Myles Cockburn

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc e-Health Tools for Targeting and Improving Melanoma Screening: A Review
    Abhilasha Tyagi
    Keck School of Medicine of USC, Los Angeles, CA 90089, USA
    J Skin Cancer 2012:437502. 2012
  2. pmc An effective and efficient approach for manually improving geocoded data
    Daniel W Goldberg
    Department of Computer Science, University of Southern California, Los Angeles, CA, USA
    Int J Health Geogr 7:60. 2008
  3. pmc Prostate cancer and ambient pesticide exposure in agriculturally intensive areas in California
    Myles Cockburn
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Am J Epidemiol 173:1280-8. 2011
  4. ncbi request reprint Twins as willing research participants: successes from studies nested within the California Twin Program
    Myles G Cockburn
    Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Twin Res Hum Genet 9:927-32. 2006
  5. pmc Parkinson's disease risk from ambient exposure to pesticides
    Anthony Wang
    Epidemiology, UCLA School of Public Health, Box 951772, 650 Charles E Young Drive, Los Angeles, CA 90095 1772, USA
    Eur J Epidemiol 26:547-55. 2011
  6. pmc Assessing the influence of traffic-related air pollution on risk of term low birth weight on the basis of land-use-based regression models and measures of air toxics
    Jo Kay C Ghosh
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, USA
    Am J Epidemiol 175:1262-74. 2012
  7. pmc α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease
    Nicole M Gatto
    Departmen of Epidemiology, University of California Los Angeles, Los Angeles, CA, USA
    Neuroepidemiology 35:191-5. 2010
  8. doi request reprint The relative importance of genetics and environment on mammographic density
    Giske Ursin
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 18:102-12. 2009
  9. pmc Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease
    Arthur G Fitzmaurice
    From the Department of Neurology A G F, B R, J M B, David Geffen School of Medicine at UCLA, Los Angeles Department of Molecular Toxicology A G F, B R, J M B, University of California, Los Angeles Departments of Epidemiology S L R, B R and Environmental Health Sciences B R, UCLA Fielding School of Public Health, Los Angeles Department of Preventive Medicine M C, Keck School of Medicine of USC, Los Angeles and Parkinson s Disease Research, Education, and Clinical Center J M B, Greater Los Angeles Veterans Affairs Medical Center, Los Angeles, CA
    Neurology 82:419-26. 2014
  10. pmc Solar UV radiation and cancer in young children
    Christina Lombardi
    Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 22:1118-28. 2013

Detail Information

Publications46

  1. pmc e-Health Tools for Targeting and Improving Melanoma Screening: A Review
    Abhilasha Tyagi
    Keck School of Medicine of USC, Los Angeles, CA 90089, USA
    J Skin Cancer 2012:437502. 2012
    ..Future research needs to formally evaluate the potential role of e-Health tools in melanoma prevention...
  2. pmc An effective and efficient approach for manually improving geocoded data
    Daniel W Goldberg
    Department of Computer Science, University of Southern California, Los Angeles, CA, USA
    Int J Health Geogr 7:60. 2008
    ..The present work investigates the time and effort required to correct geocodes contained in five health-related datasets that represent examples of data commonly used in Health GIS...
  3. pmc Prostate cancer and ambient pesticide exposure in agriculturally intensive areas in California
    Myles Cockburn
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Am J Epidemiol 173:1280-8. 2011
    ..The associations appear specific to compounds with a plausible biologic role in prostate carcinogenesis...
  4. ncbi request reprint Twins as willing research participants: successes from studies nested within the California Twin Program
    Myles G Cockburn
    Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Twin Res Hum Genet 9:927-32. 2006
    ..However, in most analyses, the participating sample of twins does not differ substantially from the underlying sample from the CTP. Future work will focus on improving methods of re-contacting cohort members...
  5. pmc Parkinson's disease risk from ambient exposure to pesticides
    Anthony Wang
    Epidemiology, UCLA School of Public Health, Box 951772, 650 Charles E Young Drive, Los Angeles, CA 90095 1772, USA
    Eur J Epidemiol 26:547-55. 2011
    ..Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergic neuron death may act together to increase the risk of PD considerably...
  6. pmc Assessing the influence of traffic-related air pollution on risk of term low birth weight on the basis of land-use-based regression models and measures of air toxics
    Jo Kay C Ghosh
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, USA
    Am J Epidemiol 175:1262-74. 2012
    ..This analysis highlights the importance of both spatial and temporal contributions to air pollution in epidemiologic birth outcome studies...
  7. pmc α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease
    Nicole M Gatto
    Departmen of Epidemiology, University of California Los Angeles, Los Angeles, CA, USA
    Neuroepidemiology 35:191-5. 2010
    ..Although of great interest and suggested in prior reports, possible α-synuclein (SNCA) gene-environment interactions have not been well investigated in humans...
  8. doi request reprint The relative importance of genetics and environment on mammographic density
    Giske Ursin
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 18:102-12. 2009
    ..We investigated whether part of the presumed heritability might be attributed to differential sharing of modifiable risk factors in monozygotic (MZ) and dizygotic (DZ) twins...
  9. pmc Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease
    Arthur G Fitzmaurice
    From the Department of Neurology A G F, B R, J M B, David Geffen School of Medicine at UCLA, Los Angeles Department of Molecular Toxicology A G F, B R, J M B, University of California, Los Angeles Departments of Epidemiology S L R, B R and Environmental Health Sciences B R, UCLA Fielding School of Public Health, Los Angeles Department of Preventive Medicine M C, Keck School of Medicine of USC, Los Angeles and Parkinson s Disease Research, Education, and Clinical Center J M B, Greater Los Angeles Veterans Affairs Medical Center, Los Angeles, CA
    Neurology 82:419-26. 2014
    ..The objective of this study was to determine whether environmental and genetic alterations of neuronal aldehyde dehydrogenase (ALDH) enzymes were associated with increased Parkinson disease (PD) risk in an epidemiologic study...
  10. pmc Solar UV radiation and cancer in young children
    Christina Lombardi
    Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 22:1118-28. 2013
    ..In a large population-based case-control study in California, we tested the hypothesis that childhood cancers may be influenced by UVR...
  11. pmc Traffic-related air toxics and term low birth weight in Los Angeles County, California
    Michelle Wilhelm
    Department of Epidemiology, School of Public Health, University of California Los Angeles, 650 Charles E Young Dr, Los Angeles, CA 90095, USA
    Environ Health Perspect 120:132-8. 2012
    ..Numerous studies have linked criteria air pollutants with adverse birth outcomes, but there is less information on the importance of specific emission sources, such as traffic, and air toxics...
  12. doi request reprint The association between ambient exposure to organophosphates and Parkinson's disease risk
    Anthony Wang
    Department of Epidemiology, University of California, Los Angeles UCLA Fielding School of Public Health, Los Angeles, California, USA
    Occup Environ Med 71:275-81. 2014
    ..This study examines the risk of developing PD associated with specific organophosphate (OP) pesticides and their mechanisms of toxicity...
  13. pmc Epidemiology of rhabdoid tumors of early childhood
    Julia E Heck
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA, USA
    Pediatr Blood Cancer 60:77-81. 2013
    ..Little is known about their etiology. The purpose of this study was to describe the epidemiology of rhabdoid tumors and examine their relation to perinatal characteristics...
  14. pmc Childhood cancer and traffic-related air pollution exposure in pregnancy and early life
    Julia E Heck
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, California, USA
    Environ Health Perspect 121:1385-91. 2013
    ..The literature on traffic-related air pollution and childhood cancers is inconclusive, and little is known on rarer cancer types...
  15. pmc Perinatal characteristics and retinoblastoma
    Julia E Heck
    Department of Epidemiology, Fielding School of Public Health, University of California, Box 951772, 650 Charles E Young Drive, Los Angeles, CA 90095 1772, USA
    Cancer Causes Control 23:1567-75. 2012
    ..The etiology of retinoblastoma remains poorly understood. In the present study, we examined associations between perinatal factors and retinoblastoma risk in California children...
  16. pmc Traffic-related air toxics and preterm birth: a population-based case-control study in Los Angeles County, California
    Michelle Wilhelm
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA, USA
    Environ Health 10:89. 2011
    ..We used three exposure data sources to examine risks of preterm birth in Los Angeles women when exposed to high levels of traffic-related air pollutants--including specific toxics--during pregnancy...
  17. ncbi request reprint The simultaneous assessment of constitutional, behavioral, and environmental factors in the development of large nevi
    Myles Cockburn
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 16:200-6. 2007
    ..We report on the simultaneous assessment of behavioral, constitutional, and environmental risk factors for the prevalence of large nevi in a population-based study of 33,305 individuals and compare those to risk factors for melanoma...
  18. pmc Well-water consumption and Parkinson's disease in rural California
    Nicole M Gatto
    Department of Epidemiology, University of California Los Angeles, Los Angeles, California 90095 1772, USA
    Environ Health Perspect 117:1912-8. 2009
    ..Investigators have hypothesized that consuming pesticide-contaminated well water plays a role in Parkinson's disease (PD), and several previous epidemiologic studies support this hypothesis...
  19. ncbi request reprint Prenatal exposure to air toxics and risk of Wilms' tumor in 0- to 5-year-old children
    Anshu Shrestha
    From the Department of Epidemiology Drs Shrestha, Ritz, Wilhelm, and Heck, Fielding School of Public Health, University of California Los Angeles Precision Health Economics Dr Shrestha Department of Biostatistics Mr Qiu, Fielding School of Public Health, University of California Los Angeles and Department of Preventive Medicine Dr Cockburn, Keck School of Medicine, University of Southern California, Los Angeles
    J Occup Environ Med 56:573-8. 2014
    ..To study prenatal air toxic exposure and Wilms' tumor in children...
  20. pmc Case-control study of birth characteristics and the risk of hepatoblastoma
    Julia E Heck
    Department of Epidemiology, School of Public Health, University of California, 650 Charles E Young Drive, Box 951772, Los Angeles, CA 90095 1772, USA
    Cancer Epidemiol 37:390-5. 2013
    ..Hepatoblastoma is a malignant embryonal tumor typically diagnosed in children younger than five years of age. Little is known on hepatoblastoma etiology...
  21. pmc Trends in childhood brain tumor incidence, 1973-2009
    Roberta McKean-Cowdin
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 2001 N Soto St, Los Angeles, CA, 90089, USA
    J Neurooncol 115:153-60. 2013
    ..Changes in incidence rates of subtypes of tumors over this time period reflect changes both in classification of CBT and in diagnostic techniques...
  22. pmc Ambient air pollution and autism in Los Angeles county, California
    Tracy Ann Becerra
    Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California 90095 1772, USA
    Environ Health Perspect 121:380-6. 2013
    ..The prevalence of autistic disorder (AD), a serious developmental condition, has risen dramatically over the past two decades, but high-quality population-based research addressing etiology is limited...
  23. pmc Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease
    Arthur G Fitzmaurice
    Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 110:636-41. 2013
    ..This ALDH model for PD etiology may help explain the selective vulnerability of dopaminergic neurons in PD and provide a potential mechanism through which environmental toxicants contribute to PD pathogenesis...
  24. ncbi request reprint Efficacy of skin self-examination for the early detection of melanoma
    Reyhaneh Hamidi
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9175, USA
    Int J Dermatol 49:126-34. 2010
    ..Assessment of the accuracy and efficacy of SSE should proceed using standardized definitions and measurements such that it is easier to pool data on the overall value of SSE as a screening modality...
  25. ncbi request reprint The occurrence of chronic disease and other conditions in a large population-based cohort of native Californian twins
    Myles Cockburn
    University of Southern California Keck School of Medicine, California, USA
    Twin Res 5:460-7. 2002
    ..We outline our plans for cohort expansion, additional studies using the cohort, and future plans for inviting collaboration...
  26. ncbi request reprint Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Int J Cancer 103:815-21. 2003
    ..pylori reduces risk of esophageal and gastric cardia adenocarcinoma in this population. Our findings confirm the positive association between risk of distal gastric cancer and infection with H. pylori infection, especially CagA+ strains...
  27. ncbi request reprint IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Blood 103:3216-21. 2004
    ..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma...
  28. ncbi request reprint Th1 and Th2 cytokines and IgE levels in identical twins with varying levels of cigarette consumption
    Wendy Cozen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9175, USA
    J Clin Immunol 24:617-22. 2004
    ..4 pg/mL; p=0.03). No statistically significant differences in INF-gamma, IL-4, or IgE levels were observed. Smoking appears to be associated with increased levels of IL-13...
  29. ncbi request reprint Etiologic clues from the similarity of histology-specific trends in esophageal and lung cancers
    Myles G Cockburn
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, California, USA
    Cancer Causes Control 16:1065-74. 2005
    ..Squamous cell lung cancers, while caused by smoking, are believed to be caused by different constituents of tobacco smoke than lung adenocarcinomas. Smoking is also a risk factor for esophageal cancers...
  30. ncbi request reprint Developing epidemic of melanoma in the Hispanic population of California
    Myles G Cockburn
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, California 90089, USA
    Cancer 106:1162-8. 2006
    ..S. California has among the highest rates of melanoma in the world, yet little is known about trends in melanoma in its Hispanic population...
  31. ncbi request reprint Gender differences in determinants of smoking initiation and persistence in California twins
    Ann S Hamilton
    Department of Preventive Medicine, University of Southern California, Los Angeles, USA
    Cancer Epidemiol Biomarkers Prev 15:1189-97. 2006
    ..To determine the effects of genetic versus environmental influences on smoking initiation (SI) and smoking persistence (SP)...
  32. ncbi request reprint An estimate of physical activity prevalence in a large population-based cohort
    Steven A Hawkins
    Department of Kinesiology and Nutritional Science, California State University Los Angeles, 5151 State University Drive, Los Angeles, CA 90032 8162, USA
    Med Sci Sports Exerc 36:253-60. 2004
    ....
  33. pmc Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9175, USA
    Blood 111:3377-82. 2008
    ..8-fold (P=.03) increase in YAHL risk. Thus, both case-twins and their unaffected cotwins had a decreased ability to produce IL-12, which may contribute to YAHL susceptibility...
  34. doi request reprint Use of an electrostatic dust cloth for self-administered home allergen collection
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9175, United States of America
    Twin Res Hum Genet 11:150-5. 2008
    ....
  35. pmc Moderated mediation regarding the sun-safe behaviors of U.S. Latinos: advancing the theory and evidence for acculturation-focused research and interventions
    Valentina A Andreeva
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Immigr Minor Health 12:691-8. 2010
    ..The findings suggest ways of refining the theoretical and empirical rationale for sun safety research and interventions with Latinos. Studies should replicate these models with longitudinal data...
  36. pmc Acculturation and sun-safe behaviors among US Latinos: findings from the 2005 Health Information National Trends Survey
    Valentina A Andreeva
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Am J Public Health 99:734-41. 2009
    ..We examined the relationship between acculturation and sun safety among US Latinos...
  37. pmc A simple intervention to reinforce awareness of tanning bed use and skin cancer in non-medical skin care professionals in Southern California
    Angie T Ng
    Keck School of Medicine, University of Southern California, CA, USA
    Int J Dermatol 51:1307-12. 2012
    ....
  38. pmc Dopamine transporter genetic variants and pesticides in Parkinson's disease
    Beate R Ritz
    Department of Epidemiology, Center for Occupational and Environmental Health, UCLA School of Public Health, University of California at Los Angeles, Los Angeles, California 90095 1772, USA
    Environ Health Perspect 117:964-9. 2009
    ..Research suggests that independent and joint effects of genetic variability in the dopamine transporter (DAT) locus and pesticides may influence Parkinson's disease (PD) risk...
  39. ncbi request reprint The objective assessment of lifetime cumulative ultraviolet exposure for determining melanoma risk
    Zaria Tatalovich
    Department of Geography, University of Southern California, Los Angeles, CA 90089 0255, United States
    J Photochem Photobiol B 85:198-204. 2006
    ..While there was some attenuation of risk when we excluded data from people resident overseas (as all other studies we are aware of have done), this did not significantly impact subsequent risk estimates of UV exposure on melanoma...
  40. pmc Birth characteristics and risk of lymphoma in young children
    Erin L Marcotte
    Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Box 951772, 650 Charles E Young Drive, Los Angeles, CA 90095 1772, USA
    Cancer Epidemiol 38:48-55. 2014
    ..Lymphoma is the third most common childhood malignancy and comprises two types, Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). The etiology of pediatric lymphomas is largely unknown, but has been suggested to have prenatal origins...
  41. pmc Challenges in identifying Native Hawaiians and Pacific Islanders in population-based cancer registries in the U.S
    Lihua Liu
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immigr Minor Health 13:860-6. 2011
    ..Improved data collection methods and practices in identifying NHPIs in population-based cancer registries are needed and caution in interpreting cancer data for NHPIs is warranted...
  42. ncbi request reprint Measurement of ultraviolet exposure in epidemiological studies of skin and skin cancers
    Scott Drayton Worswick
    Department of Dermatology at Keck USC School of Medicine, Los Angeles, CA, USA
    Photochem Photobiol 84:1462-72. 2008
    ..Finally, we touch upon the results of articles that link UV exposure to skin cancer and what this means for the future of UV-induced skin cancer research...
  43. pmc Paraoxonase 1, agricultural organophosphate exposure, and Parkinson disease
    Angelika D Manthripragada
    Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095, USA
    Epidemiology 21:87-94. 2010
    ..Susceptibility to pesticides may be modified by genetic variants of xenobiotic enzymes, such as paraoxonase, that play a role in metabolizing some organophosphates...
  44. ncbi request reprint A population-based description of glioblastoma multiforme in Los Angeles County, 1974-1999
    Indro Chakrabarti
    Department of Neurosurgery, University of Southern California Keck School of Medicine, Los Angeles, 90032, USA
    Cancer 104:2798-806. 2005
    ..The authors analyzed the pattern of glioblastoma multiforme (GBM) occurrence in Los Angeles County, California to shed light on the incidence and descriptive epidemiology of this type of brain tumor...
  45. ncbi request reprint Population-based linkage of AIDS and cancer registries: importance of linkage algorithm
    Dennis Deapen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
    Am J Prev Med 33:134-6. 2007
    ..This study evaluates linkage algorithms used in 1997 for Los Angeles County by the AIDS-Cancer Match Registry to estimate the risk of cancer among people with HIV/AIDS...
  46. ncbi request reprint Control selection and pesticide exposure assessment via GIS in prostate cancer studies
    Jennifer C Marusek
    University of California Los Angeles, 90095 1772, USA
    Am J Prev Med 30:S109-16. 2006
    ..The utility of a geographic information system (GIS)-based model for assessing residential exposure to pesticides is examined in a population-based case-control setting among groups easily recruited as control subjects...

Research Grants10

  1. Prostate cancer and pesticide exposure pilot study
    Myles Cockburn; Fiscal Year: 2005
    ..In particular, we will demonstrate the feasibility of our case selection method, and methods of obtaining buccal DNA for genetic hypotheses. ..
  2. Defining critical aspects of environmental ultraviolet exposure in melanogenesis
    Myles Cockburn; Fiscal Year: 2009
    ....
  3. Defining critical aspects of environmental ultraviolet exposure in melanogenesis
    Myles G Cockburn; Fiscal Year: 2010
    ..abstract_text> ..
  4. Improving early detection of melanoma with skin self examination
    Myles Cockburn; Fiscal Year: 2009
    ..Southern California KPSC is a population of millions, among those at highest melanoma risk in the world. ..
  5. Defining critical aspects of environmental ultraviolet exposure in melanogenesis
    Myles Cockburn; Fiscal Year: 2009
    ....
  6. Improving early detection of melanoma with skin self examination
    Myles Cockburn; Fiscal Year: 2007
    ..Southern California KPSC is a population of millions, among those at highest melanoma risk in the world. ..
  7. Melanoma genes in high-risk twins
    Myles Cockburn; Fiscal Year: 2006
    ..This work will set the scene for future studies assessing the relative importance of genes and environment in melanoma risk. ..
  8. Improving early detection of melanoma with skin self examination
    Myles G Cockburn; Fiscal Year: 2010
    ..Southern California KPSC is a population of millions, among those at highest melanoma risk in the world. ..