Myron Cohen

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc HIV treatment as prevention: the utility and limitations of ecological observation
    M Kumi Smith
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS Med 9:e1001260. 2012
  2. pmc Antiretroviral treatment of HIV-1 prevents transmission of HIV-1: where do we go from here?
    Myron S Cohen
    Department of Medicine, University of North Carolina, Chapel Hill, NC, USA Department of Microbiology, University of North Carolina, Chapel Hill, NC, USA Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA Electronic address
    Lancet 382:1515-24. 2013
  3. pmc Integrated syphilis/HIV screening in China: a qualitative analysis
    Joseph D Tucker
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    BMC Health Serv Res 10:58. 2010
  4. pmc Amplified transmission of HIV-1: missing link in the HIV pandemic
    Myron S Cohen
    Department of Medicine, Microbiology and Immunology, The Schools of Medicine and Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Trans Am Clin Climatol Assoc 117:213-24; discussion 225. 2006
  5. pmc Treatment to prevent transmission of HIV-1
    Myron S Cohen
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Clin Infect Dis 50:S85-95. 2010
  6. ncbi request reprint Syphilis returns to china ... With a vengeance
    Myron S Cohen
    The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Sex Transm Dis 33:724-5. 2006
  7. ncbi request reprint Narrative review: antiretroviral therapy to prevent the sexual transmission of HIV-1
    Myron S Cohen
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7030, USA
    Ann Intern Med 146:591-601. 2007
  8. doi request reprint Preventing sexual transmission of HIV
    Myron S Cohen
    University of North Carolina School of Medicine, Chapel Hill, 27599 7030, USA
    Clin Infect Dis 45:S287-92. 2007
  9. pmc Antiretroviral therapy for prevention of HIV infection: new clues from an animal model
    Myron S Cohen
    Institute for Global Health and Infectious Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Med 5:e30. 2008
  10. pmc The spread, treatment, and prevention of HIV-1: evolution of a global pandemic
    Myron S Cohen
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA
    J Clin Invest 118:1244-54. 2008

Detail Information

Publications82

  1. pmc HIV treatment as prevention: the utility and limitations of ecological observation
    M Kumi Smith
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS Med 9:e1001260. 2012
    ..By examining the strengths and weaknesses of ecological analyses, we aim to aid understanding of the findings from these studies to inform future policy decisions regarding the use of ART for HIV prevention...
  2. pmc Antiretroviral treatment of HIV-1 prevents transmission of HIV-1: where do we go from here?
    Myron S Cohen
    Department of Medicine, University of North Carolina, Chapel Hill, NC, USA Department of Microbiology, University of North Carolina, Chapel Hill, NC, USA Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA Electronic address
    Lancet 382:1515-24. 2013
    ..These concerns are very difficult to resolve. Ongoing community-based prospective trials of early ART are likely to help to establish the population-level benefit of ART, and-if successful-to galvanise treatment as prevention...
  3. pmc Integrated syphilis/HIV screening in China: a qualitative analysis
    Joseph D Tucker
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    BMC Health Serv Res 10:58. 2010
    ..South China faces expanding syphilis and sexually transmitted HIV epidemics, but health systems characteristics important for scaling up syphilis and HIV testing have not been defined...
  4. pmc Amplified transmission of HIV-1: missing link in the HIV pandemic
    Myron S Cohen
    Department of Medicine, Microbiology and Immunology, The Schools of Medicine and Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Trans Am Clin Climatol Assoc 117:213-24; discussion 225. 2006
    ..Prevention of sexual transmission of HIV likely requires maximal suppression of genital tract HIV viral burden, either through treatment of STDS or use of antiretroviral agents...
  5. pmc Treatment to prevent transmission of HIV-1
    Myron S Cohen
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Clin Infect Dis 50:S85-95. 2010
    ..In this article, we review the data supporting the use of ART to prevent HIV transmission and critically examine the public health implications of this strategy...
  6. ncbi request reprint Syphilis returns to china ... With a vengeance
    Myron S Cohen
    The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Sex Transm Dis 33:724-5. 2006
  7. ncbi request reprint Narrative review: antiretroviral therapy to prevent the sexual transmission of HIV-1
    Myron S Cohen
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7030, USA
    Ann Intern Med 146:591-601. 2007
    ..This article provides a review of the data on the use of ART to prevent the sexual transmission of HIV and identify challenges to improving and clarifying this approach...
  8. doi request reprint Preventing sexual transmission of HIV
    Myron S Cohen
    University of North Carolina School of Medicine, Chapel Hill, 27599 7030, USA
    Clin Infect Dis 45:S287-92. 2007
    ..In the absence of more-reliable options, such as a vaccine, factors that define HIV infectivity and susceptibility and factors that amplify the risk of HIV transmission, may serve as critical targets for containment of the HIV epidemic...
  9. pmc Antiretroviral therapy for prevention of HIV infection: new clues from an animal model
    Myron S Cohen
    Institute for Global Health and Infectious Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Med 5:e30. 2008
  10. pmc The spread, treatment, and prevention of HIV-1: evolution of a global pandemic
    Myron S Cohen
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA
    J Clin Invest 118:1244-54. 2008
    ....
  11. pmc Prevention of the sexual transmission of HIV-1: preparing for success
    Myron S Cohen
    Dept of Medicine, University of North Carolina, Chapel Hill, USA
    J Int AIDS Soc 11:4. 2008
    ..Above all, prevention of HIV requires decision-makers to focus resources on strategies that are most effective. Finally, treatment of HIV and prevention of HIV must be considered and deployed together...
  12. pmc Recent key advances in human immunodeficiency virus medicine and implications for China
    Kai Sun
    School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    AIDS Res Ther 7:12. 2010
    ..Lastly, we review important achievements of and future challenges facing China as she steps into her eighth year of the National Free Antiretroviral Treatment Program...
  13. pmc Prevention of HIV-1 infection with early antiretroviral therapy
    Myron S Cohen
    University of North Carolina at Chapel Hill, Institute for Global Health and Infectious Diseases, Suite 2115, Bioinformatics Bldg, 130 Mason Farm Rd, CB 7030, Chapel Hill, NC 27599, USA
    N Engl J Med 365:493-505. 2011
    ..Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples...
  14. ncbi request reprint Thomas Parran Award Lecture: transmission and prevention of transmission of HIV-1
    Myron S Cohen
    Department of Medicine, The Schools of Medicine and Public Health, The University of North Carolina at Chapel Hill, 27599 7030, USA
    Sex Transm Dis 33:338-41. 2006
  15. ncbi request reprint Human experimentation with Neisseria gonorrhoeae: progress and goals
    M S Cohen
    Department of Medicine, University of North Carolina at Chapel Hill 27599 7030, USA
    J Infect Dis 179:S375-9. 1999
    ..The experimental model has proven to be an efficient means of studying gonococcal infection and focusing vaccine development. In addition, this model should allow vaccines to be tested quickly and efficiently...
  16. ncbi request reprint Trichomoniasis in men and HIV infection: data from 2 outpatient clinics at Lilongwe Central Hospital, Malawi
    Matthew A Price
    School of Medicine, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7030, USA
    J Infect Dis 190:1448-55. 2004
    ..Among men presenting for care for symptomatic sexually transmitted infections (STIs) in Malawi, trichomoniasis is not considered for first-line treatment...
  17. ncbi request reprint Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research Group
    M S Cohen
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7030, USA
    Lancet 349:1868-73. 1997
    ..We investigated the hypothesis that STDs increase the likelihood of transmission of HIV-1 through increased concentration of the virus in semen...
  18. ncbi request reprint Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trial
    Matthew A Price
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Sex Transm Dis 30:516-22. 2003
    ..Male urethritis is generally treated syndromically, but failure of empirical treatment is common...
  19. ncbi request reprint The use of specimens from various genitourinary sites in men, to detect Trichomonas vaginalis infection
    S Cornelia Kaydos-Daniels
    Department of Epidemiology, University of North Carolina School of Public Health, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    J Infect Dis 189:1926-31. 2004
    ..Semen was the most sensitive single specimen, and, in 25.6% of cases, only semen specimens tested positive. Thus, prevalence of T. vaginalis infection in men is underestimated if only 1 specimen is tested...
  20. pmc Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection
    Christopher D Pilcher
    Center for Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    AIDS 21:1723-30. 2007
    ..This study was conducted to compare viral dynamics in blood and semen between subjects with antibody negative, acute HIV-1 infection and other subjects with later stages of infection...
  21. ncbi request reprint Frequent detection of acute primary HIV infection in men in Malawi
    Christopher D Pilcher
    Departments of Medicine and Epidemiology at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    AIDS 18:517-24. 2004
    ..Acute (antibody-negative) HIV infection is associated with high transmission potential but is rarely recognized...
  22. ncbi request reprint Improving the accuracy of syndromic diagnosis of genital ulcer disease in Malawi
    Cathrine Hoyo
    Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Sex Transm Dis 32:231-7. 2005
    ..However, the etiologic pathogens of GUD vary temporally and geographically, and current criteria may not reflect changes in the prevalence of specific pathogens...
  23. ncbi request reprint Use of antiretroviral drugs to prevent sexual transmission of HIV
    Myron S Cohen
    Division of Infectious Diseases, University of North Carolina Hospitals, Chapel Hill, North Carolina, USA
    Curr Clin Top Infect Dis 22:214-51. 2002
  24. ncbi request reprint HIV and sexually transmitted diseases: lethal synergy
    Myron S Cohen
    University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Top HIV Med 12:104-7. 2004
    ..Greater efforts are needed in identifying acute HIV infection in STD clinics. This article summarizes a presentation by Myron S. Cohen, MD, at the International AIDS Society-USA course in Chicago in May...
  25. pmc A tale of two countries: rethinking sexual risk for HIV among young people in South Africa and the United States
    Audrey E Pettifor
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    J Adolesc Health 49:237-243.e1. 2011
    ....
  26. ncbi request reprint HIV-1 populations in blood and breast milk are similar
    Gavin J Henderson
    UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Virology 330:295-303. 2004
    ..The absence of unique variants and the lack of significant differences in the relative abundance of variants between these compartments support the conclusion that viruses in the blood plasma and breast milk are well equilibrated...
  27. ncbi request reprint Can antiretroviral therapy be used to prevent sexual transmission of human immunodeficiency virus type 1?
    Mina Hosseinipour
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Infect Dis 34:1391-5. 2002
    ..In this article, we explore the rationale for using antiretroviral therapy to prevent sexual transmission of HIV, as well as the limitations of this approach...
  28. doi request reprint Notifying partners of patients with early syphilis in Madagascar: case-finding effectiveness and public health implications
    Maria R Khan
    Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park, MD, USA
    Trop Med Int Health 15:1090-8. 2010
    ..To evaluate the case-finding effectiveness of a clinic-based partner notification effort for early syphilis in Madagascar...
  29. pmc Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection
    Nancie M Archin
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e9390. 2010
    ....
  30. ncbi request reprint HIV and parasitic infection and the effect of treatment among adult outpatients in Malawi
    Mina C Hosseinipour
    University of North Carolina Project, Lilongwe, Malawi
    J Infect Dis 195:1278-82. 2007
    ..Successful treatment of parasitic infections had no effect on HIV RNA levels. Although common, parasitic infections did not impact HIV RNA levels...
  31. ncbi request reprint Highly efficient HIV transmission to young women in South Africa
    Audrey E Pettifor
    Division of Infectious Diseases, School of Medicine, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    AIDS 21:861-5. 2007
    ..Such findings have led to hypotheses that the probability of HIV transmission from men to women must be far higher than previously appreciated...
  32. pmc Methods for detection of Trichomonas vaginalis in the male partners of infected women: implications for control of trichomoniasis
    Marcia M Hobbs
    Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    J Clin Microbiol 44:3994-9. 2006
    ..vaginalis in male partners required multiple specimens. The majority of male sexual partners in this study were infected, emphasizing the importance of partner evaluation and treatment...
  33. ncbi request reprint Rapid, real-time detection of acute HIV infection in patients in Africa
    Susan A Fiscus
    Department of Microbiology and Immunology, University of North Carolina UNC at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    J Infect Dis 195:416-24. 2007
    ..We conducted a prospective study to evaluate methods of detecting clients with sexually transmitted diseases (STDs) who were acutely coinfected with human immunodeficiency virus (HIV) in Lilongwe, Malawi...
  34. ncbi request reprint Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention
    Arlene C Sena
    Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Clin Infect Dis 44:13-22. 2007
    ..Nucleic acid amplification tests can increase detection of T. vaginalis in men compared with culture...
  35. pmc Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithm
    Kimberly A Powers
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    AIDS 21:2237-42. 2007
    ..To facilitate the efficient use of these tests, we sought to develop a risk score algorithm for identifying likely AHI cases and targeting the tests towards those individuals...
  36. pmc Differential extracellular and intracellular concentrations of zidovudine and lamivudine in semen and plasma of HIV-1-infected men
    Julie B Dumond
    University of North Carolina at Chapel Hill, 3318 Kerr Hall, CB 7360, Chapel Hill, NC 27599 7360, USA
    J Acquir Immune Defic Syndr 48:156-62. 2008
    ..To quantitate extracellular and intracellular zidovudine (ZDV) and lamivudine (3TC) concentrations in blood and semen of HIV-1-infected men...
  37. pmc Keep them in school: the importance of education as a protective factor against HIV infection among young South African women
    Audrey E Pettifor
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Int J Epidemiol 37:1266-73. 2008
    ..This analysis focuses on the subset of sexually experienced young women with only one reported lifetime sex partner (n = 1708)...
  38. pmc Rethinking the heterosexual infectivity of HIV-1: a systematic review and meta-analysis
    Kimberly A Powers
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Lancet Infect Dis 8:553-63. 2008
    ..001 was estimated among stable couples with low prevalences of high-risk cofactors, and represents a lower bound. Cofactor effects are important to include in epidemic models, policy considerations, and prevention messages...
  39. doi request reprint Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi, 2007
    Lillian B Brown
    Division of Infectious Diseases, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Sex Transm Dis 37:169-72. 2010
    ..We sought to establish current laboratory-based Neisseria gonorrhoeae antibiotic susceptibility patterns for Malawi and describe the pattern of susceptibility since syndromic management began...
  40. pmc Acute HIV infection among pregnant women in Malawi
    Cynthia L Gay
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    Diagn Microbiol Infect Dis 66:356-60. 2010
    ..Dual HIV rapid tests have high sensitivity and specificity. HIV testing should be repeated in the third trimester and/or at delivery...
  41. ncbi request reprint Detection of acute infections during HIV testing in North Carolina
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA
    N Engl J Med 352:1873-83. 2005
    ..North Carolina has added nucleic acid amplification testing for the human immunodeficiency virus (HIV) to standard HIV antibody tests to detect persons with acute HIV infection who are viremic but antibody-negative...
  42. pmc Development and validation of a PCR-based enzyme-linked immunosorbent assay with urine for use in clinical research settings to detect Trichomonas vaginalis in women
    S Cornelia Kaydos
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Microbiol 40:89-95. 2002
    ..For clinical research settings in which vaginal specimens are not available and culture conditions are not feasible, urine-based PCR-ELISA may be useful for the detection of trichomoniasis in women...
  43. ncbi request reprint Prostate-specific antigen to ascertain reliability of self-reported coital exposure to semen
    Maria F Gallo
    Family Health International FHI, Research Triangle Park, North Carolina, USA
    Sex Transm Dis 33:476-9. 2006
    ..The objective of this study was to assess the validity of women's reports of recent unprotected sex by testing for prostate-specific antigen (PSA) in vaginal samples...
  44. ncbi request reprint Targeted screening for Trichomonas vaginalis with culture using a two-step method in women presenting for STD evaluation
    Heidi Swygard
    Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, 27599 7030, USA
    Sex Transm Dis 31:659-64. 2004
    ..Trichomonas vaginalis is the most common nonviral sexually transmitted pathogen. Wet mount microscopy performs poorly compared with culture; however, universal screening using culture would be cost-prohibitive...
  45. ncbi request reprint Prevalence of chlamydial and gonococcal infections among young adults in the United States
    William C Miller
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill 27599 7435, USA
    JAMA 291:2229-36. 2004
    ..Although screening for Chlamydia trachomatis is widely recommended among young adult women, little information is available regarding the prevalence of chlamydial and gonococcal infections in the general young adult population...
  46. ncbi request reprint Brief but efficient: acute HIV infection and the sexual transmission of HIV
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Infect Dis 189:1785-92. 2004
    ..We examined whether viral dynamics in the genital tract during the natural history of acute human immunodeficiency virus type 1 (HIV-1) infection could explain efficient heterosexual transmission of HIV...
  47. pmc Acute HIV revisited: new opportunities for treatment and prevention
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, 27599 7215, USA
    J Clin Invest 113:937-45. 2004
    ..In this review article, we will highlight critical opportunities for HIV treatment and prevention that are presented by these diagnostic strategies...
  48. ncbi request reprint Human immunodeficiency virus type 1 RNA in breast-milk components
    Irving F Hoffman
    Center for Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
    J Infect Dis 188:1209-12. 2003
    ..Whole milk demonstrated higher sensitivity and mean concentration than any other single component. Sensitivity was enhanced by analyzing all 4 components of breast milk...
  49. ncbi request reprint The prevalence of trichomoniasis in young adults in the United States
    William C Miller
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    Sex Transm Dis 32:593-8. 2005
    ..The prevalence of trichomoniasis in the general population of the United States is unknown. This study provides the first population-based prevalence estimates of trichomoniasis among young adults in the United States...
  50. ncbi request reprint The role of sexually transmitted diseases in HIV transmission
    Shannon R Galvin
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
    Nat Rev Microbiol 2:33-42. 2004
    ..Targeted STD detection and treatment should have a central role in HIV prevention in these emerging epidemics...
  51. ncbi request reprint Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women
    Sherene S Min
    Schools of Medicine, University of North Carolina, Chapel Hill 27599 7360, USA
    J Acquir Immune Defic Syndr 37:1577-80. 2004
    ..Of 8 ARVs, CVF concentrations ranged from <10% to >100% of BP concentrations. These large differences in CVF penetration suggest that further research into ARV pharmacokinetics and drug efficacy in the FGT is necessary...
  52. ncbi request reprint Pharmacokinetic and pharmacodynamic investigation of efavirenz in the semen and blood of human immunodeficiency virus type 1-infected men
    Y Sunila Reddy
    School of Pharmacy, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Infect Dis 186:1339-43. 2002
    ..In SP, EFV reaches concentrations above the HIV-1 IC(90)(WT) throughout the dosing interval. EFV-containing regimens effectively suppress HIV-1 RNA in SP...
  53. ncbi request reprint Potential effect of HIV type 1 antiretroviral and herpes simplex virus type 2 antiviral therapy on transmission and acquisition of HIV type 1 infection
    Connie L Celum
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 191:S107-14. 2005
    ..The rationale for antiretroviral and HSV-2-specific interventions and studies to test these strategies are described...
  54. pmc Attrition among human immunodeficiency virus (HIV)- infected patients initiating antiretroviral therapy in China, 2003-2010
    Hao Zhu
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e39414. 2012
    ..However, some patients may not benefit from combination antiretroviral therapy (cART) because of inadequate access to HIV care, including attrition after care initiation...
  55. pmc Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar
    Kathleen Van Damme
    Department of Medicine, Division of Infectious Diseases, University of North Carolina, Madagascar UNC Mad, Antananarivo, Madagascar
    Sex Transm Dis 36:775-6. 2009
    ....
  56. pmc Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection
    Marc C Levesque
    Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS Med 6:e1000107. 2009
    ..While the effect of HIV-1 on depletion of gut CD4(+) T cells in acute HIV-1 infection is well described, we studied blood and tissue B cells soon after infection to determine the effect of early HIV-1 on these cells...
  57. pmc Validation of a urine-based PCR-enzyme-linked immunosorbent assay for use in clinical research settings to detect Trichomonas vaginalis in men
    S Cornelia Kaydos-Daniels
    Departments of Epidemiology Medicine Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina UNC Project, Lilongwe, Malawi
    J Clin Microbiol 41:318-23. 2003
    ..For clinical research settings in which urethral swabs are not available and culture is not feasible, the urine-based PCR-ELISA may be useful for detection of trichomoniasis in men...
  58. pmc The pharmacokinetics and viral activity of tenofovir in the male genital tract
    Manoli Vourvahis
    Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 7360, USA
    J Acquir Immune Defic Syndr 47:329-33. 2008
    ..To measure tenofovir (TFV) concentrations in the male genital tract (GT) after single and multiple doses of tenofovir disoproxil fumarate (TDF) and evaluate the HIV-1 RNA response to monotherapy...
  59. ncbi request reprint Predicting adolescents' longitudinal risk for sexually transmitted infection: results from the National Longitudinal Study of Adolescent Health
    Carol A Ford
    Adolescent Medicine Program, School of Medicine, University of North Carolina at Chapel Hill, 27599 7220, USA
    Arch Pediatr Adolesc Med 159:657-64. 2005
    ..Influencing adolescents' sexual behaviors has the potential to influence trajectories of risk for sexually transmitted infections (STIs) among young adults...
  60. ncbi request reprint Human papillomavirus and cervical neoplasia among female sex workers in Madagascar
    Jennifer S Smith
    Gillings School of Global Public Health, University of Carolina, Chapel Hill, NC, USA
    Int J Gynecol Cancer 20:1593-6. 2010
    ..Human papillomavirus (HPV) prevalence and type distribution were estimated among 90 female sex workers (FSWs) aged 18 to 58 years in Antananarivo, Madagascar...
  61. ncbi request reprint Determination of amprenavir, a HIV-1 protease inhibitor, in human seminal plasma using high-performance liquid chromatography-tandem mass spectrometry
    Arlene S Pereira
    Department of Pathology, School of Medicine, University of North Carolina, Chapel Hill 27599, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 766:307-17. 2002
    ..Recently, this simple and sensitive method was used to determine amprenavir concentrations in seminal samples collected from HIV-1 positive subjects receiving amprenavir antiretroviral therapy as part of a multicenter clinical trial...
  62. doi request reprint The detection of acute HIV infection
    Myron S Cohen
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    J Infect Dis 202:S270-7. 2010
    ..We conclude that further technical advances are essential to allow more widespread detection of patients with AHI and to affect HIV treatment outcomes and transmission prevention...
  63. pmc Quantification of Chlamydia trachomatis elementary bodies in urine by ligase chain reaction
    Michael E Blocker
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Clin Microbiol 40:3631-4. 2002
    ..qLCR will be useful for studies of chlamydial infection aimed at understanding the associations of organism burden with clinical manifestations and transmission...
  64. ncbi request reprint Use of nutritional and water hygiene packages for diarrhoeal prevention among HIV-exposed infants in Lilongwe, Malawi: an evaluation of a pilot prevention of mother-to-child transmission post-natal care service
    Jiayin Xue
    The University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Trop Med Int Health 15:1156-62. 2010
    ..To evaluate a pilot prevention of mother-to-child transmission post-natal programme in Lilongwe, Malawi, through observed retention and infant diarrhoeal rates...
  65. pmc Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis
    Julie B Dumond
    School of Pharmacy, University of North Carolina at Chapel Hill, North Carolina, USA
    AIDS 21:1899-907. 2007
    ..To describe first dose and steady state antiretroviral drug exposure in the female genital tract...
  66. pmc Prevalence of HIV infection among young adults in the United States: results from the Add Health study
    Martina Morris
    Department of Sociology, University of Washington, Seattle, WA 98125, USA
    Am J Public Health 96:1091-7. 2006
    ..We estimated HIV prevalence rates among young adults in the United States...
  67. ncbi request reprint Syphilis in China: results of a national surveillance programme
    Zhi Qiang Chen
    National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, 12 Jiangwangmiao Street, Nanjing 210042, China
    Lancet 369:132-8. 2007
    ..Sporadic reports have provided clues to the magnitude of the spread of syphilis, but a national surveillance effort is needed to provide data for planning and intervention...
  68. ncbi request reprint China's syphilis epidemic: a systematic review of seroprevalence studies
    Charles C Lin
    University of California, San Francisco School of Medicine, San Francisco, California, USA
    Sex Transm Dis 33:726-36. 2006
    ..The objective of this study was to investigate syphilis prevalence among low- and high-risk groups in China...
  69. ncbi request reprint Estimating correlation by using a general linear mixed model: evaluation of the relationship between the concentration of HIV-1 RNA in blood and semen
    Hrishikesh Chakraborty
    Quintiles Inc, Research Triangle Park, NC, USA
    Stat Med 22:1457-64. 2003
    ..These results have important implications for studies related to the sexual transmission of HIV, and development of HIV prevention strategies...
  70. ncbi request reprint Population-based study of chlamydial infection in China: a hidden epidemic
    William L Parish
    Population Research Center, National Opinion Research Center University of Chicago, Chicago, Ill, USA
    JAMA 289:1265-73. 2003
    ..Sexually transmitted diseases are increasing rapidly in China. Surveillance data imperfectly indicate current prevalence and risk factors...
  71. ncbi request reprint When people with HIV get syphilis: triple jeopardy
    Myron S Cohen
    Sex Transm Dis 33:149-50. 2006
  72. ncbi request reprint Distribution of the CCR5 gene 32-base pair deletion and CCR5 expression in Chinese minorities
    Tao Feng
    Department of Clinical Immunology, Peking Union Medical College Hospital, Beijing, People s Republic of China
    J Acquir Immune Defic Syndr 32:131-4. 2003
    ..CCR5 expression appears to be greater in the Dai minority than in the other minorities investigated. The mechanism for this increased expression requires further study...
  73. pmc Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
    Brandon F Keele
    Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL 35223, USA
    Proc Natl Acad Sci U S A 105:7552-7. 2008
    ....
  74. ncbi request reprint HIV antiretroviral postexposure prophylaxis: a cautionary note
    Myron S Cohen
    Clin Infect Dis 41:1514-6. 2005
  75. ncbi request reprint Detection of Acute and Established HIV Infections in Sexually Transmitted Disease Clinics in Guangxi, China: Implications for Screening and Prevention of HIV Infection
    Xiang Sheng Chen
    National Center for STD Control, Nanjing, 210042, China
    J Infect Dis 196:1654-61. 2007
    ..Human immunodeficiency virus (HIV) has spread throughout China and to some degree has penetrated the general heterosexual population in some regions...
  76. ncbi request reprint Amplified HIV transmission and new approaches to HIV prevention
    Myron S Cohen
    J Infect Dis 191:1391-3. 2005
  77. ncbi request reprint Surplus men, sex work, and the spread of HIV in China
    Joseph D Tucker
    AIDS 19:539-47. 2005
    ..From a sociological perspective, we believe that surplus men and sex workers will have a profound effect on the future of HIV spread in China and on the success or failure of future interventions...
  78. ncbi request reprint The cost-effectiveness of treating male trichomoniasis to avert HIV transmission in men seeking sexually transmitted disease care in Malawi
    Matthew A Price
    International AIDS Vaccine Initiative, New York, NY, USA
    J Acquir Immune Defic Syndr 43:202-9. 2006
    ..We examined the cost-effectiveness of providing first-line treatment for male trichomoniasis in Malawi, a condition not commonly considered in syndromic management throughout sub-Saharan Africa...
  79. pmc Risk of syphilis in STI clinic patients: a cross-sectional study of 11,500 cases in Guangxi, China
    Susan P Y Wong
    National Center for STD Control, Nanjing, China
    Sex Transm Infect 83:351-6. 2007
    ..To measure prevalence of syphilis among the STI clinic population in Guangxi, China, and to assess the socioeconomic and behavioural characteristics associated with the infection...
  80. ncbi request reprint STD treatment: how can it improve HIV prevention in the South?
    Stuart M Berman
    Division of STD Prevention, CDC, Atlanta, Georgia 30333, USA
    Sex Transm Dis 33:S50-7. 2006
    ..A high percentage of the population is black, and STD/HIV rates are particularly high among this group. Control and treatment of STDs offers promise as an HIV prevention strategy, and nowhere more than in the South...
  81. ncbi request reprint AIDS. Promote HIV chemoprophylaxis research, don't prevent it
    Robert M Grant
    Gladstone Institute of Virology and Immunology, San Francisco, CA, USA
    Science 309:2170-1. 2005
  82. ncbi request reprint HIV/AIDS risk among brothel-based female sex workers in China: assessing the terms, content, and knowledge of sex work
    Yingying Huang
    Department of Sociology, Peoples University, Beijing, China
    Sex Transm Dis 31:695-700. 2004
    ..Sexual transmission of HIV in China is rapidly increasing, in part driven by commercial sex work...

Research Grants13

  1. HIV IN SEMEN--EFFECTS OF STDS AND ANTIVIRAL THERAPY
    Myron Cohen; Fiscal Year: 2004
    ..The results of these studies should provide further insight into the regulation of excretion of HIV in semen, transmission of HIV, and to inform public health HIV prevention policies. ..
  2. HIV IN SEMEN--EFFECTS OF STDS AND ANTIVIRAL THERAPY
    Myron Cohen; Fiscal Year: 2001
    ..The results of these studies should provide further insight into the regulation of excretion of HIV in semen, transmission of HIV, and to inform public health HIV prevention policies. ..
  3. INFECTIOUS DISEASE PATHOGENESIS RESEARCH TRAINING
    Myron Cohen; Fiscal Year: 2007
    ..In summary, we believe the mentors, the trainees and the environment are well suited to support the goals of the application, and ongoing critical research issues in the pathogenesis and epidemiology of infectious diseases. ..
  4. HIV IN SEMEN-EFFECTS OF STDS AND ANTIVIRAL THERAPY
    Myron Cohen; Fiscal Year: 2007
    ..We believe the studies proposed in this Application will provide unique insight into the biology of acute HIV infection and HIV transmission, and information critical for both biological and behavioral prevention strategies. ..
  5. HIV IN SEMEN--EFFECTS OF STDS
    Myron Cohen; Fiscal Year: 1999
    ..We believe that this information will be important in further development of both behavioral and vaccine HIV prevention strategies. ..
  6. HIV IN SEMEN--EFFECTS OF STDS AND ANTIVIRAL THERAPY
    Myron Cohen; Fiscal Year: 2002
    ..The results of these studies should provide further insight into the regulation of excretion of HIV in semen, transmission of HIV, and to inform public health HIV prevention policies. ..
  7. HIV IN SEMEN--EFFECTS OF STDS AND ANTIVIRAL THERAPY
    Myron Cohen; Fiscal Year: 2003
    ..The results of these studies should provide further insight into the regulation of excretion of HIV in semen, transmission of HIV, and to inform public health HIV prevention policies. ..
  8. HIV IN SEMEN--EFFECTS OF STDS AND ANTIVIRAL THERAPY
    Myron Cohen; Fiscal Year: 2000
    ..The results of these studies should provide further insight into the regulation of excretion of HIV in semen, transmission of HIV, and to inform public health HIV prevention policies. ..