Ronald Cohen

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency
    Ronald N Cohen
    Section of Pediatric and Adult Endocrinology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 91:239-47. 2006
  2. ncbi request reprint Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia
    Ronald N Cohen
    Section of Endocrinology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 88:4832-9. 2003
  3. ncbi request reprint In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone
    Helen H Kim
    Section of Reproductive Endocrinology and Infertility, The University of Chicago, 5841 South Maryland Avenue, MC 2050, Chicago, Illinois 60637, USA
    Mol Endocrinol 21:457-71. 2007
  4. ncbi request reprint An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements
    Karla A Temple
    Department of Medicine, and Committee on Molecular Metabolism and Nutrition, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:3529-40. 2005
  5. pmc Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface
    Tania M Ortiga-Carvalho
    Department of Medicine and Committee on Molecular Metabolism and Nutrition, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA
    J Clin Invest 115:2517-23. 2005
  6. ncbi request reprint A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone
    Sharon Y Wu
    Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Mail Code 3090, Chicago, Illinois 60645, USA
    J Clin Endocrinol Metab 91:1887-95. 2006
  7. pmc Altering PPARgamma ligand selectivity impairs adipogenesis by thiazolidinediones but not hormonal inducers
    Shanika P Samarasinghe
    Section of Endocrinology, Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 17:965-72. 2009
  8. ncbi request reprint Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform
    Tania M Ortiga-Carvalho
    Department of Medicine, Pritzker School of the Medicine, The University of Chicago, Illinois 60637, USA
    Endocrinology 145:1625-33. 2004
  9. pmc Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo
    Nobuyuki Shibusawa
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC1027, Chicago, Illinois 60637, USA
    J Clin Invest 112:588-97. 2003
  10. ncbi request reprint The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis
    Christine Yu
    Section of Endocrinology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:13600-5. 2005

Collaborators

  • Matthew Brady
  • S Refetoff
  • SALLY M RADOVICK
  • Fredric E Wondisford
  • Roy Weiss
  • Laurie E Cohen
  • Roberto M Lang
  • Koshi Hashimoto
  • Helmut Grasberger
  • Helen H Kim
  • J Pohlenz
  • ANDREW M WOLFE
  • Maria M Sutanto
  • Tania M Ortiga-Carvalho
  • Karla A Temple
  • Christine Yu
  • Xiao Hui Liao
  • Nobuyuki Shibusawa
  • Honggang Ye
  • Kathleen R Markan
  • Shanika P Samarasinghe
  • Melissa S Symons
  • Sharon Y Wu
  • Joaquin Lado-Abeal
  • Dianne Deplewski
  • Anita Makowski
  • Margaret B Allison
  • Hiroya Sakuma
  • Kelly K Ferguson
  • Michael J Jurczak
  • Daniel N Johnson
  • Arpad M Danos
  • Dursun A Senses
  • Nese E Yar
  • Enver Simsek
  • Janet Noel
  • Amisra Nikrodhanond
  • Alain Verloes
  • Sarah R Wondisford
  • Marie Christine Lebrethon
  • Kathleen Markan
  • Alexandra M Dumitrescu
  • Danielle S Machado
  • Karen J Oliveira
  • David Geenen
  • Carmen C Pazos-Moura
  • M Charles Liberman
  • Amisra A Nikrodhanond
  • Anthony N Hollenberg
  • Meredithe L Applebury
  • Janet T Robbins
  • Sabrina Brzostek

Detail Information

Publications18

  1. ncbi request reprint The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency
    Ronald N Cohen
    Section of Pediatric and Adult Endocrinology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 91:239-47. 2006
    ....
  2. ncbi request reprint Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia
    Ronald N Cohen
    Section of Endocrinology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 88:4832-9. 2003
    ..These data suggest that enhancement of transcriptional repression during pituitary organogenesis is a novel mechanism for the development of congenital pituitary disorders...
  3. ncbi request reprint In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone
    Helen H Kim
    Section of Reproductive Endocrinology and Infertility, The University of Chicago, 5841 South Maryland Avenue, MC 2050, Chicago, Illinois 60637, USA
    Mol Endocrinol 21:457-71. 2007
    ..Luciferase activity was, however, still present in the ovary. Our findings provide evidence that Otx2 may have a critical role in directing tissue-specific expression of the mGnRH gene to the neuron, but not the ovary...
  4. ncbi request reprint An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements
    Karla A Temple
    Department of Medicine, and Committee on Molecular Metabolism and Nutrition, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:3529-40. 2005
    ..Thus, unlike RXR, PPARgamma exhibits promiscuity in binding on a PPRE, suggesting that the definition of a PPRE for PPARgamma may need to be expanded...
  5. pmc Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface
    Tania M Ortiga-Carvalho
    Department of Medicine and Committee on Molecular Metabolism and Nutrition, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA
    J Clin Invest 115:2517-23. 2005
    ..Therefore, the AF-2 domain of TR-beta is required for positive and, paradoxically, for negative regulation by TH in vivo...
  6. ncbi request reprint A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone
    Sharon Y Wu
    Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Mail Code 3090, Chicago, Illinois 60645, USA
    J Clin Endocrinol Metab 91:1887-95. 2006
    ..Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome of variable tissue hyporesponsiveness to thyroid hormone (TH)...
  7. pmc Altering PPARgamma ligand selectivity impairs adipogenesis by thiazolidinediones but not hormonal inducers
    Shanika P Samarasinghe
    Section of Endocrinology, Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 17:965-72. 2009
    ..We propose that the endogenous ligand has distinct properties that allow for promiscuity within the hydrophobic PPAR ligand-binding pocket, yet fosters appropriate cofactor recruitment and release to allow adipogenesis to proceed...
  8. ncbi request reprint Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform
    Tania M Ortiga-Carvalho
    Department of Medicine, Pritzker School of the Medicine, The University of Chicago, Illinois 60637, USA
    Endocrinology 145:1625-33. 2004
    ..In contrast, HR in KS-mut animals did not change after either treatment. Except for cardiac hypertrophy, the presence of a germline TR-beta mutation had surprisingly little effect on cardiac function...
  9. pmc Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo
    Nobuyuki Shibusawa
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC1027, Chicago, Illinois 60637, USA
    J Clin Invest 112:588-97. 2003
    ..Inner ear development, although not completely normal, can occur in the absence of TR DNA-binding, suggesting that an alternative and perhaps novel thyroid hormone-signaling pathway may mediate these effects...
  10. ncbi request reprint The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis
    Christine Yu
    Section of Endocrinology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:13600-5. 2005
    ..These data suggest that the nuclear receptor corepressors decrease PPARgamma transcriptional activity and repress the adipogenic program in 3T3-L1 cells...
  11. ncbi request reprint SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain
    Maria M Sutanto
    Section of Endocrinology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC 1027, Chicago, IL 60637, United States
    Mol Cell Endocrinol 267:138-43. 2007
    ..These data suggest that PPARgamma and RARalpha interact with SMRT via distinct mechanisms. These differences will be important as ligands are designed that lead to specific patterns of nuclear receptor recruitment of corepressors...
  12. pmc The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo
    Maria M Sutanto
    Committee on Molecular Metabolism and Nutrition, Division of the Biological Sciences, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:18485-95. 2010
    ..These finding suggest that SMRT regulates leptin expression and limits the ability of fat mass to expand with increased caloric intake, but that SMRT also negatively regulates adipocyte insulin sensitivity...
  13. ncbi request reprint SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain
    Maria M Sutanto
    Section of Endocrinology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC 1027, Chicago, IL 60637, USA
    Mol Cell Endocrinol 259:43-9. 2006
    ..These data suggest that PPARgamma and RARalpha interact with SMRT via distinct mechanisms. These differences will be important as ligands are designed that lead to specific patterns of nuclear receptor recruitment of corepressors...
  14. pmc Enhanced glycogen metabolism in adipose tissue decreases triglyceride mobilization
    Kathleen R Markan
    Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Chicago, 900 East 57th St, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 299:E117-25. 2010
    ..Cumulatively, these results support the notion that the adipocyte possesses a set point for glycogen, which is altered in response to nutritional cues, enabling the coordination of adipose glycogen turnover with lipid metabolism...
  15. ncbi request reprint A de novo mutation in an already mutant nucleotide of the thyroid hormone receptor beta gene perpetuates resistance to thyroid hormone
    Joaquin Lado-Abeal
    University of Chicago, MC 3090, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 90:1760-7. 2005
    ..Because the occurrence by chance is extremely unlikely, it is postulated that the presence of three guanines in the sequence created by the mutant nucleotide of the proposita results in a mutagenic site prone to de novo mutation...
  16. ncbi request reprint Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor
    Anita Makowski
    Thyroid Unit, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 17:273-86. 2003
    ..Together these data suggest that the specific recruitment of NCoR by the TR through a unique motif allows for stabilization of the repression complex on target elements...
  17. pmc Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice
    Joachim Pohlenz
    Children s Hospital of Johannes Gutenberg, University of Mainz, Mainz, Germany
    J Clin Invest 109:469-73. 2002
    ..Therefore, haploinsufficiency of the TTF1 gene results in a predominantly neurological phenotype and secondary hyperthyrotropinemia...

Research Grants6

  1. COREPRESSORS AND NEGATIVE REGULATION BY THYROID HORMONE
    Ronald Cohen; Fiscal Year: 2002
    ..This project will be performed by Dr. Ronald Cohen under the guidance of Dr...
  2. Role of corepressors in the adipocyte
    Ronald Cohen; Fiscal Year: 2006
    ..It is anticipated that an examination of corepressor action on adipocyte function will allow for a greater understanding of the balance of forces regulating adipocyte action and the development of obesity and insulin resistance. ..
  3. Role of SMRT and NCoR in adipocyte differentiation and function
    Ronald Cohen; Fiscal Year: 2007
    ..These results will be helpful in the design of new medications to treat patients with diabetes. ..
  4. Role of SMRT and NCoR in adipocyte differentation and function
    Ronald Cohen; Fiscal Year: 2009
    ..These results will be helpful in the design of new medications to treat patients with diabetes ..
  5. Role of SMRT and NCoR in adipocyte differentation and function
    Ronald N Cohen; Fiscal Year: 2010
    ..These results will be helpful in the design of new medications to treat patients with diabetes ..