Mitchell Jay Cohen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Acute traumatic coagulopathy: clinical characterization and mechanistic investigation
    Mitchell Jay Cohen
    Department of Surgery San Francisco General Hospital, The University of California San Francisco, San Francisco, CA, USA Electronic address
    Thromb Res 133:S25-7. 2014
  2. pmc Altering physiological networks using drugs: steps towards personalized physiology
    Adam D Grossman
    Department of Bioengineering, Stanford University, Stanford, CA, USA
    BMC Med Genomics 6:S7. 2013
  3. pmc Clinical and mechanistic drivers of acute traumatic coagulopathy
    Mitchell Jay Cohen
    Division of General Surgery, Department of Surgery, School of Medicine, University of California San Francisco, San Francisco, California, USA
    J Trauma Acute Care Surg 75:S40-7. 2013
  4. doi request reprint Towards hemostatic resuscitation: the changing understanding of acute traumatic biology, massive bleeding, and damage-control resuscitation
    Mitchell Jay Cohen
    Department of Surgery, San Francisco General Hospital and the University of California, San Francisco, 1001 Potrero Avenue, Ward 3A, San Francisco, CA 94110, USA
    Surg Clin North Am 92:877-91, viii. 2012
  5. doi request reprint Use of models in identification and prediction of physiology in critically ill surgical patients
    M J Cohen
    Department of Surgery, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, Ward 3A, San Francisco, California 94110, USA
    Br J Surg 99:487-93. 2012
  6. pmc Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients
    Mitchell Jay Cohen
    Department of Surgery, University of California San Francisco, San Francisco, CA 94110, USA
    Ann Surg 255:379-85. 2012
  7. pmc Reappraising the concept of massive transfusion in trauma
    Simon J Stanworth
    NHS Blood and Transplant, Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ, UK
    Crit Care 14:R239. 2010
  8. pmc Infection in the intensive care unit alters physiological networks
    Adam D Grossman
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    BMC Bioinformatics 10:S4. 2009
  9. doi request reprint Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway
    Mitchell Jay Cohen
    Departments of Surgery, San Francisco General Hospital, University of California, San Francisco, USA
    J Trauma 63:1254-61; discussion 1261-2. 2007
  10. doi request reprint Protein C depletion early after trauma increases the risk of ventilator-associated pneumonia
    Mitchell J Cohen
    Department of Surgery, University of California, San Francisco, California, USA
    J Trauma 67:1176-81. 2009

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Acute traumatic coagulopathy: clinical characterization and mechanistic investigation
    Mitchell Jay Cohen
    Department of Surgery San Francisco General Hospital, The University of California San Francisco, San Francisco, CA, USA Electronic address
    Thromb Res 133:S25-7. 2014
    ..Finally it will discuss the ongoing state of the science and suggest topics for continued biological and clinical study...
  2. pmc Altering physiological networks using drugs: steps towards personalized physiology
    Adam D Grossman
    Department of Bioengineering, Stanford University, Stanford, CA, USA
    BMC Med Genomics 6:S7. 2013
    ..We constructed correlation networks from physiologic data to demonstrate changes associated with pressor use in the intensive care unit...
  3. pmc Clinical and mechanistic drivers of acute traumatic coagulopathy
    Mitchell Jay Cohen
    Division of General Surgery, Department of Surgery, School of Medicine, University of California San Francisco, San Francisco, California, USA
    J Trauma Acute Care Surg 75:S40-7. 2013
    ..The PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study provided a unique opportunity to characterize coagulation and the effects of resuscitation on ATC after severe trauma...
  4. doi request reprint Towards hemostatic resuscitation: the changing understanding of acute traumatic biology, massive bleeding, and damage-control resuscitation
    Mitchell Jay Cohen
    Department of Surgery, San Francisco General Hospital and the University of California, San Francisco, 1001 Potrero Avenue, Ward 3A, San Francisco, CA 94110, USA
    Surg Clin North Am 92:877-91, viii. 2012
    ..Finally, the current state of the science suggests future basic science and clinical investigation that will drive changes in transfusion and resuscitation in severely injured military personnel and civilian patients...
  5. doi request reprint Use of models in identification and prediction of physiology in critically ill surgical patients
    M J Cohen
    Department of Surgery, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, Ward 3A, San Francisco, California 94110, USA
    Br J Surg 99:487-93. 2012
    ..Advances toward this goal and a brief overview of various modelling and statistical techniques constitute the purpose of this review...
  6. pmc Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients
    Mitchell Jay Cohen
    Department of Surgery, University of California San Francisco, San Francisco, CA 94110, USA
    Ann Surg 255:379-85. 2012
    ..Whether this early coagulopathy and later propensity to infection, multiple organ failure and mortality are associated with the activation of PC pathway has not been demonstrated and constitutes the aim of this study...
  7. pmc Reappraising the concept of massive transfusion in trauma
    Simon J Stanworth
    NHS Blood and Transplant, Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ, UK
    Crit Care 14:R239. 2010
    ..We also examined whether the concept was useful in that early prediction of massive transfusion requirements could allow early activation of blood bank protocols...
  8. pmc Infection in the intensive care unit alters physiological networks
    Adam D Grossman
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    BMC Bioinformatics 10:S4. 2009
    ..However, medical sources of clinical physiological data are only now starting to find use in bioinformatics research...
  9. doi request reprint Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway
    Mitchell Jay Cohen
    Departments of Surgery, San Francisco General Hospital, University of California, San Francisco, USA
    J Trauma 63:1254-61; discussion 1261-2. 2007
    ..The objective of the present study was to determine the importance of hypoperfusion and protein C activation in causing early coagulopathy in TBI patients...
  10. doi request reprint Protein C depletion early after trauma increases the risk of ventilator-associated pneumonia
    Mitchell J Cohen
    Department of Surgery, University of California, San Francisco, California, USA
    J Trauma 67:1176-81. 2009
    ..Furthermore, trauma patients with tissue injury and shock are at higher risk for the development of VAP...
  11. doi request reprint 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients--beyond lactate and base deficit
    Mitchell J Cohen
    Department of Surgery, University of California, San Francisco, California, USA
    J Trauma 69:31-40. 2010
    ....
  12. pmc Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans
    Mitchell J Cohen
    Department of Surgery, Ward 3A, San Francisco General Hospital, 1001 Potrero Avenue, Room 3C 38, San Francisco, CA 94110, USA
    J Trauma 68:1273-8. 2010
    ....
  13. pmc Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis
    Mitchell J Cohen
    Department of Surgery, University of California, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Crit Care 14:R10. 2010
    ..We hypothesized that processing of multivariate data using hierarchical clustering techniques would allow identification of otherwise hidden patient physiologic patterns that would be predictive of outcome...
  14. pmc Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion
    Mitchell J Cohen
    The Department of Surgery, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    Crit Care 13:R174. 2009
    ..However, whether HMGB1 is released early after trauma hemorrhage in humans and is associated with the development of an inflammatory response and coagulopathy is not known and therefore constitutes the aim of the present study...
  15. doi request reprint Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis
    Lucy Z Kornblith
    From the Department of Surgery, San Francisco General Hospital, University of California, San Francisco, San Francisco, California
    J Trauma Acute Care Surg 76:255-6; discussion 262-3. 2014
    ....
  16. pmc Cause and timing of death in massively transfused trauma patients
    Michael W Cripps
    Division of Burn Trauma Critical Care, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9158, USA
    J Trauma Acute Care Surg 75:S255-62. 2013
    ..The purpose of this study was to characterize the cause of death in severely injured trauma patients to define potential responses to resuscitation...
  17. pmc Finding the sweet spot: identification of optimal glucose levels in critically injured patients
    Matthew E Kutcher
    Department of Surgery at San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    J Trauma 71:1108-14. 2011
    ....
  18. pmc Extracellular histone release in response to traumatic injury: implications for a compensatory role of activated protein C
    Matthew E Kutcher
    Department of Surgery at San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    J Trauma Acute Care Surg 73:1389-94. 2012
    ..We hypothesized that extracellular histone levels would be increased and associated with poor outcomes after traumatic injury...
  19. pmc Criteria for empiric treatment of hyperfibrinolysis after trauma
    Matthew E Kutcher
    Department of Surgery, University of California, San Francisco, CA, USA
    J Trauma Acute Care Surg 73:87-93. 2012
    ..We hypothesized that analysis of patients with thromboelastography-diagnosed hyperfibrinolysis would identify clinical criteria for empiric antifibrinolytic treatment in the absence of thromboelastography...
  20. doi request reprint Trauma training in simulation: translating skills from SIM time to real time
    M Margaret Knudson
    Department of Surgery, University of California, San Francisco, California, USA
    J Trauma 64:255-63; discussion 263-4. 2008
    ..Simulation may have a role in this educational process, but only if it can be demonstrated that skills learned in a simulated environment translate into enhanced performance in real-life trauma situations...
  21. doi request reprint The "found down" patient: a diagnostic dilemma
    Lucy Z Kornblith
    Department of Surgery, San Francisco General Hospital, and University of California, San Francisco, CA 94110, USA
    J Trauma Acute Care Surg 74:1548-52. 2013
    ..Occult injury is an important part of the differential diagnosis in these patients. Rational use of trauma resources and optimal care of these patients requires clear triage criteria and timely evaluation...
  22. doi request reprint Coagulopathy after traumatic brain injury
    Mathieu Laroche
    Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
    Neurosurgery 70:1334-45. 2012
    ..The current and emerging diagnostic tools, radiological findings, treatment options, and prognosis are discussed...
  23. doi request reprint Prohemostatic interventions in trauma: resuscitation-associated coagulopathy, acute traumatic coagulopathy, hemostatic resuscitation, and other hemostatic interventions
    Benjamin M Howard
    Department of Surgery, University of California, San Francisco, California 94110, USA
    Semin Thromb Hemost 38:250-8. 2012
    ..These interventions show promising effects but their efficacy in reducing clinically important outcome parameters need to be confirmed in clinical studies...
  24. pmc Characterization of platelet dysfunction after trauma
    Matthew E Kutcher
    Department of Surgery, University of California, San Francisco, CA, USA
    J Trauma Acute Care Surg 73:13-9. 2012
    ..The increased morbidity and mortality associated with coagulopathy and thrombocytopenia after trauma are well described. However, few studies have assessed platelet function after injury...