Sean Colgan

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function
    Thomas Weissmüller
    1Mucosal Inflammation Program, University of Colorado, 12700 E 19th Ave, Aurora, CO 80045, USA
    FASEB J 28:256-64. 2014
  2. pmc The inflammatory tissue microenvironment in IBD
    Sean P Colgan
    Division of Gastroenterology, Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA
    Inflamm Bowel Dis 19:2238-44. 2013
  3. pmc Adenosine and gastrointestinal inflammation
    Sean P Colgan
    Department of Medicine and Mucosal Inflammation Program, University of Colorado School of Medicine, 12700 East 19th Ave, MS B 146, Aurora, CO 80045, USA
    J Mol Med (Berl) 91:157-64. 2013
  4. doi request reprint Contributions of neutrophils to resolution of mucosal inflammation
    Sean P Colgan
    Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Immunol Res 55:75-82. 2013
  5. pmc Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery
    Sean P Colgan
    Departments of Medicine and Anesthesiology and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Annu Rev Physiol 74:153-75. 2012
  6. doi request reprint Hypoxia: an alarm signal during intestinal inflammation
    Sean P Colgan
    Division of Gastroenterology, Mucosal Inflammation Program, University of Colorado Denver, 12700 E 19th Avenue MS B146, Aurora, CO 80045, USA
    Nat Rev Gastroenterol Hepatol 7:281-7. 2010
  7. ncbi request reprint Natural killer T cells in mucosal homeostasis
    Arthur Kaser
    Division of Gastroenterology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Ann N Y Acad Sci 1029:154-68. 2004
  8. ncbi request reprint CD1d-restricted T cell pathways at the epithelial-lymphocyte-luminal interface
    Arthur Kaser
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pediatr Gastroenterol Nutr 39:S719-22. 2004
  9. pmc Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization
    Christopher F MacManus
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    FASEB J 25:1856-64. 2011

Research Grants

Collaborators

Detail Information

Publications9

  1. pmc HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function
    Thomas Weissmüller
    1Mucosal Inflammation Program, University of Colorado, 12700 E 19th Ave, Aurora, CO 80045, USA
    FASEB J 28:256-64. 2014
    ..These findings provide an important link between hypoxia and metabolic conditions associated with inflammation and angiogenesis...
  2. pmc The inflammatory tissue microenvironment in IBD
    Sean P Colgan
    Division of Gastroenterology, Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA
    Inflamm Bowel Dis 19:2238-44. 2013
    ..Here, we review the current understanding of metabolic microenvironments within the intestine in IBD, with discussion of the advantages and disadvantages of targeting these pathways to treat patients with IBD...
  3. pmc Adenosine and gastrointestinal inflammation
    Sean P Colgan
    Department of Medicine and Mucosal Inflammation Program, University of Colorado School of Medicine, 12700 East 19th Ave, MS B 146, Aurora, CO 80045, USA
    J Mol Med (Berl) 91:157-64. 2013
    ..Here, we review contributions of Ado to cell and tissue stress responses, with a particular emphasis on the gastrointestinal mucosa...
  4. doi request reprint Contributions of neutrophils to resolution of mucosal inflammation
    Sean P Colgan
    Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Immunol Res 55:75-82. 2013
    ..Here, we highlight several recent examples of how PMN coordinate the resolution of ongoing inflammation, with a particular focus on the gastrointestinal mucosa...
  5. pmc Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery
    Sean P Colgan
    Departments of Medicine and Anesthesiology and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Annu Rev Physiol 74:153-75. 2012
    ..Such information has provided new insights into disease pathogenesis and, importantly, will provide insights into new therapeutic targets...
  6. doi request reprint Hypoxia: an alarm signal during intestinal inflammation
    Sean P Colgan
    Division of Gastroenterology, Mucosal Inflammation Program, University of Colorado Denver, 12700 E 19th Avenue MS B146, Aurora, CO 80045, USA
    Nat Rev Gastroenterol Hepatol 7:281-7. 2010
    ..We also discuss the pros and cons of targeting these pathways to treat patients with IBD...
  7. ncbi request reprint Natural killer T cells in mucosal homeostasis
    Arthur Kaser
    Division of Gastroenterology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Ann N Y Acad Sci 1029:154-68. 2004
    ..In this review, we focus on recent observations on the characteristics of CD1d-restricted pathways in mucosal compartments, after a brief introduction into the biology of CD1d and CD1d-restricted T cells...
  8. ncbi request reprint CD1d-restricted T cell pathways at the epithelial-lymphocyte-luminal interface
    Arthur Kaser
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pediatr Gastroenterol Nutr 39:S719-22. 2004
    ..In this review, we focus on recent observations in the characteristics of CD1d-restricted pathways in mucosal compartments after a brief introduction to the biology of CD1d and CD1d-restricted T cells...
  9. pmc Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization
    Christopher F MacManus
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    FASEB J 25:1856-64. 2011
    ..Taken together, these results identify ADM as an endogenously generated vascular mediator that functions as a mucosal protective factor through fine tuning of HIF activity...

Research Grants21

  1. Neutrophils and Vascular Endothelial Permeability
    Sean Colgan; Fiscal Year: 2006
    ..The overall aim of this proposal is to elucidate the molecular pathways critical to vascular barrier regulation in hypoxia and during inflammation. ..
  2. Hypoxia and Inflammation at the Vascular Interface
    Sean P Colgan; Fiscal Year: 2010
    ..In particular, these studies are designed to identify, test and unify hypotheses that adenosine functions as an endogenous anti-inflammatory through distinct mechanisms. ..
  3. ROLE OF EPITHELIA IN ISCHEMIA/REPERFUSION INJURY
    Sean Colgan; Fiscal Year: 2004
    ..The overall aim of this proposal is to elucidate the transcriptional signaling events mediating mucosal epithelial responses to hypoxia and inflammation. ..
  4. NEUTROPHIL-ENDOTHELIAL AND VASCULAR PERMEABILITY
    Sean Colgan; Fiscal Year: 2002
    ..abstract_text> ..
  5. Role of Epithelia In Ischemia Reperfusion Injury
    Sean P Colgan; Fiscal Year: 2010
    ..The overall aim of this proposal is to elucidate the transcriptional signaling events mediating mucosal epithelial responses to hypoxia and inflammation. ..