Ethan David Cohen

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway
    Ethan David Cohen
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:2538-49. 2009
  2. pmc Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development
    Ying Tian
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 18:275-87. 2010
  3. pmc Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut
    Ashley M Goss
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 17:290-8. 2009
  4. pmc Wnt ligands signal in a cooperative manner to promote foregut organogenesis
    Mayumi F Miller
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:15348-53. 2012
  5. pmc Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression
    Ashley M Goss
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 356:541-52. 2011
  6. pmc High throughput genomic screen identifies multiple factors that promote cooperative Wnt signaling
    Mayumi F Miller
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e55782. 2013
  7. pmc Wnt5a and Wnt11 are essential for second heart field progenitor development
    Ethan David Cohen
    Department of Medicine, Division of Endocrinology, University of Rochester, Rochester, NY 14642, USA
    Development 139:1931-40. 2012
  8. pmc A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
    Yuzhen Zhang
    Department of Medicine, University of Pennsylvania, 956 BRB II III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 40:862-70. 2008
  9. pmc The importance of Wnt signaling in cardiovascular development
    Ying Tian
    Department of Medicine, University of Pennsylvania, 956 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Pediatr Cardiol 31:342-8. 2010
  10. pmc Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling
    Ethan David Cohen
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Invest 117:1794-804. 2007

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway
    Ethan David Cohen
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:2538-49. 2009
    ..Together, these data define a Wnt/Tnc/Pdgfr signaling axis that is critical for smooth muscle development and disease progression in the lung...
  2. pmc Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development
    Ying Tian
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 18:275-87. 2010
    ..These data reveal a molecular pathway regulating the posterior cardiac mesoderm and demonstrate that cardiovascular defects caused by loss of Wnt signaling can be rescued pharmacologically in vivo...
  3. pmc Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut
    Ashley M Goss
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 17:290-8. 2009
    ..Together, these data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut...
  4. pmc Wnt ligands signal in a cooperative manner to promote foregut organogenesis
    Mayumi F Miller
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:15348-53. 2012
    ..These data suggest a model in which Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung...
  5. pmc Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression
    Ashley M Goss
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 356:541-52. 2011
    ..These studies place Wnt2 high in a hierarchy of signaling molecules that promote the earliest aspects of lung airway smooth muscle development...
  6. pmc High throughput genomic screen identifies multiple factors that promote cooperative Wnt signaling
    Mayumi F Miller
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e55782. 2013
    ..These data identify a broad homeobox code, which acts to increase Wnt signaling through transcriptional repression...
  7. pmc Wnt5a and Wnt11 are essential for second heart field progenitor development
    Ethan David Cohen
    Department of Medicine, Division of Endocrinology, University of Rochester, Rochester, NY 14642, USA
    Development 139:1931-40. 2012
    ..These data show that Wnt5a and Wnt11 are essential regulators of the response of second heart field progenitors to Wnt/β-catenin signaling and that they act by restraining Wnt/β-catenin signaling during cardiac development...
  8. pmc A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
    Yuzhen Zhang
    Department of Medicine, University of Pennsylvania, 956 BRB II III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 40:862-70. 2008
    ..Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration...
  9. pmc The importance of Wnt signaling in cardiovascular development
    Ying Tian
    Department of Medicine, University of Pennsylvania, 956 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Pediatr Cardiol 31:342-8. 2010
    ....
  10. pmc Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling
    Ethan David Cohen
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Invest 117:1794-804. 2007
    ..These data reveal what we believe to be a novel Wnt-FGF signaling axis required for expansion of Isl-1-positive AHF progenitors and suggest future therapies to increase the number and function of these cells for cardiac regeneration...
  11. pmc A house with many rooms: how the heart got its chambers with foxn4
    Ethan David Cohen
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 22:706-10. 2008
  12. doi request reprint Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal
    Ethan David Cohen
    Cardiovascular Institute, Institute for Regenerative Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 135:789-98. 2008
    ..Here, we discuss the roles for Wnt signaling in cardiac and vascular development, and focus on the emerging role of Wnt signaling in cardiovascular morphogenesis and progenitor cell self-renewal...

Research Grants2

  1. Is non-canonical Wnt signaling required in cardiac neural crest cells?
    Ethan David Cohen; Fiscal Year: 2007
    ..Experiments described in this proposal will determine if disrupting non-canonical Wnt signaling can contribute to congenital heart defects. This.information may lead to new detection or treatment strategies. ..