Laurence A Cole

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. doi The utility of six over-the-counter (home) pregnancy tests
    Laurence A Cole
    Department of Obstetrics and Gynecology, USA hCG Reference Service, University of New Mexico, Albuquerque, NM 87131, USA
    Clin Chem Lab Med 49:1317-22. 2011
  2. doi Total hCG tests
    Laurence A Cole
    The USA hCG Reference Service, Women s Health Research, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Clin Chim Acta 412:2216-22. 2011
  3. ncbi Gestational trophoblastic diseases: 4. Presentation with persistent low positive human chorionic gonadotropin test results
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, MSC10 5580 1, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Gynecol Oncol 102:165-72. 2006
  4. ncbi A single serum test for measuring early pregnancy outcome with high predictive value
    Jaime M Sutton-Riley
    Department of Obstetrics and Gynecology, University of New Mexico, NM 87131, USA
    Clin Biochem 39:682-7. 2006
  5. doi The normal variabilities of the menstrual cycle
    Laurence A Cole
    Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Fertil Steril 91:522-7. 2009
  6. ncbi Hyperglycosylated human chorionic gonadotropin and the source of pregnancy failures
    Yasushi Sasaki
    USA hCG Reference Service, Division of Women s Health Research, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Fertil Steril 89:1781-6. 2008
  7. pmc hCG, the wonder of today's science
    Laurence A Cole
    USA hCG Reference Service, Albuquerque NM 87104, USA
    Reprod Biol Endocrinol 10:24. 2012
  8. doi hCG and hyperglycosylated hCG in the establishment and evolution of hemochorial placentation
    Laurence A Cole
    USA hCG Reference Service Reference Service, Women s Health Research, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    J Reprod Immunol 82:112-8. 2009
  9. ncbi Gestational trophoblastic diseases: 3. Human chorionic gonadotropin-free beta-subunit, a reliable marker of placental site trophoblastic tumors
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Gynecol Oncol 102:160-4. 2006
  10. ncbi Management of gestational trophoblastic disease and other cases with low serum levels of human chorionic gonadotropin
    Sarah A Khanlian
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque 87131 0001, USA
    J Reprod Med 51:812-8. 2006

Collaborators

Detail Information

Publications51

  1. doi The utility of six over-the-counter (home) pregnancy tests
    Laurence A Cole
    Department of Obstetrics and Gynecology, USA hCG Reference Service, University of New Mexico, Albuquerque, NM 87131, USA
    Clin Chem Lab Med 49:1317-22. 2011
    ..It is moving from all manual tests to digital tests, with a monitor reading the bands and informing women they are pregnant. A thorough study is needed to investigate the validity of claims and evolving usefulness of devices...
  2. doi Total hCG tests
    Laurence A Cole
    The USA hCG Reference Service, Women s Health Research, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Clin Chim Acta 412:2216-22. 2011
    ..All tests claim to be total hCG tests but do not define what total means. Total hCG test needs to detect all hCG variants in order to be used for all hCG test clinical applications. Here we assess this ability...
  3. ncbi Gestational trophoblastic diseases: 4. Presentation with persistent low positive human chorionic gonadotropin test results
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, MSC10 5580 1, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Gynecol Oncol 102:165-72. 2006
    ..Such chemotherapy and surgery were ineffective and unwarranted. This study identifies the causes of persistent low level of hCG and provides guidelines for the management of these patients, preventing unnecessary treatment in the future...
  4. ncbi A single serum test for measuring early pregnancy outcome with high predictive value
    Jaime M Sutton-Riley
    Department of Obstetrics and Gynecology, University of New Mexico, NM 87131, USA
    Clin Biochem 39:682-7. 2006
    ..Diagnosing a failing pregnancy is often done in emergency departments where simplified and accelerated testing methods are needed. Here, we investigated hyperglycosylated hCG (hCG-H) for predicting pregnancy failure...
  5. doi The normal variabilities of the menstrual cycle
    Laurence A Cole
    Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Fertil Steril 91:522-7. 2009
    ..To address conflicts in the normal variabilities of the menstrual cycle using the newest generation test methods and to establish normal ranges for use in clinical practice...
  6. ncbi Hyperglycosylated human chorionic gonadotropin and the source of pregnancy failures
    Yasushi Sasaki
    USA hCG Reference Service, Division of Women s Health Research, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Fertil Steril 89:1781-6. 2008
    ..To investigate the proportion of hyperglycosylated human chorionic gonadotropin (hCG-H) produced at the time of implantation as a predictor of pregnancy success...
  7. pmc hCG, the wonder of today's science
    Laurence A Cole
    USA hCG Reference Service, Albuquerque NM 87104, USA
    Reprod Biol Endocrinol 10:24. 2012
    ..Secondly, hCG exists in 5 common forms. Finally, it has so many functions ranging from control of human pregnancy to human cancer. This review examines these molecules in detail...
  8. doi hCG and hyperglycosylated hCG in the establishment and evolution of hemochorial placentation
    Laurence A Cole
    USA hCG Reference Service Reference Service, Women s Health Research, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    J Reprod Immunol 82:112-8. 2009
    ..We propose here that inadequate regular CG and hyperglycosylated CG molecules are the evolutionary causes of these obstetric complications in humans...
  9. ncbi Gestational trophoblastic diseases: 3. Human chorionic gonadotropin-free beta-subunit, a reliable marker of placental site trophoblastic tumors
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Gynecol Oncol 102:160-4. 2006
    ..Because treatments for these conditions are different, a means of differentiating PSTT from other diagnoses is important. We investigate the usefulness of hCG-free beta-subunit to make this discrimination...
  10. ncbi Management of gestational trophoblastic disease and other cases with low serum levels of human chorionic gonadotropin
    Sarah A Khanlian
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque 87131 0001, USA
    J Reprod Med 51:812-8. 2006
    ..The hCG free beta assay is an invaluable test in discriminating PSTT from other GTDs, thereby aiding the determination of appropriate treatment options...
  11. ncbi Hyperglycosylated hCG in gestational implantation and in choriocarcinoma and testicular germ cell malignancy tumorigenesis
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    J Reprod Med 51:919-29. 2006
    ....
  12. ncbi Hyperglycosylated hCG: a variant with separate biological functions to regular hCG
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM 87104, United States
    Mol Cell Endocrinol 260:228-36. 2007
    ..hCG-H is also an absolute tumor marker for malignant or invasive gestational trophoblastic disease, it can discriminate active and inactive (quiescent) disease, and the need for chemotherapy...
  13. doi Background hCG in non-pregnant individuals: need for more sensitive point-of-care and over-the-counter pregnancy tests
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Clin Biochem 42:168-75. 2009
    ..A large clinical trial is needed examining background hCG (hCG levels in absence of pregnancy) and determining whether sensitivities can be improved to avoid false negative detection...
  14. doi USA hCG reference service, 10-year report
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87109, USA
    Clin Biochem 43:1013-22. 2010
    ..The USA hCG Reference Service has been dealing with cases of persistent low levels of hCG and gestational trophoblastic diseases for 10years. Here we present the complete experience...
  15. ncbi Normal production of human chorionic gonadotropin in perimenopausal and menopausal women and after oophorectomy
    Laurence A Cole
    The USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Int J Gynecol Cancer 19:1556-9. 2009
    ..Last year our group discussed this finding in a correspondence to the editor in the March 15th issue of New England Journal of Medicine, yet the misinterpretation of low-level hCG in these women seems to have increased in magnitude...
  16. ncbi HCG tests in the management of gestational trophoblastic diseases
    Laurence A Cole
    Department of Obstetrics and Gynecology, University of New Mexico Health Science Center, Albuquerque, New Mexico, USA
    Clin Obstet Gynecol 46:523-40. 2003
  17. pmc New discoveries on the biology and detection of human chorionic gonadotropin
    Laurence A Cole
    USA hCG Reference Service, Obstetrics and Gynecology, and Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM, USA
    Reprod Biol Endocrinol 7:8. 2009
    ..There are very few molecules with such wide and varying functions as regular hCG and its variants, and very few tests with such a wide spectrum of clinical applications as total hCG...
  18. ncbi Blood test for placental site trophoblastic tumor and nontrophoblastic malignancy for evaluating patients with low positive human chorionic gonadotropin results
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque 87131 0001, USA
    J Reprod Med 53:457-64. 2008
    ....
  19. doi Hyperglycosylated hCG in the management of quiescent and chemorefractory gestational trophoblastic diseases
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87109, USA
    Gynecol Oncol 116:3-9. 2010
    ..Here we examine the USA hCG Reference Service experience with both diseases...
  20. ncbi Inappropriate management of women with persistent low hCG results
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
    J Reprod Med 49:423-32. 2004
    ..The continued needless treatment of patients with quiescent GTD, even after multiple publications, is entirely avoidable. Unfortunately, the number of needlessly treated cases referred to the Reference Service is increasing...
  21. ncbi The need for an hCG assay that appropriately detects trophoblastic disease and other hCG-producing cancers
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131, USA
    J Reprod Med 51:793-811. 2006
    ....
  22. ncbi Sensitivity of over-the-counter pregnancy tests: comparison of utility and marketing messages
    Laurence A Cole
    Department of Obstetrics and Gynecology, MSC10 5580, University of New Mexico Health Sciences Center, Albuquerque 87131 0001, USA
    J Am Pharm Assoc (2003) 45:608-15. 2005
    ..To determine the sensitivity of seven over-the-counter pregnancy tests (OTC-PTs) using urine containing a mixture of human chorionic gonadotropin (hCG)-related molecules as found on the first day of missed menstrual period...
  23. ncbi Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG
    Laurence A Cole
    Department of Obstetrics and Gynecology, MSC10 5580 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Gynecol Oncol 102:145-50. 2006
    ..We investigated the biological function of hCG-H in invasion in vitro and in vivo and the use of hCG-H antibodies in blocking tumorigenesis and cancer growth in vivo...
  24. ncbi Evolution of the human brain, chorionic gonadotropin and hemochorial implantation of the placenta: insights into origins of pregnancy failures, preeclampsia and choriocarcinoma
    Laurence A Cole
    USA hCG Reference Service and Division of Women s Health, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque 87131, USA
    J Reprod Med 53:549-57. 2008
    ..It is also of note that human CG-H drives invasion by gestational trophoblastic neoplasms that have been described only in humans...
  25. doi The hCG assay or pregnancy test
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Clin Chem Lab Med 50:617-30. 2012
    ....
  26. doi Familial HCG syndrome
    Laurence A Cole
    USA hCG Reference Service, Albuquerque, NM 87104, USA
    J Reprod Immunol 93:52-7. 2012
    ..In these cases of Familial hCG Syndrome only biologically inactive variants of hCG were detected. It is inferred that in Familial hCG Syndrome, hCG gene expression does not interfere with fertility...
  27. ncbi Easy fix for clinical laboratories for the false-positive defect with the Abbott AxSym total beta-hCG test
    Laurence A Cole
    Department of Obstetrics and Gynecology, USA hCG Reference Service, University of New Mexico, Albuquerque, NM 87131, USA
    Clin Biochem 37:344-9. 2004
    ..We investigated the source of this abundance of cases and a simple fix that may be used by clinical laboratories...
  28. doi Individual deviations in human chorionic gonadotropin concentrations during pregnancy
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Am J Obstet Gynecol 204:349.e1-7. 2011
    ..Serum and urine human chorionic gonadotropin (hCG) vary greatly during the course of pregnancy. We investigated the cause of this variation...
  29. ncbi Gestational trophoblastic diseases: 2. Hyperglycosylated hCG as a reliable marker of active neoplasia
    Laurence A Cole
    USA hCG Reference Service, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Gynecol Oncol 102:151-9. 2006
    ....
  30. ncbi Selecting an appropriate hCG test for managing gestational trophoblastic disease and cancer
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico Health Science Center, Albuquerque, NM 871331, USA
    J Reprod Med 49:545-53. 2004
    ..K. RIA; none are false positive with the DPC Immulite test. Results clearly show that the DPC Immulite/Immulite 2000 is the only appropriate assay for monitoring patients with gestational trophoblastic disease or cancer...
  31. ncbi Choriocarcinoma and gestational trophoblastic disease
    Harriet O Smith
    University of New Mexico Health Sciences Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, 2211 Lomas Boulevard NE, Albuquerque, NM 87131 5286, USA
    Obstet Gynecol Clin North Am 32:661-84. 2005
    ..The rates of GTN and choriocarcinoma are decreasing and survival has dramatically improved...
  32. ncbi Hyperglycosylated human chorionic gonadotropin and human chorionic gonadotropin free beta-subunit: tumor markers and tumor promoters
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, 87131, USA
    J Reprod Med 53:499-512. 2008
    ..It is somewhat irregular for 2 structural variants of a molecule to have independent actions, actions very different to the gonadotropic function of the established hormone hCG...
  33. ncbi Detection of hCG in trophoblastic disease. The USA hCG reference service experience
    Laurence A Cole
    Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, 2211 Lomas Boulevard Northeast, ACC 4th Floor, Albuquerque, NM 87131 5286, USA
    J Reprod Med 47:433-44. 2002
    ..hCG tests are identified that give a disproportionate number of false positive results. Finally, guidelines are presented for selecting an hCG test...
  34. doi Hyperglycosylated hCG and pregnancy failures
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    J Reprod Immunol 93:119-22. 2012
    ..Low hyperglycosylated hCG concentrations are associated with pregnancy failure. Whether this association is a primary cause of pregnancy failure or is simply a marker for an abnormal conceptus requires further investigation...
  35. doi Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ: interchangeable cancer promoters
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, Health Sciences Center MSC10 5580, 1 University of New Mexico, Albuquerque, NM 87104, USA
    Mol Cell Endocrinol 349:232-8. 2012
    ..The question therefore arises, are Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ interrelated or interchangable promoters of cancer?..
  36. ncbi Sialic acid-deficient invasive trophoblast antigen (sd-ITA): a new urinary variant for gestational Down syndrome screening
    Jaime M Sutton
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque 87131 0001, USA
    Prenat Diagn 24:194-7. 2004
    ..With the objective of developing an improved Down syndrome screening test, we examined the charge, or sialic acid variants, of ITA...
  37. ncbi Between-method variation in human chorionic gonadotropin test results
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Clin Chem 50:874-82. 2004
    ..4- to 2.3-fold among commercial human chorionic gonadotropin (hCG) assays. The relative contributions of calibrators, standards, hCG charge isoforms, and major structural variants to this variation have not been quantified...
  38. doi The quagmire of hCG and hCG testing in gynecologic oncology
    Carolyn Y Muller
    USA hCG Reference Service 1, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Gynecol Oncol 112:663-72. 2009
    ..The series of hCG molecules as tumor markers will be reviewed to help the clinician best diagnose these often difficult clinical problems...
  39. ncbi Gestation trophoblastic diseases: management of cases with persistent low human chorionic gonadotropin results
    Laurence A Cole
    Division of Women s Health Research, Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, 2211 Lomas Boulevard NE, Albuquerque, NM 87131 5286, USA
    Obstet Gynecol Clin North Am 32:615-26. 2005
    ..Three distinct sources are discussed for persistent low hCG results: quiescence gestational trophoblastic disease, false-positive hCG results, and pituitary hCG...
  40. doi The need for a quantitative urine hCG assay
    Laurence A Cole
    USA hCG Reference Service, University of New Mexico, Albuquerque, NM 87104, USA
    Clin Biochem 42:676-83. 2009
    ..We examine levels of urinary hCG, its usefulness in pregnancy testing, and advantages of urine testing in false positive hCG cases and cancer cases...
  41. doi Detection of perimenopause or postmenopause human chorionic gonadotropin: an unnecessary source of alarm
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico Albuquerque, NM, USA
    Am J Obstet Gynecol 198:275.e1-7. 2008
    ..We describe the problem and a concise approach to this management dilemma in menopausal women...
  42. doi Minimally-aggressive gestational trophoblastic neoplasms
    Laurence A Cole
    USA hCG Reference Service, Albuquerque, NM 87109, USA
    Gynecol Oncol 125:145-50. 2012
    ..Initially we used hyperglycosylated hCG, a limited availability test, to identify this syndrome. Here we propose also using hCG doubling rate to detect this syndrome...
  43. pmc Biological functions of hCG and hCG-related molecules
    Laurence A Cole
    USA hCG Reference Service, University of New Mexico, Albuquerque, NM 87131, USA
    Reprod Biol Endocrinol 8:102. 2010
    ....
  44. doi Human chorionic gonadotropin and associated molecules
    Laurence A Cole
    Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque NM 87131, USA
    Expert Rev Mol Diagn 9:51-73. 2009
    ..hCG tests are essential in managing gestational trophoblastic diseases, whether hydatidiform mole, invasive mole or choriocarcinoma, and are very useful in management of testicular malignancies and other germ cell malignancies...
  45. doi Human chorionic gonadotropin tests
    Laurence A Cole
    USA hCG Reference Service, University of New Mexico, Albuquerque, NM 87131, USA
    Expert Rev Mol Diagn 9:721-47. 2009
    ..hCG tests are essential in managing gestational trophoblastic diseases, whether hydatidiform mole, invasive mole or choriocarcinoma, and are very useful in management of testicular malignancies and other germ cell malignancies...
  46. ncbi Persistent low levels of human chorionic gonadotropin: A premalignant gestational trophoblastic disease
    Sarah A Khanlian
    USA hCG Reference Service, Division of Women s Health Research, Department of Obstetrics and Gynecology, University of New Mexico, 2211 Lomas Boulevard NE, Albuquerque, NM 87131, USA
    Am J Obstet Gynecol 188:1254-9. 2003
    ..This study was undertaken to evaluate the significance of persistent low-level human chorionic gonadotropin (hCG) titers (usually <50 IU/L) in the absence of clinical evidence of pregnancy or gestational trophoblastic disease...
  47. ncbi Inherited human chorionic gonadotropin
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, MSC10 5580, 1 University of New Mexico, Albuquerque, NM 87131, USA
    J Reprod Med 55:99-102. 2010
    ..To investigate 405 cases of persistent low concentrations of human chorionic gonadotropin (hCG)...
  48. ncbi Production of human chorionic gonadotropin during the normal menstrual cycle
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    J Reprod Med 54:245-50. 2009
    ....
  49. ncbi Accuracy of home pregnancy tests at the time of missed menses
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
    Am J Obstet Gynecol 190:100-5. 2004
    ..The purpose of this study was to investigate the validity of home pregnancy tests (HPTs) around the time of the missed menses...
  50. ncbi Human chorionic gonadotropin testing for early pregnancy viability and complications
    Suzy Davies
    The United States Human Chorionic Gonadotropin Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, 2211 Lomas Boulevard Northeast, Albuquerque, NM 87131, USA
    Clin Lab Med 23:257-64, vii. 2003
    ..The use of hCG measurement and hCG doubling rates, progesterone measurements, and transvaginal ultrasound in identifying ectopic pregnancies and failing pregnancies also is reviewed...
  51. ncbi Hyperglycosylated hCG (invasive trophoblast antigen, ITA) a key antigen for early pregnancy detection
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    Clin Biochem 36:647-55. 2003
    ..It is the principal form of hCG produced in the first weeks of gestation. We investigated the importance of hyperglycosylated hCG in pregnancy testing and its detection by current hCG tests...