Research Topics
| Ronald ClymanSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Mechanisms regulating the ductus arteriosusRonald I Clyman
School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, Calif, USA
Biol Neonate 89:330-5. 2006..In this review, comparative physiology between the full term and preterm newborn and the barriers preventing the necessary cascade of events leading to permanent constriction of the PDA are reviewed...
The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasiaRonald I Clyman
Departments of Pediatrics and the Cardiovascular Research Institute, UCSF Box 0544, HSW 1408, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA Electronic address
Semin Perinatol 37:102-7. 2013....
Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?Ronald I Clyman
Department of Pediatrics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
Semin Perinatol 36:123-9. 2012..By contrast, ductus ligation, while eliminating the detrimental effects of a PDA on lung development, may create its own set of morbidities that counteract many of the benefits derived from ductus closure...- The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trialRonald Clyman
Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
J Pediatr 154:873-6. 2009..To reexamine data from a randomized controlled trial of prophylactic ductus ligation to determine whether ligation contributes directly to the development of bronchopulmonary dysplasia (BPD) in extremely low birth weight infants... - Calcium-dependent and calcium-sensitizing pathways in the mature and immature ductus arteriosusRonald I Clyman
Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, 513 Parnassus Ave, Rm 1408 HSW, UCSF Box 0544, San Francisco, CA 94143 0544, USA
Am J Physiol Regul Integr Comp Physiol 293:R1650-6. 2007..Stimulation of Ca(2+) entry through reverse-mode Na(+)/Ca(2+) exchange or CPA-induced SOC channel activity constrict the DA and eliminate differences between immature and mature DA during both hypoxia and normoxia... - The effects of caffeine on the preterm sheep ductus arteriosusRonald I Clyman
Cardiovascular Research Institute and Department of Pediatrics, University of California San Francisco, San Francisco, California 94143, USA
Pediatr Res 62:167-9. 2007..In conclusion, we found no evidence of a direct effect of therapeutic caffeine concentrations on ductus contractility... - Indomethacin prophylaxis for preterm infants: the impact of 2 multicentered randomized controlled trials on clinical practiceRonald I Clyman
Cardiovascular Research Institute and Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 0544, USA
J Pediatr 150:46-50.e2. 2007..The TIPP trial failed to find a benefit in its primary outcome (improved survival/neurodevelopmental outcome); this negative result may have discouraged indomethacin prophylaxis use... - In utero indomethacin alters O2 delivery to the fetal ductus arteriosus: implications for postnatal patencySeth H Goldbarg
Cardiovascular Research Institute, University of California, San Francisco, California 94143-0544, USA
Am J Physiol Regul Integr Comp Physiol 282:R184-90. 2002..These findings suggest that the hypoxic cell death that occurs during the early stages of indomethacin-induced constriction is primarily due to changes in vasa vasorum blood flow and muscle media thickness... - Vasa vasorum hypoperfusion is responsible for medial hypoxia and anatomic remodeling in the newborn lamb ductus arteriosusHiroki Kajino
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
Pediatr Res 51:228-35. 2002..3x the maximally tolerated limit... - Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatmentNidhi A Shah
Department of Pediatrics, University of California San Francisco CA, USA
J Pediatr 158:919-923.e1-2. 2011..To determine whether low platelet counts are related to the incidence of patent ductus arteriosus (PDA) after indomethacin treatment in preterm human infants... - Effects of hypoxia, hypoglycemia, and muscle shortening on cell death in the sheep ductus arteriosusSeth Goldbarg
Box 0544, HSE 1492, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143-0544, U.S.A
Pediatr Res 54:204-11. 2003..We also hypothesize that cell death in the ductus wall may involve pathways that are not dependent on caspase-3 or -7 activation... - Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor controlNahid Waleh
Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, Calif 94143 0544, USA
Circulation 110:2326-32. 2004..We explored these pathways to identify the mechanisms responsible for the increased sensitivity of the immature ductus to PGE2... - Prolonged indomethacin exposure is associated with decreased white matter injury detected with magnetic resonance imaging in premature newborns at 24 to 28 weeks' gestation at birthSteven P Miller
Department of Neurology, University of California, San Francisco, California, USA
Pediatrics 117:1626-31. 2006..Our objective was to determine the risk factors for MRI-detectable white matter injury in infants delivered before 28 weeks' gestation who were treated with prophylactic indomethacin... - Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newbornsRoberta L Keller
Department of Pediatrics, Cardiovascular Research Institute, Pharmacy, University of California San Francisco, CA 94143, USA
Pediatr Res 58:1216-21. 2005..However, the combined administration of L-NMMA and indomethacin was limited by acute side effects in this treatment protocol... - VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosusRonald I Clyman
Cardiovascular Research Institute, University of California, San Francisco, California 94143-0544, USA
Am J Physiol Regul Integr Comp Physiol 282:R199-206. 2002..05) increase in vasa vasorum ingrowth and neointima formation. We conclude that VEGF plays an important role in the formation of neointimal mounds and vasa vasorum ingrowth during permanent ductus closure... - Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trialPriya Jegatheesan
Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, California 94143 0544, USA
J Pediatr 153:183-9. 2008..We conducted a multicenter, randomized, controlled trial to determine whether higher doses of indomethacin would improve the rate of patent ductus arteriosus (PDA) closure... - Feeding practices and patent ductus arteriosus ligation preferences-are they related?Nami Jhaveri
Cardiovascular Research Institute and Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 0544, USA
Am J Perinatol 27:667-74. 2010..S. and non-U.S. neonatologists, in their reported desire to ligate infants who did not require mechanical ventilation, was no longer present... - Factors associated with permanent closure of the ductus arteriosus: a role for prolonged indomethacin therapyDolores Quinn
Cardiovascular Research Institute, Department of Pediatrics, University of California, San Francisco, California 94143-0544, USA
Pediatrics 110:e10. 2002..Other therapeutic approaches will need to be developed before permanent closure is likely to occur in this group of immature infants... - Persistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosusRoberta L Keller
Department of Pediatrics, University of California, San Francisco 94143, USA
Pediatrics 112:583-7. 2003..Additional indomethacin treatment is unlikely to produce permanent ductus closure... - Risk factors for persistent ductus arteriosus patency during indomethacin treatmentNancy Chorne
Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, California, USA
J Pediatr 151:629-34. 2007..To test the hypothesis that patent ductus arteriosus that fail to close with prostaglandin inhibition may be regulated by mechanisms that act independently of prostaglandin production... - Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatmentNami Jhaveri
Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
J Pediatr 157:381-7, 387.e1. 2010..To examine whether a more conservative approach to treating patent ductus arteriosus (PDA) is associated with an increase or decrease in morbidity compared with an approach involving early PDA ligation... - Renal effects of cyclooxygenase-2 inhibition in fetal lambsHiroki Kajino
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
Biol Neonate 82:257-62. 2002..These effects are similar to those reported for the nonselective COX-1/-2 inhibitor, indomethacin. COX-2 appears to play an important role in promoting free water excretion in the fetal lamb... - Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidityNancy Chorne
Department of Pediatrics, University of California, San Francisco, CA, USA
Pediatrics 119:1165-74. 2007.... - The role of monocyte-derived cells and inflammation in baboon ductus arteriosus remodelingNahid Waleh
Cardiovascular Research Institute, Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143-0544, USA
Pediatr Res 57:254-62. 2005..Based on these data, we conclude that the inflammatory response following postnatal ductus constriction may be as necessary for ductus remodeling as it is for atherosclerotic remodeling... - Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in miceJeff Reese
Department of Pediatrics, Vanderbilt University Medical Center, 1125 MRB IV Bldg, 2215 B Garland Avenue, Nashville, TN 37232 0656, USA
Am J Physiol Regul Integr Comp Physiol 291:R1717-1723. 2006..They are consistent with a novel role for prostaglandins in ductus arteriosus contractile development... - ATP depletion and cell death in the neonatal lamb ductus arteriosusMax Levin
Wallenberg Laboratory for Cardiovascular Research, , , Sweden
Pediatr Res 57:801-5. 2005..The increased glycolytic capacity of the immature ductus may enable it to tolerate episodes of hypoxia and nutrient shortage, making it more resistant to developing postnatal cell death and permanent closure... - Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lungDonald McCurnin
Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA
Pediatrics 121:945-56. 2008..The goal was to study the pulmonary, biochemical, and morphologic effects of a persistent patent ductus arteriosus in a preterm baboon model of bronchopulmonary dysplasia... - Postnatal constriction, ATP depletion, and cell death in the mature and immature ductus arteriosusMax Levin
Wallenberg Laboratory for Cardiovascular Rsearch, , , Sweden
Am J Physiol Regul Integr Comp Physiol 290:R359-64. 2006..This may explain its decreasing contractile response to oxygen, indomethacin, and other contractile agents with increasing postnatal age... - Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lungTiina M Asikainen
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Proc Natl Acad Sci U S A 102:10212-7. 2005..Through actions characterized above, FG-4095 could have desirable effects in enhancing lung growth in BPD... - Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivoTiina M Asikainen
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Rm. J-318, Denver, CO 80206, USA
Am J Physiol Lung Cell Mol Physiol 291:L588-95. 2006..These results indicate that HIF stimulation by PHD inhibition enhances lung angiogenesis in the primate model of BPD... - Transcriptional regulation during development of the ductus arteriosusKathryn N Ivey
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA
Circ Res 103:388-95. 2008.... - Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosusAsmaa Bouayad
FRCP C Research Center, Sainte Justine Hospital, 3175 Cote Ste Catherine, Montreal, Quebec H3T 1C5, Canada
Am J Physiol Regul Integr Comp Physiol 286:R903-9. 2004..It is concluded that PAF contributes in regulating DA tone by governing mPGES, COX-2, and ensuing PGE(2) levels in the perinate... - Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosusLing Yi Chang
Department of Medicine, University of Colorado, Denver, Colorado 80204, USA
Pediatr Res 63:299-302. 2008..In contrast with pharmacologic closure of the PDA, surgical closure failed to improve either pulmonary function or alveolar surface area in baboons with a moderate PDA shunt... - Patent ductus arteriosus: evidence for and against treatmentRonald I Clyman
J Pediatr 150:216-9. 2007 - Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurityTiina M Asikainen
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Rm. J-318, Denver, Colorado 80206, USA
FASEB J 20:1698-700. 2006..These findings indicate that HIF stimulation by PHD inhibition ameliorates pathological and physiological consequences of BPD...
Research Grants
- Vessel Remodeling During Ductus Arteriosus ClosureRonald Clyman; Fiscal Year: 2007..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..
- VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURERonald Clyman; Fiscal Year: 2004..These studies should increase our understanding of what initiates and sustains the process of ductus closure after birth and why it does not occur in the preterm infant. ..
- VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURERonald Clyman; Fiscal Year: 2000..These studies should increase our understanding of what initiates and sustains the process of ductus remodeling after birth and why it does not occur in the preterm infant. ..
- VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURERonald Clyman; Fiscal Year: 1993....
- Vessel Remodeling During Ductus Arteriosus ClosureRonald I Clyman; Fiscal Year: 2010..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..