Research Topics
Species | Steven W ColeSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Molecular pathways: beta-adrenergic signaling in cancerSteven W Cole
Division of Hematology Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1678, USA
Clin Cancer Res 18:1201-6. 2012....- Foxl2 functions in sex determination and histogenesis throughout mouse ovary developmentJose Elias Garcia-Ortiz
Laboratory of Genetics, NIA NIH IRP, Baltimore, MD, USA
BMC Dev Biol 9:36. 2009..g., Rspo1. Here we report expression profiling of mouse ovaries that lack Foxl2 alone or in combination with Wnt4 or Kit/c-Kit... - Computational identification of gene-social environment interaction at the human IL6 locusSteven W Cole
Department of Medicine and Norman Cousins Center, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:5681-6. 2010.... - Social regulation of gene expression in human leukocytesSteve W Cole
Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
Genome Biol 8:R189. 2007.... - Elevating the perspective on human stress genomicsSteve W Cole
Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, CA, USA
Psychoneuroendocrinology 35:955-62. 2010.... - Social regulation of leukocyte homeostasis: the role of glucocorticoid sensitivitySteve W Cole
Department of Medicine, UCLA School of Medicine, Cousins Center for PNI, UCLA AIDS Institute, Jonsson Comprehensive Cancer Center, The UCLA Molecular Biology Institute, and HopeLab Foundation, Los Angeles, CA 90095 1678, USA
Brain Behav Immun 22:1049-55. 2008.... - Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids: insights from in vivo cell trafficking dynamics in rhesus macaquesSteve W Cole
Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, 11 934 Factor Building, Los Angeles, California 90095 1678, USA
Psychosom Med 71:591-7. 2009..To determine whether chronic social stress can desensitize leukocytes to normal physiologic regulation by endogenous glucocorticoids... 
Psychosocial influences on HIV-1 disease progression: neural, endocrine, and virologic mechanismsSteve W Cole
Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, the Norman Cousins Center, Jonsson Comprehensive Cancer Center, UCLA AIDS Institute, California 90095 1678, USA
Psychosom Med 70:562-8. 2008..As such, neural and endocrine parameters might provide useful biomarkers for gauging the promise of behavioral interventions and suggest novel adjunctive strategies for controlling HIV-1 disease progression...
Expression-based monitoring of transcription factor activity: the TELiS databaseSteve W Cole
UCLA Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
Bioinformatics 21:803-10. 2005..TELiS thus provides a simple, rapid and sensitive tool for identifying transcription control pathways mediating observed gene expression dynamics...- Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescenceSteven W Cole
Department of Medicine, Norman Cousins Center, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, CA, USA
Dev Psychol 47:1173-80. 2011.... - Controlling false-negative errors in microarray differential expression analysis: a PRIM approachSteve W Cole
Department of Medicine, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
Bioinformatics 19:1808-16. 2003.... - Personality and serotonin transporter genotype interact with social context to affect immunity and viral set-point in simian immunodeficiency virus diseaseJohn P Capitanio
California National Primate Research Center, Department of Psychology, University of California, One Shields Avenue, Davis, CA 95616, USA
Brain Behav Immun 22:676-89. 2008.... - Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesisErica K Sloan
Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, UCLA AIDS Institute, Cousins Center for Psychoneuroimmunology at the Semel Institute of Neuroscience and Human Behavior, Los Angeles, California 90095 1678, USA
J Neurosci 27:8857-65. 2007..These data reveal a surprising degree of behaviorally induced plasticity in the structure of lymphoid innervation and define a novel pathway by which social factors can modulate immune response and viral pathogenesis... - Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytesSteven W Cole
Division of Hematology Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA 90095 1678, USA
Proc Natl Acad Sci U S A 108:3080-5. 2011..affine social conditions... - Inflammatory biomarkers for persistent fatigue in breast cancer survivorsAlicia Collado-Hidalgo
Cousins Center for Psychoneuroimmunology, University of California at Los Angeles Semel Institute for Neuroscience and Human Behavior, Los Angeles, California 90095-7076, USA
Clin Cancer Res 12:2759-66. 2006..83). CONCLUSION: These results extend links between fatigue and inflammatory markers to show a functional alteration in proinflammatory cytokine response to lipopolysaccharide and define a prognostic biomarker of behavioral fatigue... - Enhanced replication of simian immunodeficiency virus adjacent to catecholaminergic varicosities in primate lymph nodesErica K Sloan
Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, UCLA AIDS Institute, Los Angeles, California 90095-1678, USA
J Virol 80:4326-35. 2006.... - Mindfulness meditation training effects on CD4+ T lymphocytes in HIV-1 infected adults: a small randomized controlled trialJ David Creswell
Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, 300 Medical Plaza, Suite 3109, Los Angeles, CA 90095, USA
Brain Behav Immun 23:184-8. 2009..These findings provide an initial indication that mindfulness meditation training can buffer CD4+ T lymphocyte declines in HIV-1 infected adults. Clinical Trials Registration: clinicaltrials.gov, Identifier: NCT00600561... - Examining the influence of beta blockers and ACE inhibitors on the risk for breast cancer recurrence: results from the LACE cohortPatricia A Ganz
UCLA Schools of Public Health and Medicine, Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095 6900, USA
Breast Cancer Res Treat 129:549-56. 2011..These observations need to be confirmed and suggest that greater attention should focus on the potential role of these commonly used medications in BC outcomes... - A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgroundsAndrew J Fuligni
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Box 62, Los Angeles, CA 90024, USA
Psychosom Med 71:329-33. 2009..To examine the association between the experience of daily interpersonal stress and levels of C-reactive protein (CRP), an inflammatory marker that is a key indicator of cardiovascular risk, during the teenage years... - Social temperament and lymph node innervationErica K Sloan
Cousins Center for PNI, Semel Institute of Neuroscience and Human Behavior, Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA 90095 7076, USA
Brain Behav Immun 22:717-26. 2008..These findings are consistent with the hypothesis that structural differences in lymphoid tissue innervation might potentially contribute to relationships between social temperament and immunobiology... - SIV infection decreases sympathetic innervation of primate lymph nodes: the role of neurotrophinsErica K Sloan
University of California Los Angeles, Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, CA, USA
Brain Behav Immun 22:185-94. 2008.... - Daily family assistance and inflammation among adolescents from Latin American and European backgroundsAndrew J Fuligni
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
Brain Behav Immun 23:803-9. 2009..Additional work should explore the family context that drives high levels of assistance among adolescents, as well as the variety of ways adolescents may derive meaning from this activity... - Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanismsMichael R Irwin
Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095 7057, USA
J Pharmacol Exp Ther 320:507-15. 2007..Targeting sympathovagal balance might represent a novel strategy for partial amelioration of impairments of innate immunity in cocaine dependence... - Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoidsJulienne E Bower
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, 300 UCLA Medical Plaza, Room 3306, Box 957076 Los Angeles, CA 90095 7076, USA
Brain Behav Immun 21:251-8. 2007..05). These data provide further evidence of enhanced inflammatory processes in fatigued breast cancer survivors and suggest that these processes may stem in part from decreased glucocorticoid response to stress... - Fatigue and gene expression in human leukocytes: increased NF-κB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigueJulienne E Bower
UCLA Department of Psychology, 1285 Franz Hall, P O Box 951563, Los Angeles, CA 90095 1563, United States
Brain Behav Immun 25:147-50. 2011.... - T-cell homeostasis in breast cancer survivors with persistent fatigueJulienne E Bower
Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, UCLA Neuropsychiatric Institute, CA 90095 7076, USA
J Natl Cancer Inst 95:1165-8. 2003..These results require confirmation in a larger study that is specifically designed to address this hypothesis... - Reciprocal regulation of the neural and innate immune systemsMichael R Irwin
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 UCLA Medical Plaza, University of California, Los Angeles, California 90095 7076, USA
Nat Rev Immunol 11:625-32. 2011..CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases... - Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancerXiaofeng Zhou
Dental Research Institute, School of Dentistry and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA, USA
Expert Rev Mol Diagn 6:39-50. 2006..Potential solutions that may help overcome these challenges are also offered... - The sympathetic nervous system induces a metastatic switch in primary breast cancerErica K Sloan
UCLA Norman Cousins Center, Semel Institute for Neuroscience and Human Behavior, Medical Plaza 300, Room 3129, Los Angeles, CA 90095, USA
Cancer Res 70:7042-52. 2010.... - Human immunodeficiency virus type 1 infection and replication in normal human oral keratinocytesXuan Liu
Department of Oral and Maxillofacial Surgery, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Virol 77:3470-6. 2003..Coculture studies showed that infectious HIV-1 virions can also be conveyed from NHOKs to activated peripheral blood lymphocytes, suggesting a potential role of oral epithelial cells in the transmission of HIV infection... - Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistributionVanessa A Richlin
Case Western Reserve School of Medicine, Los Angeles, CA 90095 1678, USA
Brain Behav Immun 18:231-7. 2004..Implications for future efforts to analyze stress effects on leukocyte gene expression are considered... - Psychological risk factors for HIV pathogenesis: mediation by the autonomic nervous systemSteve W Cole
Department of Medicine, University of California, Los Angeles, Los Angeles, California 90095-1678, USA
Biol Psychiatry 54:1444-56. 2003..Such findings also suggest novel targets for adjunctive therapy in long-term control of HIV-1 disease... - Stress-induced remodeling of lymphoid innervationErica K Sloan
Norman Cousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, UCLA School of Medicine, USA
Brain Behav Immun 22:15-21. 2008..The finding that behavioral stress can tonically alter lymph node neural structure suggests that behavioral factors could exert long-term regulatory influences on the initiation, maintenance, and resolution of immune responses... - Transcriptional modulation of the developing immune system by early life social adversitySteven W Cole
Department of Medicine, Division of Hematology Oncology, and Department of Psychiatry and Biobehavioral Sciences, University of California School of Medicine, Los Angeles, CA 90095
Proc Natl Acad Sci U S A 109:20578-83. 2012.... - beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTAMargaret Chang
Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1678, USA
J Virol 79:13538-47. 2005..These findings also suggest novel therapeutic strategies for controlling the activity of this oncogenic gammaherpesvirus in vivo... - Alcohol enhances HIV type 1 infection in normal human oral keratinocytes by up-regulating cell-surface CXCR4 coreceptorHongying Chen
Department of Oral and Maxillofacial Surgery, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA
AIDS Res Hum Retroviruses 20:513-9. 2004..These data suggest that alcohol may influence oral HIV transmission by altering the cellular compartmentalization of CXCR4 in cells of the oral cavity... - Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancerCharles N Landen
Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
Cancer Res 67:10389-96. 2007.... - A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signalingGregory E Miller
Department of Psychology, University of British Columbia, Vancouver, Canada
Biol Psychiatry 64:266-72. 2008..Chronic stressors are known to increase vulnerability to medical illness, but the mechanisms underlying this phenomenon are poorly understood... - Life course transitions and natural disaster: marriage, birth, and divorce following Hurricane HugoCatherine L Cohan
Department of Human Development and Family Studies, Pennsylvania State University, University Park Campus, Pennsylvania, USA
J Fam Psychol 16:14-25. 2002..Taken together, the results suggested that a life-threatening event motivated people to take significant action in their close relationships that altered their life course... - Improvement in cancer-related knowledge following use of a psychoeducational video game for adolescents and young adults with cancerIvan L Beale
School of Psychology, University of New South Wales, New South Wales, Australia
J Adolesc Health 41:263-70. 2007..A video game, "Re-Mission," was developed to actively involve young people with cancer in their own treatment. Re-Mission provides opportunities to learn about cancer and its treatment... - A video game improves behavioral outcomes in adolescents and young adults with cancer: a randomized trialPamela M Kato
Department of Pediatrics, Stanford Hospital, Stanford, California, USA
Pediatrics 122:e305-17. 2008....
Research Grants
- TRANSCRIPTION-REGULATING VECTORS FOR ANTIVIRAL VACCINESSteve Cole; Fiscal Year: 2002..abstract_text> ..
- Combinatorial Genomics in CancerSteve Cole; Fiscal Year: 2007..The bioinformatic tools produced in these studies will create a generalized analytic infrastructure for mapping complex etiologies in cancer and deploying patient-specific targeted therapies. ..
- Autonomic nervous system control of HIV-1 replicationSteve Cole; Fiscal Year: 2005..Such interventions would enhance the efficacy of current antiretroviral treatment regimens by opposing physiologic processes that support ongoing pathogenesis. ..
- Combinatorial Genomics in CancerSteve W Cole; Fiscal Year: 2010..The bioinformatic tools produced in these studies will create a generalized analytic infrastructure for mapping complex etiologies in cancer and deploying patient-specific targeted therapies. ..