Steven W Cole

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Nervous system regulation of the cancer genome
    Steven W Cole
    Division of Hematology Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    Brain Behav Immun 30:S10-8. 2013
  2. pmc Molecular pathways: beta-adrenergic signaling in cancer
    Steven W Cole
    Division of Hematology Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1678, USA
    Clin Cancer Res 18:1201-6. 2012
  3. pmc Foxl2 functions in sex determination and histogenesis throughout mouse ovary development
    Jose Elias Garcia-Ortiz
    Laboratory of Genetics, NIA NIH IRP, Baltimore, MD, USA
    BMC Dev Biol 9:36. 2009
  4. pmc Social regulation of leukocyte homeostasis: the role of glucocorticoid sensitivity
    Steve W Cole
    Department of Medicine, UCLA School of Medicine, Cousins Center for PNI, UCLA AIDS Institute, Jonsson Comprehensive Cancer Center, The UCLA Molecular Biology Institute, and HopeLab Foundation, Los Angeles, CA 90095 1678, USA
    Brain Behav Immun 22:1049-55. 2008
  5. pmc Social regulation of gene expression in human leukocytes
    Steve W Cole
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    Genome Biol 8:R189. 2007
  6. pmc Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence
    Steven W Cole
    Department of Medicine, Norman Cousins Center, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, CA, USA
    Dev Psychol 47:1173-80. 2011
  7. ncbi Expression-based monitoring of transcription factor activity: the TELiS database
    Steve W Cole
    UCLA Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
    Bioinformatics 21:803-10. 2005
  8. pmc Elevating the perspective on human stress genomics
    Steve W Cole
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, CA, USA
    Psychoneuroendocrinology 35:955-62. 2010
  9. pmc Computational identification of gene-social environment interaction at the human IL6 locus
    Steven W Cole
    Department of Medicine and Norman Cousins Center, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:5681-6. 2010
  10. ncbi Controlling false-negative errors in microarray differential expression analysis: a PRIM approach
    Steve W Cole
    Department of Medicine, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
    Bioinformatics 19:1808-16. 2003

Research Grants

Collaborators

Detail Information

Publications44

  1. pmc Nervous system regulation of the cancer genome
    Steven W Cole
    Division of Hematology Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    Brain Behav Immun 30:S10-8. 2013
    ....
  2. pmc Molecular pathways: beta-adrenergic signaling in cancer
    Steven W Cole
    Division of Hematology Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1678, USA
    Clin Cancer Res 18:1201-6. 2012
    ....
  3. pmc Foxl2 functions in sex determination and histogenesis throughout mouse ovary development
    Jose Elias Garcia-Ortiz
    Laboratory of Genetics, NIA NIH IRP, Baltimore, MD, USA
    BMC Dev Biol 9:36. 2009
    ..g., Rspo1. Here we report expression profiling of mouse ovaries that lack Foxl2 alone or in combination with Wnt4 or Kit/c-Kit...
  4. pmc Social regulation of leukocyte homeostasis: the role of glucocorticoid sensitivity
    Steve W Cole
    Department of Medicine, UCLA School of Medicine, Cousins Center for PNI, UCLA AIDS Institute, Jonsson Comprehensive Cancer Center, The UCLA Molecular Biology Institute, and HopeLab Foundation, Los Angeles, CA 90095 1678, USA
    Brain Behav Immun 22:1049-55. 2008
    ....
  5. pmc Social regulation of gene expression in human leukocytes
    Steve W Cole
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    Genome Biol 8:R189. 2007
    ....
  6. pmc Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence
    Steven W Cole
    Department of Medicine, Norman Cousins Center, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, CA, USA
    Dev Psychol 47:1173-80. 2011
    ....
  7. ncbi Expression-based monitoring of transcription factor activity: the TELiS database
    Steve W Cole
    UCLA Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
    Bioinformatics 21:803-10. 2005
    ..The interlocking JAVA applications namely, PromoterScan and PromoterStats carry out these tasks, and together constitute the TELiS database for reverse inference of transcription factor activity...
  8. pmc Elevating the perspective on human stress genomics
    Steve W Cole
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, CA, USA
    Psychoneuroendocrinology 35:955-62. 2010
    ....
  9. pmc Computational identification of gene-social environment interaction at the human IL6 locus
    Steven W Cole
    Department of Medicine and Norman Cousins Center, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:5681-6. 2010
    ....
  10. ncbi Controlling false-negative errors in microarray differential expression analysis: a PRIM approach
    Steve W Cole
    Department of Medicine, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
    Bioinformatics 19:1808-16. 2003
    ....
  11. ncbi Psychosocial influences on HIV-1 disease progression: neural, endocrine, and virologic mechanisms
    Steve W Cole
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, the Norman Cousins Center, Jonsson Comprehensive Cancer Center, UCLA AIDS Institute, California 90095 1678, USA
    Psychosom Med 70:562-8. 2008
    ..As such, neural and endocrine parameters might provide useful biomarkers for gauging the promise of behavioral interventions and suggest novel adjunctive strategies for controlling HIV-1 disease progression...
  12. pmc Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids: insights from in vivo cell trafficking dynamics in rhesus macaques
    Steve W Cole
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, 11 934 Factor Building, Los Angeles, California 90095 1678, USA
    Psychosom Med 71:591-7. 2009
    ..To determine whether chronic social stress can desensitize leukocytes to normal physiologic regulation by endogenous glucocorticoids...
  13. ncbi Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesis
    Erica K Sloan
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, UCLA AIDS Institute, Cousins Center for Psychoneuroimmunology at the Semel Institute of Neuroscience and Human Behavior, Los Angeles, California 90095 1678, USA
    J Neurosci 27:8857-65. 2007
    ..These data reveal a surprising degree of behaviorally induced plasticity in the structure of lymphoid innervation and define a novel pathway by which social factors can modulate immune response and viral pathogenesis...
  14. pmc Personality and serotonin transporter genotype interact with social context to affect immunity and viral set-point in simian immunodeficiency virus disease
    John P Capitanio
    California National Primate Research Center, Department of Psychology, University of California, One Shields Avenue, Davis, CA 95616, USA
    Brain Behav Immun 22:676-89. 2008
    ....
  15. pmc Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes
    Steven W Cole
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA 90095 1678, USA
    Proc Natl Acad Sci U S A 108:3080-5. 2011
    ..affine social conditions...
  16. ncbi Inflammatory biomarkers for persistent fatigue in breast cancer survivors
    Alicia Collado-Hidalgo
    Cousins Center for Psychoneuroimmunology, University of California at Los Angeles Semel Institute for Neuroscience and Human Behavior, Los Angeles, California 90095 7076, USA
    Clin Cancer Res 12:2759-66. 2006
    ..This study seeks to define immunologic and inflammatory variables associated with persistent post-treatment fatigue in breast cancer survivors...
  17. pmc Enhanced replication of simian immunodeficiency virus adjacent to catecholaminergic varicosities in primate lymph nodes
    Erica K Sloan
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, UCLA AIDS Institute, Los Angeles, California 90095 1678, USA
    J Virol 80:4326-35. 2006
    ....
  18. pmc Cytokine genetic variations and fatigue among patients with breast cancer
    Julienne E Bower
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    J Clin Oncol 31:1656-61. 2013
    ....
  19. pmc Transcriptional modulation of the developing immune system by early life social adversity
    Steven W Cole
    Department of Medicine, Division of Hematology Oncology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 109:20578-83. 2012
    ....
  20. pmc Mindfulness meditation training effects on CD4+ T lymphocytes in HIV-1 infected adults: a small randomized controlled trial
    J David Creswell
    Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, 300 Medical Plaza, Suite 3109, Los Angeles, CA 90095, USA
    Brain Behav Immun 23:184-8. 2009
    ..These findings provide an initial indication that mindfulness meditation training can buffer CD4+ T lymphocyte declines in HIV-1 infected adults. Clinical Trials Registration: clinicaltrials.gov, Identifier: NCT00600561...
  21. pmc Examining the influence of beta blockers and ACE inhibitors on the risk for breast cancer recurrence: results from the LACE cohort
    Patricia A Ganz
    UCLA Schools of Public Health and Medicine, Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095 6900, USA
    Breast Cancer Res Treat 129:549-56. 2011
    ..These observations need to be confirmed and suggest that greater attention should focus on the potential role of these commonly used medications in BC outcomes...
  22. pmc A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgrounds
    Andrew J Fuligni
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Box 62, Los Angeles, CA 90024, USA
    Psychosom Med 71:329-33. 2009
    ..To examine the association between the experience of daily interpersonal stress and levels of C-reactive protein (CRP), an inflammatory marker that is a key indicator of cardiovascular risk, during the teenage years...
  23. pmc Daily family assistance and inflammation among adolescents from Latin American and European backgrounds
    Andrew J Fuligni
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Brain Behav Immun 23:803-9. 2009
    ..Additional work should explore the family context that drives high levels of assistance among adolescents, as well as the variety of ways adolescents may derive meaning from this activity...
  24. ncbi T-cell homeostasis in breast cancer survivors with persistent fatigue
    Julienne E Bower
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, UCLA Neuropsychiatric Institute, CA 90095 7076, USA
    J Natl Cancer Inst 95:1165-8. 2003
    ..These results require confirmation in a larger study that is specifically designed to address this hypothesis...
  25. pmc Social temperament and lymph node innervation
    Erica K Sloan
    Cousins Center for PNI, Semel Institute of Neuroscience and Human Behavior, Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA 90095 7076, USA
    Brain Behav Immun 22:717-26. 2008
    ..These findings are consistent with the hypothesis that structural differences in lymphoid tissue innervation might potentially contribute to relationships between social temperament and immunobiology...
  26. pmc SIV infection decreases sympathetic innervation of primate lymph nodes: the role of neurotrophins
    Erica K Sloan
    University of California Los Angeles, Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, CA, USA
    Brain Behav Immun 22:185-94. 2008
    ....
  27. pmc Fatigue and gene expression in human leukocytes: increased NF-κB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue
    Julienne E Bower
    UCLA Department of Psychology, 1285 Franz Hall, P O Box 951563, Los Angeles, CA 90095 1563, United States
    Brain Behav Immun 25:147-50. 2011
    ....
  28. ncbi Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids
    Julienne E Bower
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, 300 UCLA Medical Plaza, Room 3306, Box 957076 Los Angeles, CA 90095 7076, USA
    Brain Behav Immun 21:251-8. 2007
    ..05). These data provide further evidence of enhanced inflammatory processes in fatigued breast cancer survivors and suggest that these processes may stem in part from decreased glucocorticoid response to stress...
  29. ncbi Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanisms
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095 7057, USA
    J Pharmacol Exp Ther 320:507-15. 2007
    ..Targeting sympathovagal balance might represent a novel strategy for partial amelioration of impairments of innate immunity in cocaine dependence...
  30. pmc Social regulation of human gene expression: mechanisms and implications for public health
    Steven W Cole
    Steven W Cole is with the Division of Hematology Oncology, School of Medicine, University of California, Los Angeles
    Am J Public Health 103:S84-92. 2013
    ..The embedding of individual genomes within a broader metagenomic network provides a framework for integrating molecular, physiologic, and social perspectives on human health. ..
  31. pmc Reciprocal regulation of the neural and innate immune systems
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 UCLA Medical Plaza, University of California, Los Angeles, California 90095 7076, USA
    Nat Rev Immunol 11:625-32. 2011
    ..CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases...
  32. ncbi Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA, USA
    Expert Rev Mol Diagn 6:39-50. 2006
    ..Potential solutions that may help overcome these challenges are also offered...
  33. pmc The sympathetic nervous system induces a metastatic switch in primary breast cancer
    Erica K Sloan
    UCLA Norman Cousins Center, Semel Institute for Neuroscience and Human Behavior, Medical Plaza 300, Room 3129, Los Angeles, CA 90095, USA
    Cancer Res 70:7042-52. 2010
    ....
  34. ncbi Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution
    Vanessa A Richlin
    Case Western Reserve School of Medicine, Los Angeles, CA 90095 1678, USA
    Brain Behav Immun 18:231-7. 2004
    ..Implications for future efforts to analyze stress effects on leukocyte gene expression are considered...
  35. pmc Human immunodeficiency virus type 1 infection and replication in normal human oral keratinocytes
    Xuan Liu
    Department of Oral and Maxillofacial Surgery, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Virol 77:3470-6. 2003
    ..Coculture studies showed that infectious HIV-1 virions can also be conveyed from NHOKs to activated peripheral blood lymphocytes, suggesting a potential role of oral epithelial cells in the transmission of HIV infection...
  36. pmc Stress-induced remodeling of lymphoid innervation
    Erica K Sloan
    Norman Cousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, UCLA School of Medicine, USA
    Brain Behav Immun 22:15-21. 2008
    ..The finding that behavioral stress can tonically alter lymph node neural structure suggests that behavioral factors could exert long-term regulatory influences on the initiation, maintenance, and resolution of immune responses...
  37. ncbi Psychological risk factors for HIV pathogenesis: mediation by the autonomic nervous system
    Steve W Cole
    Department of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1678, USA
    Biol Psychiatry 54:1444-56. 2003
    ..Epidemiologic studies have identified psychological risk factors for specific physical diseases, but the biological mechanisms mediating these relationships remain poorly defined...
  38. pmc beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA
    Margaret Chang
    Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
    J Virol 79:13538-47. 2005
    ..These findings also suggest novel therapeutic strategies for controlling the activity of this oncogenic gammaherpesvirus in vivo...
  39. ncbi Alcohol enhances HIV type 1 infection in normal human oral keratinocytes by up-regulating cell-surface CXCR4 coreceptor
    Hongying Chen
    Department of Oral and Maxillofacial Surgery, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    AIDS Res Hum Retroviruses 20:513-9. 2004
    ..These data suggest that alcohol may influence oral HIV transmission by altering the cellular compartmentalization of CXCR4 in cells of the oral cavity...
  40. ncbi Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer
    Charles N Landen
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Cancer Res 67:10389-96. 2007
    ....
  41. pmc A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling
    Gregory E Miller
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Biol Psychiatry 64:266-72. 2008
    ..Chronic stressors are known to increase vulnerability to medical illness, but the mechanisms underlying this phenomenon are poorly understood...
  42. ncbi Life course transitions and natural disaster: marriage, birth, and divorce following Hurricane Hugo
    Catherine L Cohan
    Department of Human Development and Family Studies, Pennsylvania State University, University Park Campus, Pennsylvania, USA
    J Fam Psychol 16:14-25. 2002
    ..Taken together, the results suggested that a life-threatening event motivated people to take significant action in their close relationships that altered their life course...
  43. ncbi Improvement in cancer-related knowledge following use of a psychoeducational video game for adolescents and young adults with cancer
    Ivan L Beale
    School of Psychology, University of New South Wales, New South Wales, Australia
    J Adolesc Health 41:263-70. 2007
    ..A video game, "Re-Mission," was developed to actively involve young people with cancer in their own treatment. Re-Mission provides opportunities to learn about cancer and its treatment...
  44. doi A video game improves behavioral outcomes in adolescents and young adults with cancer: a randomized trial
    Pamela M Kato
    Department of Pediatrics, Stanford Hospital, Stanford, California, USA
    Pediatrics 122:e305-17. 2008
    ....

Research Grants10

  1. TRANSCRIPTION-REGULATING VECTORS FOR ANTIVIRAL VACCINES
    Steve Cole; Fiscal Year: 2002
    ..abstract_text> ..
  2. Combinatorial Genomics in Cancer
    Steve Cole; Fiscal Year: 2009
    ..The bioinformatic tools produced in these studies will create a generalized analytic infrastructure for mapping complex etiologies in cancer and deploying patient-specific targeted therapies. ..
  3. Combinatorial Genomics in Cancer
    Steve Cole; Fiscal Year: 2007
    ..The bioinformatic tools produced in these studies will create a generalized analytic infrastructure for mapping complex etiologies in cancer and deploying patient-specific targeted therapies. ..
  4. Combinatorial Genomics in Cancer
    Steve Cole; Fiscal Year: 2006
    ..The bioinformatic tools produced in these studies will create a generalized analytic infrastructure for mapping complex etiologies in cancer and deploying patient-specific targeted therapies. ..
  5. Autonomic nervous system control of HIV-1 replication
    Steve Cole; Fiscal Year: 2005
    ..Such interventions would enhance the efficacy of current antiretroviral treatment regimens by opposing physiologic processes that support ongoing pathogenesis. ..
  6. Autonomic nervous system control of HIV-1 replication
    Steve Cole; Fiscal Year: 2004
    ..Such interventions would enhance the efficacy of current antiretroviral treatment regimens by opposing physiologic processes that support ongoing pathogenesis. ..
  7. Autonomic nervous system control of HIV-1 replication
    Steve Cole; Fiscal Year: 2003
    ..Such interventions would enhance the efficacy of current antiretroviral treatment regimens by opposing physiologic processes that support ongoing pathogenesis. ..
  8. Autonomic nervous system control of HIV-1 replication
    Steve Cole; Fiscal Year: 2002
    ..Such interventions would enhance the efficacy of current antiretroviral treatment regimens by opposing physiologic processes that support ongoing pathogenesis. ..
  9. Combinatorial Genomics in Cancer
    Steve W Cole; Fiscal Year: 2010
    ..The bioinformatic tools produced in these studies will create a generalized analytic infrastructure for mapping complex etiologies in cancer and deploying patient-specific targeted therapies. ..