Ronald Clyman

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Mechanisms regulating the ductus arteriosus
    Ronald I Clyman
    School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, Calif, USA
    Biol Neonate 89:330-5. 2006
  2. pmc Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones
    Ronald I Clyman
    Department of Pediatric, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA Electronic address
    J Pediatr 164:1449-55.e1. 2014
  3. pmc Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus
    Ronald Clyman
    Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 0544, USA
    J Pediatr 163:406-11. 2013
  4. pmc The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia
    Ronald I Clyman
    Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
    Semin Perinatol 37:102-7. 2013
  5. pmc Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?
    Ronald I Clyman
    Department of Pediatrics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Semin Perinatol 36:123-9. 2012
  6. pmc Indomethacin prophylaxis for preterm infants: the impact of 2 multicentered randomized controlled trials on clinical practice
    Ronald I Clyman
    Cardiovascular Research Institute and Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 0544, USA
    J Pediatr 150:46-50.e2. 2007
  7. ncbi request reprint The effects of caffeine on the preterm sheep ductus arteriosus
    Ronald I Clyman
    Cardiovascular Research Institute and Department of Pediatrics, University of California San Francisco, San Francisco, California 94143, USA
    Pediatr Res 62:167-9. 2007
  8. ncbi request reprint Calcium-dependent and calcium-sensitizing pathways in the mature and immature ductus arteriosus
    Ronald I Clyman
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, 513 Parnassus Ave, Rm 1408 HSW, UCSF Box 0544, San Francisco, CA 94143 0544, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1650-6. 2007
  9. pmc The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trial
    Ronald Clyman
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
    J Pediatr 154:873-6. 2009
  10. pmc Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment
    Nidhi A Shah
    Department of Pediatrics, University of California San Francisco CA, USA
    J Pediatr 158:919-923.e1-2. 2011

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Mechanisms regulating the ductus arteriosus
    Ronald I Clyman
    School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, Calif, USA
    Biol Neonate 89:330-5. 2006
    ..In this review, comparative physiology between the full term and preterm newborn and the barriers preventing the necessary cascade of events leading to permanent constriction of the PDA are reviewed...
  2. pmc Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones
    Ronald I Clyman
    Department of Pediatric, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA Electronic address
    J Pediatr 164:1449-55.e1. 2014
    ..To test the hypothesis that an impaired adrenal response to stress might play a role in the hypotension that follows patent ductus arteriosus (PDA) ligation...
  3. pmc Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus
    Ronald Clyman
    Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 0544, USA
    J Pediatr 163:406-11. 2013
    ....
  4. pmc The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia
    Ronald I Clyman
    Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
    Semin Perinatol 37:102-7. 2013
    ....
  5. pmc Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?
    Ronald I Clyman
    Department of Pediatrics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Semin Perinatol 36:123-9. 2012
    ..By contrast, ductus ligation, while eliminating the detrimental effects of a PDA on lung development, may create its own set of morbidities that counteract many of the benefits derived from ductus closure...
  6. pmc Indomethacin prophylaxis for preterm infants: the impact of 2 multicentered randomized controlled trials on clinical practice
    Ronald I Clyman
    Cardiovascular Research Institute and Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 0544, USA
    J Pediatr 150:46-50.e2. 2007
    ..The TIPP trial failed to find a benefit in its primary outcome (improved survival/neurodevelopmental outcome); this negative result may have discouraged indomethacin prophylaxis use...
  7. ncbi request reprint The effects of caffeine on the preterm sheep ductus arteriosus
    Ronald I Clyman
    Cardiovascular Research Institute and Department of Pediatrics, University of California San Francisco, San Francisco, California 94143, USA
    Pediatr Res 62:167-9. 2007
    ..In conclusion, we found no evidence of a direct effect of therapeutic caffeine concentrations on ductus contractility...
  8. ncbi request reprint Calcium-dependent and calcium-sensitizing pathways in the mature and immature ductus arteriosus
    Ronald I Clyman
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, 513 Parnassus Ave, Rm 1408 HSW, UCSF Box 0544, San Francisco, CA 94143 0544, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1650-6. 2007
    ..Stimulation of Ca(2+) entry through reverse-mode Na(+)/Ca(2+) exchange or CPA-induced SOC channel activity constrict the DA and eliminate differences between immature and mature DA during both hypoxia and normoxia...
  9. pmc The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trial
    Ronald Clyman
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
    J Pediatr 154:873-6. 2009
    ..To reexamine data from a randomized controlled trial of prophylactic ductus ligation to determine whether ligation contributes directly to the development of bronchopulmonary dysplasia (BPD) in extremely low birth weight infants...
  10. pmc Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment
    Nidhi A Shah
    Department of Pediatrics, University of California San Francisco CA, USA
    J Pediatr 158:919-923.e1-2. 2011
    ..To determine whether low platelet counts are related to the incidence of patent ductus arteriosus (PDA) after indomethacin treatment in preterm human infants...
  11. ncbi request reprint In utero indomethacin alters O2 delivery to the fetal ductus arteriosus: implications for postnatal patency
    Seth H Goldbarg
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0544, USA
    Am J Physiol Regul Integr Comp Physiol 282:R184-90. 2002
    ..These findings suggest that the hypoxic cell death that occurs during the early stages of indomethacin-induced constriction is primarily due to changes in vasa vasorum blood flow and muscle media thickness...
  12. ncbi request reprint Vasa vasorum hypoperfusion is responsible for medial hypoxia and anatomic remodeling in the newborn lamb ductus arteriosus
    Hiroki Kajino
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Pediatr Res 51:228-35. 2002
    ..3x the maximally tolerated limit...
  13. ncbi request reprint VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus
    Ronald I Clyman
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0544, USA
    Am J Physiol Regul Integr Comp Physiol 282:R199-206. 2002
    ..05) increase in vasa vasorum ingrowth and neointima formation. We conclude that VEGF plays an important role in the formation of neointimal mounds and vasa vasorum ingrowth during permanent ductus closure...
  14. ncbi request reprint Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns
    Roberta L Keller
    Department of Pediatrics, Cardiovascular Research Institute, Pharmacy, University of California San Francisco, CA 94143, USA
    Pediatr Res 58:1216-21. 2005
    ..However, the combined administration of L-NMMA and indomethacin was limited by acute side effects in this treatment protocol...
  15. ncbi request reprint Prolonged indomethacin exposure is associated with decreased white matter injury detected with magnetic resonance imaging in premature newborns at 24 to 28 weeks' gestation at birth
    Steven P Miller
    Department of Neurology, University of California, San Francisco, California, USA
    Pediatrics 117:1626-31. 2006
    ..Our objective was to determine the risk factors for MRI-detectable white matter injury in infants delivered before 28 weeks' gestation who were treated with prophylactic indomethacin...
  16. ncbi request reprint Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control
    Nahid Waleh
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, San Francisco, Calif 94143 0544, USA
    Circulation 110:2326-32. 2004
    ..We explored these pathways to identify the mechanisms responsible for the increased sensitivity of the immature ductus to PGE2...
  17. ncbi request reprint Effects of hypoxia, hypoglycemia, and muscle shortening on cell death in the sheep ductus arteriosus
    Seth Goldbarg
    Box 0544, HSE 1492, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0544, U S A
    Pediatr Res 54:204-11. 2003
    ..We also hypothesize that cell death in the ductus wall may involve pathways that are not dependent on caspase-3 or -7 activation...
  18. doi request reprint Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial
    Priya Jegatheesan
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, California 94143 0544, USA
    J Pediatr 153:183-9. 2008
    ..We conducted a multicenter, randomized, controlled trial to determine whether higher doses of indomethacin would improve the rate of patent ductus arteriosus (PDA) closure...
  19. ncbi request reprint Factors associated with permanent closure of the ductus arteriosus: a role for prolonged indomethacin therapy
    Dolores Quinn
    Cardiovascular Research Institute, Department of Pediatrics, University of California, San Francisco, California 94143 0544, USA
    Pediatrics 110:e10. 2002
    ..We hypothesized that infants who received additional doses of indomethacin after the standard 3-dose course might develop an even tighter degree of ductus constriction and increase their chance of developing permanent closure...
  20. doi request reprint Feeding practices and patent ductus arteriosus ligation preferences-are they related?
    Nami Jhaveri
    Cardiovascular Research Institute and Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 0544, USA
    Am J Perinatol 27:667-74. 2010
    ..S. and non-U.S. neonatologists, in their reported desire to ligate infants who did not require mechanical ventilation, was no longer present...
  21. ncbi request reprint Persistent Doppler flow predicts lack of response to multiple courses of indomethacin in premature infants with recurrent patent ductus arteriosus
    Roberta L Keller
    Department of Pediatrics, University of California, San Francisco 94143, USA
    Pediatrics 112:583-7. 2003
    ..The objective of this study was to determine the rate of permanent ductus closure after a second course of indomethacin for a recurrent, symptomatic PDA and to identify the factors associated with permanent ductus closure...
  22. ncbi request reprint Risk factors for persistent ductus arteriosus patency during indomethacin treatment
    Nancy Chorne
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, California, USA
    J Pediatr 151:629-34. 2007
    ..To test the hypothesis that patent ductus arteriosus that fail to close with prostaglandin inhibition may be regulated by mechanisms that act independently of prostaglandin production...
  23. pmc Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatment
    Nami Jhaveri
    Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
    J Pediatr 157:381-7, 387.e1. 2010
    ..To examine whether a more conservative approach to treating patent ductus arteriosus (PDA) is associated with an increase or decrease in morbidity compared with an approach involving early PDA ligation...
  24. ncbi request reprint Renal effects of cyclooxygenase-2 inhibition in fetal lambs
    Hiroki Kajino
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Biol Neonate 82:257-62. 2002
    ..These effects are similar to those reported for the nonselective COX-1/-2 inhibitor, indomethacin. COX-2 appears to play an important role in promoting free water excretion in the fetal lamb...
  25. ncbi request reprint Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity
    Nancy Chorne
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Pediatrics 119:1165-74. 2007
    ....
  26. ncbi request reprint The role of monocyte-derived cells and inflammation in baboon ductus arteriosus remodeling
    Nahid Waleh
    Cardiovascular Research Institute, Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143 0544, USA
    Pediatr Res 57:254-62. 2005
    ..Based on these data, we conclude that the inflammatory response following postnatal ductus constriction may be as necessary for ductus remodeling as it is for atherosclerotic remodeling...
  27. ncbi request reprint Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung
    Donald McCurnin
    Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA
    Pediatrics 121:945-56. 2008
    ..The goal was to study the pulmonary, biochemical, and morphologic effects of a persistent patent ductus arteriosus in a preterm baboon model of bronchopulmonary dysplasia...
  28. ncbi request reprint Postnatal constriction, ATP depletion, and cell death in the mature and immature ductus arteriosus
    Max Levin
    Wallenberg Laboratory for Cardiovascular Rsearch, Goteborg University, Goteborg, Sweden
    Am J Physiol Regul Integr Comp Physiol 290:R359-64. 2006
    ..This may explain its decreasing contractile response to oxygen, indomethacin, and other contractile agents with increasing postnatal age...
  29. pmc Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice
    Jeff Reese
    Department of Pediatrics, Vanderbilt University Medical Center, 1125 MRB IV Bldg, 2215 B Garland Avenue, Nashville, TN 37232 0656, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1717-1723. 2006
    ..They are consistent with a novel role for prostaglandins in ductus arteriosus contractile development...
  30. ncbi request reprint ATP depletion and cell death in the neonatal lamb ductus arteriosus
    Max Levin
    Wallenberg Laboratory for Cardiovascular Research, Goteborg University, SE 413 45 Goteborg, Sweden
    Pediatr Res 57:801-5. 2005
    ..The increased glycolytic capacity of the immature ductus may enable it to tolerate episodes of hypoxia and nutrient shortage, making it more resistant to developing postnatal cell death and permanent closure...
  31. ncbi request reprint Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus
    Ling Yi Chang
    Department of Medicine, University of Colorado, Denver, Colorado 80204, USA
    Pediatr Res 63:299-302. 2008
    ..In contrast with pharmacologic closure of the PDA, surgical closure failed to improve either pulmonary function or alveolar surface area in baboons with a moderate PDA shunt...
  32. ncbi request reprint Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Rm J 318, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 291:L588-95. 2006
    ..These results indicate that HIF stimulation by PHD inhibition enhances lung angiogenesis in the primate model of BPD...
  33. ncbi request reprint Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Rm J 318, Denver, Colorado 80206, USA
    FASEB J 20:1698-700. 2006
    ..These findings indicate that HIF stimulation by PHD inhibition ameliorates pathological and physiological consequences of BPD...
  34. pmc Patent ductus arteriosus: evidence for and against treatment
    Ronald I Clyman
    J Pediatr 150:216-9. 2007
  35. ncbi request reprint Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus
    Asmaa Bouayad
    FRCP C Research Center, Sainte Justine Hospital, 3175 Cote Ste Catherine, Montreal, Quebec H3T 1C5, Canada
    Am J Physiol Regul Integr Comp Physiol 286:R903-9. 2004
    ..It is concluded that PAF contributes in regulating DA tone by governing mPGES, COX-2, and ensuing PGE(2) levels in the perinate...
  36. pmc Transcriptional regulation during development of the ductus arteriosus
    Kathryn N Ivey
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA
    Circ Res 103:388-95. 2008
    ....
  37. pmc Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung
    Tiina M Asikainen
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 102:10212-7. 2005
    ..Through actions characterized above, FG-4095 could have desirable effects in enhancing lung growth in BPD...

Research Grants16

  1. Vessel Remodeling During Ductus Arteriosus Closure
    Ronald Clyman; Fiscal Year: 2009
    ..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..
  2. Vessel Remodeling During Ductus Arteriosus Closure
    Ronald Clyman; Fiscal Year: 2007
    ..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..
  3. VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURE
    Ronald Clyman; Fiscal Year: 2004
    ..These studies should increase our understanding of what initiates and sustains the process of ductus closure after birth and why it does not occur in the preterm infant. ..
  4. VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURE
    Ronald Clyman; Fiscal Year: 2003
    ..These studies should increase our understanding of what initiates and sustains the process of ductus closure after birth and why it does not occur in the preterm infant. ..
  5. VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURE
    Ronald Clyman; Fiscal Year: 2002
    ..These studies should increase our understanding of what initiates and sustains the process of ductus closure after birth and why it does not occur in the preterm infant. ..
  6. VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURE
    Ronald Clyman; Fiscal Year: 2001
    ..These studies should increase our understanding of what initiates and sustains the process of ductus closure after birth and why it does not occur in the preterm infant. ..
  7. VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURE
    Ronald Clyman; Fiscal Year: 2000
    ..These studies should increase our understanding of what initiates and sustains the process of ductus remodeling after birth and why it does not occur in the preterm infant. ..
  8. VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURE
    Ronald Clyman; Fiscal Year: 1993
    ....
  9. VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURE
    Ronald Clyman; Fiscal Year: 1992
    ....
  10. VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURE
    Ronald Clyman; Fiscal Year: 1999
    ..These studies should increase our understanding of what initiates and sustains the process of ductus remodeling after birth and why it does not occur in the preterm infant. ..
  11. Vessel Remodeling During Ductus Arteriosus Closure
    Ronald I Clyman; Fiscal Year: 2010
    ..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..