Susan Cohn

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix
    Alexandre Chlenski
    Robert H Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Int J Cancer 118:310-6. 2006
  2. doi request reprint Progression-free survival of two cases of high-risk neuroblastoma with refractory/relapsed disease following surgery alone
    Elizabeth Sokol
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    Pediatr Blood Cancer 60:512-4. 2013
  3. pmc Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumors
    Alexandre Chlenski
    Department of Pediatrics, University of Chicago, KCBD Rm 5100, Chicago, IL 60637, USA
    Mol Cancer 9:138. 2010
  4. pmc Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines
    Qiwei Yang
    Department of Pediatrics, University of Chicago, 900 Ease 57th Street, KCBD Rm, 5100 Chicago, IL 60637, USA
    BMC Cancer 10:286. 2010
  5. pmc The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report
    Susan L Cohn
    Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:289-97. 2009
  6. pmc Racial and ethnic disparities in risk and survival in children with neuroblastoma: a Children's Oncology Group study
    Tara O Henderson
    Comer Children s Hospital and University of Chicago, Chicago, IL, USA
    J Clin Oncol 29:76-82. 2011
  7. doi request reprint Modulation of matrix remodeling by SPARC in neoplastic progression
    Alexandre Chlenski
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, United States
    Semin Cell Dev Biol 21:55-65. 2010
  8. ncbi request reprint Advances in the diagnosis and treatment of neuroblastoma
    Joanna L Weinstein
    Department of Pediatrics and Robert H Lurie Comprehensive Cancer Center, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
    Oncologist 8:278-92. 2003
  9. pmc Presence of cancer-associated fibroblasts inversely correlates with Schwannian stroma in neuroblastoma tumors
    Rana Zeine
    Department of Pathology, Northwestern University, Chicago, IL, USA
    Mod Pathol 22:950-8. 2009
  10. pmc Lung metastases in neuroblastoma at initial diagnosis: A report from the International Neuroblastoma Risk Group (INRG) project
    Steven G DuBois
    Department of Pediatrics, University of California, San Francisco, California, USA
    Pediatr Blood Cancer 51:589-92. 2008

Research Grants

  1. The Role of SPARC in Neuroblastoma Angiogenesis
    Susan Cohn; Fiscal Year: 2007
  2. PEDIATRIC ONCOLOGY GROUP
    Susan Cohn; Fiscal Year: 2002

Collaborators

Detail Information

Publications27

  1. ncbi request reprint SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix
    Alexandre Chlenski
    Robert H Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Int J Cancer 118:310-6. 2006
    ..Our studies suggest that SPARC may regulate tumor growth by inhibiting angiogenesis, inducing tumor cell apoptosis and mediating changes in the deposition and organization of the tumor microenvironment...
  2. doi request reprint Progression-free survival of two cases of high-risk neuroblastoma with refractory/relapsed disease following surgery alone
    Elizabeth Sokol
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    Pediatr Blood Cancer 60:512-4. 2013
    ..These cases demonstrate that refractory/relapsed neuroblastoma is clinically heterogeneous and highlight the need for better biomarkers to optimize patient care...
  3. pmc Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumors
    Alexandre Chlenski
    Department of Pediatrics, University of Chicago, KCBD Rm 5100, Chicago, IL 60637, USA
    Mol Cancer 9:138. 2010
    ..Peptide FS-E is structurally complex and difficult to produce, limiting its potential as a therapeutic in the clinic...
  4. pmc Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines
    Qiwei Yang
    Department of Pediatrics, University of Chicago, 900 Ease 57th Street, KCBD Rm, 5100 Chicago, IL 60637, USA
    BMC Cancer 10:286. 2010
    ....
  5. pmc The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report
    Susan L Cohn
    Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:289-97. 2009
    ..The International Neuroblastoma Risk Group (INRG) classification system was developed to establish a consensus approach for pretreatment risk stratification...
  6. pmc Racial and ethnic disparities in risk and survival in children with neuroblastoma: a Children's Oncology Group study
    Tara O Henderson
    Comer Children s Hospital and University of Chicago, Chicago, IL, USA
    J Clin Oncol 29:76-82. 2011
    ..To evaluate differences in disease presentation and survival by race and ethnicity, data from the Children's Oncology Group (COG) were analyzed...
  7. doi request reprint Modulation of matrix remodeling by SPARC in neoplastic progression
    Alexandre Chlenski
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, United States
    Semin Cell Dev Biol 21:55-65. 2010
    ..Understanding the mechanism of matrix remodeling and its regulation by SPARC is essential for the development of new treatment strategies for highly aggressive cancers...
  8. ncbi request reprint Advances in the diagnosis and treatment of neuroblastoma
    Joanna L Weinstein
    Department of Pediatrics and Robert H Lurie Comprehensive Cancer Center, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois, USA
    Oncologist 8:278-92. 2003
    ..This review discusses the current risk-based treatment approaches for children with neuroblastoma and recent advances in biologic therapy...
  9. pmc Presence of cancer-associated fibroblasts inversely correlates with Schwannian stroma in neuroblastoma tumors
    Rana Zeine
    Department of Pathology, Northwestern University, Chicago, IL, USA
    Mod Pathol 22:950-8. 2009
    ..A deeper understanding of the function cancer-associated fibroblasts have in neuroblastoma angiogenesis may guide future development of stroma-directed therapeutic strategies...
  10. pmc Lung metastases in neuroblastoma at initial diagnosis: A report from the International Neuroblastoma Risk Group (INRG) project
    Steven G DuBois
    Department of Pediatrics, University of California, San Francisco, California, USA
    Pediatr Blood Cancer 51:589-92. 2008
    ..We aimed to describe the incidence, clinical characteristics, and outcome of patients with lung metastasis at initial diagnosis using a large international database...
  11. doi request reprint Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group
    Jennifer Schneiderman
    Children s Memorial Hospital, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    J Clin Oncol 26:913-8. 2008
    ..To determine the clinical significance of MYCN amplification in children with favorable-stage NB, we performed a retrospective review of data from the Pediatric Oncology Group (POG) biology study 9047...
  12. ncbi request reprint Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome
    Qiwei Yang
    The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Clin Cancer Res 13:3191-7. 2007
    ..To investigate the clinical significance of epigenetic changes in neuroblastoma, we evaluated the relationship between clinicopathologic variables and the pattern of gene methylation in neuroblastoma cell lines and tumors...
  13. ncbi request reprint SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis
    Alexandre Chlenski
    The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Cancer Res 62:7357-63. 2002
    ..SPARC may be an effective candidate for the treatment of children with clinically aggressive, Schwannian stroma-poor NB tumors...
  14. ncbi request reprint 'Cross-talk' between Schwannian stroma and neuroblasts promotes neuroblastoma tumor differentiation and inhibits angiogenesis
    Shuqing Liu
    Department of Pediatrics, Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
    Cancer Lett 228:125-31. 2005
    ....
  15. doi request reprint The quinoxaline anti-tumor agent (R+)XK469 inhibits neuroblastoma tumor growth
    Nisha C Kakodkar
    Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    Pediatr Blood Cancer 56:164-7. 2011
    ..These preclinical results, coupled with the favorable clinical response, demonstrate that (R+)XK469 and similar anti-tumor agents may be effective in the treatment of high-risk neuroblastoma and warrant further testing...
  16. ncbi request reprint Neuroblastoma angiogenesis is inhibited with a folded synthetic molecule corresponding to the epidermal growth factor-like module of the follistatin domain of SPARC
    Alexandre Chlenski
    The Robert H Lurie Comprehensive Cancer Center and Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Cancer Res 64:7420-5. 2004
    ..Our data show that the EGF-like module of the SPARC FS domain is angiosuppressive, and its structural conformation is critical for antiangiogenic activity...
  17. ncbi request reprint Prominent microvascular proliferation in clinically aggressive neuroblastoma
    Radhika Peddinti
    Department of Pediatrics, Children s Memorial Hospital, Chicago, Illinois, USA
    Clin Cancer Res 13:3499-506. 2007
    ....
  18. ncbi request reprint Thrombospondin-1 peptide ABT-510 combined with valproic acid is an effective antiangiogenesis strategy in neuroblastoma
    Qiwei Yang
    The Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 5841 Maryland Avenue, Chicago, IL 60637, USA
    Cancer Res 67:1716-24. 2007
    ..Our results indicate that ABT-510 combined with VPA may be an effective antiangiogenic treatment strategy for children with high-risk neuroblastoma...
  19. ncbi request reprint The regulation of angiogenesis in neuroblastoma
    Alexandre Chlenski
    Department of Pediatrics and the Robert H Lurie Comprehensive Cancer Center, Northwestern University, The Feinberg School of Medicine, Chicago, IL, USA
    Cancer Lett 197:47-52. 2003
    ..This review summarizes our current understanding of the regulation of angiogenesis in neuroblastoma...
  20. ncbi request reprint Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma
    Qi Wei Yang
    The Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    Cancer Res 63:6299-310. 2003
    ..Demethylating agents may prove to be effective candidates for the treatment of children with NB...
  21. ncbi request reprint MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma
    Chitra F Manohar
    The Robert H Lurie Comprehensive Cancer Center, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
    Oncogene 23:753-62. 2004
    ..These findings indicate that by interacting with E-box elements within the promoter, MYCN can upregulate MRP1 expression and modulate drug resistance in NB...
  22. ncbi request reprint Methylation-associated silencing of the heat shock protein 47 gene in human neuroblastoma
    Qiwei Yang
    The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Cancer Res 64:4531-8. 2004
    ..Our studies support a role for Hsp47 in the regulation of collagen type I and IV production in NB cells and suggest that the level of collagen expression may influence NB tumor phenotype...
  23. ncbi request reprint Scintigraphic response by 123I-metaiodobenzylguanidine scan correlates with event-free survival in high-risk neuroblastoma
    Howard M Katzenstein
    Division of Hematology Oncology, Department of Pediatrics, Northwestern University, Children s Memorial Hospital, 2300 Children s Plaza, Box 30, Chicago, IL 60614, USA
    J Clin Oncol 22:3909-15. 2004
    ..To investigate whether response to induction therapy, evaluated by metaiodobenzylguanadine (MIBG) and bone scintigraphy, correlates with event-free survival (EFS) in children with high-risk neuroblastoma (NB)...
  24. ncbi request reprint Association of epigenetic inactivation of RASSF1A with poor outcome in human neuroblastoma
    Qiwei Yang
    The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Clin Cancer Res 10:8493-500. 2004
    ..To investigate the prevalence and potential clinical significance of epigenetic aberrations in neuroblastoma (NB)...
  25. pmc Cross-talk between Schwann cells and neuroblasts influences the biology of neuroblastoma xenografts
    Shuqing Liu
    Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illnois, USA
    Am J Pathol 166:891-900. 2005
    ..Our results indicate that infiltrating Schwann cells of mouse origin are capable of promoting human neuroblast differentiation, inducing apoptosis, and inhibiting proliferation and angiogenesis in vivo...
  26. ncbi request reprint Excellent local tumor control regardless of extent of surgical resection after treatment on the Chicago Pilot II protocol for neuroblastoma
    Marybeth Browne
    Department of Surgery, Children s Memorial Hospital, Chicago, IL 60614, USA
    J Pediatr Surg 41:271-6. 2006
    ..Our aim was to investigate the impact of the extent of surgical resection on local recurrence and survival in high-risk patients treated with the Chicago Pilot II protocol...
  27. ncbi request reprint Treatment of high-risk neuroblastoma with triple-tandem high-dose therapy and stem-cell rescue: results of the Chicago Pilot II Study
    Morris Kletzel
    Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    J Clin Oncol 20:2284-92. 2002
    ....

Research Grants5

  1. The Role of SPARC in Neuroblastoma Angiogenesis
    Susan Cohn; Fiscal Year: 2007
    ..The long-term goal of this research grant is to generate potent anti-angiogenic SPARC-derived molecules that will prove to be effective in the treatment of children with highly vascular, clinically aggressive NB. ..
  2. PEDIATRIC ONCOLOGY GROUP
    Susan Cohn; Fiscal Year: 2002
    ....