Research Topics
| A J CochranSummaryAffiliation: University of California Country: USA Publications
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Publications
Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010"Paolo A Ascierto
Department of Melanoma, Sarcoma, and Head and Neck Disease, Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy
J Transl Med 9:32. 2011..Four topics of discussion were identified: New pathways in Melanoma, Biomarkers, Clinical Trials and New Molecules and Strategies...
The place of lymphatic mapping and sentinel node biopsy in oncologyAlistair J Cochran
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
Int J Clin Oncol 8:139-50. 2003..They also provide unique opportunities for basic and translational research...- Prediction of metastatic melanoma in nonsentinel nodes and clinical outcome based on the primary melanoma and the sentinel nodeAlistair J Cochran
Department of Pathology and Laboratory Medicine, School of Public Health at UCLA, Los Angeles, CA 90095 1732, USA
Mod Pathol 17:747-55. 2004..0001, Breslow, P=0.0001 and dendritic cell density, P=0.0007) and death from melanoma (tumor burden, P=0.0001, Breslow, P=0.0001 and dendritic cell density, P=0.0026)... - Optimal surgery for cutaneous melanoma requires accurate and complete pathologic informationAlistair J Cochran
Department of Pathology, Center for the Health Sciences, University of California-Los Angeles Medical Center, 10833 Le Conte Avenue, Los Angeles, CA 90095-1732, USA
Facial Plast Surg Clin North Am 11:23-32. 2003 - Optimized assessment of sentinel lymph nodes for metastatic melanoma: implications for regional surgery and overall treatment planningAlistair J Cochran
Departments of Pathology and Laboratory Medicine and Surgery, University of California, Los Angeles School of Medicine, Los Angeles, California, USA
Ann Surg Oncol 11:156S-61S. 2004..The most robust of these predictors is relative tumor area, and this may be used as the basis of practical predictive algorithms... - Tumour-induced immune modulation of sentinel lymph nodesAlistair J Cochran
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California at Los Angeles, California 90095, USA
Nat Rev Immunol 6:659-70. 2006..Immune modulation of the lymph nodes can be reversed by granulocyte/macrophage colony-stimulating factor (GM-CSF), a finding that has implications for the future therapy of lymph-node metastases... 
Pathobiology of the sentinel nodeAlistair J Cochran
Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095 1732, USA
Curr Opin Oncol 20:190-5. 2008..Large-scale studies that have been recently conducted and that are ongoing suggest a therapeutic role for lymphatic mapping/sentinel node biopsy in the management and prognosis of melanoma patients with early lymph node metastases...- Update on lymphatic mapping and sentinel node biopsy in the management of patients with melanocytic tumoursAlistair J Cochran
Department of Pathology, David Geffen School of Medicine at UCLA, the Jonsson Comprehensive Cancer Center, Los Angeles, California, USA
Pathology 36:478-84. 2004..To communicate best practices for sentinel lymph node evaluation and assessment of prognosis for patients with melanoma... - Principles of sentinel lymph node identification: background and clinical implicationsA J Cochran
Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90095 1732, USA
Langenbecks Arch Surg 385:252-60. 2000..While LM/SL is now almost standard practice in the US, the results of clinical trials are awaited to determine whether LM/SL can replace ELND and TLND in the management of early-stage melanoma... - The role of lymphatic mapping and sentinel node biopsy in the management of atypical and anomalous melanocytic lesionsAlistair J Cochran
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
J Cutan Pathol 37:54-9. 2010..We report our experience managing patients with these problematic tumors and discuss our approaches to determining the true location of lesional cells in sentinel nodes... - Pathologic reporting and special diagnostic techniques for melanomaAlistair J Cochran
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
Surg Oncol Clin N Am 15:231-51. 2006.... - Sentinel lymph nodes show profound downregulation of antigen-presenting cells of the paracortex: implications for tumor biology and treatmentA J Cochran
Department of Pathology and Laboratory Medicine, University of California Los Angeles, School of Medicine, Los Angeles, California 90095 1713, USA
Mod Pathol 14:604-8. 2001..They also offer an hypothesis to explain the failure of the immune surveillance mechanisms to identify and respond to a small primary melanoma that expresses immunogenic tumor antigens... - Melanoma metastases through the lymphatic systemA J Cochran
Department of Pathology, University of California Los Angeles School of Medicine, 90095 1713, USA
Surg Clin North Am 80:1683-93. 2000..The pathologist should carefully review the published literature before attempting to evaluate sentinel nodes from patients with an unfamiliar form of cancer... - The shifting patterns of metastatic melanomaA J Cochran
Departments of Pathology and Laboratory Medicine and Surgery, UCLA School of Medicine, Los Angeles, California, USA
Clin Lab Med 20:759-83, vii. 2000..Differences in clinical outcome indicate critical variations in pathobiology at different stages in disease evolution. Prevention of the evolution of melanoma is critical, especially beyond the stage of nodal involvement... - Pathologic analysis of sentinel lymph nodes in melanoma patients: current and future trendsAlice A Roberts
Department of Pathology and Laboratory Medicine, Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Surg Oncol 85:152-61. 2004..As long as lymph node metastases are used for staging solid malignancies, surgical pathologists are likely to encounter SLN excisional biopsies as a part of their routine practice... - Molecular classification of melanomas and nevi using gene expression microarray signatures and formalin-fixed and paraffin-embedded tissueStephen S Koh
UCLA Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1732, USA
Mod Pathol 22:538-46. 2009..Our successful use of a standard formalin-fixed and paraffin-embedded tissue further supports the practicability of combining molecular diagnostic testing with histopathology in evaluation of difficult melanocytic lesions... - Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCRJing Guo
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Exp Mol Pathol 74:140-7. 2003..We have attempted to optimize this interesting approach and have applied it to the detection of relevant melanoma markers in tissue culture lines... - Current practice and future directions in pathology and laboratory evaluation of the sentinel nodeA J Cochran
Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90095-1732, USA
Ann Surg Oncol 8:13S-17S. 2001..Studies are in progress to determine whether molecular biology techniques will detect additional nodes that contain truly occult tumor deposits... - Variations in lymphokine generation by individual lymph nodes draining human malignant tumorsD R Wen
Division of Surgical Oncology, Jonsson Comprehensive Cancer Center, Los Angeles, California
Cancer Immunol Immunother 30:277-82. 1989..Our findings further support the hypothesis that lymph nodes nearest to tumors are relatively immune-suppressed in vivo... - RT in situ PCR detection of MART-1 and TRP-2 mRNA in formalin-fixed, paraffin-embedded tissues of melanoma and neviEijun Itakura
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Mod Pathol 21:326-33. 2008..We conclude that the RT in situ PCR technique can be successfully applied to FFPE tissue to determine the cellular sources of gene expression observed by conventional PCR approaches... - Immunohistochemical characteristics of melanomaSteven J Ohsie
Department of Pathology and Laboratory Medicine, Geffen UCLA School of Medicine, Los Angeles, CA 90095 1732, USA
J Cutan Pathol 35:433-44. 2008..Ki67 remains the most useful adjunct in distinguishing benign from malignant melanocytic tumors. None of the markers reviewed has been shown conclusively to have prognostic value for melanocytic neoplasms... - Intratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockadeAntoni Ribas
Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, California 90095 1782, USA
Clin Cancer Res 15:390-9. 2009..In this study, biopsies of selected accessible tumor lesions from patients treated with tremelimumab were examined to further elucidate the mechanism of its antitumor activity... - Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanomaLisa H Butterfield
Department of Surgery, Division of Surgical Oncology, UCLA Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1782, USA
Clin Cancer Res 9:998-1008. 2003.... - Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanomaAntoni Ribas
Department of Medicine, Division of Hematology Oncology, University of California at Los Angeles, Los Angeles, California 90095 1782, USA
Clin Cancer Res 15:6267-76. 2009..The combination was tested in a phase I clinical trial in patients with advanced melanoma... - Is MAGE-1 expression in metastatic malignant melanomas really helpful?Nupoor A Gajjar
Department of Pathology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095, USA
Am J Surg Pathol 28:883-8. 2004.... - Accurate evaluation of nodal tissues for the presence of tumor is central to the sentinel node approachAlistair J Cochran
Department of Pathology and Laboratory Medicine and Surgery, David Geffen School of Medicine at UCLA and the Jonsson Comprehensive Cancer Center, Los Angeles, California, USA
Cancer Treat Res 127:207-20. 2005 - The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyreneShengli Shi
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
Carcinogenesis 30:1957-61. 2009..These observations demonstrate that Arnt is required for tumor initiation by B[a]P in this system... - Lymphatic mapping and sentinel node biopsy: the data unclouded by speculationAlistair J Cochran
Arch Dermatol 144:687-8; author reply 688-9. 2008 - Early diagnosis of malignant melanoma: Proposal of a working formulation for the management of cutaneous pigmented lesions from the Melanoma Cooperative GroupPaolo A Ascierto
Unit of Clinical Immunology, National Tumor Institute G Pascale, I 80131 Naples, Italy
Int J Oncol 22:1209-15. 2003..From these comparisons, we propose new guidelines for the management of CPL to provide a standard diagnostic and therapeutic approaches and to foster the early identification of lesions at risk for malignant transformation... - Sentinel node biopsy: not only a staging tool?Richard Essner
John Wayne Cancer Institute, Santa Monica, CA 90404, USA
Recent Results Cancer Res 160:133-48. 2002.... - Authors' response to a letter to the editor re: Sentinel node biopsy for early-stage melanomaDonald L Morton
Ann Surg 245:828-9. 2007 - Sentinel-node biopsy or nodal observation in melanomaDonald L Morton
Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
N Engl J Med 355:1307-17. 2006..We evaluated the contribution of sentinel-node biopsy to outcomes in patients with newly diagnosed melanoma... - Quantitative analysis of melanoma-induced cytokine-mediated immunosuppression in melanoma sentinel nodesJonathan H Lee
John Wayne Cancer Institute, Santa Monica, California 90404, USA
Clin Cancer Res 11:107-12. 2005..CONCLUSIONS: Our data provide molecular evidence of cytokine-mediated SN immunosuppression that is associated with presence of melanoma. Furthermore, SN immunosuppression can potentially be reversed by a cytokine therapy... - American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancerGary H Lyman
University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
J Clin Oncol 23:7703-20. 2005..To develop a guideline for the use of sentinel node biopsy (SNB) in early stage breast cancer... - Intraoperative frozen-section evaluation can reduce accuracy of pathologic assessment of sentinel nodes in melanoma patientsRichard A Scolyer
J Am Coll Surg 201:821-3; author reply 823-4. 2005 - Detection of clinically relevant melanoma metastases requires focused, not exhaustive, evaluation of sentinel lymph nodesAlistair J Cochran
Am J Surg Pathol 30:419-20; author reply 420-1. 2006 - Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-I, an international multicenter trialDonald L Morton
John Wayne Cancer Institute, Santa Monica, CA 90404, USA
Ann Surg 242:302-11; discussion 311-3. 2005..LM/SNB should become standard care for staging the regional lymph nodes of patients with primary cutaneous melanoma... - Immune responses in the draining lymph nodes against cancer: implications for immunotherapySuyu Shu
Center for Surgery Research, The Cleveland Clinic Foundation, Cleveland, OH, USA
Cancer Metastasis Rev 25:233-42. 2006..A clinical trial is now being carried out to test the immunogenicity and therapeutic effects of fusion hybrids for the treatment of metastatic melanoma... - Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastasesDonald L Morton
Roy E Coats Research Laboratories of the John Wayne Cancer Insstitute at Saint John s Health Center, Santa Monica, CA 90404, USA
Ann Surg 238:538-49; discussion 549-50. 2003.... - Treatment of locoregional metastases of malignant melanomas with radiotherapy and intralesional beta-interferon injectionEberhard Paul
Hautklinik am Klinikum Nürnberg Nord, Nurnberg, Germany, Praxis und Klinik für Strahlentherapie am Klinikum Nürnberg Nord, Nurnberg, Germany
Melanoma Res 13:611-7. 2003..In conclusion, combined treatment with radiotherapy and intratumoral injection of beta-interferon controlled local tumour growth in inoperable metastatic malignant melanomas... - Dermatoscopic and histopathological diagnosis of primary and metastatic melanoma: report of a workshop at the Third Research Meeting on Melanoma, Milan, Italy, May 2003Ignazio Stanganelli
Skin Cancer Unit, CPO, Ravenna and Cutaneous Oncology Unit, Niguarda Ca' Granda Hospital, Milan, Italy
Melanoma Res 14:231-5. 2004..This report is a brief summary of the main themes covered... - Hidradenocarcinoma: a histological and immunohistochemical studyChristine J Ko
Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA, USA
J Cutan Pathol 33:726-30. 2006..In making the diagnosis of hidradenocarcinoma, it may be unnecessary to separate hidradenocarcinoma into eccrine and apocrine categories, and although Ki67 and p53 may be helpful, histological parameters remain paramount...