regulated in part by 14-3-3 binding, which in turn is controlled by PKD phosphorylation...
  8. ncbi The RAS effector RIN1 modulates the formation of aversive memories
    Ajay Dhaka
    Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
    J Neurosci 23:748-57. 2003
    ..These results indicate that RIN1 serves as an inhibitory modulator of neuronal plasticity in aversive memory formation...

Research Grants16

  1. Mechanism of RIN1 Signaling in Neuronal Plasticity
    John Colicelli; Fiscal Year: 2007
    ..Special focus will be placed on dendritic spine remodeling because the connection of this phenomenon to learning remains conjectural. ..
  2. EFFECTORS AND REGULATORS OF NORMAL AND ONCOGENIC RAS
    John Colicelli; Fiscal Year: 1992
    ..The results of these studies should greatly expand our knowledge of the function of ras in mammalian cells. They should also lead to a better understanding of oncogenesis in general...
  3. EFFECTORS AND REGULATORS OF NORMAL AND ONCOGENIC RAS
    John Colicelli; Fiscal Year: 1993
    ..The results of these studies should greatly expand our knowledge of the function of ras in mammalian cells. They should also lead to a better understanding of oncogenesis in general...
  4. EFFECTORS AND REGULATORS OF NORMAL AND ONCOGENIC RAS
    John Colicelli; Fiscal Year: 2001
    ..These studies, directed at the role of Rin1 function in Ras-mediated signal transduction, should facilitate their understanding of normal cellular processes including differentiation and mitosis as well as cancer pathologies. ..
  5. Mechanism of RIN1 Signaling in Neuronal Plasticity
    John Colicelli; Fiscal Year: 2006
    ..Special focus will be placed on dendritic spine remodeling because the connection of this phenomenon to learning remains conjectural. ..
  6. Mechanism of RIN1 Signaling in Neuronal Plasticity
    John Colicelli; Fiscal Year: 2005
    ..Special focus will be placed on dendritic spine remodeling because the connection of this phenomenon to learning remains conjectural. ..
  7. Mechanism of RIN1 Signaling in Neuronal Plasticity
    John Colicelli; Fiscal Year: 2003
    ..Special focus will be placed on dendritic spine remodeling because the connection of this phenomenon to learning remains conjectural. ..
  8. EFFECTORS AND REGULATORS OF NORMAL AND ONCOGENIC RAS
    John Colicelli; Fiscal Year: 2002
    ..These studies, directed at the role of Rin1 function in Ras-mediated signal transduction, should facilitate their understanding of normal cellular processes including differentiation and mitosis as well as cancer pathologies. ..
  9. EFFECTORS AND REGULATORS OF NORMAL AND ONCOGENIC RAS
    John Colicelli; Fiscal Year: 1999
    ..These studies, directed at the role of Rin1 function in Ras-mediated signal transduction, should facilitate their understanding of normal cellular processes including differentiation and mitosis as well as cancer pathologies. ..
  10. Mechanism of RIN1 Signaling in Neuronal Plasticity
    John Colicelli; Fiscal Year: 2004
    ..Special focus will be placed on dendritic spine remodeling because the connection of this phenomenon to learning remains conjectural. ..
  11. EFFECTORS AND REGULATORS OF NORMAL AND ONCOGENIC RAS
    John Colicelli; Fiscal Year: 2000
    ..These studies, directed at the role of Rin1 function in Ras-mediated signal transduction, should facilitate their understanding of normal cellular processes including differentiation and mitosis as well as cancer pathologies. ..
  12. A Novel Screen for Compounds that Outflank BCR-ABL Drug-Resistance
    John Colicelli; Fiscal Year: 2009
    ....
  13. A Novel Screen for Compounds that Outflank BCR-ABL Drug-Resistance
    JOHN J COLICELLI; Fiscal Year: 2010
    ....