Affiliation: University of California
Coffinier C, Chang S, Nobumori C, Tu Y, Farber E, Toth J, et al
. Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A. 2010;107:5076-81 pubmed publisher
..These studies establish an essential function for lamin B2 in neuronal migration and brain development. ..
Coffinier C, Hudon S, Farber E, Chang S, Hrycyna C, Young S, et al
. HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A. 2007;104:13432-7 pubmed
..6 microM; tipranavir, 1.2 +/- 0.4 microM). We conclude that the HIV-PIs inhibit ZMPSTE24, leading to an accumulation of farnesyl-prelamin A. The inhibition of ZMPSTE24 by HIV-PIs could play a role in the side effects of these drugs. ..
Coffinier C, Hudon S, Lee R, Farber E, Nobumori C, Miner J, et al
. A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. J Biol Chem. 2008;283:9797-804 pubmed publisher
..Ritonavir, like lopinavir, inhibits ZMPSTE24 and leads to an accumulation of prelamin A. ..
Coffinier C, Jung H, Li Z, Nobumori C, Yun U, Farber E, et al
. Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. J Biol Chem. 2010;285:20818-26 pubmed publisher
..We conclude that prelamin A processing is dispensable in mice and that direct synthesis of mature lamin A has little if any effect on the targeting of lamin A to the nuclear rim in mouse tissues. ..
Coffinier C, Fong L, Young S. LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins. Nucleus. 2010;1:407-11 pubmed publisher
Coffinier C, Jung H, Nobumori C, Chang S, Tu Y, Barnes R, et al
. Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell. 2011;22:4683-93 pubmed publisher