A J Cochran

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010"
    Paolo A Ascierto
    Department of Melanoma, Sarcoma, and Head and Neck Disease, Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy
    J Transl Med 9:32. 2011
  2. ncbi request reprint The place of lymphatic mapping and sentinel node biopsy in oncology
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Int J Clin Oncol 8:139-50. 2003
  3. ncbi request reprint Prediction of metastatic melanoma in nonsentinel nodes and clinical outcome based on the primary melanoma and the sentinel node
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, School of Public Health at UCLA, Los Angeles, CA 90095 1732, USA
    Mod Pathol 17:747-55. 2004
  4. ncbi request reprint Optimal surgery for cutaneous melanoma requires accurate and complete pathologic information
    Alistair J Cochran
    Department of Pathology, Center for the Health Sciences, University of California Los Angeles Medical Center, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Facial Plast Surg Clin North Am 11:23-32. 2003
  5. ncbi request reprint Optimized assessment of sentinel lymph nodes for metastatic melanoma: implications for regional surgery and overall treatment planning
    Alistair J Cochran
    Departments of Pathology and Laboratory Medicine and Surgery, University of California, Los Angeles School of Medicine, Los Angeles, California, USA
    Ann Surg Oncol 11:156S-61S. 2004
  6. ncbi request reprint Tumour-induced immune modulation of sentinel lymph nodes
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California at Los Angeles, California 90095, USA
    Nat Rev Immunol 6:659-70. 2006
  7. doi request reprint Pathobiology of the sentinel node
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095 1732, USA
    Curr Opin Oncol 20:190-5. 2008
  8. ncbi request reprint Update on lymphatic mapping and sentinel node biopsy in the management of patients with melanocytic tumours
    Alistair J Cochran
    Department of Pathology, David Geffen School of Medicine at UCLA, the Jonsson Comprehensive Cancer Center, Los Angeles, California, USA
    Pathology 36:478-84. 2004
  9. ncbi request reprint Principles of sentinel lymph node identification: background and clinical implications
    A J Cochran
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90095 1732, USA
    Langenbecks Arch Surg 385:252-60. 2000
  10. doi request reprint The role of lymphatic mapping and sentinel node biopsy in the management of atypical and anomalous melanocytic lesions
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Cutan Pathol 37:54-9. 2010

Collaborators

Detail Information

Publications42

  1. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010"
    Paolo A Ascierto
    Department of Melanoma, Sarcoma, and Head and Neck Disease, Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy
    J Transl Med 9:32. 2011
    ..Four topics of discussion were identified: New pathways in Melanoma, Biomarkers, Clinical Trials and New Molecules and Strategies...
  2. ncbi request reprint The place of lymphatic mapping and sentinel node biopsy in oncology
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Int J Clin Oncol 8:139-50. 2003
    ..They also provide unique opportunities for basic and translational research...
  3. ncbi request reprint Prediction of metastatic melanoma in nonsentinel nodes and clinical outcome based on the primary melanoma and the sentinel node
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, School of Public Health at UCLA, Los Angeles, CA 90095 1732, USA
    Mod Pathol 17:747-55. 2004
    ..0001, Breslow, P=0.0001 and dendritic cell density, P=0.0007) and death from melanoma (tumor burden, P=0.0001, Breslow, P=0.0001 and dendritic cell density, P=0.0026)...
  4. ncbi request reprint Optimal surgery for cutaneous melanoma requires accurate and complete pathologic information
    Alistair J Cochran
    Department of Pathology, Center for the Health Sciences, University of California Los Angeles Medical Center, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Facial Plast Surg Clin North Am 11:23-32. 2003
  5. ncbi request reprint Optimized assessment of sentinel lymph nodes for metastatic melanoma: implications for regional surgery and overall treatment planning
    Alistair J Cochran
    Departments of Pathology and Laboratory Medicine and Surgery, University of California, Los Angeles School of Medicine, Los Angeles, California, USA
    Ann Surg Oncol 11:156S-61S. 2004
    ..The most robust of these predictors is relative tumor area, and this may be used as the basis of practical predictive algorithms...
  6. ncbi request reprint Tumour-induced immune modulation of sentinel lymph nodes
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California at Los Angeles, California 90095, USA
    Nat Rev Immunol 6:659-70. 2006
    ..Immune modulation of the lymph nodes can be reversed by granulocyte/macrophage colony-stimulating factor (GM-CSF), a finding that has implications for the future therapy of lymph-node metastases...
  7. doi request reprint Pathobiology of the sentinel node
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095 1732, USA
    Curr Opin Oncol 20:190-5. 2008
    ..Large-scale studies that have been recently conducted and that are ongoing suggest a therapeutic role for lymphatic mapping/sentinel node biopsy in the management and prognosis of melanoma patients with early lymph node metastases...
  8. ncbi request reprint Update on lymphatic mapping and sentinel node biopsy in the management of patients with melanocytic tumours
    Alistair J Cochran
    Department of Pathology, David Geffen School of Medicine at UCLA, the Jonsson Comprehensive Cancer Center, Los Angeles, California, USA
    Pathology 36:478-84. 2004
    ..To communicate best practices for sentinel lymph node evaluation and assessment of prognosis for patients with melanoma...
  9. ncbi request reprint Principles of sentinel lymph node identification: background and clinical implications
    A J Cochran
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90095 1732, USA
    Langenbecks Arch Surg 385:252-60. 2000
    ..While LM/SL is now almost standard practice in the US, the results of clinical trials are awaited to determine whether LM/SL can replace ELND and TLND in the management of early-stage melanoma...
  10. doi request reprint The role of lymphatic mapping and sentinel node biopsy in the management of atypical and anomalous melanocytic lesions
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Cutan Pathol 37:54-9. 2010
    ..We report our experience managing patients with these problematic tumors and discuss our approaches to determining the true location of lesional cells in sentinel nodes...
  11. ncbi request reprint Pathologic reporting and special diagnostic techniques for melanoma
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Surg Oncol Clin N Am 15:231-51. 2006
    ....
  12. ncbi request reprint Sentinel lymph nodes show profound downregulation of antigen-presenting cells of the paracortex: implications for tumor biology and treatment
    A J Cochran
    Department of Pathology and Laboratory Medicine, University of California Los Angeles, School of Medicine, Los Angeles, California 90095 1713, USA
    Mod Pathol 14:604-8. 2001
    ..They also offer an hypothesis to explain the failure of the immune surveillance mechanisms to identify and respond to a small primary melanoma that expresses immunogenic tumor antigens...
  13. ncbi request reprint Melanoma metastases through the lymphatic system
    A J Cochran
    Department of Pathology, University of California Los Angeles School of Medicine, 90095 1713, USA
    Surg Clin North Am 80:1683-93. 2000
    ..The pathologist should carefully review the published literature before attempting to evaluate sentinel nodes from patients with an unfamiliar form of cancer...
  14. ncbi request reprint The shifting patterns of metastatic melanoma
    A J Cochran
    Departments of Pathology and Laboratory Medicine and Surgery, UCLA School of Medicine, Los Angeles, California, USA
    Clin Lab Med 20:759-83, vii. 2000
    ..Differences in clinical outcome indicate critical variations in pathobiology at different stages in disease evolution. Prevention of the evolution of melanoma is critical, especially beyond the stage of nodal involvement...
  15. ncbi request reprint Pathologic analysis of sentinel lymph nodes in melanoma patients: current and future trends
    Alice A Roberts
    Department of Pathology and Laboratory Medicine, Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Surg Oncol 85:152-61. 2004
    ..As long as lymph node metastases are used for staging solid malignancies, surgical pathologists are likely to encounter SLN excisional biopsies as a part of their routine practice...
  16. doi request reprint Molecular classification of melanomas and nevi using gene expression microarray signatures and formalin-fixed and paraffin-embedded tissue
    Stephen S Koh
    UCLA Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1732, USA
    Mod Pathol 22:538-46. 2009
    ..Our successful use of a standard formalin-fixed and paraffin-embedded tissue further supports the practicability of combining molecular diagnostic testing with histopathology in evaluation of difficult melanocytic lesions...
  17. ncbi request reprint Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR
    Jing Guo
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Exp Mol Pathol 74:140-7. 2003
    ..We have attempted to optimize this interesting approach and have applied it to the detection of relevant melanoma markers in tissue culture lines...
  18. ncbi request reprint Current practice and future directions in pathology and laboratory evaluation of the sentinel node
    A J Cochran
    Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90095-1732, USA
    Ann Surg Oncol 8:13S-17S. 2001
    ..Studies are in progress to determine whether molecular biology techniques will detect additional nodes that contain truly occult tumor deposits...
  19. ncbi request reprint Variations in lymphokine generation by individual lymph nodes draining human malignant tumors
    D R Wen
    Division of Surgical Oncology, Jonsson Comprehensive Cancer Center, Los Angeles, California
    Cancer Immunol Immunother 30:277-82. 1989
    ..Our findings further support the hypothesis that lymph nodes nearest to tumors are relatively immune-suppressed in vivo...
  20. doi request reprint RT in situ PCR detection of MART-1 and TRP-2 mRNA in formalin-fixed, paraffin-embedded tissues of melanoma and nevi
    Eijun Itakura
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Mod Pathol 21:326-33. 2008
    ..We conclude that the RT in situ PCR technique can be successfully applied to FFPE tissue to determine the cellular sources of gene expression observed by conventional PCR approaches...
  21. doi request reprint Immunohistochemical characteristics of melanoma
    Steven J Ohsie
    Department of Pathology and Laboratory Medicine, Geffen UCLA School of Medicine, Los Angeles, CA 90095 1732, USA
    J Cutan Pathol 35:433-44. 2008
    ..Ki67 remains the most useful adjunct in distinguishing benign from malignant melanocytic tumors. None of the markers reviewed has been shown conclusively to have prognostic value for melanocytic neoplasms...
  22. doi request reprint Intratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockade
    Antoni Ribas
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, California 90095 1782, USA
    Clin Cancer Res 15:390-9. 2009
    ..In this study, biopsies of selected accessible tumor lesions from patients treated with tremelimumab were examined to further elucidate the mechanism of its antitumor activity...
  23. ncbi request reprint Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanoma
    Lisa H Butterfield
    Department of Surgery, Division of Surgical Oncology, UCLA Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1782, USA
    Clin Cancer Res 9:998-1008. 2003
    ..The purpose of this study was to determine the toxicity and immunological effects of three different doses and two routes of administration of autologous dendritic cells (DCs) pulsed with the MART-1(27-35) immunodominant epitope...
  24. pmc Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma
    Antoni Ribas
    Department of Medicine, Division of Hematology Oncology, University of California at Los Angeles, Los Angeles, California 90095 1782, USA
    Clin Cancer Res 15:6267-76. 2009
    ..The combination was tested in a phase I clinical trial in patients with advanced melanoma...
  25. ncbi request reprint Is MAGE-1 expression in metastatic malignant melanomas really helpful?
    Nupoor A Gajjar
    Department of Pathology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90095, USA
    Am J Surg Pathol 28:883-8. 2004
    ....
  26. ncbi request reprint Accurate evaluation of nodal tissues for the presence of tumor is central to the sentinel node approach
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine and Surgery, David Geffen School of Medicine at UCLA and the Jonsson Comprehensive Cancer Center, Los Angeles, California, USA
    Cancer Treat Res 127:207-20. 2005
  27. pmc The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene
    Shengli Shi
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    Carcinogenesis 30:1957-61. 2009
    ..These observations demonstrate that Arnt is required for tumor initiation by B[a]P in this system...
  28. ncbi request reprint Lymphatic mapping and sentinel node biopsy: the data unclouded by speculation
    Alistair J Cochran
    Arch Dermatol 144:687-8; author reply 688-9. 2008
  29. ncbi request reprint Early diagnosis of malignant melanoma: Proposal of a working formulation for the management of cutaneous pigmented lesions from the Melanoma Cooperative Group
    Paolo A Ascierto
    Unit of Clinical Immunology, National Tumor Institute G Pascale, I 80131 Naples, Italy
    Int J Oncol 22:1209-15. 2003
    ..From these comparisons, we propose new guidelines for the management of CPL to provide a standard diagnostic and therapeutic approaches and to foster the early identification of lesions at risk for malignant transformation...
  30. ncbi request reprint Sentinel node biopsy: not only a staging tool?
    Richard Essner
    John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    Recent Results Cancer Res 160:133-48. 2002
    ....
  31. pmc Authors' response to a letter to the editor re: Sentinel node biopsy for early-stage melanoma
    Donald L Morton
    Ann Surg 245:828-9. 2007
  32. ncbi request reprint Sentinel-node biopsy or nodal observation in melanoma
    Donald L Morton
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    N Engl J Med 355:1307-17. 2006
    ..We evaluated the contribution of sentinel-node biopsy to outcomes in patients with newly diagnosed melanoma...
  33. ncbi request reprint Quantitative analysis of melanoma-induced cytokine-mediated immunosuppression in melanoma sentinel nodes
    Jonathan H Lee
    John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Clin Cancer Res 11:107-12. 2005
    ..The goals of this study are to evaluate the role of melanoma in SN immunosuppression and to assess reversibility of SN immunosuppression by a cytokine therapy...
  34. ncbi request reprint American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer
    Gary H Lyman
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Clin Oncol 23:7703-20. 2005
    ..To develop a guideline for the use of sentinel node biopsy (SNB) in early stage breast cancer...
  35. ncbi request reprint Intraoperative frozen-section evaluation can reduce accuracy of pathologic assessment of sentinel nodes in melanoma patients
    Richard A Scolyer
    J Am Coll Surg 201:821-3; author reply 823-4. 2005
  36. ncbi request reprint Detection of clinically relevant melanoma metastases requires focused, not exhaustive, evaluation of sentinel lymph nodes
    Alistair J Cochran
    Am J Surg Pathol 30:419-20; author reply 420-1. 2006
  37. pmc Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-I, an international multicenter trial
    Donald L Morton
    John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    Ann Surg 242:302-11; discussion 311-3. 2005
    ....
  38. ncbi request reprint Immune responses in the draining lymph nodes against cancer: implications for immunotherapy
    Suyu Shu
    Center for Surgery Research, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Cancer Metastasis Rev 25:233-42. 2006
    ..A clinical trial is now being carried out to test the immunogenicity and therapeutic effects of fusion hybrids for the treatment of metastatic melanoma...
  39. pmc Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastases
    Donald L Morton
    Roy E Coats Research Laboratories of the John Wayne Cancer Insstitute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Ann Surg 238:538-49; discussion 549-50. 2003
    ....
  40. ncbi request reprint Treatment of locoregional metastases of malignant melanomas with radiotherapy and intralesional beta-interferon injection
    Eberhard Paul
    Hautklinik am Klinikum Nürnberg Nord, Nurnberg, Germany, Praxis und Klinik für Strahlentherapie am Klinikum Nürnberg Nord, Nurnberg, Germany
    Melanoma Res 13:611-7. 2003
    ..In conclusion, combined treatment with radiotherapy and intratumoral injection of beta-interferon controlled local tumour growth in inoperable metastatic malignant melanomas...
  41. ncbi request reprint Dermatoscopic and histopathological diagnosis of primary and metastatic melanoma: report of a workshop at the Third Research Meeting on Melanoma, Milan, Italy, May 2003
    Ignazio Stanganelli
    Skin Cancer Unit, CPO, Ravenna and Cutaneous Oncology Unit, Niguarda Ca Granda Hospital, Milan, Italy
    Melanoma Res 14:231-5. 2004
    ..This report is a brief summary of the main themes covered...
  42. ncbi request reprint Hidradenocarcinoma: a histological and immunohistochemical study
    Christine J Ko
    Department of Dermatology, Drexel University College of Medicine, Philadelphia, PA, USA
    J Cutan Pathol 33:726-30. 2006
    ..In making the diagnosis of hidradenocarcinoma, it may be unnecessary to separate hidradenocarcinoma into eccrine and apocrine categories, and although Ki67 and p53 may be helpful, histological parameters remain paramount...