Craig R Cohen
Affiliation: University of Washington
- Detection of novel organisms associated with salpingitis, by use of 16S rDNA polymerase chain reactionJennifer K Hebb
Department of Medicine, Division of Infectious Diseases, University of Washington, Seattle, Washington 98104, USA
J Infect Dis 190:2109-20. 2004..The finding of novel phylotypes associated with salpingitis has important implications for the etiology, pathogenesis, and treatment of this important reproductive-tract disease syndrome...
- The ABCs of HIV prevention in men: associations with HIV risk and protective behaviorsMatthew S Steele
Program for Appropriate Technology in Health PATH, Seattle, WA, USA
J Acquir Immune Defic Syndr 43:571-6. 2006..To elucidate associations between beliefs in abstinence, fidelity, and condom use (the "ABCs" of preventing HIV and other sexually transmitted infections) and associated self-reported risk behaviors among Kenyan men...
- Increased interleukin-10 in the the endocervical secretions of women with non-ulcerative sexually transmitted diseases: a mechanism for enhanced HIV-1 transmission?C R Cohen
Department of Obstetrics and Gynecology, University of Washington, Seattle 98195 6460, USA
AIDS 13:327-32. 1999..Therefore, we performed this study to assess whether non-ulcerative STD are associated with detection of IL-10 in the female genital tract...
- Etiology of persistent tubo-ovarian abscess in Nairobi, KenyaCraig R Cohen
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
Infect Dis Obstet Gynecol 11:45-51. 2003..To study the microbial etiology of tubo-ovarian abscess (TOA)...
- Immunogenetic correlates for Chlamydia trachomatis-associated tubal infertilityCraig R Cohen
Departments of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA
Obstet Gynecol 101:438-44. 2003..To understand immunogenetic mechanisms of Chlamydia trachomatis infection and tubal scarring...
- Human leukocyte antigen class II DQ alleles associated with Chlamydia trachomatis tubal infertilityC R Cohen
Department of Obstetrics and Gynecology, University of Washington, Seattle 98104 6460, USA
Obstet Gynecol 95:72-7. 2000..To investigate epidemiologic tubal infertility risk factors and the relationship between HLA class II alleles and Chlamydia trachomatis tubal infertility...
- Antiretroviral prophylaxis for HIV prevention in heterosexual men and womenJared M Baeten
Department of Global Health, University of Washington, Seattle, WA 98104, USA
N Engl J Med 367:399-410. 2012..Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations...
- Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan womenCaroline Mitchell
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 62:143-8. 2013..01). HIV-1 DNA shedding was associated with increased concentrations of IL-1β and IL-6 and lower secretory leukocyte protease inhibitor among US women but not Kenyan women...
- Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysisDeborah Donnell
Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Lancet 375:2092-8. 2010..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners...
- Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trialJairam R Lingappa
Department of Global Health, Seattle, WA, USA
Lancet 375:824-33. 2010..Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of acyclovir on HIV-1 progression...
- mgpB and mgpC sequence diversity in Mycoplasma genitalium is generated by segmental reciprocal recombination with repetitive chromosomal sequencesStefanie L Iverson-Cabral
Department of Pathobiology, University of Washington, Seattle, WA 98104, USA
Mol Microbiol 66:55-73. 2007..genitalium by the mutual exchange of sequences makes this organism unique among bacterial pathogens...
- Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trialJared M Baeten
Department of Global Health, University of Washington, Seattle, WA, USA Department of Medicine, University of Washington, Seattle, WA, USA Department of Epidemiology, University of Washington, Seattle, WA, USA Electronic address
Lancet Infect Dis 14:1055-64. 2014..We assessed the efficacy of single-agent tenofovir disoproxil fumarate relative to combination emtricitabine plus tenofovir disoproxil fumarate as PrEP...
- Characteristics of HIV-1 serodiscordant couples enrolled in a clinical trial of antiretroviral pre-exposure prophylaxis for HIV-1 preventionAndrew Mujugira
Department of Global Health, University of Washington, Seattle, Washington, United States of America
PLoS ONE 6:e25828. 2011..We describe the trial design and characteristics of the study cohort...
- Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners studyJairam R Lingappa
Department of Global Health, University of Washington, Seattle, Washington, United States of America
PLoS ONE 4:e5272. 2009..We describe the baseline characteristics of this cohort...
- Independent association of hygiene, socioeconomic status, and circumcision with reduced risk of HIV infection among Kenyan menAmalia S Meier
Department of Laboratory Medicine, Center for AIDS and STD, University of Washington, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 43:117-8. 2006..1; 95% confidence interval [CI], 1.4-19.1) and inversely associated with being circumcised (OR, 0.12; 95% CI, 0.02-0.91), but also independently associated with a combined measure of hygiene (OR, 0.41; 95% CI, 0.19-0.90)...
- Texting improves testing: a randomized trial of two-way SMS to increase postpartum prevention of mother-to-child transmission retention and infant HIV testingThomas A Odeny
aKenya Medical Research Institute KEMRI, Nairobi, Kenya bDepartment of Epidemiology cDepartment of Global Health dDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington eDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California fDepartment of Medicine, University of Washington, Seattle, Washington, USA gInstitute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya
AIDS 28:2307-12. 2014..We aimed to determine whether interactive text messages improved rates of clinic attendance and early infant HIV testing in the Nyanza region of Kenya...
- Mortality and burden of disease in a cohort of HIV-seropositive adults in Nairobi, KenyaChristina W Mwachari
Centre for Respiratory Disease Research, Kenya Medical Research Institute, PO Box 54840, Nairobi, Kenya
Int J STD AIDS 15:120-6. 2004..0, 95% confidence interval 1.7-5.1). These findings may help to target high-risk populations and guide OI prevention and treatment strategies including decisions regarding initiation of antiretroviral therapy in sub-Saharan Africa...
- High medication adherence during periconception periods among HIV-1-uninfected women participating in a clinical trial of antiretroviral pre-exposure prophylaxisLynn T Matthews
Division of Infectious Disease and Center for Global Health, Massachusetts General Hospital, Boston, MA Division of Infectious Disease, Beth Israel Deaconess Medical Center, Boston, MA Department of Global Health, University of Washington, Seattle, WA Kenya Medical Research Institute, Nairobi, Kenya Department of Obstetrics, Gynecology and Reproductive Sciences, Bixby Center for Global Reproductive Health, University of California San Francisco, San Francisco, CA Department of Medicine, Johns Hopkins University, Baltimore, MD Department of Medicine, University of Washington, Seattle, WA and Department of Epidemiology, University of Washington, Seattle, WA
J Acquir Immune Defic Syndr 67:91-7. 2014..Understanding medication adherence in this population may inform whether PrEP is a feasible safer conception strategy...
- Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, KenyaJenell S Coleman
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Acquir Immune Defic Syndr 63:245-8. 2013..42 log10; 95% confidence interval: 0.10 to 0.75). The LNG-IUD did not increase genital HIV-1 RNA shedding after 6 months of use...
- Intrastrain heterogeneity of the mgpB gene in Mycoplasma genitalium is extensive in vitro and in vivo and suggests that variation is generated via recombination with repetitive chromosomal sequencesStefanie L Iverson-Cabral
Department of Medicine, Harborview Medical Center, R and T Building, 325 9th Avenue, Box 359779, Seattle, WA 98104, USA
Infect Immun 74:3715-26. 2006..These observations support the hypothesis that recombination occurs between the mgpB gene and MgPar sequences and that the resulting antigenically distinct MgPa variants may contribute to immune evasion and persistence of infection...
- Developing content for a mHealth intervention to promote postpartum retention in prevention of mother-to-child HIV transmission programs and early infant diagnosis of HIV: a qualitative studyThomas A Odeny
Center for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
PLoS ONE 9:e106383. 2014..We aimed to use theory-informed methods to develop text messages targeted at facilitating these steps...
- Integration of HIV Care with Primary Health Care Services: Effect on Patient Satisfaction and Stigma in Rural KenyaThomas A Odeny
Family Aids Care and Education Services, Kisumu, Kenya Kenya Medical Research Institute, Nairobi, Kenya Department of Epidemiology, University of Washington, Seattle, USA
AIDS Res Treat 2013:485715. 2013..37 95% CI 1.33-8.52). Integration of HIV services into primary care services was associated with significant increases in patient satisfaction in certain domains, with no negative effect on satisfaction...
- Interaction between lactobacilli, bacterial vaginosis-associated bacteria, and HIV Type 1 RNA and DNA Genital shedding in U.S. and Kenyan womenCaroline Mitchell
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
AIDS Res Hum Retroviruses 29:13-9. 2013..6; 0.40, 0.91). Vaginal Lactobacillus species were associated with lower risk of genital HIV-1 shedding, while the presence of certain BV-associated species may increase that risk...
- Association of hormonal contraception and HIV-seroprevalence in Nairobi, KenyaAmy Criniti
Department of Obstetrics and Gynecology, University of Washington, Seattle, USA
AIDS 17:2667-9. 2003..5, 95% confidence interval 0.3-0.7) than women using DMPA. This association was most pronounced among POCP users of lower parity...
- Stigma as experienced by women accessing prevention of parent-to-child transmission of HIV services in Karnataka, IndiaLisa Rahangdale
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA
AIDS Care 22:836-42. 2010..Based on these formative data, PPTCT program planners should consider further research and interventions aimed at diminishing institutional and interpersonal HIV-associated stigma experienced by pregnant women...
- Risk factors for pneumonia in urban-dwelling HIV-infected women: a case-control study in Nairobi, KenyaJeremy Penner
McMaster University, Hamilton, Canada
J Acquir Immune Defic Syndr 32:223-8. 2003..5; 95% CI, 1.1-2.1) remained at increased risk of pneumonia. If confirmed by prospective investigation, these findings could help identify persons and subpopulations of HIV-infected women with the greatest risk of pneumonia...
- Chronic diarrhoea in HIV-1-infected adults in Nairobi, Kenya: evaluation of risk factors and the WHO treatment algorithmChristina W Mwachari
AIDS 17:2124-6. 2003
- Mycoplasma genitalium infection and persistence in a cohort of female sex workers in Nairobi, KenyaCraig R Cohen
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, CA, USA
Sex Transm Dis 34:274-9. 2007..The objective of this study was to assess the risk factors for and persistence of Mycoplasma genitalium (MG) in a highly exposed female population in Kenya...
- Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon- gammaCraig R Cohen
Department of Obstetrics, Gynecology, and Reproductive Science, University of California, San Francisco, San Francisco, California 94105, USA
J Infect Dis 192:591-9. 2005..This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development...
- Sustained changes in sexual behavior by female sex workers after completion of a randomized HIV prevention trialElizabeth N Ngugi
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
J Acquir Immune Defic Syndr 45:588-94. 2007..Behavioral interventions in female sex workers (FSWs) are associated with changes in sexual behavior and reduced rates of sexually transmitted infections (STIs) and HIV We examined the sustainability of such interventions...
- Effect of human immunodeficiency virus-1 infection on treatment outcome of acute salpingitisNelly R Mugo
Department of Obstetrics and Gynecology, Kenyatta National Hospital, Nairobi, Kenya
Obstet Gynecol 107:807-12. 2006..To examine the effect of human immunodeficiency virus (HIV)-1 infection on treatment outcome of laparoscopically verified acute salpingitis...
- Sexual identity and risk of HIV/STI among men who have sex with men in NairobiAnjali Sharma
Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
Sex Transm Dis 35:352-4. 2008
- Probiotics: potential to prevent HIV and sexually transmitted infections in womenMichael Bolton
Department of Medicine, Emory University, Atlanta, Georgia, USA
Sex Transm Dis 35:214-25. 2008..If results from such a trial demonstrate efficacy, future studies should be designed to determine whether a probiotic can significantly lower the risk for HIV and STIs in at-risk female populations...
- Bacterial vaginosis: risk factors among Kenyan women and their male partnersElizabeth A Bukusi
Kenya Medical Research Institute, Center for Microbiology Research, Nairobi, Kenya
Sex Transm Dis 33:361-7. 2006..To simultaneously examine associations of bacterial vaginosis (BV) with potential risk factors in both the female and her male partner...
- Diarrheal disease among HIV-infected adults in Karnataka, India: evaluation of risk factors and etiologyMarissa L Becker
Department of Medical Microbiology, Department of Community Health Sciences, and Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Am J Trop Med Hyg 76:718-22. 2007..Important risk factors for diarrhea were identified. Protection by TMP/SMX reinforces the importance of prophylaxis. These data suggest that treatment with an antibiotic and anti-parasitic medication may be effective...
- Safety, acceptability, and tolerability of 3 topical microbicides among heterosexual Kenyan menElizabeth A Bukusi
Kenya Medical Research Institute, Nairobi, Kenya
J Acquir Immune Defic Syndr 44:423-8. 2007..To compare the acceptability, tolerability, and safety of 3 topical microbicide formulations (62% ethyl alcohol in emollient gel and 0.1% and 0.4% benzalkonium chloride on a sanitary wipe) for use on male genitalia...
- Sex preparation and diaphragm acceptability in sex work in Nairobi, KenyaAnjali Sharma
Centre for Microbiology Research, Kenya Medical Research Institute, Kenyatta National Hospital, PO Box 19464 00202, Nairobi, Kenya
Sex Health 3:261-8. 2006..Currently, contraceptive diaphragm users are advised to leave the diaphragm in situ without concomitant use of other intravaginal substances for at least 6 h after intercourse...
- Association between Mycoplasma genitalium and acute endometritisCraig R Cohen
Lancet 359:765-6. 2002..02). Our results suggest that infection with M genitalium is strongly associated with acute endometritis in this population...
- Infectious correlates of HIV-1 shedding in the female upper and lower genital tractsJenell S Coleman
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94105, USA
AIDS 21:755-9. 2007..To determine the effects of vaginal, cervical, and endometrial infections on shedding of HIV-1 RNA in the female genital tract...