Research Topics
Species | Sarah ClintonSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophreniaSarah M Clinton
Department of Psychiatry and Mental Health Research Institute, Universiyt of Michgan medical School, MI 48109 0720, USA
Am J Psychiatry 160:1100-9. 2003..They hypothesized that this reduction is associated with specific NR(1) isoforms and that NMDA receptor-related postsynaptic density proteins are abnormally expressed...
Individual differences in novelty-seeking and emotional reactivity correlate with variation in maternal behaviorSarah M Clinton
Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Horm Behav 51:655-64. 2007..Future work should explore neural and hormonal mechanisms which drive these HR-LR differences in maternal behavior and their impact on the development of the offspring...- Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivitySarah Clinton
Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Psychoneuroendocrinology 33:162-77. 2008..Future work will explore neural mechanisms which underlie the different behavioral and neuroendocrine consequences of PS in HR versus LR animals... - Schizophrenia as a disorder of neuroplasticityRobert E McCullumsmith
Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Int Rev Neurobiol 59:19-45. 2004..We suggest that schizophrenia can be considered a disorder of plasticity, associated with molecular abnormalities of the glutamate synapse... - Effects of a selectively bred novelty-seeking phenotype on the motivation to take cocaine in male and female ratsJennifer A Cummings
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
Biol Sex Differ 2:3. 2011..abstract:.. - Neural and environmental factors impacting maternal behavior differences in high- versus low-novelty-seeking ratsSarah M Clinton
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA
Horm Behav 57:463-73. 2010..Overall these studies shed light on the interplay between the genetics of mothers and infants in driving differences in maternal style... - Up-regulation of NMDA receptor subunit and post-synaptic density protein expression in the thalamus of elderly patients with schizophreniaSarah M Clinton
Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, 48109, USA
J Neurochem 98:1114-25. 2006..Further, these findings provide additional evidence of NMDA receptor alterations in schizophrenia, which may play an important role in the neurobiology of the illness... - Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: involvement of the intracellular signal integrating proteins calcyon and spinophilinSarah M Clinton
Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Am J Psychiatry 162:1859-71. 2005..In this study, the authors studied this question by measuring in postmortem brain the expression of molecules associated with dopaminergic neurotransmission... - Thalamic dysfunction in schizophrenia: neurochemical, neuropathological, and in vivo imaging abnormalitiesSarah M Clinton
Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Schizophr Res 69:237-53. 2004..We review these neurochemical findings, as well as the growing body of postmortem and in vivo imaging evidence that supports the hypothesis of thalamic dysfunction in schizophrenia... - Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar DisorderSarah M Clinton
Department of Psychiatry, Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109 0720, USA
Neuropsychopharmacology 29:1353-62. 2004.... - The effects of novelty-seeking phenotypes and sex differences on acquisition of cocaine self-administration in selectively bred High-Responder and Low-Responder ratsBrooke A Davis
Molecular and Behavioral Neuroscience Institute, University of Michigan, MI 48109, United States
Pharmacol Biochem Behav 90:331-8. 2008..In conclusion, female rats, like males, exhibit HR-LR phenotypes that predict rapidity of acquiring cocaine self-administration. Moreover, HR females self-administer more cocaine than HR males and both LR groups... - Effect of cocaine on Fas-associated protein with death domain in the rat brain: individual differences in a model of differential vulnerability to drug abuseMaría Julia García-Fuster
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
Neuropsychopharmacology 34:1123-34. 2009..Interestingly, animals selectively bred for differential propensity to substance abuse show basal differences in the expression of this protein, suggesting FADD may also be a molecular correlate for the HR/LR phenotype... - Neonatal FGF2 alters cocaine self-administration in the adult ratCortney A Turner
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
Pharmacol Biochem Behav 92:100-4. 2009..Thus, FGF2 may be an antecedent of vulnerability for drug-taking behavior and may provide clues to novel therapeutic approaches for the treatment of addiction... - A new role for FGF2 as an endogenous inhibitor of anxietyJAVIER A PEREZ
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 29:6379-87. 2009.... - An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addictionShelly B Flagel
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
Neuropsychopharmacology 35:388-400. 2010.... - Molecular abnormalities of the glutamate synapse in the thalamus in schizophreniaJames H Meador-Woodruff
Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
Ann N Y Acad Sci 1003:75-93. 2003..Our data suggest that schizophrenia is associated with abnormal glutamate receptor-related intracellular signaling in the thalamus, and point to novel targets for innovative drug discovery... - Cocaine interacts with the novelty-seeking trait to modulate FGFR1 gene expression in the ratCortney A Turner
Molecular and Behavioral Neuroscience Institute, 205 Zina Pitcher Place, University of Michigan, Ann Arbor, MI 48109, USA
Neurosci Lett 446:105-7. 2008..These results suggest that cocaine interacts with the novelty-seeking trait to alter gene expression. Thus, the FGF system may contribute to individual differences in the response to drugs of abuse...