E F Coccaro

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint A novel approach to assess inter-rater reliability in the use of the Overt Aggression Scale-Modified
    Jean Endicott
    New York State Psychiatric Institute, Unit 123, 1051 Riverside Drive, New York 10032, USA
    Psychiatry Res 112:153-9. 2002
  2. doi request reprint Cerebrospinal fluid 5-hydroxyindolacetic acid correlates directly with negative affective intensity, but not affective lability, in human subjects
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Int J Neuropsychopharmacol 16:261-9. 2013
  3. doi request reprint Personality disorder--not otherwise specified evidence of validity and consideration for DSM-5
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Compr Psychiatry 53:907-14. 2012
  4. doi request reprint Cerebrospinal fluid substance P-like immunoreactivity correlates with aggression in personality disordered subjects
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Biol Psychiatry 72:238-43. 2012
  5. doi request reprint Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, USA
    Am J Psychiatry 169:577-88. 2012
  6. doi request reprint Affective intensity and lability: heritability in adult male twins
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    J Affect Disord 136:1011-6. 2012
  7. doi request reprint Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, United States
    J Psychiatr Res 44:137-42. 2010
  8. ncbi request reprint Association of C-reactive protein elevation with trait aggression and hostility in personality disordered subjects: a pilot study
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, United States
    J Psychiatr Res 40:460-5. 2006
  9. doi request reprint A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA
    J Clin Psychiatry 70:653-62. 2009
  10. ncbi request reprint Prevalence and features of intermittent explosive disorder in a clinical setting
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Clin Psychiatry 66:1221-7. 2005

Detail Information

Publications61

  1. ncbi request reprint A novel approach to assess inter-rater reliability in the use of the Overt Aggression Scale-Modified
    Jean Endicott
    New York State Psychiatric Institute, Unit 123, 1051 Riverside Drive, New York 10032, USA
    Psychiatry Res 112:153-9. 2002
    ..The method described here may be useful in future assessments of inter-rater reliability...
  2. doi request reprint Cerebrospinal fluid 5-hydroxyindolacetic acid correlates directly with negative affective intensity, but not affective lability, in human subjects
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Int J Neuropsychopharmacol 16:261-9. 2013
    ..This relationship was independent of aggression, life history of mood disorder and general personality traits...
  3. doi request reprint Personality disorder--not otherwise specified evidence of validity and consideration for DSM-5
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Compr Psychiatry 53:907-14. 2012
    ..Accordingly, PD-NOS by GDCPD is as valid a PD as any other specific PD by DSM criteria...
  4. doi request reprint Cerebrospinal fluid substance P-like immunoreactivity correlates with aggression in personality disordered subjects
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Biol Psychiatry 72:238-43. 2012
    ..Laboratory animal studies of substance P suggest a facilitory role for this undecapeptide in the modulation of aggression, but no studies of substance P have yet been reported with regard to human aggression...
  5. doi request reprint Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5
    Emil F Coccaro
    Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, USA
    Am J Psychiatry 169:577-88. 2012
    ..Overall, these data suggest that the diagnostic validity for the integrated research criteria is substantial and is now sufficient for recognition and inclusion in DSM-5...
  6. doi request reprint Affective intensity and lability: heritability in adult male twins
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    J Affect Disord 136:1011-6. 2012
    ..Despite the importance of these aspects of affective regulation, there are no twin study data to shed light on the genetic and environmental components of these constructs...
  7. doi request reprint Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, United States
    J Psychiatr Res 44:137-42. 2010
    ..Results from the examination of IED as a categorical aggression variable suggest that Research, rather than DSM-IV, criteria better identify individuals with reduced numbers of platelet 5-HTT sites...
  8. ncbi request reprint Association of C-reactive protein elevation with trait aggression and hostility in personality disordered subjects: a pilot study
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, United States
    J Psychiatr Res 40:460-5. 2006
    ..In this pilot study, the author tests the hypothesis that pCRP elevations are associated with the traits of aggression and hostility in personality disordered subjects, a group at high risk for the presence of aggression and hostility...
  9. doi request reprint A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA
    J Clin Psychiatry 70:653-62. 2009
    ..Since central serotonergic (5-HT) system dysfunction is related to impulsive aggressive behavior, pharmacologic enhancement of 5-HT activity should reduce impulsive aggressive behavior in individuals with IED...
  10. ncbi request reprint Prevalence and features of intermittent explosive disorder in a clinical setting
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Clin Psychiatry 66:1221-7. 2005
    ....
  11. doi request reprint Attributional and emotional responses to socially ambiguous cues: validation of a new assessment of social/emotional information processing in healthy adults and impulsive aggressive patients
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Psychiatr Res 43:915-25. 2009
    ..Implications regarding the cognitive and emotional correlates of aggression are discussed...
  12. ncbi request reprint Comparative proteomic analysis with postmortem prefrontal cortex tissues of suicide victims versus controls
    Katja Schlicht
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 41:493-501. 2007
    ..Proteomics is a powerful method to investigate modifications in protein expression...
  13. ncbi request reprint CSF testosterone: relationship to aggression, impulsivity, and venturesomeness in adult males with personality disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Psychiatr Res 41:488-92. 2007
    ....
  14. ncbi request reprint PennTwins: a population-based cohort for twin studies
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Twin Res Hum Genet 9:998-1005. 2006
    ..Thus, despite a relatively low overall response rate (12% of all twins born in Pennsylvania from 1959-1978), there is no evidence that the sample differs in any meaningful respect from the larger population...
  15. ncbi request reprint Plasma homovanillic acid correlates inversely with history of learning problems in healthy volunteer and personality disordered subjects
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, MC 3077, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Psychiatry Res 149:297-302. 2007
    ..Replication is needed in treated and untreated ADHD samples to confirm these initial results...
  16. pmc Aggression, suicidality, and intermittent explosive disorder: serotonergic correlates in personality disorder and healthy control subjects
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 35:435-44. 2010
    ..These data have particular relevance to the notion of impulsive aggression and the biological validity of IED...
  17. ncbi request reprint Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression
    Emil F Coccaro
    Department of Psychiatry, Biological Sciences Division and the Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637 1470, USA
    Biol Psychiatry 62:168-78. 2007
    ..In this study we employed a social-emotional probe of amygdala-OFC function in individuals with impulsive aggression...
  18. ncbi request reprint Intermittent explosive disorder
    E F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Curr Psychiatry Rep 2:67-71. 2000
    ....
  19. doi request reprint Corticolimbic function in impulsive aggressive behavior
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois
    Biol Psychiatry 69:1153-9. 2011
    ..We review psychiatric disorders, including borderline personality disorder and antisocial personality disorder, characterized by elevated reactive aggression, focusing on abnormalities in these three neural systems...
  20. doi request reprint Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Compr Psychiatry 52:119-25. 2011
    ..We conclude that the IED-IR criteria can be reliably applied and have sufficient validity to warrant consideration as DSM-V criteria for IED...
  21. ncbi request reprint Norepinephrine function in personality disorder: plasma free MHPG correlates inversely with life history of aggression
    Emil F Coccaro
    Department of Psychiatry, University of Chicago, Illinois 60637, USA
    CNS Spectr 8:731-6. 2003
    ..In this study, the relationship between plasma free NE metabolite, plasma free 3-methoxy-4-hydroxyphenylglycol (pMHPG), and impulsive aggression was explored in subjects with personality disorder...
  22. ncbi request reprint Intermittent explosive disorder and impulsive aggression: the time for serious study is now
    Emil F Coccaro
    Department of Psychiatry, University of Chicago, MC 3077, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Curr Psychiatry Rep 6:1-2. 2004
  23. ncbi request reprint Platelet serotonin content correlates inversely with life history of aggression in personality-disordered subjects
    Joseph S Goveas
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, MC 3077, Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60615, USA
    Psychiatry Res 126:23-32. 2004
    ..Similar to other studies of platelet 5-HT markers, these data suggest that platelet 5-HT content may also reflect central 5-HT alterations and may be used as a biological marker in appropriate patient samples...
  24. doi request reprint A family history study of intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Psychiatr Res 44:1101-5. 2010
    ..Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial...
  25. ncbi request reprint Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, University of Chicago, IL 60637, USA
    J Clin Psychiatry 65:820-4. 2004
    ..To determine the lifetime and 1-month prevalence of intermittent explosive disorder (IED) by both DSM-IV and research criteria in a community sample...
  26. doi request reprint GH response to intravenous clonidine challenge: absence of relationship with behavioral irritability, aggression, or impulsivity in human subjects
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, United States
    Psychiatry Res 178:443-5. 2010
    ..Unlike a previous investigation, this study provides little support for a role of post-synaptic alpha(2)-noradrenergic receptor sensitivity in aggression in healthy or personality disordered subjects...
  27. doi request reprint Cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid: reciprocal relationships with impulsive aggression in human subjects
    Emil F Coccaro
    Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, 5841, South Maryland Avenue, Chicago, IL 60637, USA
    J Neural Transm 117:241-8. 2010
    ....
  28. ncbi request reprint Impact of trait impulsivity and state aggression on divalproex versus placebo response in borderline personality disorder
    Eric Hollander
    Department of Psychiatry, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1230, New York, NY 10029 6574, USA
    Am J Psychiatry 162:621-4. 2005
    ....
  29. pmc Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder
    K Luan Phan
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48105, USA
    Biol Psychiatry 66:691-4. 2009
    ..The goal of this study was to investigate brain frontal WM abnormalities using diffusion tensor imaging (DTI) in patients with social anxiety disorder...
  30. doi request reprint Placebo-controlled, randomized trial of fluoxetine in the treatment of aggression in male intimate partner abusers
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, Chicago, Illinois
    Int Clin Psychopharmacol 23:337-41. 2008
    ..Despite the small sample, these results do not support the hypothesis that treatment with an SSRI is associated with a reduction in aggressive behavior among men with a history of intimate partner abuse...
  31. ncbi request reprint Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects
    J Gelernter
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven Campus, 06516, USA
    Am J Psychiatry 155:1332-8. 1998
    ..The authors attempted to replicate this finding...
  32. ncbi request reprint Prolactin response to D-fenfluramine in outpatients with major depression
    R J Kavoussi
    Department of Psychiatry, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA
    Psychiatry Res 79:199-205. 1998
    ..5 mg/kg. The possible implications of these findings are discussed with respect to theories regarding biological vulnerabilities to major depression...
  33. ncbi request reprint Divalproex sodium for impulsive aggressive behavior in patients with personality disorder
    R J Kavoussi
    Department of Psychiatry, MCP Hahnemann School of Medicine, Philadelphia, PA, USA
    J Clin Psychiatry 59:676-80. 1998
    ....
  34. ncbi request reprint Divalproex in the treatment of impulsive aggression: efficacy in cluster B personality disorders
    Eric Hollander
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 28:1186-97. 2003
    ....
  35. doi request reprint History of mild to moderate traumatic brain injury and aggression in physically healthy participants with and without personality disorder
    Sherise D Ferguson
    University of Chicago, Chicago, IL, USA
    J Pers Disord 23:230-9. 2009
    ..These data suggest that lifetime history of mild TBI is associated with history of aggression regardless of history of psychiatric disorder...
  36. doi request reprint Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Psychoneuroendocrinology 34:1567-73. 2009
    ..We hypothesized that CSF Oxytocin levels would be inversely related to dimensional measures of lifetime aggression...
  37. ncbi request reprint Childhood trauma and personality disorder: positive correlation with adult CSF corticotropin-releasing factor concentrations
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Psychiatry 162:995-7. 2005
    ....
  38. pmc Indices of orbitofrontal and prefrontal function in Cluster B and Cluster C personality disorders
    Anthony C Ruocco
    Department of Psychiatry, University of Chicago Medical Center, Chicago, IL, USA
    Psychiatry Res 170:282-5. 2009
    ..The present study is among the first to report neurocognitive findings for the full range of Cluster B personality disorders and any Cluster C personality disorder...
  39. ncbi request reprint Neuroimaging and personality disorders
    Michael S McCloskey
    Department of Psychiatry, MC 3077, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Curr Psychiatry Rep 7:65-72. 2005
    ....
  40. doi request reprint Plasma homovanillic acid correlates inversely with history of childhood trauma in personality disordered and healthy control adults
    Royce Lee
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Chicago, Chicago, USA
    J Neural Transm 117:1327-34. 2010
    ....
  41. ncbi request reprint Plasma oxytocin in response to pharmaco-challenge to D-fenfluramine and placebo in healthy men
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry MC 3077, Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Psychiatry Res 118:129-36. 2003
    ..g. aggression) than that of less central outcome parameters of 5-HT responsiveness (e.g. prolactin)...
  42. ncbi request reprint Intermittent explosive disorder-integrated research diagnostic criteria: convergent and discriminant validity
    Michael S McCloskey
    Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Psychiatr Res 40:231-42. 2006
    ..Furthermore, the IED-IR subjects evidenced more behavioral aggression than their DSM-IED counterparts...
  43. ncbi request reprint Developmental psychopathology and neurobiology of aggression
    Jackie K Gollan
    University of Chicago, Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, IL 60637, USA
    Dev Psychopathol 17:1151-71. 2005
    ..Finally, we comment on the data of the relative stability of aggression in BPD, adolescence as a developmental stage of potential vulnerability, and the course of aggressive behavior during the life span...
  44. pmc Evaluation of behavioral impulsivity and aggression tasks as endophenotypes for borderline personality disorder
    Michael S McCloskey
    Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, United States
    J Psychiatr Res 43:1036-48. 2009
    ....
  45. ncbi request reprint The relationship between impulsive verbal aggression and intermittent explosive disorder
    Michael S McCloskey
    Department of Psychiatry, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Aggress Behav 34:51-60. 2008
    ..These results support the clinical importance of frequent VA for future iterations of the IED criteria set...
  46. pmc Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder
    Michael S McCloskey
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, MC 3077, Chicago, IL 60637, USA
    Psychiatry Res 158:248-50. 2008
    ..Results showed 16% of IED subjects reported self-aggression, with 12.5% reporting suicide attempts and 7.4% reporting non-lethal self-injurious behaviors. Additional risk factors were identified...
  47. doi request reprint Cerebrospinal fluid GABA concentration: relationship with impulsivity and history of suicidal behavior, but not aggression, in human subjects
    Royce Lee
    Department of Psychiatry, The University of Chicago School of Medicine, Chicago, IL 60637, USA
    J Psychiatr Res 43:353-9. 2009
    ..Further work assessing this and other aspects of the central GABA system in personality disordered subjects are warranted...
  48. ncbi request reprint CSF corticotropin-releasing factor in personality disorder: relationship with self-reported parental care
    Royce J Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 31:2289-95. 2006
    ..The cross-sectional design of the study, however, limits causal inferences...
  49. doi request reprint Cognitive-behavioral therapy for intermittent explosive disorder: a pilot randomized clinical trial
    Michael S McCloskey
    The University of Chicago, Department of Psychiatry, Chicago, IL 60637, USA
    J Consult Clin Psychol 76:876-86. 2008
    ..Posttreatment effect sizes were large. These effects were maintained at 3-month follow-up. Findings provide initial support for the use of multicomponent cognitive-behavioral therapy in the treatment of IED...
  50. doi request reprint Effects of acute alcohol intoxication and paroxetine on aggression in men
    Michael S McCloskey
    Pritzker School of Medicine, Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Alcohol Clin Exp Res 33:581-90. 2009
    ..The purpose of this study was to examine the role of the serotonin (5-HT) system in alcohol-related aggression...
  51. doi request reprint Acute tryptophan depletion and self-injurious behavior in aggressive patients and healthy volunteers
    Michael S McCloskey
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, MC 3077, Chicago, IL, 60637, USA
    Psychopharmacology (Berl) 203:53-61. 2009
    ..Studies to date, however, have relied on nonexperimental designs to examine this relationship, limiting the causal inferences that can be drawn about the role of 5-HT in self-aggressive behavior...
  52. doi request reprint Moderating effects of childhood maltreatment on associations between social information processing and adult aggression
    P Chen
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, CNPRU, Chicago, IL, USA
    Psychol Med 42:1293-304. 2012
    ..Few studies have examined the importance of childhood maltreatment independent of SIP in the etiology of adult aggression. Furthermore, moderating effects of childhood maltreatment on the SIP-aggression links have not been explored...
  53. ncbi request reprint Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients
    Michael J Minzenberg
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 31:197-203. 2006
    ..In addition, D(2) receptor dysfunction may play a role in impulsivity, whereas 5-HT(1A) cell-body autoreceptor function may be spared in these disorders...
  54. ncbi request reprint Assessment of behavioral and cognitive impulsivity: development and validation of the Lifetime History of Impulsive Behaviors Interview
    Catherine A Schmidt
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, University of Chicago, MC 3077, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Psychiatry Res 126:107-21. 2004
    ..No relationship was obtained between the LHIB and laboratory analogue measures. While evidence of discriminant validity was mixed, these data suggest that the LHIB may be a useful instrument for the assessment of impulsive behavior...
  55. pmc Identifying differences in biased affective information processing in major depression
    Jackie K Gollan
    Department of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, 446 East Ontario Street, Suite 7 204, Chicago, IL 60611, USA
    Psychiatry Res 159:18-24. 2008
    ....
  56. ncbi request reprint High prevalence of personality disorders among healthy volunteers for research: implications for control group bias
    Scott C Bunce
    Clinical Neuroscience Research Unit, Department of Psychiatry, Drexel University College of Medicine, Philadelphia, PA, USA
    J Psychiatr Res 39:421-30. 2005
    ..Implications are discussed for routine Axis II screening of volunteers for research with specific diagnostic instruments...
  57. pmc Emotional experience modulates brain activity during fixation periods between tasks
    Sean Pitroda
    Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Neurosci Lett 443:72-6. 2008
    ....
  58. ncbi request reprint Molecular genetics of personality
    Kurtis L Noblett
    Department of Psychiatry, MC 3077, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Curr Psychiatry Rep 7:73-80. 2005
    ..This article endeavors to review and evaluate the most recent literature within the context of this burgeoning field. Some considerations for future research are presented in summary...
  59. ncbi request reprint Consensus report on impulsive aggression as a symptom across diagnostic categories in child psychiatry: implications for medication studies
    Peter S Jensen
    Center for the Advancement of Children s Mental Health, Columbia University NYSPI 1051 Riverside Drive, Unit 78, New York, NY 10032, USA
    J Am Acad Child Adolesc Psychiatry 46:309-22. 2007
    ..If so, how should IA be assessed, pharmacological studies designed, and ethical issues addressed?..
  60. pmc Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder
    Mary Best
    Department of Psychology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:8448-53. 2002
    ..These results extend the link between dysfunction of the orbital/medial prefrontal circuit and impulsive aggressive behavior...
  61. pmc The prevalence and correlates of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Arch Gen Psychiatry 63:669-78. 2006
    ..Little is known about the epidemiology of intermittent explosive disorder (IED)...

Research Grants22

  1. Intermittent Explosive Disorder: A Family Study
    EMIL COCCARO; Fiscal Year: 2005
    ..e., relatives of IED probands with and without IED). ..
  2. Impulsive Aggression : A Twin Study of Behavior and 5-HT
    EMIL COCCARO; Fiscal Year: 2006
    ..abstract_text> ..
  3. Fluoxetine and Divalproex:Treatment Correlates in Intermittent Explosive Disorder
    EMIL COCCARO; Fiscal Year: 2007
    ..Duration of treatment will be twelve weeks. ..
  4. Fluoxetine and Divalproex:Treatment Correlated IED (RMI)
    EMIL COCCARO; Fiscal Year: 2005
    ..Duration of treatment will be twelve weeks. ..
  5. Social Information Processing: Assessment Development
    EMIL COCCARO; Fiscal Year: 2007
    ..Development of such measures is critical for the further scientific study of SIP and for its integration in neurobiologhical research. ..
  6. Understanding The Pathways To Aggression
    EMIL FRANK COCCA; Fiscal Year: 2010
    ..To gain a better understanding of these potential genetic mechanisms, twin studies can be used to identify biologically-based traits that may serve as endophenotpyes for aggression and related behaviors. ..
  7. SSRIs and Self-harm in Borderline Personality Disorder
    Michael S McCloskey; Fiscal Year: 2010
    ..Selfharm will also be assessed using a laboratory analogue task (SAP) at baseline and again after the eight week trial. Age, 5-HT dysfunction and emotion dysregulation will be evaluated as potential moderators of SSRI response. ..