Research Topics
Genomes and GenesSpecies | Myles CockburnSummaryAffiliation: University of Southern California Country: USA Publications
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Publications
An effective and efficient approach for manually improving geocoded dataDaniel W Goldberg
Department of Computer Science, University of Southern California, Los Angeles, CA, USA
Int J Health Geogr 7:60. 2008..The present work investigates the time and effort required to correct geocodes contained in five health-related datasets that represent examples of data commonly used in Health GIS...
Twins as willing research participants: successes from studies nested within the California Twin ProgramMyles G Cockburn
Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
Twin Res Hum Genet 9:927-32. 2006..However, in most analyses, the participating sample of twins does not differ substantially from the underlying sample from the CTP. Future work will focus on improving methods of re-contacting cohort members...- Prostate cancer and ambient pesticide exposure in agriculturally intensive areas in CaliforniaMyles Cockburn
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
Am J Epidemiol 173:1280-8. 2011..The associations appear specific to compounds with a plausible biologic role in prostate carcinogenesis... 
Parkinson's disease risk from ambient exposure to pesticidesAnthony Wang
Epidemiology, UCLA School of Public Health, Box 951772, 650 Charles E Young Drive, Los Angeles, CA 90095 1772, USA
Eur J Epidemiol 26:547-55. 2011..Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergic neuron death may act together to increase the risk of PD considerably...- Assessing the influence of traffic-related air pollution on risk of term low birth weight on the basis of land-use-based regression models and measures of air toxicsJo Kay C Ghosh
Department of Epidemiology, School of Public Health, University of California, Los Angeles, USA
Am J Epidemiol 175:1262-74. 2012..This analysis highlights the importance of both spatial and temporal contributions to air pollution in epidemiologic birth outcome studies... - α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's diseaseNicole M Gatto
Departmen of Epidemiology, University of California Los Angeles, Los Angeles, CA, USA
Neuroepidemiology 35:191-5. 2010..Although of great interest and suggested in prior reports, possible α-synuclein (SNCA) gene-environment interactions have not been well investigated in humans... - The relative importance of genetics and environment on mammographic densityGiske Ursin
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, California, USA
Cancer Epidemiol Biomarkers Prev 18:102-12. 2009..We investigated whether part of the presumed heritability might be attributed to differential sharing of modifiable risk factors in monozygotic (MZ) and dizygotic (DZ) twins... - Traffic-related air toxics and term low birth weight in Los Angeles County, CaliforniaMichelle Wilhelm
Department of Epidemiology, School of Public Health, University of California Los Angeles, 650 Charles E Young Dr, Los Angeles, CA 90095, USA
Environ Health Perspect 120:132-8. 2012..Numerous studies have linked criteria air pollutants with adverse birth outcomes, but there is less information on the importance of specific emission sources, such as traffic, and air toxics... - Traffic-related air toxics and preterm birth: a population-based case-control study in Los Angeles County, CaliforniaMichelle Wilhelm
Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA, USA
Environ Health 10:89. 2011..We used three exposure data sources to examine risks of preterm birth in Los Angeles women when exposed to high levels of traffic-related air pollutants--including specific toxics--during pregnancy... - Well-water consumption and Parkinson's disease in rural CaliforniaNicole M Gatto
Department of Epidemiology, University of California Los Angeles, Los Angeles, California 90095 1772, USA
Environ Health Perspect 117:1912-8. 2009..Investigators have hypothesized that consuming pesticide-contaminated well water plays a role in Parkinson's disease (PD), and several previous epidemiologic studies support this hypothesis... - The simultaneous assessment of constitutional, behavioral, and environmental factors in the development of large neviMyles Cockburn
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 16:200-6. 2007..We report on the simultaneous assessment of behavioral, constitutional, and environmental risk factors for the prevalence of large nevi in a population-based study of 33,305 individuals and compare those to risk factors for melanoma... - Efficacy of skin self-examination for the early detection of melanomaReyhaneh Hamidi
Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9175, USA
Int J Dermatol 49:126-34. 2010..Assessment of the accuracy and efficacy of SSE should proceed using standardized definitions and measurements such that it is easier to pool data on the overall value of SSE as a screening modality... - Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagusAnna H Wu
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
Int J Cancer 103:815-21. 2003..pylori reduces risk of esophageal and gastric cardia adenocarcinoma in this population. Our findings confirm the positive association between risk of distal gastric cancer and infection with H. pylori infection, especially CagA+ strains... - The occurrence of chronic disease and other conditions in a large population-based cohort of native Californian twinsMyles Cockburn
University of Southern California Keck School of Medicine, California, USA
Twin Res 5:460-7. 2002..We outline our plans for cohort expansion, additional studies using the cohort, and future plans for inviting collaboration... - Developing epidemic of melanoma in the Hispanic population of CaliforniaMyles G Cockburn
Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, California 90089, USA
Cancer 106:1162-8. 2006..S. California has among the highest rates of melanoma in the world, yet little is known about trends in melanoma in its Hispanic population... - IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Blood 103:3216-21. 2004..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma... - Th1 and Th2 cytokines and IgE levels in identical twins with varying levels of cigarette consumptionWendy Cozen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9175, USA
J Clin Immunol 24:617-22. 2004..4 pg/mL; p=0.03). No statistically significant differences in INF-gamma, IL-4, or IgE levels were observed. Smoking appears to be associated with increased levels of IL-13... - Etiologic clues from the similarity of histology-specific trends in esophageal and lung cancersMyles G Cockburn
Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, California, USA
Cancer Causes Control 16:1065-74. 2005..Squamous cell lung cancers, while caused by smoking, are believed to be caused by different constituents of tobacco smoke than lung adenocarcinomas. Smoking is also a risk factor for esophageal cancers... - Moderated mediation regarding the sun-safe behaviors of U.S. Latinos: advancing the theory and evidence for acculturation-focused research and interventionsValentina A Andreeva
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
J Immigr Minor Health 12:691-8. 2010..The findings suggest ways of refining the theoretical and empirical rationale for sun safety research and interventions with Latinos. Studies should replicate these models with longitudinal data... - Acculturation and sun-safe behaviors among US Latinos: findings from the 2005 Health Information National Trends SurveyValentina A Andreeva
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Am J Public Health 99:734-41. 2009..We examined the relationship between acculturation and sun safety among US Latinos... - An estimate of physical activity prevalence in a large population-based cohortSteven A Hawkins
Department of Kinesiology and Nutritional Science, California State University Los Angeles, 5151 State University Drive, Los Angeles, CA 90032 8162, USA
Med Sci Sports Exerc 36:253-60. 2004.... - Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9175, USA
Blood 111:3377-82. 2008..8-fold (P=.03) increase in YAHL risk. Thus, both case-twins and their unaffected cotwins had a decreased ability to produce IL-12, which may contribute to YAHL susceptibility... - Gender differences in determinants of smoking initiation and persistence in California twinsAnn S Hamilton
Department of Preventive Medicine, University of Southern California, Los Angeles, USA
Cancer Epidemiol Biomarkers Prev 15:1189-97. 2006..To determine the effects of genetic versus environmental influences on smoking initiation (SI) and smoking persistence (SP)... - Use of an electrostatic dust cloth for self-administered home allergen collectionWendy Cozen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9175, United States of America
Twin Res Hum Genet 11:150-5. 2008.... - The objective assessment of lifetime cumulative ultraviolet exposure for determining melanoma riskZaria Tatalovich
Department of Geography, University of Southern California, Los Angeles, CA 90089 0255, United States
J Photochem Photobiol B 85:198-204. 2006..While there was some attenuation of risk when we excluded data from people resident overseas (as all other studies we are aware of have done), this did not significantly impact subsequent risk estimates of UV exposure on melanoma... - Dopamine transporter genetic variants and pesticides in Parkinson's diseaseBeate R Ritz
Department of Epidemiology, Center for Occupational and Environmental Health, UCLA School of Public Health, University of California at Los Angeles, Los Angeles, California 90095 1772, USA
Environ Health Perspect 117:964-9. 2009..Research suggests that independent and joint effects of genetic variability in the dopamine transporter (DAT) locus and pesticides may influence Parkinson's disease (PD) risk... - Ambient air pollution and autism in Los Angeles county, CaliforniaTracy Ann Becerra
Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California 90095 1772, USA
Environ Health Perspect 121:380-6. 2013..The prevalence of autistic disorder (AD), a serious developmental condition, has risen dramatically over the past two decades, but high-quality population-based research addressing etiology is limited... - Perinatal characteristics and retinoblastomaJulia E Heck
Department of Epidemiology, Fielding School of Public Health, University of California, Box 951772, 650 Charles E Young Drive, Los Angeles, CA 90095 1772, USA
Cancer Causes Control 23:1567-75. 2012..The etiology of retinoblastoma remains poorly understood. In the present study, we examined associations between perinatal factors and retinoblastoma risk in California children... - Challenges in identifying Native Hawaiians and Pacific Islanders in population-based cancer registries in the U.SLihua Liu
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Immigr Minor Health 13:860-6. 2011..Improved data collection methods and practices in identifying NHPIs in population-based cancer registries are needed and caution in interpreting cancer data for NHPIs is warranted... - Measurement of ultraviolet exposure in epidemiological studies of skin and skin cancersScott Drayton Worswick
Department of Dermatology at Keck USC School of Medicine, Los Angeles, CA, USA
Photochem Photobiol 84:1462-72. 2008..Finally, we touch upon the results of articles that link UV exposure to skin cancer and what this means for the future of UV-induced skin cancer research... - Paraoxonase 1, agricultural organophosphate exposure, and Parkinson diseaseAngelika D Manthripragada
Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095, USA
Epidemiology 21:87-94. 2010..Susceptibility to pesticides may be modified by genetic variants of xenobiotic enzymes, such as paraoxonase, that play a role in metabolizing some organophosphates... - Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson diseaseArthur G Fitzmaurice
Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 110:636-41. 2013..This ALDH model for PD etiology may help explain the selective vulnerability of dopaminergic neurons in PD and provide a potential mechanism through which environmental toxicants contribute to PD pathogenesis... - A population-based description of glioblastoma multiforme in Los Angeles County, 1974-1999Indro Chakrabarti
Department of Neurosurgery, University of Southern California Keck School of Medicine, Los Angeles, 90032, USA
Cancer 104:2798-806. 2005..The authors analyzed the pattern of glioblastoma multiforme (GBM) occurrence in Los Angeles County, California to shed light on the incidence and descriptive epidemiology of this type of brain tumor... - Population-based linkage of AIDS and cancer registries: importance of linkage algorithmDennis Deapen
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Am J Prev Med 33:134-6. 2007..This study evaluates linkage algorithms used in 1997 for Los Angeles County by the AIDS-Cancer Match Registry to estimate the risk of cancer among people with HIV/AIDS... - Control selection and pesticide exposure assessment via GIS in prostate cancer studiesJennifer C Marusek
University of California Los Angeles, 90095-1772, USA
Am J Prev Med 30:S109-16. 2006..The use of randomly sampled controls from Medicare and residential parcels listings independent of subject response seems to result in the opportunity for relatively unbiased estimates of pesticide exposures...
Research Grants
- Prostate cancer and pesticide exposure pilot studyMyles Cockburn; Fiscal Year: 2005..In particular, we will demonstrate the feasibility of our case selection method, and methods of obtaining buccal DNA for genetic hypotheses. ..
- Defining critical aspects of environmental ultraviolet exposure in melanogenesisMyles Cockburn; Fiscal Year: 2009....
- Defining critical aspects of environmental ultraviolet exposure in melanogenesisMyles G Cockburn; Fiscal Year: 2010..abstract_text> ..
- Improving early detection of melanoma with skin self examinationMyles Cockburn; Fiscal Year: 2009..Southern California KPSC is a population of millions, among those at highest melanoma risk in the world. ..
- Defining critical aspects of environmental ultraviolet exposure in melanogenesisMyles Cockburn; Fiscal Year: 2009....
- Improving early detection of melanoma with skin self examinationMyles Cockburn; Fiscal Year: 2007..Southern California KPSC is a population of millions, among those at highest melanoma risk in the world. ..
- Melanoma genes in high-risk twinsMyles Cockburn; Fiscal Year: 2006..This work will set the scene for future studies assessing the relative importance of genes and environment in melanoma risk. ..
- Improving early detection of melanoma with skin self examinationMyles G Cockburn; Fiscal Year: 2010..Southern California KPSC is a population of millions, among those at highest melanoma risk in the world. ..