Emil F Coccaro

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. doi request reprint Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, IL Electronic address
    Compr Psychiatry 55:260-7. 2014
  2. pmc Cerebrospinal fluid glutamate concentration correlates with impulsive aggression in human subjects
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
    J Psychiatr Res 47:1247-53. 2013
  3. doi request reprint Cerebrospinal fluid neuropeptide Y-like immunoreactivity correlates with impulsive aggression in human subjects
    Emil F Coccaro
    Department of Psychiatry and Behavioral Neuroscience, Clinical Neuroscience Research Unit, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Biol Psychiatry 72:997-1003. 2012
  4. doi request reprint Acute tryptophan depletion and self-injurious behavior in aggressive patients and healthy volunteers
    Michael S McCloskey
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, MC 3077, Chicago, IL, 60637, USA
    Psychopharmacology (Berl) 203:53-61. 2009
  5. pmc Aggression, suicidality, and intermittent explosive disorder: serotonergic correlates in personality disorder and healthy control subjects
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 35:435-44. 2010
  6. doi request reprint Modulation of central serotonin affects emotional information processing in impulsive aggressive personality disorder
    Royce J Lee
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    J Clin Psychopharmacol 32:329-35. 2012
  7. doi request reprint Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, United States
    J Psychiatr Res 44:137-42. 2010
  8. doi request reprint Corticolimbic function in impulsive aggressive behavior
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois
    Biol Psychiatry 69:1153-9. 2011
  9. ncbi request reprint The relationship between impulsive verbal aggression and intermittent explosive disorder
    Michael S McCloskey
    Department of Psychiatry, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Aggress Behav 34:51-60. 2008
  10. doi request reprint Inter-relationship between different platelet measures of 5-HT and their relationship to aggression in human subjects
    Robert Marseille
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Prog Neuropsychopharmacol Biol Psychiatry 36:277-81. 2012

Detail Information

Publications57

  1. doi request reprint Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, IL Electronic address
    Compr Psychiatry 55:260-7. 2014
    ....
  2. pmc Cerebrospinal fluid glutamate concentration correlates with impulsive aggression in human subjects
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
    J Psychiatr Res 47:1247-53. 2013
    ..Thus, glutamate function may contribute to the complex central neuromodulation of impulsive aggression in human subjects. ..
  3. doi request reprint Cerebrospinal fluid neuropeptide Y-like immunoreactivity correlates with impulsive aggression in human subjects
    Emil F Coccaro
    Department of Psychiatry and Behavioral Neuroscience, Clinical Neuroscience Research Unit, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Biol Psychiatry 72:997-1003. 2012
    ..While recent animal studies of neuropeptide Y (NPY) have suggested a facilitator role for central NPY in the modulation of aggression, no human studies of central NPY have yet been reported regarding aggression...
  4. doi request reprint Acute tryptophan depletion and self-injurious behavior in aggressive patients and healthy volunteers
    Michael S McCloskey
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, MC 3077, Chicago, IL, 60637, USA
    Psychopharmacology (Berl) 203:53-61. 2009
    ..Studies to date, however, have relied on nonexperimental designs to examine this relationship, limiting the causal inferences that can be drawn about the role of 5-HT in self-aggressive behavior...
  5. pmc Aggression, suicidality, and intermittent explosive disorder: serotonergic correlates in personality disorder and healthy control subjects
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 35:435-44. 2010
    ..These data have particular relevance to the notion of impulsive aggression and the biological validity of IED...
  6. doi request reprint Modulation of central serotonin affects emotional information processing in impulsive aggressive personality disorder
    Royce J Lee
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    J Clin Psychopharmacol 32:329-35. 2012
    ..The purpose of this study was to test the hypothesis that depletion of serotonin reserves by tryptophan depletion affects emotional information processing in susceptible individuals...
  7. doi request reprint Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, United States
    J Psychiatr Res 44:137-42. 2010
    ..Results from the examination of IED as a categorical aggression variable suggest that Research, rather than DSM-IV, criteria better identify individuals with reduced numbers of platelet 5-HTT sites...
  8. doi request reprint Corticolimbic function in impulsive aggressive behavior
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois
    Biol Psychiatry 69:1153-9. 2011
    ..We review psychiatric disorders, including borderline personality disorder and antisocial personality disorder, characterized by elevated reactive aggression, focusing on abnormalities in these three neural systems...
  9. ncbi request reprint The relationship between impulsive verbal aggression and intermittent explosive disorder
    Michael S McCloskey
    Department of Psychiatry, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Aggress Behav 34:51-60. 2008
    ..These results support the clinical importance of frequent VA for future iterations of the IED criteria set...
  10. doi request reprint Inter-relationship between different platelet measures of 5-HT and their relationship to aggression in human subjects
    Robert Marseille
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Prog Neuropsychopharmacol Biol Psychiatry 36:277-81. 2012
    ....
  11. doi request reprint Placebo-controlled, randomized trial of fluoxetine in the treatment of aggression in male intimate partner abusers
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, Chicago, Illinois
    Int Clin Psychopharmacol 23:337-41. 2008
    ..Despite the small sample, these results do not support the hypothesis that treatment with an SSRI is associated with a reduction in aggressive behavior among men with a history of intimate partner abuse...
  12. doi request reprint Cerebrospinal fluid substance P-like immunoreactivity correlates with aggression in personality disordered subjects
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Biol Psychiatry 72:238-43. 2012
    ..Laboratory animal studies of substance P suggest a facilitory role for this undecapeptide in the modulation of aggression, but no studies of substance P have yet been reported with regard to human aggression...
  13. doi request reprint Cerebrospinal fluid 5-hydroxyindolacetic acid correlates directly with negative affective intensity, but not affective lability, in human subjects
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Int J Neuropsychopharmacol 16:261-9. 2013
    ..This relationship was independent of aggression, life history of mood disorder and general personality traits...
  14. pmc Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobia
    K Luan Phan
    Department of Psychiatry, University of Illinois at Chicago, and Mental Health Service Line, Jesse Brown VA Medical Center, Chicago, IL 60608, USA
    Biol Psychiatry 73:329-36. 2013
    ..Although selective serotonin reuptake inhibitor (SSRI) treatment is known to be an effective treatment, little is known about the mechanism through which these agents exert their anxiolytic effects at a brain level in gSP...
  15. doi request reprint Attributional and emotional responses to socially ambiguous cues: validation of a new assessment of social/emotional information processing in healthy adults and impulsive aggressive patients
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Psychiatr Res 43:915-25. 2009
    ..Implications regarding the cognitive and emotional correlates of aggression are discussed...
  16. doi request reprint Cognitive-behavioral therapy for intermittent explosive disorder: a pilot randomized clinical trial
    Michael S McCloskey
    The University of Chicago, Department of Psychiatry, Chicago, IL 60637, USA
    J Consult Clin Psychol 76:876-86. 2008
    ..Posttreatment effect sizes were large. These effects were maintained at 3-month follow-up. Findings provide initial support for the use of multicomponent cognitive-behavioral therapy in the treatment of IED...
  17. ncbi request reprint CSF corticotropin-releasing factor in personality disorder: relationship with self-reported parental care
    Royce J Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 31:2289-95. 2006
    ..The cross-sectional design of the study, however, limits causal inferences...
  18. pmc Indices of orbitofrontal and prefrontal function in Cluster B and Cluster C personality disorders
    Anthony C Ruocco
    Department of Psychiatry, University of Chicago Medical Center, Chicago, IL, USA
    Psychiatry Res 170:282-5. 2009
    ..The present study is among the first to report neurocognitive findings for the full range of Cluster B personality disorders and any Cluster C personality disorder...
  19. doi request reprint Cortisol responses to ipsapirone challenge correlate with aggression, while basal cortisol levels correlate with impulsivity, in personality disorder and healthy volunteer subjects
    Marcela Almeida
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, Division of Biological Sciences and Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Psychiatr Res 44:874-80. 2010
    ....
  20. pmc Evaluation of behavioral impulsivity and aggression tasks as endophenotypes for borderline personality disorder
    Michael S McCloskey
    Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, United States
    J Psychiatr Res 43:1036-48. 2009
    ....
  21. doi request reprint Effects of acute alcohol intoxication and paroxetine on aggression in men
    Michael S McCloskey
    Pritzker School of Medicine, Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Alcohol Clin Exp Res 33:581-90. 2009
    ..The purpose of this study was to examine the role of the serotonin (5-HT) system in alcohol-related aggression...
  22. doi request reprint Cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid: reciprocal relationships with impulsive aggression in human subjects
    Emil F Coccaro
    Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, 5841, South Maryland Avenue, Chicago, IL 60637, USA
    J Neural Transm 117:241-8. 2010
    ....
  23. ncbi request reprint Prevalence and features of intermittent explosive disorder in a clinical setting
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Clin Psychiatry 66:1221-7. 2005
    ....
  24. ncbi request reprint Developmental psychopathology and neurobiology of aggression
    Jackie K Gollan
    University of Chicago, Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, IL 60637, USA
    Dev Psychopathol 17:1151-71. 2005
    ..Finally, we comment on the data of the relative stability of aggression in BPD, adolescence as a developmental stage of potential vulnerability, and the course of aggressive behavior during the life span...
  25. pmc How do depressed and healthy adults interpret nuanced facial expressions?
    Jackie K Gollan
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Abnorm Psychol 119:804-10. 2010
    ..Moreover, depressed subjects showed an impaired ability to accurately identify subtle facial expressions, indicating that depressive symptoms influence accuracy of emotional recognition...
  26. doi request reprint Cerebrospinal fluid GABA concentration: relationship with impulsivity and history of suicidal behavior, but not aggression, in human subjects
    Royce Lee
    Department of Psychiatry, The University of Chicago School of Medicine, Chicago, IL 60637, USA
    J Psychiatr Res 43:353-9. 2009
    ..Further work assessing this and other aspects of the central GABA system in personality disordered subjects are warranted...
  27. ncbi request reprint Childhood trauma and personality disorder: positive correlation with adult CSF corticotropin-releasing factor concentrations
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Psychiatry 162:995-7. 2005
    ....
  28. ncbi request reprint Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression
    Emil F Coccaro
    Department of Psychiatry, Biological Sciences Division and the Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637 1470, USA
    Biol Psychiatry 62:168-78. 2007
    ..In this study we employed a social-emotional probe of amygdala-OFC function in individuals with impulsive aggression...
  29. doi request reprint Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Compr Psychiatry 52:119-25. 2011
    ..We conclude that the IED-IR criteria can be reliably applied and have sufficient validity to warrant consideration as DSM-V criteria for IED...
  30. doi request reprint A family history study of intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Psychiatr Res 44:1101-5. 2010
    ..Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial...
  31. doi request reprint Personality disorder--not otherwise specified evidence of validity and consideration for DSM-5
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Compr Psychiatry 53:907-14. 2012
    ..Accordingly, PD-NOS by GDCPD is as valid a PD as any other specific PD by DSM criteria...
  32. doi request reprint Life history of impulsive behavior: development and validation of a new questionnaire
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, MC 3077, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Psychiatr Res 46:346-52. 2012
    ....
  33. ncbi request reprint Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity
    Michael S McCloskey
    Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Psychiatr Res 40:231-42. 2006
    ..Furthermore, the IED-IR subjects evidenced more behavioral aggression than their DSM-IED counterparts...
  34. pmc Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder
    Michael S McCloskey
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, MC 3077, Chicago, IL 60637, USA
    Psychiatry Res 158:248-50. 2008
    ..Results showed 16% of IED subjects reported self-aggression, with 12.5% reporting suicide attempts and 7.4% reporting non-lethal self-injurious behaviors. Additional risk factors were identified...
  35. pmc Identifying differences in biased affective information processing in major depression
    Jackie K Gollan
    Department of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, 446 East Ontario Street, Suite 7 204, Chicago, IL 60611, USA
    Psychiatry Res 159:18-24. 2008
    ....
  36. doi request reprint History of mild to moderate traumatic brain injury and aggression in physically healthy participants with and without personality disorder
    Sherise D Ferguson
    University of Chicago, Chicago, IL, USA
    J Pers Disord 23:230-9. 2009
    ..These data suggest that lifetime history of mild TBI is associated with history of aggression regardless of history of psychiatric disorder...
  37. doi request reprint Elevated plasma inflammatory markers in individuals with intermittent explosive disorder and correlation with aggression in humans
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, Illinois
    JAMA Psychiatry 71:158-65. 2014
    ..Despite this, to our knowledge, no studies of aggression and inflammatory markers have been reported in psychiatric patients or in individuals with recurrent, problematic, impulsive aggressive behavior...
  38. ncbi request reprint High prevalence of personality disorders among healthy volunteers for research: implications for control group bias
    Scott C Bunce
    Clinical Neuroscience Research Unit, Department of Psychiatry, Drexel University College of Medicine, Philadelphia, PA, USA
    J Psychiatr Res 39:421-30. 2005
    ..Implications are discussed for routine Axis II screening of volunteers for research with specific diagnostic instruments...
  39. pmc Lifetime history of cigarette smoking associated with aggression and impulsivity in both healthy and personality disordered volunteers
    Elias Dakwar
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    J Pers Disord 25:645-55. 2011
    ..These data suggest that lifetime history of cigarette smoking is associated with elevations in life history of aggression regardless of the presence of psychiatric disorder in nontreatment seeking individuals...
  40. doi request reprint Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, USA
    Am J Psychiatry 169:577-88. 2012
    ..Overall, these data suggest that the diagnostic validity for the integrated research criteria is substantial and is now sufficient for recognition and inclusion in DSM-5...
  41. ncbi request reprint Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Psychoneuroendocrinology 34:1567-73. 2009
    ..We hypothesized that CSF Oxytocin levels would be inversely related to dimensional measures of lifetime aggression...
  42. doi request reprint GH response to intravenous clonidine challenge: absence of relationship with behavioral irritability, aggression, or impulsivity in human subjects
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, United States
    Psychiatry Res 178:443-5. 2010
    ..Unlike a previous investigation, this study provides little support for a role of post-synaptic alpha(2)-noradrenergic receptor sensitivity in aggression in healthy or personality disordered subjects...
  43. doi request reprint Affective intensity and lability: heritability in adult male twins
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    J Affect Disord 136:1011-6. 2012
    ..Despite the importance of these aspects of affective regulation, there are no twin study data to shed light on the genetic and environmental components of these constructs...
  44. pmc Emotional experience modulates brain activity during fixation periods between tasks
    Sean Pitroda
    Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Neurosci Lett 443:72-6. 2008
    ....
  45. ncbi request reprint Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, University of Chicago, IL 60637, USA
    J Clin Psychiatry 65:820-4. 2004
    ..To determine the lifetime and 1-month prevalence of intermittent explosive disorder (IED) by both DSM-IV and research criteria in a community sample...
  46. doi request reprint The neurochemistry of human aggression
    Rachel Yanowitch
    Clinical Neuroscience Research Unit, Department of Psychiatry, The University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
    Adv Genet 75:151-69. 2011
    ..Data reviewed in this chapter include emoiric information from neurochemical, pharmaco-challenge, molecular genetic and neuroimaging studies...
  47. ncbi request reprint Plasma homovanillic acid correlates inversely with history of learning problems in healthy volunteer and personality disordered subjects
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, MC 3077, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Psychiatry Res 149:297-302. 2007
    ..Replication is needed in treated and untreated ADHD samples to confirm these initial results...
  48. ncbi request reprint CSF testosterone: relationship to aggression, impulsivity, and venturesomeness in adult males with personality disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Psychiatr Res 41:488-92. 2007
    ....
  49. ncbi request reprint Association of C-reactive protein elevation with trait aggression and hostility in personality disordered subjects: a pilot study
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, United States
    J Psychiatr Res 40:460-5. 2006
    ..In this pilot study, the author tests the hypothesis that pCRP elevations are associated with the traits of aggression and hostility in personality disordered subjects, a group at high risk for the presence of aggression and hostility...
  50. ncbi request reprint A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA
    J Clin Psychiatry 70:653-62. 2009
    ..Since central serotonergic (5-HT) system dysfunction is related to impulsive aggressive behavior, pharmacologic enhancement of 5-HT activity should reduce impulsive aggressive behavior in individuals with IED...
  51. doi request reprint Plasma homovanillic acid correlates inversely with history of childhood trauma in personality disordered and healthy control adults
    Royce Lee
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Chicago, Chicago, USA
    J Neural Transm 117:1327-34. 2010
    ....
  52. ncbi request reprint Platelet serotonin content correlates inversely with life history of aggression in personality-disordered subjects
    Joseph S Goveas
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, MC 3077, Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60615, USA
    Psychiatry Res 126:23-32. 2004
    ..Similar to other studies of platelet 5-HT markers, these data suggest that platelet 5-HT content may also reflect central 5-HT alterations and may be used as a biological marker in appropriate patient samples...
  53. pmc Multivariate behavior genetic analyses of aggressive behavior subtypes
    Michelle T Yeh
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, CNPRU, Chicago, IL, USA
    Behav Genet 40:603-17. 2010
    ..43 to .63. The results of this study highlight the heterogeneous nature of the aggression construct and the need to consider differences in genetic and environmental influences on individual aggressive behaviors in a multivariate context...
  54. ncbi request reprint History of childhood maltreatment in Intermittent Explosive Disorder and suicidal behavior
    Jennifer R Fanning
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
    J Psychiatr Res 56:10-7. 2014
    ..The results suggest pathways by which environmental factors may influence impulsivity and aggression and, in turn, clinically significant self- and other-directed aggression. ..
  55. ncbi request reprint Hostile attributional bias, negative emotional responding, and aggression in adults: moderating effects of gender and impulsivity
    Pan Chen
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, CNPRU, Chicago, Illinois
    Aggress Behav 38:47-63. 2012
    ..The current study provides evidence for the utility of HAB and negative emotional responding as predictors of adult aggression and further suggests that gender and impulsivity may moderate their links with aggression...
  56. ncbi request reprint Neuroimaging and personality disorders
    Michael S McCloskey
    Department of Psychiatry, MC 3077, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Curr Psychiatry Rep 7:65-72. 2005
    ....
  57. ncbi request reprint Molecular genetics of personality
    Kurtis L Noblett
    Department of Psychiatry, MC 3077, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Curr Psychiatry Rep 7:73-80. 2005
    ..This article endeavors to review and evaluate the most recent literature within the context of this burgeoning field. Some considerations for future research are presented in summary...