Christopher S Coffey

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc The Association of the Metabolic Syndrome with PAI-1 and t-PA Levels
    Christopher S Coffey
    Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Cardiol Res Pract 2011:541467. 2011
  2. doi request reprint Overview, hurdles, and future work in adaptive designs: perspectives from a National Institutes of Health-funded workshop
    Christopher S Coffey
    Department of Biostatistics, University of Iowa, Iowa City, USA
    Clin Trials 9:671-80. 2012
  3. doi request reprint C-reactive protein as a prognostic marker after lacunar stroke: levels of inflammatory markers in the treatment of stroke study
    Mitchell S V Elkind
    From the Department of Neurology, College of Physicians and Surgeons M S V E, J M L, Department of Epidemiology, Mailman School of Public Health M S V E, J M L, and Gertrude H Sergievsky Center M S V E, Columbia University, New York, NY Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL L A M, Y Z Department of Biostatistics, University of Iowa, Iowa City, IA C S C Department of Neurology, University of Texas at Houston, Houston, TX A R School of Medicine, Universidad Espíritu Santo Ecuador, Guayaquil, Ecuador O H D B Department of Neurology, Hospital Alberto Sabogal, Lima, Peru E J P Department of Neurology, University of Kentucky, Lexington, KY L C P Department of Neurology, University of San Diego, San Diego, CA B C M Department of Neurology, Pontificia Universidad Catolica de Chile, Santiago, Chile J T School of Nursing and Secondary Prevention of Small Subcortical Strokes SPS3 Coordinating Center, University of Texas Health Science Center at San Antonio, San Antonio, TX C W and Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC
    Stroke 45:707-16. 2014
  4. pmc Adaptive trial designs: a review of barriers and opportunities
    John A Kairalla
    Department of Biostatistics, University of Florida, PO Box 117450, Gainesville, FL 32611 7450, USA
    Trials 13:145. 2012
  5. ncbi request reprint Detection of gene x gene interactions in genome-wide association studies of human population data
    Solomon K Musani
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Hered 63:67-84. 2007
  6. ncbi request reprint Reporting of model validation procedures in human studies of genetic interactions
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nutrition 20:69-73. 2004
  7. pmc Monitoring futility in a two-by-two factorial design: the SPS3 experience
    Leslie A McClure
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Clin Trials 10:250-6. 2013
  8. ncbi request reprint Stroke and the statistics of the aspirin/clopidogrel secondary prevention trials
    George Howard
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Curr Opin Neurol 20:71-7. 2007
  9. ncbi request reprint Is Bayesian analysis ready for use in phase III randomized clinical trials? Beware the sound of the sirens
    George Howard
    Department of Biostatistics, University of Alabama at Birmingham, AL 35294 0022, USA
    Stroke 36:1622-3. 2005
  10. pmc An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    BMC Bioinformatics 5:49. 2004

Detail Information

Publications15

  1. pmc The Association of the Metabolic Syndrome with PAI-1 and t-PA Levels
    Christopher S Coffey
    Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Cardiol Res Pract 2011:541467. 2011
    ..Conclusions. Our study demonstrates that those with the Met S have significantly higher levels of PAI-1 and t-PA antigen, factors known to increase the risk of cardiovascular disease...
  2. doi request reprint Overview, hurdles, and future work in adaptive designs: perspectives from a National Institutes of Health-funded workshop
    Christopher S Coffey
    Department of Biostatistics, University of Iowa, Iowa City, USA
    Clin Trials 9:671-80. 2012
    ..These recommendations have since been presented, discussed, and vetted in a number of venues including the University of Pennsylvania Conference on Statistical Issues in Clinical Trials and the Society for Clinical Trials annual meeting...
  3. doi request reprint C-reactive protein as a prognostic marker after lacunar stroke: levels of inflammatory markers in the treatment of stroke study
    Mitchell S V Elkind
    From the Department of Neurology, College of Physicians and Surgeons M S V E, J M L, Department of Epidemiology, Mailman School of Public Health M S V E, J M L, and Gertrude H Sergievsky Center M S V E, Columbia University, New York, NY Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL L A M, Y Z Department of Biostatistics, University of Iowa, Iowa City, IA C S C Department of Neurology, University of Texas at Houston, Houston, TX A R School of Medicine, Universidad Espíritu Santo Ecuador, Guayaquil, Ecuador O H D B Department of Neurology, Hospital Alberto Sabogal, Lima, Peru E J P Department of Neurology, University of Kentucky, Lexington, KY L C P Department of Neurology, University of San Diego, San Diego, CA B C M Department of Neurology, Pontificia Universidad Catolica de Chile, Santiago, Chile J T School of Nursing and Secondary Prevention of Small Subcortical Strokes SPS3 Coordinating Center, University of Texas Health Science Center at San Antonio, San Antonio, TX C W and Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC
    Stroke 45:707-16. 2014
    ..We hypothesized that high-sensitivity C-reactive protein (hsCRP) predicts recurrent ischemic stroke after recent lacunar stroke...
  4. pmc Adaptive trial designs: a review of barriers and opportunities
    John A Kairalla
    Department of Biostatistics, University of Florida, PO Box 117450, Gainesville, FL 32611 7450, USA
    Trials 13:145. 2012
    ..However, the interested reader will find that we provide current references to focused reviews and original theoretical sources which lead to details of the current state of the art in theory and practice...
  5. ncbi request reprint Detection of gene x gene interactions in genome-wide association studies of human population data
    Solomon K Musani
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Hered 63:67-84. 2007
    ..Instead, a combination of approaches with the aim of balancing their specific strengths may be the optimal approach to investigate gene x gene interactions in human data...
  6. ncbi request reprint Reporting of model validation procedures in human studies of genetic interactions
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nutrition 20:69-73. 2004
  7. pmc Monitoring futility in a two-by-two factorial design: the SPS3 experience
    Leslie A McClure
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Clin Trials 10:250-6. 2013
    ....
  8. ncbi request reprint Stroke and the statistics of the aspirin/clopidogrel secondary prevention trials
    George Howard
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Curr Opin Neurol 20:71-7. 2007
    ....
  9. ncbi request reprint Is Bayesian analysis ready for use in phase III randomized clinical trials? Beware the sound of the sirens
    George Howard
    Department of Biostatistics, University of Alabama at Birmingham, AL 35294 0022, USA
    Stroke 36:1622-3. 2005
  10. pmc An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    BMC Bioinformatics 5:49. 2004
    ..One advantage of the MDR method is that it provides an internal prediction error for validation. We summarize our use of this internal prediction error for model validation...
  11. pmc Sample size re-estimation in an on-going NIH-sponsored clinical trial: the secondary prevention of small subcortical strokes experience
    Leslie A McClure
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    Contemp Clin Trials 33:1088-93. 2012
    ..Failure to account for this could result in an under-powered study. Thus, we performed a sample size re-estimation, and describe the experience herein...
  12. ncbi request reprint Adaptive clinical trials: progress and challenges
    Christopher S Coffey
    Department of Biostatistics, School of Public Health, University of Alabama Birmingham, Birmingham, Alabama, USA
    Drugs R D 9:229-42. 2008
    ..In this review, we summarize the existing methods and current controversies with the intent of providing a clarification that will enable these individuals to participate in these much-needed discussions...
  13. pmc Challenges of decision making regarding futility in a randomized trial: the Interventional Management of Stroke III experience
    Sharon D Yeatts
    From the Data Coordination Unit, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC S D Y, R H M, L D F, R F W, Y Y P Department of Biostatistics, University of Iowa, Iowa City, IA C S C Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA P D L Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, OH J P B Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY M R D T and Department of Radiology, Temple University School of Medicine, Philadelphia, PA C A J
    Stroke 45:1408-14. 2014
    ..In April 2012, after 656 subjects were randomized, further enrollment was terminated by the National Institute of Neurological Disorders and Stroke based on the prespecified criterion for futility using conditional power<20%...
  14. ncbi request reprint The effects of intentional weight loss as a latent variable problem
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Stat Med 24:941-54. 2005
    ....
  15. ncbi request reprint Properties of internal pilots with the univariate approach to repeated measures
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Stat Med 22:2469-85. 2003
    ..At this time, we caution against using an internal pilot design with repeated measures without first conducting simulations to document the amount of test size inflation possible for the conditions of interest...