Noam A Cohen

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Tobacco smoke mediated induction of sinonasal microbial biofilms
    Natalia Goldstein-Daruech
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e15700. 2011
  2. doi request reprint Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion
    Robert J Lee
    1Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, Ravdin Bldg, 5th Floor, 3400 Spruce St, Philadelphia, PA 19104, USA
    FASEB J 27:5094-103. 2013
  3. doi request reprint Biofilms in chronic rhinosinusitis: a review
    Michael Cohen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol Allergy 23:255-60. 2009
  4. doi request reprint Prevention and management of lacrimal duct injury
    Noam A Cohen
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, 5th floor Ravdin Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 43:781-8. 2010
  5. ncbi request reprint Familial aggregation of sinonasal polyps correlates with severity of disease
    Noam A Cohen
    Department of Otorhinolaryngology, Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 134:601-4. 2006
  6. ncbi request reprint Epithelium, cilia, and mucus: their importance in chronic rhinosinusitis
    Marcelo B Antunes
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Ravdin Building 5th Floor, 3400 Spruce Street, Philadelphia, PA 19004, USA
    Immunol Allergy Clin North Am 29:631-43. 2009
  7. doi request reprint Polyhydrated ionogen with MgBr2 accelerates in vitro respiratory epithelial healing
    David Depoortere
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Rhinol Allergy 27:333-7. 2013
  8. doi request reprint Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient
    Alexander G Chiu
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 22:34-7. 2008
  9. doi request reprint Effects of an LL-37-derived antimicrobial peptide in an animal model of biofilm Pseudomonas sinusitis
    Sri Kiran Chennupati
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol Allergy 23:46-51. 2009
  10. ncbi request reprint Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction
    Bei Chen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 21:346-53. 2007

Collaborators

Detail Information

Publications76

  1. pmc Tobacco smoke mediated induction of sinonasal microbial biofilms
    Natalia Goldstein-Daruech
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e15700. 2011
    ....
  2. doi request reprint Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion
    Robert J Lee
    1Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, Ravdin Bldg, 5th Floor, 3400 Spruce St, Philadelphia, PA 19104, USA
    FASEB J 27:5094-103. 2013
    ..Conversely, a loss of VIP-activated secretion in patients with CF may impair mucociliary transport, contributing to increased incidences of sinonasal infections and rhinosinusitis...
  3. doi request reprint Biofilms in chronic rhinosinusitis: a review
    Michael Cohen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol Allergy 23:255-60. 2009
    ..Thus, bacterial biofilms were hypothesized to contribute to the progression and persistence of chronic rhinosinusitis...
  4. doi request reprint Prevention and management of lacrimal duct injury
    Noam A Cohen
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, 5th floor Ravdin Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 43:781-8. 2010
    ..However, complications do occur with inadvertent violation of the orbit and cranial vault the subject of substantial publications while lacrimal duct injury (LDI) following FESS has been relatively neglected...
  5. ncbi request reprint Familial aggregation of sinonasal polyps correlates with severity of disease
    Noam A Cohen
    Department of Otorhinolaryngology, Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 134:601-4. 2006
    ..Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP...
  6. ncbi request reprint Epithelium, cilia, and mucus: their importance in chronic rhinosinusitis
    Marcelo B Antunes
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Ravdin Building 5th Floor, 3400 Spruce Street, Philadelphia, PA 19004, USA
    Immunol Allergy Clin North Am 29:631-43. 2009
    ..In this article the components of mucociliary clearance, including cilia, mucus production, and cilia beat frequency, are reviewed and alterations of the system discussed regarding contribution to the disease process...
  7. doi request reprint Polyhydrated ionogen with MgBr2 accelerates in vitro respiratory epithelial healing
    David Depoortere
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Rhinol Allergy 27:333-7. 2013
    ..We set out to determine if this effect was reproducible in an in vitro respiratory epithelial culture system...
  8. doi request reprint Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient
    Alexander G Chiu
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 22:34-7. 2008
    ....
  9. doi request reprint Effects of an LL-37-derived antimicrobial peptide in an animal model of biofilm Pseudomonas sinusitis
    Sri Kiran Chennupati
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol Allergy 23:46-51. 2009
    ..We hypothesize that a 24 amino acid peptide derivative of LL-37 will show efficacy against biofilm-forming P. aeruginosa in an established animal model of sinusitis...
  10. ncbi request reprint Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction
    Bei Chen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 21:346-53. 2007
    ....
  11. doi request reprint Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention
    Nithin D Adappa
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int Forum Allergy Rhinol 3:184-7. 2013
    ..Based on this data, we hypothesize that supertasters are less likely to require sinus surgery compared with heterozygous or nontasters and that supertasters have improved surgical outcomes...
  12. pmc T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
    Robert J Lee
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Invest 122:4145-59. 2012
    ..These data suggest that T2R38 is an upper airway sentinel in innate defense and that genetic variation contributes to individual differences in susceptibility to respiratory infection...
  13. doi request reprint Physiologic alterations in the murine model after nasal fungal antigenic exposure
    Ayesha N Khalid
    Division of Otolaryngology Head and Neck Surgery, Pennsylvania State College of Medicine, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 139:695-701. 2008
    ..To determine whether a recently developed murine model of fungus-induced sinonasal inflammation demonstrated alterations in ciliary activity and expression of inflammatory cytokines...
  14. doi request reprint Prevalence of biofilm-forming bacteria in chronic rhinosinusitis
    Anthony A Prince
    The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Rhinol 22:239-45. 2008
    ..We sought to determine the prevalence of biofilm-forming cultures obtained from patients with CRS and clinical factors that may contribute to biofilm formation...
  15. doi request reprint An in vitro model of Pseudomonas aeruginosa biofilms on viable airway epithelial cell monolayers
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
    Am J Rhinol 22:235-8. 2008
    ..To better understand the interactions of bacterial biofilms with respiratory epithelium, we describe an in vitro model of biofilm sinusitis by establishing mature biofilms on airway epithelial air-liquid interface cultures...
  16. doi request reprint Transient receptor potential vanilloid type 4 channel expression in chronic rhinosinusitis
    Geeta Bhargave
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 22:7-12. 2008
    ..Thus, the goal of this study was to establish the expression pattern of TRPV4 in human sinonasal mucosa and determine whether expression is altered in chronic rhinosinusitis (CRS)...
  17. ncbi request reprint Murine tracheal and nasal septal epithelium for air-liquid interface cultures: a comparative study
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 21:533-7. 2007
    ..Our hypothesis is that the murine nasal septum is a better source of ciliated respiratory epithelium to develop respiratory epithelial air-liquid interface models...
  18. ncbi request reprint Altered sinonasal ciliary dynamics in chronic rhinosinusitis
    Bei Chen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol 20:325-9. 2006
    ..Additionally, these studies have only analyzed basal CBF. The goal of this study was to compare the basal as well as the stimulated sinonasal CBF in patients with CRS versus controls...
  19. doi request reprint One-way valve bottle contamination rates in the immediate post-functional endoscopic sinus surgery period
    Jennifer M Kofonow
    Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol Allergy 25:393-6. 2011
    ..An alternative delivery system uses a one-way valve to reduce saline backflow and may limit bottle contamination. Our sole objective was to determine whether this system in post-FESS patients eliminates microbial bottle contamination...
  20. doi request reprint Biofilms correlate with TH1 inflammation in the sinonasal tissue of patients with chronic rhinosinusitis
    Adrianna M Hekiert
    Department of Otorhinolaryngology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Otolaryngol Head Neck Surg 141:448-53. 2009
    ..Determine the prevalence of bacterial biofilms in surgical chronic rhinosinusitis (CRS) patients and characterize the inflammatory response associated with biofilm CRS...
  21. doi request reprint Clinical factors associated with bacterial biofilm formation in chronic rhinosinusitis
    Zi Zhang
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Otolaryngol Head Neck Surg 144:457-62. 2011
    ..However, the mechanism behind biofilm formation in chronic rhinosinusitis remains poorly defined. The aim of this study is to evaluate clinical factors that may be associated with bacterial biofilm formation in chronic rhinosinusitis...
  22. doi request reprint Antibiotic eluting chitosan glycerophosphate implant in the setting of acute bacterial sinusitis: a rabbit model
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol Allergy 24:129-32. 2010
    ..The purpose of this study was to assess the potential for CGP as an antibiotic impregnated implant in a rabbit model of acute bacterial sinusitis...
  23. doi request reprint Chitosan glycerophosphate-based semirigid dexamethasone eluting biodegradable stent
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol Allergy 23:76-9. 2009
    ..The purpose of this study was to optimize the chitosan formulation to produce a pliable sheet, to assess the innate longevity and inflammatory potential of the polymer, and to study the in vivo rate of dexamethasone release over time...
  24. doi request reprint The novel dry extract BNO 1011 stimulates chloride transport and ciliary beat frequency in human respiratory epithelial cultures
    James L Kreindler
    Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol Allergy 26:439-43. 2012
    ..We evaluated the pharmacologic effects of the novel dry extract BNO 1011 on human respiratory epithelial cultures specifically addressing electrolyte transport and cilia beat frequency (CBF)...
  25. doi request reprint Safety evaluation of sinus surfactant solution on respiratory cilia function
    Alexander G Chiu
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Int Forum Allergy Rhinol 1:280-3. 2011
    ..This study evaluates the safety of this solution on respiratory cilia function...
  26. ncbi request reprint In vivo effects of citric acid/zwitterionic surfactant cleansing solution on rabbit sinus mucosa
    Edwin Tamashiro
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol Allergy 23:597-601. 2009
    ..The purpose of this study was to determine the effects of CAZS on sinonasal epithelium In vivo compared with normal saline...
  27. ncbi request reprint Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas sinonasal biofilms
    Alexander G Chiu
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    J Antimicrob Chemother 59:1130-4. 2007
    ..This is the first study to evaluate the effects of a topical antibiotic on Pseudomonas biofilms in an animal model of sinusitis...
  28. doi request reprint Polyhydrated ionogen enhances postoperative sinonasal ciliated remucosalization
    David Depoortere
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int Forum Allergy Rhinol 1:83-7. 2011
    ..Recently a novel anti-protease compound, polyhydrated-ionogen (PHI) with Mg(2+)/Br(-), demonstrated improved dermal wound healing. We set out to investigate the effect of PHI Mg(2+)/Br(-) on sinus remucosalization following surgery...
  29. doi request reprint Spontaneous CSF leaks: a paradigm for definitive repair and management of intracranial hypertension
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104 4206, USA
    Otolaryngol Head Neck Surg 138:715-20. 2008
    ..To report our outcomes with the repair of spontaneous cerebrospinal fluid (CSF) leaks and to demonstrate how management of underlying intracranial hypertension improves outcomes...
  30. ncbi request reprint Intraoperative IGS/CT updates for complex endoscopic frontal sinus surgery
    Sri Kiran Chennupati
    Division of Rhinology, Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    ORL J Otorhinolaryngol Relat Spec 70:268-70. 2008
    ..We describe the potential applications of xCAT, a new intraoperative mobile volume CT scanner and its utility in providing surgical navigation updates in the operating room...
  31. ncbi request reprint Cilia dysfunction
    David A Gudis
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Ravdin Building, 5th Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 43:461-72, vii. 2010
    ..Ciliary dysfunction may be primary, the result of genetic mutations resulting in abnormal cilia structure, or secondary, the result of environmental, infectious or inflammatory stimuli that disrupt normal motility or coordination...
  32. doi request reprint Laser-welded endoscopic endoluminal repair of iatrogenic esophageal perforation: an animal model
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 139:713-7. 2008
    ..To test the feasibility of laser tissue welding (LTW) in creating an endoscopic transluminal repair of esophageal perforation...
  33. ncbi request reprint Dose-dependent effects of topical tobramycin in an animal model of Pseudomonas sinusitis
    Marcelo B Antunes
    Department of Otorhinolaryngology, Division of Rhinology, University of Pennsylvania, Philadelphia 19104, USA
    Am J Rhinol 21:423-7. 2007
    ..Despite their popularity, there is limited data in the literature to support its use. This study is the first to examine the effects of topical tobramycin in an animal model of Pseudomonas sinusitis...
  34. ncbi request reprint Regional analysis of sinonasal ciliary beat frequency
    Jeffrey Shaari
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 20:150-4. 2006
    ..We analyzed CBF from the inferior turbinate, uncinate process, and sphenoethmoid recess in nonsinusitis patients to determine regional variability of ciliary activity within the sinonasal cavity...
  35. doi request reprint Molecular modulation of airway epithelial ciliary response to sneezing
    Ke Qing Zhao
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    FASEB J 26:3178-87. 2012
    ..Apical ATP release with subsequent calcium mobilization and PKA activation are involved in sinonasal ciliary response to sneezing, which is blunted in patients with upper-airway disease...
  36. doi request reprint Pulse steroid therapy inhibits murine subglottic granulation
    Ankona Ghosh
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Otolaryngol Head Neck Surg 148:284-90. 2013
    ..Changes in inflammatory markers will allow us to identify potential targets for immunological therapy...
  37. pmc Acquired cilia dysfunction in chronic rhinosinusitis
    David Gudis
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Rhinol Allergy 26:1-6. 2012
    ..The complex structure and regulatory mechanisms that dictate the form and function of normal cilia are not entirely understood, but it is clear that ciliary dysfunction results in impaired respiratory defense...
  38. ncbi request reprint Revision endoscopic sinus surgery
    Noam A Cohen
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 39:417-35, vii. 2006
    ..Medical management and endoscopic surveillance postoperatively is continued until a stable cavity is achieved...
  39. ncbi request reprint Clinical outcomes of endoscopic and endoscopic-assisted resection of inverted papillomas: a 15-year experience
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 21:591-600. 2007
    ..The aim of this retrospective study was to review the experience with the endoscopic and endoscopic-assisted resection of IPs at a major academic tertiary care facility and assess long-term outcomes...
  40. ncbi request reprint Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency
    Noam A Cohen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Laryngoscope 119:2269-74. 2009
    ..The present study investigates the consequences of cigarette smoke exposure on ciliary function and transepithelial chloride (Cl(-)) secretion, a major determinant of ASL...
  41. doi request reprint Inflammatory protein expression in human subglottic stenosis tissue mirrors that in a murine model
    Sunny Haft
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania
    Ann Otol Rhinol Laryngol 123:65-70. 2014
    ..We also sought to compare this human array to cytokine expression from a murine model of SGS in order to confirm the effective translational nature of our animal model...
  42. doi request reprint Molecular basis of tobacco-induced bacterial biofilms: an in vitro study
    Marcelo B Antunes
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 147:876-84. 2012
    ..To evaluate changes in the expression of biofilm-related genes when exposed to tobacco smoke and oxidative stress...
  43. ncbi request reprint Regulation of murine sinonasal cilia function by microbial secreted factors
    Jessica C Shen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Int Forum Allergy Rhinol 2:104-10. 2012
    ..Recent literature suggests that different bacterial species are associated with varied disease severity. We examined the immediate effect of microbial secreted factors on sinonasal ciliary function...
  44. doi request reprint The effects of retinoic acid on ciliary function of regenerated sinus mucosa
    Vanessa R Erickson
    Division of Rhinology, Department of Otolaryngology, Stanford University, Stanford, California, USA
    Am J Rhinol 22:334-6. 2008
    ..However, the functional status of the regenerated cilia has not been studied. Our objective was to evaluate the ciliary beat frequency (CBF) of regenerated sinus mucosa treated with topical RA in a rabbit model...
  45. ncbi request reprint Sinonasal mucociliary clearance in health and disease
    Noam A Cohen
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Medical Center, 5 Silverstein Ravdin, 3400 Spruce St, Philadelphia, PA 19104, USA
    Ann Otol Rhinol Laryngol Suppl 196:20-6. 2006
    ..A review of the current understanding of the cellular regulation of respiratory ciliary activity and its contribution to chronic rhinosinusitis is presented...
  46. pmc Culture-inappropriate antibiotic therapy decreases quality of life improvement after sinus surgery
    Zi Zhang
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
    Int Forum Allergy Rhinol 4:403-10. 2014
    ..We aimed to determine whether culture-inappropriate postoperative antibiotic therapy was associated with less quality-of-life (QOL) improvement following functional endoscopic sinus surgery (FESS)...
  47. pmc The effect of diabetes mellitus on chronic rhinosinusitis and sinus surgery outcome
    Zi Zhang
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    Int Forum Allergy Rhinol 4:315-20. 2014
    ..We sought to determine the effects of DM on CRS culture results and quality of life (QOL) after functional endoscopic sinus surgery (FESS)...
  48. pmc The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery
    Nithin D Adappa
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA
    Int Forum Allergy Rhinol 4:3-7. 2014
    ....
  49. doi request reprint The emerging role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis
    Robert J Lee
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Rhinol Allergy 27:283-6. 2013
    ..This study provides an overview of our current knowledge of T2R38 function in sinonasal defense and the implications for patients with chronic rhinosinusitis (CRS)...
  50. ncbi request reprint Murine nasal septa for respiratory epithelial air-liquid interface cultures
    Marcelo B Antunes
    University of Pennsylvania, Philadelphia, PA, USA
    Biotechniques 43:195-6, 198, 200 passim. 2007
    ..The nasal septum increases the yield of respiratory epithelial cells up to 8-fold...
  51. doi request reprint Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis
    Yinyan Lai
    Otorhinolaryngology Hospital, First Affiliated Hospital of Sun Yat sen University, Sun Yat Sen University, Guangzhou, China
    J Allergy Clin Immunol 128:1207-1215.e1. 2011
    ..Recently, centrosomal protein 110 (Cp110) was shown to prevent the terminal step in ciliary maturation (ie, elongation), suggesting that Cp110 might be involved in pathological states in which ciliation is abnormal...
  52. ncbi request reprint Endonasal laser tissue welding: first human experience
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Am J Rhinol Allergy 24:244-6. 2010
    ..The objective of this study is to assess the safety and technical feasibility of endoscopic LTW in human sinonasal mucosa...
  53. ncbi request reprint Traumatic brain injury-induced ependymal ciliary loss decreases cerebral spinal fluid flow
    Guoxiang Xiong
    1 Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
    J Neurotrauma 31:1396-404. 2014
    ..Interestingly, injury-induced ventricular system pathology resolves completely by 30 days after injury as ependymal cell ciliogenesis restores cilia density to uninjured levels in the affected lateral ventricle. ..
  54. ncbi request reprint Biofilms in chronic rhinosinusitis
    Jeffrey D Suh
    Division of Rhinology, Department of ORL HNS, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Otolaryngol Head Neck Surg 18:27-31. 2010
    ..We will discuss these changes as well as emerging treatment options...
  55. doi request reprint In vivo laser tissue welding in the rabbit maxillary sinus
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4206, USA
    Am J Rhinol 22:625-8. 2008
    ..We performed this study to determine whether LTW can create durable tissue bonds in sinonasal mucosa that support normal wound healing and produce minimal collateral thermal injury...
  56. doi request reprint Laser tissue welding in lung and tracheobronchial repair: an animal model
    Benjamin S Bleier
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 138:345-9. 2010
    ..Laser tissue welding (LTW) is an alternative method that produces wound repairs that are significantly stronger than those of fibrin glue and may be used to repair air leaks...
  57. ncbi request reprint Synchronous verrucous carcinoma and inverted papilloma of the lacrimal sac: case report and clinical update
    Cheryl Gustafson
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, 5th Floor, Ravdin Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Ear Nose Throat J 92:E1. 2013
    ..One month after the intranasal resection, a left dacryocystectomy was performed; histopathologic examination revealed that an invasive verrucous squamous cell carcinoma had arisen within the inverted papilloma. ..
  58. ncbi request reprint Quantification of ciliary beat frequency in sinonasal epithelial cells using differential interference contrast microscopy and high-speed digital video imaging
    Ioana Schipor
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol 20:124-7. 2006
    ..This is the first report of sinonasal epithelial CBF analysis performed using high-speed video digital analysis...
  59. pmc Surfactants in the management of rhinopathologies
    Philip L Rosen
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol Allergy 27:177-80. 2013
    ..Because of these unique physical properties several in vitro, ex vivo, and human trials have examined the role of surfactants as stand-alone or adjunct therapy in recalcitrant chronic rhinosinusitis (CRS)...
  60. doi request reprint Keratinocyte chemoattractant (interleukin-8) regulation of sinonasal cilia function in a murine model
    Jessica C Shen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int Forum Allergy Rhinol 2:75-9. 2012
    ..Thus, we set out to determine whether exogenously applied recombinant keratinocyte chemoattractant (KC), mouse homologue of interleukin-8 (IL-8), modulates ciliary function...
  61. ncbi request reprint Surfactant protein B detection and gene expression in chronic rhinosinusitis
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 117:1296-301. 2007
    ..Our objective was to detect the presence of SP-B, measure alterations in several forms of chronic rhinosinusitis (CRS), and localize cellular protein expression...
  62. ncbi request reprint Laser-assisted cerebrospinal fluid leak repair: an animal model to test feasibility
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4206, USA
    Otolaryngol Head Neck Surg 137:810-4. 2007
    ..To test the feasibility of laser tissue welding as a method of creating an endonasal tissue bond for the purpose of cerebrospinal fluid leak repair...
  63. ncbi request reprint Surgical decisions in the management of frontal sinus osteomas
    Alexander G Chiu
    Department of Otorhinolaryngology Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, Pennsylvania 19103, USA
    Am J Rhinol 19:191-7. 2005
    ..The aim of this study is to review our recent experience with the surgical management of frontal sinus osteomas, and the anatomic features that make specific lesions more or less amenable to endoscopic resection...
  64. pmc Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells
    Amy N Savitski
    Division of Pulmonary Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Respir Res 10:120. 2009
    ..Therefore, pharmacological agents that increase either apical membrane chloride conductance or basolateral membrane potassium conductance might be of therapeutic benefit in patients with diseases related to SHS exposure...
  65. ncbi request reprint Endoscopic sinus surgery: where we are-and where we're going
    Noam A Cohen
    Department of Otorhinolaryngology Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Curr Opin Otolaryngol Head Neck Surg 13:32-8. 2005
    ..The anatomic boundaries of the nasal endoscope continue to be redefined. This paper will review the recent advances in the field of surgical rhinology as well as discuss directions for the future...
  66. ncbi request reprint Endoscopic resection of a venous hemangioma of the optic nerve sheath
    Daniel L Monin
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ear Nose Throat J 84:586, 588, 590 passim. 2005
    ..The intervention resulted in minimal morbidity, demonstrating yet again that this surgical approach is a safe and effective way to treat lesions of the orbital apex...
  67. pmc A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells
    Ke Qing Zhao
    Department of Otorhinolaryngology Head and Neck Surgery, Eye and Ear, Nose and Throat Hospital, School of Shanghai Medicine, Fudan University, Shanghai, Peoples Republic of China
    Am J Physiol Lung Cell Mol Physiol 302:L4-L12. 2012
    ..Our data provide further evidence that potassium channels, in particular K2P channels, are expressed and functional in the apical membrane of airway epithelial cells where they may be targets for therapeutic manipulation...
  68. ncbi request reprint Long-term follow-up of a multiloculated arachnoid cyst of the middle cranial fossa
    Marc A Cohen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Ravdin Bldg, 5th Floor, 3400 Spruce St, Philadelphia, PA 19104, USA
    Ear Nose Throat J 86:338-41. 2007
    ..We report the radiographic progression of this lesion during more than a decade of follow-up, and we review the literature pertaining to the presentation, pathophysiology, and treatment of arachnoid cysts...
  69. ncbi request reprint Mucociliary clearance--a critical upper airway host defense mechanism and methods of assessment
    Marcelo B Antunes
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Curr Opin Allergy Clin Immunol 7:5-10. 2007
    ..We review the methods used to analyze mucociliary clearance...
  70. ncbi request reprint An animal model for the study of topical medications in sinusitis
    Alexander G Chiu
    Department of Otorhinolaryngology Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol 21:5-9. 2007
    ..The aim of this study was to develop an animal model that will provide objective data in studying the efficacy of topical medications and establish a platform for translation to human clinical trials...
  71. pmc Pharmacologic activation of the innate immune system to prevent respiratory viral infections
    Guanjun Cheng
    Thoracic Oncology Research Laboratory, 1015F ARC, University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    Am J Respir Cell Mol Biol 45:480-8. 2011
    ..Development of this approach in humans could be valuable for protecting health care professionals and "first responders" in the early stages of viral pandemics or bioterror attacks...
  72. pmc GABA and glutamate are not colocalized in mossy fiber terminals of developing rodent hippocampus
    Guoxiang Xiong
    Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Brain Res 1474:40-9. 2012
    ..The two types of terminals appeared to be mutually exclusive, and showed no colocalization. Thus, our results do not support the hypothesis that GABA is released as a neurotransmitter from mossy fiber terminals during development...
  73. doi request reprint Cellular adaptive inflammation mediates airway granulation in a murine model of subglottic stenosis
    Ankona Ghosh
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Otolaryngol Head Neck Surg 144:927-33. 2011
    ..To determine the contribution of B- and T-cell-mediated inflammation in a murine airway granulation model...
  74. ncbi request reprint Cellular neurothekeoma of the maxilla
    Noam A Cohen
    Division of Otolaryngology, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, First Floor, Richard Wood Center, Philadelphia, PA 19104, USA
    Ann Otol Rhinol Laryngol 113:384-7. 2004
    ..This lesion should be considered as part of the differential diagnosis of pediatric soft tissue head and neck masses. We discuss the presentation, evaluation, and treatment of these rare benign lesions...
  75. ncbi request reprint Proteolysis of beta-trace Protein?
    Neil G Hockstein
    Otolaryngol Head Neck Surg 133:310; author reply 310-1. 2005
  76. ncbi request reprint Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function
    Radmila Sarac
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 25:1836-46. 2005
    ..In addition, the homologous mutation in cytoplasmic domains of Kir2.1 (L330R) did not disrupt association, suggesting that the overall structural integrity of this region is critical for inward rectifier function...