Research Topics
Species | ROSALIND ANNE COLEMANSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Clinical and genetic characterization of Chanarin-Dorfman syndrome patients: first report of large deletions in the ABHD5 geneChiara Redaelli
Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy
Orphanet J Rare Dis 5:33. 2010..The clinical phenotype involves multiple organs and systems, including liver, eyes, ears, skeletal muscle and central nervous system (CNS). Mutations in ABHD5/CGI58 gene are associated with CDS...
Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways?Rosalind A Coleman
University of North Carolina, Chapel Hill, 27599 7461, USA
J Nutr 132:2123-6. 2002..It should be emphasized that although the data for acyl-CoA channeling are strong, they are indirect. Rigorous testing of these predictions will be required...- Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid compositionLinda E Hammond
Department of Nutrition Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mol Cell Biol 22:8204-14. 2002..The increase in arachidonate may be functionally significant in terms of eicosanoid production... - How do I fatten thee? Let me count the waysRosalind A Coleman
Department of Nutrition and Pediatrics, University of North Carolina, CB 7461, Chapel Hill, NC 27599, USA
Cell Metab 5:87-9. 2007..The recent identification of a new GPAT isoform (Cao et al., 2006) suggests a role for GPAT isoforms in nutrient-mediated signaling... - Enzymes of triacylglycerol synthesis and their regulationRosalind A Coleman
Departments of Nutrition and Pediatrics, University of North Carolina, Chapel Hill, NC, USA
Prog Lipid Res 43:134-76. 2004.... - Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid compositionLei O Li
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 284:27816-26. 2009.... - Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient miceLinda E Hammond
Department of Nutrition, CB 7461, 2301 Michael Hooker Research Building, Columbia Street, University of North Carolina, Chapel Hill, NC 27599, USA
Exp Mol Pathol 82:210-9. 2007..Thus, Gpat1-/- liver exhibits increased oxidative stress and sensitivity of the mitochondrial permeability transition pore, and a balanced increase in apoptosis and proliferation... - Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAsLinda E Hammond
Department of Nutrition, University of North Carolina, North Chapel Hill, Carolina 27599, USA
J Biol Chem 280:25629-36. 2005.... - Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondriaTal M Lewin
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 279:13488-95. 2004..We conclude that a novel GPAT (mtGPAT2) with antigenic epitopes similar to those of mtGPAT is detectable in mitochondria from the livers of mtGPAT(-/-) mice... - Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid compositionTal M Lewin
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
Biochim Biophys Acta 1781:352-8. 2008.... - Ontogeny of mRNA expression and activity of long-chain acyl-CoA synthetase (ACSL) isoforms in Mus musculus heartHendrik de Jong
Department of Nutrition, University of North Carolina at Chapel Hill, CB 7461, NC 27599, USA
Biochim Biophys Acta 1771:75-82. 2007..Our data support the hypothesis that each ACSL has a specific role in the channeling of FA towards distinct metabolic fates... - Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cellsDouglas G Mashek
Department of Nutrition, University of North Carolina, Chapel Hill, 27599, USA
J Biol Chem 281:945-50. 2006..These results suggest that uptake of fatty acids into cells is regulated by metabolism and that overexpressed ACSL5 partitions exogenously derived fatty acids toward TAG synthesis and storage... - Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesisAngela A Wendel
Department of Nutrition, CB 7461, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Biochim Biophys Acta 1791:501-6. 2009..Much work remains to fully delineate the regulation of each GPAT isoform and its individual role in triacylglycerol synthesis... - Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membraneTal M Lewin
Department of Nutrition and Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA
Arch Biochem Biophys 404:263-70. 2002..We also determined that, unlike ACS1 and 5, ACS4 is not an intrinsic membrane protein. This suggests that ACS4 is probably targeted and linked to MAM and peroxisomes by interactions with other proteins... - Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytesTal M Lewin
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Physiol Endocrinol Metab 288:E835-44. 2005..Thus, in isolated hepatocytes, mtGPAT1 may synthesize a cytosolic pool of TAG that cannot be secreted... - Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytesLei O Li
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 281:37246-55. 2006..Thus, consistent with the hypothesis that individual ACSLs partition FA, Ad-Acsl1 increased FA reacylation and channeled FA toward diacylglycerol and phospholipid synthesis and away from cholesterol ester synthesis... - Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistanceCynthia A Nagle
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 282:14807-15. 2007..These results indicate that increased flux through the pathway of hepatic de novo triacylglycerol synthesis can cause hepatic and systemic insulin resistance in the absence of obesity or a lipogenic diet... - Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- miceCynthia A Nagle
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
J Lipid Res 49:823-31. 2008.... - Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2)Shuli Wang
Department of Nutrition, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Arch Biochem Biophys 465:347-58. 2007..In vitro translation showed a single product of 89 kDa. Unlike GPAT1, GPAT2 mRNA abundance in liver was not altered by fasting or refeeding. GPAT2 is likely to have a specialized function in testis... - Regulation of myocardial triacylglycerol synthesis and metabolismTal M Lewin
Department of Nutrition, School of Public Health, University of North Carolina, CB #7400, Pittsboro Street, Chapel Hill, NC 27599, USA
Biochim Biophys Acta 1634:63-75. 2003..These pathways are discussed in the context of the central role myocardial triacylglycerol plays in cardiac energy metabolism and heart disease... - Glycerol-3-phosphate acyltransferase 1 is essential for the immune response to infection with coxsackievirus B3 in miceErik A Karlsson
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
J Nutr 139:779-83. 2009..Innate mechanisms may be affected by altered membrane composition or host redox status, whereas the adaptive response may require GPAT1 activity itself... - Rat long chain acyl-CoA synthetase 5, but not 1, 2, 3, or 4, complements Escherichia coli fadDJorge M Caviglia
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 279:11163-9. 2004..Thus, membrane composition and protein-protein interactions may be critical in reconstituting bacterial ACS function... - Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesisJessica M Ellis
Department of Nutrition, 2301 MHRC, Dauer Drive, University of North Carolina, Chapel Hill, NC 27599, USA
Cell Metab 12:53-64. 2010..Thus, ACSL1 has a specific function in directing the metabolic partitioning of FAs toward beta-oxidation in adipocytes... - Hepatic triacylglycerol accumulation and insulin resistanceCynthia A Nagle
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Lipid Res 50:S74-9. 2009.... - Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesityAngela A Wendel
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, USA
Diabetes 59:1321-9. 2010..We asked whether ob/ob mice lacking Gpat1 would have reduced hepatic steatosis and improved insulin sensitivity... - Acyl-coenzyme A synthetases in metabolic controlJessica M Ellis
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
Curr Opin Lipidol 21:212-7. 2010.... - Early hepatic insulin resistance in mice: a metabolomics analysisLei O Li
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mol Endocrinol 24:657-66. 2010.... - Mutagenesis of rat acyl-CoA synthetase 4 indicates amino acids that contribute to fatty acid bindingLori Stinnett
Department of Nutrition, 2301 Michael Hooker Research Center, Pittsboro St, University of North Carolina, Chapel Hill, NC 27599, USA
Biochim Biophys Acta 1771:119-25. 2007..These studies suggested that the preference of ACSL4 for long-chain polyunsaturated fatty acids can be modified by altering specific amino acid residues... - Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to dietDouglas G Mashek
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
J Lipid Res 47:2004-10. 2006..They further suggest that translational or posttranslational modifications are likely to contribute to the regulation of ACSL isoforms... - Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6Cynthia G Van Horn
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Biochemistry 44:1635-42. 2005..These data further document important differences in the closely related ACSL isoforms and show that amino acid changes near the consensus nucleotide binding site alter function in the two splice variants of ACSL6... - Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophyJessica M Ellis
Department of Nutrition, CB 7461, University of North Carolina at Chapel Hill, 135 Dauer Drive, MHRC 2301, Chapel Hill, NC 27599, USA
Mol Cell Biol 31:1252-62. 2011.... - Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene familyDouglas G Mashek
Departments of Nutrition and Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA
J Lipid Res 45:1958-61. 2004..Splice variants of ACSL3, -4, -5, and -6 are cataloged. Suggestions for naming other family members and for the nonmammalian acyl-CoA synthetases are made... - Acyl-CoA synthesis, lipid metabolism and lipotoxicityLei O Li
Department of Nutrition, CB 7461, University of North Carolina, Chapel Hill, NC 27599 7461, USA
Biochim Biophys Acta 1801:246-51. 2010.... - Cellular fatty acid uptake: the contribution of metabolismDouglas G Mashek
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
Curr Opin Lipidol 17:274-8. 2006..Future studies of cellular fatty acid uptake should consider the influence of fatty acid metabolism and the possible interactions between fatty acid metabolism or metabolites and fatty acid transport proteins... - Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout miceSusanne Neschen
Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven, CN 06520, USA
Cell Metab 2:55-65. 2005..These data suggest that mtGPAT1 might serve as a novel target for treatment of hepatic steatosis and hepatic insulin resistance and that long chain acyl-CoA's do not mediate fat-induced hepatic insulin resistance in this model... - Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epitheliumAnne P Beigneux
Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095, USA
J Lipid Res 47:734-44. 2006..Thus, we identified a novel glycerolipid acyltransferase of the ER, AGPAT6, which is crucial for the production of milk fat by the mammary gland... - The C-terminal region of mitochondrial glycerol-3-phosphate acyltransferase-1 interacts with the active site region and is required for activityMagali Pellon-Maison
Instituto de Investigaciones Bioquimicas de La Plata, UNLP, La Plata, Argentina
Arch Biochem Biophys 450:157-66. 2006..These results suggest that the C-terminal domain is necessary for mtGPAT1 activity, and probably contributes to catalysis or substrate binding... - Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin actionMaria R Gonzalez-Baró
Instituto de Investigaciones Bioquímicas de La Plata CONICET UNLP, La Plata, Argentina
Am J Physiol Gastrointest Liver Physiol 292:G1195-9. 2007.... - Fatty acid transport by vectorial acylation in mammals: roles played by different isoforms of rat long-chain acyl-CoA synthetasesFumin Tong
Center for Metabolic Disease, Ordway Research Institute and Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208 3425, USA
Arch Biochem Biophys 447:46-52. 2006..This is the first study evaluating the role of the mammalian ACSLs in fatty acid transport and supports a role for ACSL1, 4, and 6 in transport by vectorial acylation... - Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophagesBardia Askari
Department of Pathology, 1959 NE Pacific St, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
Diabetes 56:1143-52. 2007..Therefore, rosiglitazone might alter the biological effects of fatty acids in these cells and in atherosclerosis... - Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV)Magali Pellon-Maison
Instituto de Investigaciones Bioquímicas de La Plata CONICET UNLP, 60 and 120, 1900 La Plata, Argentina
Biochim Biophys Acta 1771:830-8. 2007.... - The Plasmodium falciparum PfGatp is an endoplasmic reticulum membrane protein important for the initial step of malarial glycerolipid synthesisTeresa C Santiago
Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, CT 06030, USA
J Biol Chem 279:9222-32. 2004..This study, which describes the first protozoan GPAT gene, reveals an important role for the endoplasmic reticulum in the initial step of Plasmodium membrane biogenesis... - Complex expression pattern of the Barth syndrome gene product tafazzin in human cell lines and murine tissuesBiao Lu
Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0T6, Canada
Biochem Cell Biol 82:569-76. 2004..The presence of a mutation in this region in Barth syndrome patients indicates that this motif is essential for tafazzin function... - Phosphatidylcholine deficiency upregulates enzymes of triacylglycerol metabolism in CHO cellsJ Matías Caviglia
Instituto de Investigaciones Bioquimicas de La Plata, Universidad Nacional de La Plata, 1900 La Plata, Argentina
J Lipid Res 45:1500-9. 2004..In CHO MT58 cells, in which de novo PC synthesis is blocked, lysoPC acylation with fatty acid originating from TAG may represent the main pathway for generating PC...
Research Grants
- Acyl-CoA Synthetase: Structure, Function and RegulationRosalind Coleman; Fiscal Year: 2006..abstract_text> ..
- METABOLISM OF GLYCEROLIPIDS IN LIVERRosalind Coleman; Fiscal Year: 2006..The information gained could lead to advances in the therapy of disorders characterized by abnormal regulation of VLDL synthesis or triacylglycerol storage. ..
- Acyl-CoA Synthetase: Structure, Function and RegulationRosalind Coleman; Fiscal Year: 2007..This research is relevant to obesity, fatty liver, diabetes, lipotoxicity, nutrient regulation of gene expression, cancer, and mental retardation. ..
- METABOLISM OF GLYCEROLIPIDS IN LIVERROSALIND ANNE COLEMAN; Fiscal Year: 2010..This application is designed to investigate the enzymes that initiate fat synthesis in the liver in order to understand how they are regulated and how they contribute to liver pathology. ..
- Acyl-CoA Synthetase: Structure, Function and RegulationROSALIND ANNE COLEMAN; Fiscal Year: 2010..This research is relevant to obesity, fatty liver, diabetes, lipotoxicity, nutrient regulation of gene expression, cancer, and mental retardation. ..
- METABOLISM OF GLYCEROLIPIDS IN LIVERRosalind Coleman; Fiscal Year: 2002....
- Acyl-CoA Synthetase: Structure, Function and RegulationRosalind Coleman; Fiscal Year: 2009..Specifically, it will allow us to hire an additional postdoctoral fellow and an additional graduate student. ..