Gerhard Coetzee

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Identification of novel androgen receptor target genes in prostate cancer
    Unnati Jariwala
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Mol Cancer 6:39. 2007
  2. pmc Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis
    Sanjeev K Baniwal
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, USA
    Mol Cancer 9:258. 2010
  3. pmc Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells
    Claudia Andreu-Vieyra
    Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Mol Cell Biol 31:4648-62. 2011
  4. pmc A systematic approach to understand the functional consequences of non-protein coding risk regions
    Gerhard A Coetzee
    Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Cell Cycle 9:256-9. 2010
  5. ncbi request reprint Androgen and anti-androgen treatment modulates androgen receptor activity and DJ-1 stability
    Tiina Pitkänen-Arsiola
    Institute of Applied Biotechnology, University of Kuopio, Kuopio, Finland
    Prostate 66:1177-93. 2006
  6. pmc Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells
    Li Jia
    Department of Urology, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, California, USA
    Mol Cell Biol 26:7331-41. 2006
  7. ncbi request reprint Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:2285-91. 2006
  8. ncbi request reprint Androgen receptor-mediated repression of novel target genes
    Jennifer Prescott
    Department of Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Prostate 67:1371-83. 2007
  9. ncbi request reprint Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha
    Grant Buchanan
    Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, The University of Adelaide Hanson Institute, Adelaide, South Australia, Australia
    Cancer Res 67:10087-96. 2007
  10. pmc Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer
    Jian Min Yuan
    The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 29:1386-93. 2008

Research Grants

  1. AR and RUNX2 target genes in prostate cancer
    Gerhard A Coetzee; Fiscal Year: 2010
  2. AR and RUNX2 target genes in prostate cancer
    Gerhard Coetzee; Fiscal Year: 2007
  3. ANDROGEN RECEPTOR AND PROSTATE CANCER RISK IN CHINESE
    Gerhard Coetzee; Fiscal Year: 2003
  4. Genomic Enhancers at 8q24 and Prostate Cancer
    Gerhard A Coetzee; Fiscal Year: 2010

Collaborators

Detail Information

Publications25

  1. pmc Identification of novel androgen receptor target genes in prostate cancer
    Unnati Jariwala
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Mol Cancer 6:39. 2007
    ..The androgen receptor (AR) plays critical roles in both androgen-dependent and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes that mediate the receptor's roles in disease progression...
  2. pmc Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis
    Sanjeev K Baniwal
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, USA
    Mol Cancer 9:258. 2010
    ..However, little is known about the gene regulatory networks influenced by Runx2 in PCa cells. We therefore investigated genome wide mRNA expression changes in PCa cells in response to Runx2...
  3. pmc Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells
    Claudia Andreu-Vieyra
    Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Mol Cell Biol 31:4648-62. 2011
    ..quot; This allows the recruitment of histone modifiers, chromatin remodelers, and ultimately gene activation. The "receptive" state described here could help explain AR signaling activation under very low ligand concentrations...
  4. pmc A systematic approach to understand the functional consequences of non-protein coding risk regions
    Gerhard A Coetzee
    Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Cell Cycle 9:256-9. 2010
    ..Here we describe an integrated framework to allow non-protein coding loci to be annotated with respect to regulatory functions. This will facilitate identification of target genes as well as prioritize variants for functional testing...
  5. ncbi request reprint Androgen and anti-androgen treatment modulates androgen receptor activity and DJ-1 stability
    Tiina Pitkänen-Arsiola
    Institute of Applied Biotechnology, University of Kuopio, Kuopio, Finland
    Prostate 66:1177-93. 2006
    ..Mechanisms regulating the transition from hormone responsive to hormone refractory prostate cancer (PCa) have remained unclear...
  6. pmc Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells
    Li Jia
    Department of Urology, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, California, USA
    Mol Cell Biol 26:7331-41. 2006
    ..These features contribute to the androgen-independent phenotype of these cells...
  7. ncbi request reprint Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:2285-91. 2006
    ..These results suggest that IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms...
  8. ncbi request reprint Androgen receptor-mediated repression of novel target genes
    Jennifer Prescott
    Department of Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Prostate 67:1371-83. 2007
    ....
  9. ncbi request reprint Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha
    Grant Buchanan
    Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, The University of Adelaide Hanson Institute, Adelaide, South Australia, Australia
    Cancer Res 67:10087-96. 2007
    ..These findings implicate alphaSGT as a molecular rheostat of in vivo signaling competence by the AR, and provide new insight into the determinants of androgen sensitivity during prostate cancer progression...
  10. pmc Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer
    Jian Min Yuan
    The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 29:1386-93. 2008
    ..12-3.69, P = 0.02). The effect of NAT2 slow acetylation was even stronger in the presence of two or more null/low-activity GST genotypes. There were no associations between bladder cancer risk and NAT1 genotype or CYP1A2 phenotype...
  11. ncbi request reprint Androgen receptor-dependent PSA expression in androgen-independent prostate cancer cells does not involve androgen receptor occupancy of the PSA locus
    Li Jia
    Department of Urology and Preventive Medicine, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, California 90089, USA
    Cancer Res 65:8003-8. 2005
    ....
  12. ncbi request reprint The androgen receptor: unlocking the secrets of its unique transactivation domain
    Howard C Shen
    Department of Urology and Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    Vitam Horm 71:301-19. 2005
    ....
  13. ncbi request reprint GRIP1 mediates the interaction between the amino- and carboxyl-termini of the androgen receptor
    Howard C Shen
    Departments of Urology and Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Biol Chem 386:69-74. 2005
    ..Our results also indicate that AR N/C interaction enhances but is not necessary for AR transactivation activity...
  14. ncbi request reprint Androgen receptor activity at the prostate specific antigen locus: steroidal and non-steroidal mechanisms
    Li Jia
    Department of Urology, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cancer Res 1:385-92. 2003
    ..These findings provide a contextual framework for interpreting the contribution of non-steroidal activation of the AR to signaling in vivo, and have implications for prostate cancer cell growth...
  15. ncbi request reprint Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, USA
    Carcinogenesis 24:483-9. 2003
    ..On the other hand, individuals of NAT1*10 genotype exhibited no such associations...
  16. ncbi request reprint The androgen receptor CAG repeat and prostate cancer risk
    Peter E Clark
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Methods Mol Med 81:255-66. 2003
  17. pmc Dynamic methylation of histone H3 at lysine 4 in transcriptional regulation by the androgen receptor
    Joshua Kim
    Department of Urology, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, CA 90089, USA
    Nucleic Acids Res 31:6741-7. 2003
    ..The results suggest a novel role of methylated H3-K4 in transcriptional regulation...
  18. ncbi request reprint Androgen receptor signaling: mechanism of interleukin-6 inhibition
    Li Jia
    Department of Urology and Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    Cancer Res 64:2619-26. 2004
    ..Our results show that IL-6 modulates androgen action through the differential recruitment of cofactors to target genes. These findings may account for the pleiotropic actions of IL-6 in malignant prostate cells...
  19. ncbi request reprint Carotenoids/vitamin C and smoking-related bladder cancer
    J Esteban Castelao
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9181, USA
    Int J Cancer 110:417-23. 2004
    ..The carotenoid-bladder cancer association was not affected by the GSTM1, GSTT1 and GSTP1 genotypes...
  20. ncbi request reprint PC-3 cells with enhanced androgen receptor signaling: a model for clonal selection in prostate cancer
    Grant Buchanan
    Dame Roma Mitchell Cancer Research Laboratories, Department of Medicine, University of Adelaide Hanson Institute, Adelaide, Southern Australia, Australia
    Prostate 60:352-66. 2004
    ....
  21. ncbi request reprint Prostate specific antigen gene regulation by androgen receptor
    Joshua Kim
    Department of Molecular Microbiology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Cell Biochem 93:233-41. 2004
    ..Ultimately, our improved understanding of AR-regulated PSA expression could aid in developing viable therapies in treating and/or preventing advanced prostate cancer...
  22. ncbi request reprint Structural and functional consequences of glutamine tract variation in the androgen receptor
    Grant Buchanan
    Dame Roma Mitchell Cancer Research Laboratories, Adelaide University Hanson Institute, SA, Australia
    Hum Mol Genet 13:1677-92. 2004
    ..That between 91 and 99% of AR alleles in different racial-ethnic groups encode a polyQ tract in the range of Q16-Q29 suggests that N/C interaction has been preserved as an essential component of androgen-induced AR signaling...
  23. ncbi request reprint Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    Yoshimasa Saito
    Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
    Cancer Cell 9:435-43. 2006
    ..These results suggest that DNA demethylation and histone deacetylase inhibition can activate expression of miRNAs that may act as tumor suppressors...
  24. ncbi request reprint Molecular chaperones throughout the life cycle of the androgen receptor
    Jennifer Prescott
    Department of Urology and Preventive Medicine, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, CA 90089, USA
    Cancer Lett 231:12-9. 2006
    ..Regardless of whether chaperones are involved in the causation of prostate carcinogenesis, molecular chaperones provide therapeutic targets for the treatment of prostate cancer...
  25. ncbi request reprint Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels
    Binh N Trinh
    Department of Surgery, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9176, USA
    Hum Genet 111:299-302. 2002
    ..These genetic determinants of plasma folate and homocysteine levels may be useful in identifying individuals at increased risk for cardiovascular disease...

Research Grants11

  1. AR and RUNX2 target genes in prostate cancer
    Gerhard A Coetzee; Fiscal Year: 2010
    ..abstract_text> ..
  2. AR and RUNX2 target genes in prostate cancer
    Gerhard Coetzee; Fiscal Year: 2007
    ....
  3. ANDROGEN RECEPTOR AND PROSTATE CANCER RISK IN CHINESE
    Gerhard Coetzee; Fiscal Year: 2003
    ..abstract_text> ..
  4. Genomic Enhancers at 8q24 and Prostate Cancer
    Gerhard A Coetzee; Fiscal Year: 2010
    ....