Research Topics
Genomes and GenesSpecies | Gerhard CoetzeeSummaryAffiliation: University of Southern California Country: USA Publications
Research Grants
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Publications
Identification of novel androgen receptor target genes in prostate cancerUnnati Jariwala
Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, USA
Mol Cancer 6:39. 2007..The androgen receptor (AR) plays critical roles in both androgen-dependent and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes that mediate the receptor's roles in disease progression...- Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasisSanjeev K Baniwal
Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, USA
Mol Cancer 9:258. 2010..However, little is known about the gene regulatory networks influenced by Runx2 in PCa cells. We therefore investigated genome wide mRNA expression changes in PCa cells in response to Runx2... - Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cellsClaudia Andreu-Vieyra
Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Mol Cell Biol 31:4648-62. 2011..quot; This allows the recruitment of histone modifiers, chromatin remodelers, and ultimately gene activation. The "receptive" state described here could help explain AR signaling activation under very low ligand concentrations... - A systematic approach to understand the functional consequences of non-protein coding risk regionsGerhard A Coetzee
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Cell Cycle 9:256-9. 2010..Here we describe an integrated framework to allow non-protein coding loci to be annotated with respect to regulatory functions. This will facilitate identification of target genes as well as prioritize variants for functional testing... 
Androgen and anti-androgen treatment modulates androgen receptor activity and DJ-1 stabilityTiina Pitkänen-Arsiola
Institute of Applied Biotechnology, University of Kuopio, Kuopio, Finland
Prostate 66:1177-93. 2006..Mechanisms regulating the transition from hormone responsive to hormone refractory prostate cancer (PCa) have remained unclear...- Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cellsLi Jia
Department of Urology, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, California, USA
Mol Cell Biol 26:7331-41. 2006..These features contribute to the androgen-independent phenotype of these cells... - Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytomaWendy Cozen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 15:2285-91. 2006..These results suggest that IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms... - Androgen receptor-mediated repression of novel target genesJennifer Prescott
Department of Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Prostate 67:1371-83. 2007.... - Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alphaGrant Buchanan
Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, The University of Adelaide Hanson Institute, Adelaide, South Australia, Australia
Cancer Res 67:10087-96. 2007..These findings implicate alphaSGT as a molecular rheostat of in vivo signaling competence by the AR, and provide new insight into the determinants of androgen sensitivity during prostate cancer progression... - Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancerJian Min Yuan
The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Carcinogenesis 29:1386-93. 2008..12-3.69, P = 0.02). The effect of NAT2 slow acetylation was even stronger in the presence of two or more null/low-activity GST genotypes. There were no associations between bladder cancer risk and NAT1 genotype or CYP1A2 phenotype... - Androgen receptor-dependent PSA expression in androgen-independent prostate cancer cells does not involve androgen receptor occupancy of the PSA locusLi Jia
Department of Urology and Preventive Medicine, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, California 90089, USA
Cancer Res 65:8003-8. 2005.... - The androgen receptor: unlocking the secrets of its unique transactivation domainHoward C Shen
Department of Urology and Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
Vitam Horm 71:301-19. 2005.... - GRIP1 mediates the interaction between the amino- and carboxyl-termini of the androgen receptorHoward C Shen
Departments of Urology and Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Biol Chem 386:69-74. 2005..Our results also indicate that AR N/C interaction enhances but is not necessary for AR transactivation activity... - Androgen receptor activity at the prostate specific antigen locus: steroidal and non-steroidal mechanismsLi Jia
Department of Urology, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Mol Cancer Res 1:385-92. 2003..These findings provide a contextual framework for interpreting the contribution of non-steroidal activation of the AR to signaling in vivo, and have implications for prostate cancer cell growth... - Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2Manuela Gago-Dominguez
USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, USA
Carcinogenesis 24:483-9. 2003..On the other hand, individuals of NAT1*10 genotype exhibited no such associations... - The androgen receptor CAG repeat and prostate cancer riskPeter E Clark
Department of Urology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Methods Mol Med 81:255-66. 2003 - Dynamic methylation of histone H3 at lysine 4 in transcriptional regulation by the androgen receptorJoshua Kim
Department of Urology, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, CA 90089, USA
Nucleic Acids Res 31:6741-7. 2003..The results suggest a novel role of methylated H3-K4 in transcriptional regulation... - Androgen receptor signaling: mechanism of interleukin-6 inhibitionLi Jia
Department of Urology and Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
Cancer Res 64:2619-26. 2004..Our results show that IL-6 modulates androgen action through the differential recruitment of cofactors to target genes. These findings may account for the pleiotropic actions of IL-6 in malignant prostate cells... - Carotenoids/vitamin C and smoking-related bladder cancerJ Esteban Castelao
USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9181, USA
Int J Cancer 110:417-23. 2004..The carotenoid-bladder cancer association was not affected by the GSTM1, GSTT1 and GSTP1 genotypes... - PC-3 cells with enhanced androgen receptor signaling: a model for clonal selection in prostate cancerGrant Buchanan
Dame Roma Mitchell Cancer Research Laboratories, Department of Medicine, University of Adelaide/Hanson Institute, Adelaide, Southern Australia, Australia
Prostate 60:352-66. 2004.... - Prostate specific antigen gene regulation by androgen receptorJoshua Kim
Department of Molecular Microbiology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
J Cell Biochem 93:233-41. 2004..Ultimately, our improved understanding of AR-regulated PSA expression could aid in developing viable therapies in treating and/or preventing advanced prostate cancer... - Structural and functional consequences of glutamine tract variation in the androgen receptorGrant Buchanan
Dame Roma Mitchell Cancer Research Laboratories, Adelaide University/Hanson Institute, SA, Australia
Hum Mol Genet 13:1677-92. 2004..That between 91 and 99% of AR alleles in different racial-ethnic groups encode a polyQ tract in the range of Q16-Q29 suggests that N/C interaction has been preserved as an essential component of androgen-induced AR signaling... - Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cellsYoshimasa Saito
Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
Cancer Cell 9:435-43. 2006..These results suggest that DNA demethylation and histone deacetylase inhibition can activate expression of miRNAs that may act as tumor suppressors... - Molecular chaperones throughout the life cycle of the androgen receptorJennifer Prescott
Department of Urology and Preventive Medicine, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, CA 90089, USA
Cancer Lett 231:12-9. 2006..Regardless of whether chaperones are involved in the causation of prostate carcinogenesis, molecular chaperones provide therapeutic targets for the treatment of prostate cancer... - Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levelsBinh N Trinh
Department of Surgery, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9176, USA
Hum Genet 111:299-302. 2002..These genetic determinants of plasma folate and homocysteine levels may be useful in identifying individuals at increased risk for cardiovascular disease...
Research Grants
- AR and RUNX2 target genes in prostate cancerGerhard A Coetzee; Fiscal Year: 2010..abstract_text> ..
- AR and RUNX2 target genes in prostate cancerGerhard Coetzee; Fiscal Year: 2007....
- ANDROGEN RECEPTOR AND PROSTATE CANCER RISK IN CHINESEGerhard Coetzee; Fiscal Year: 2003..abstract_text> ..
- Genomic Enhancers at 8q24 and Prostate CancerGerhard A Coetzee; Fiscal Year: 2010....