Research Topics
Genomes and GenesSpecies | Mario A ClevesSummaryAffiliation: University of Arkansas for Medical Sciences Country: USA Publications
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Publications
Association between selected folate pathway polymorphisms and nonsyndromic limb reduction defects: a case-parental analysisMario A Cleves
Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, and Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
Paediatr Perinat Epidemiol 25:124-34. 2011....
Maternal urinary tract infections and selected cardiovascular malformationsMario A Cleves
Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, and Arkansas Children s Hospital, Little Rock, Arkansas 72202, USA
Birth Defects Res A Clin Mol Teratol 82:464-73. 2008..In a population-based case-control study, we investigated the association between congenital cardiovascular malformations (CVMs) and maternal urinary tract infections (UTIs)...
Congenital defects among liveborn infants with Down syndromeMario A Cleves
Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, and Arkansas Children s Hospital, Little Rock, Arkansas 72202, USA
Birth Defects Res A Clin Mol Teratol 79:657-63. 2007..This article uses a unique national hospital discharge dataset to identify the rate at which structural birth defects are identified among liveborn infants with DS...- Folic acid use by women receiving routine gynecologic careMario A Cleves
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock, Arkansas 72202 3591, USA
Obstet Gynecol 103:746-53. 2004..Many health professional groups recommend folic acid supplementation for all women able to become pregnant. In this study, we document folic acid supplement use among a sample of women receiving routine gynecologic care... - First-year survival of infants born with congenital heart defects in Arkansas (1993-1998): a survival analysis using registry dataMario A Cleves
Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, College of Medicine, Arkansas Children s Hospital, Little Rock, Arkansas 72211, USA
Birth Defects Res A Clin Mol Teratol 67:662-8. 2003..Congenital heart defects (CHDs) are among the most prevalent and fatal of all birth defects. Here we report the survival probability of infants born with CHDs in Arkansas and examine the impact of multiple malformations on survival... - Congenital heart defects and maternal biomarkers of oxidative stressCharlotte A Hobbs
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72211, USA
Am J Clin Nutr 82:598-604. 2005.... - Associations between maternal genotypes and metabolites implicated in congenital heart defectsShimul Chowdhury
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 13 Children s Way, Slot 512, Little Rock, AR 72202, USA
Mol Genet Metab 107:596-604. 2012..Previous studies have implicated maternal single nucleotide polymorphisms (SNPs) and altered metabolism in folate-related pathways as CHD risk factors... - Cluster analysis of women's prodromal and acute myocardial infarction symptoms by race and other characteristicsJean C McSweeney
College of Nursing, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Cardiovasc Nurs 25:311-22. 2010.... - Maternal folate-related gene environment interactions and congenital heart defectsCharlotte A Hobbs
Department of Pediatrics, Birth Defects Research Section, Arkansas Children s Hospital Research Institute, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, Arkansas, USA
Obstet Gynecol 116:316-22. 2010..To investigate whether women with congenital heart defect (CHD)-affected pregnancies were more likely to have functional single-nucleotide polymorphisms in genes encoding enzymes in folate-dependent pathways... - Association between congenital heart defects and small for gestational ageSadia Malik
Arkansas Center for Birth Defects Research and Prevention, Little Rock, AR, USA
Pediatrics 119:e976-82. 2007.... - A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autismS Jill James
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
Am J Med Genet B Neuropsychiatr Genet 153:1209-20. 2010..Together, these results suggest that the maternal genetics/epigenetics may influence fetal predisposition to autism... - Neural tube defects and maternal biomarkers of folate, homocysteine, and glutathione metabolismWeizhi Zhao
Section of Birth Defects Research, Department of Pediatrics, Arkansas Children's Hospital Research Institute, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, 72211, USA
Birth Defects Res A Clin Mol Teratol 76:230-6. 2006..Further analysis of relevant genetic and environmental factors is required to define the basis for these observed alterations... - Maternal smoking and congenital heart defectsSadia Malik
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, 1120 Marshall St, Little Rock, AR 72202, USA
Pediatrics 121:e810-6. 2008..In a population-based case-control study, we investigated the association between congenital heart defects and maternal smoking... - Congenital heart defects and maternal genetic, metabolic, and lifestyle factorsCharlotte A Hobbs
University of Arkansas for Medical Sciences, College of Medicine, Department of Pediatrics, Arkansas Children s Hospital Research Institute, Little Rock, AR, USA
Birth Defects Res A Clin Mol Teratol 91:195-203. 2011..The purpose of this study was to identify metabolic, genetic, and lifestyle factors that discriminate between women who have pregnancies affected by congenital heart defects (CHDs) from those who have unaffected pregnancies... - Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene: evaluating gene-environment interactionsCharlotte A Hobbs
Department of Pediatrics, Arkansas Children s Hospital Research Institute, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, AR, USA
Am J Obstet Gynecol 194:218-24. 2006..This study was undertaken to investigate the association between congenital heart defects (CHD), and maternal homocysteine, smoking, and the MTHFR 677 C>T polymorphism... - Randomized trial of a physician-based intervention to increase the use of folic acid supplements among womenJames M Robbins
Department of Pediatrics, Arkansas Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences College of Medicine, and Arkansas Children's Hospital, Little Rock, AR, USA
Am J Obstet Gynecol 192:1126-32. 2005..CONCLUSION: With little effort expended to encourage folic acid use, gynecologists could potentially reduce the risk of folate-preventable birth defects among their patients by as much as 11%... - Neural tube defects and maternal folate intake among pregnancies conceived after folic acid fortification in the United StatesBridget S Mosley
Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
Am J Epidemiol 169:9-17. 2009..Further investigation is warranted to possibly identify women who remain at increased risk of preventable neural tube defects... - Reduction in newborns with discharge coding of in utero alcohol effects in the United States, 1993 to 2002James M Robbins
Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
Arch Pediatr Adolesc Med 160:1224-31. 2006.... - Doppler tissue imaging and catheter-derived measures are not independent predictors of rejection in pediatric heart transplant recipientsRitu Sachdeva
Department of Pediatrics, Division of Pediatric Cardiology, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock, AR, USA
Int J Cardiovasc Imaging 27:947-54. 2011..None of these measures can replace the current practice of performing cardiac biopsy for surveillance of rejection... - Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolismCharlotte A Hobbs
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, AR 72211, USA
Am J Clin Nutr 81:147-53. 2005..It is well established that folic acid prevents neural tube defects. Although the mechanisms remain unclear, multivitamins containing folic acid may also protect against other birth defects, including congenital heart defects... - Demographic and environmental risk factors for gastroschisis and omphalocele in the National Birth Defects Prevention StudyT Mac Bird
Department of Pediatrics, Center for Applied Research and Evaluation, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72202 3591, USA
J Pediatr Surg 44:1546-51. 2009.... - Hospitalizations of newborns with folate-sensitive birth defects before and after fortification of foods with folic acidJames M Robbins
Arkansas Center for Birth Defects Research and Prevention, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
Pediatrics 118:906-15. 2006..Since 1998, grain products in the United States have been fortified with folic acid. Fortification may have additional benefits by reducing the national prevalence of newborn hospitalizations for other folate-sensitive birth defects... - Maternal DNA hypomethylation and congenital heart defectsShimul Chowdhury
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 13 Children s Way, Little Rock, AR 72202, USA
Birth Defects Res A Clin Mol Teratol 91:69-76. 2011.... - Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autismS Jill James
Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
Am J Med Genet B Neuropsychiatr Genet 141:947-56. 2006..We propose that an increased vulnerability to oxidative stress (endogenous or environmental) may contribute to the development and clinical manifestations of autism... - National rates of birth defects among hospitalized newbornsT M Bird
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
Birth Defects Res A Clin Mol Teratol 76:762-9. 2006..HCUP data can be used to examine the impact of public health efforts on the number of infants born with birth defects as well as the cost and consequences of variations in the hospital management of birth defects... - Interhospital transport of children requiring extracorporeal membrane oxygenation support for cardiac dysfunctionAntonio G Cabrera
Department of Pediatrics, The Lillie Frank Abercrombie Section of Pediatric Cardiology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
Congenit Heart Dis 6:202-8. 2011.... - Congenital malformations among liveborn infants with trisomies 18 and 13Stephen J Pont
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Med Genet A 140:1749-56. 2006..More than half of the newborns with both conditions died prior to discharge. This updated information can be used to inform clinical decision-making and may help providers better prepare families for infants with trisomies... - Long-term survival of inflatable penile prostheses: single surgical group experience with 2,384 first-time implants spanning two decadesSteven K Wilson
Department of Urology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
J Sex Med 4:1074-9. 2007..We conducted a historical prospective study to estimate 10 and 15 years survival of first time (virgin) implantations in 2,384 patients with four different models... - Maternal genome-wide DNA methylation patterns and congenital heart defectsShimul Chowdhury
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, United States of America
PLoS ONE 6:e16506. 2011..Our results suggest that further studies involving maternal epigenetic patterns and CHDs are warranted. Multiple candidate processes and pathways for future study have been identified... - Regional bias in birth defect prevalence rates for Arkansas: influence of incomplete ascertainment along surveillance system bordersBridget S Mosley
Arkansas Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 11219 Financial Center Parkway, Suite 250, Little Rock, AR 72211, USA
Teratology 66:S36-40. 2002..As part of the continuing evaluation of the Arkansas Reproductive Health Monitoring System (ARHMS), we assessed the effects on birth defect prevalence rates introduced by incomplete case ascertainment along surveillance boundaries... - Awareness and use of folic acid among women in the lower Mississippi DeltaJames M Robbins
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
J Rural Health 22:196-203. 2006..National and state efforts to increase folic acid awareness and use may not be reaching large segments of the population... - Preferential transmission of the MTHFR 677 T allele to infants with Down syndrome: implications for a survival advantageCharlotte A Hobbs
Arkansas Center for Birth Defects Research and Prevention, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Am J Med Genet 113:9-14. 2002..Published 2002 Wiley-Liss, Inc... - Trends in hospital discharge disposition for elderly patients with infective endocarditis: 1993 to 2003Priya Mendiratta
Donald W Reynolds Institute on Aging, Department of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
J Am Geriatr Soc 57:877-81. 2009..To examine hospital discharges of elderly patients hospitalized with infective endocarditis (IE)... - Health state preference scores of children with spina bifida and their caregiversJohn M Tilford
Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock, AR 72202 3591, USA
Qual Life Res 14:1087-98. 2005..A more modest association was found for caregiver health preference scores by lesion location. The findings can inform cost-effectiveness evaluations of interventions to treat or prevent spina bifida... - Infection reduction using antibiotic-coated inflatable penile prosthesisSteven K Wilson
University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Urology 70:337-40. 2007..American Medical Systems recently introduced an IPP with a coating of minocycline HCL and rifampin (InhibiZone). We report our experience with this coating and compare the rate of infection with our historical rate... - Air displacement plethysmography, dual-energy X-ray absorptiometry, and total body water to evaluate body composition in preschool-age childrenTina A Crook
epartment of Pediatrics, University of Arkansas for Medical Sciences, 15 Children s Way, Little Rock, AR 72202, USA
J Acad Nutr Diet 112:1993-8. 2012..Compared with D(2)O, ADP does not accurately assess percent fat mass in children aged 3 to 5 years. Thus, D(2)O, DXA, or quantitative nuclear magnetic resonance may be considered better options for assessing fat mass in young children... - Maternal use of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs), and muscular ventricular septal defectsMario A Cleves
Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Arkansas Center for Birth Defects Research and Prevention, 11219 Financial Centre Parkway, Little Rock, AR 72211, USA
Birth Defects Res A Clin Mol Teratol 70:107-13. 2004..CONCLUSIONS: Significant associations were not detected between the occurrence of mVSDs and maternal use of NSAIDs or acetaminophen adjusting for maternal fever, nor were they detected between maternal fever and mVSDs... - Racial differences in women's prodromal and acute symptoms of myocardial infarctionJean C McSweeney
University of Arkansas for Medical Sciences, Little Rock, 72205, USA
Am J Crit Care 19:63-73. 2010..A lack of knowledge of minority women's symptoms of coronary heart disease may contribute to these disparities... - Developmental status of 1-year-old infants fed breast milk, cow's milk formula, or soy formulaAline Andres
Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
Pediatrics 129:1134-40. 2012..This study characterized developmental status (mental, motor, and language) of breastfed (BF), milk-based formula-fed (MF), or soy protein-based formula-fed (SF) infants during the first year of life... - A survey of patients with inflatable penile prostheses: assessment of timing and frequency of intercourse and analysis of implant durabilityGerard D Henry
Regional Urology, Shreveport, LA, USA
J Sex Med 9:1715-21. 2012..We also examined survival-related factors for the AMS 700 CX, Mentor Alpha 1, and Mentor Alpha Narrow Base... - Genetic epidemiology and congenital malformations: from the chromosome to the cribCharlotte A Hobbs
Department of Pediatrics, Center for Birth Defects Research and Prevention, University of Arkansas for Medical Sciences, 11219 Financial Centre Pkwy, Suite 250, Little Rock, AR 72211, USA
Arch Pediatr Adolesc Med 156:315-20. 2002 - Tramadol HCL has promise in on-demand use to treat premature ejaculationEmad A Salem
Department of Urology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
J Sex Med 5:188-93. 2008..Premature ejaculation (PE) is a worldwide problem without an approved treatment. Selective serotonin reuptake inhibitors (SSRIs) are widely used "off label" as pharmacotherapeutic agents in the treatment of PE... - Tricuspid annular and septal Doppler tissue velocities are reduced in pediatric heart transplant recipients without acute rejectionRitu Sachdeva
Department of Pediatrics, Division of Pediatric Cardiology, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
J Am Soc Echocardiogr 21:720-4. 2008..We sought to determine any differences between myocardial velocities in healthy children and pediatric heart transplant recipients without acute allograft rejection and to study the clinical factors that could alter these velocities... - An empirical basis for standardizing adherence measures derived from administrative claims data among diabetic patientsSudeep Karve
Division of Pharmaceutical Evaluation and Policy, Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7122, USA
Med Care 46:1125-33. 2008.... - Physician risk attitudes and hospitalization of infants with bronchiolitisRonald L Baldwin
Department of Pediatrics, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, 800 Marshall Street, Little Rock, AR 72202, USA
Acad Emerg Med 12:142-6. 2005..To determine whether the risk attitudes of pediatric emergency physicians are related to the likelihood that otherwise healthy infants with bronchiolitis will be admitted for inpatient care... - Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesityMartin J J Ronis
Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas
Physiol Genomics 45:351-66. 2013..05) and had reduced serum triglycerides, leptin, and adiponectin relative to WT-HFD mice (P < 0.05). These data suggest that NOX2 is an important regulator of metabolic homeostasis and diet-induced obesity... - Maternal homocysteine and congenital heart defectsCharlotte A Hobbs
J Am Coll Cardiol 47:683-5. 2006 - Diabetes mellitus and birth defectsAdolfo Correa
Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Obstet Gynecol 199:237.e1-9. 2008..The purpose of this study was to examine associations between diabetes mellitus and 39 birth defects... - Management of hypoplastic left heart syndromeJohn M Tilford
Pediatrics 113:431-2; author reply 431-2. 2004 - NKX2.5 and congenital heart defects: A population-based studyCharlotte A Hobbs
Am J Med Genet A 134:223-5. 2005 - The mentor Alpha 1 penile prosthesis with reservoir lock-out valve: effective prevention of auto-inflation with improved capability for ectopic reservoir placementSteven K Wilson
Southwest Impotence Center, Van Buren, Arkansas, USA
J Urol 168:1475-8. 2002..In patients with a scarred retropubic space the lock-out valve offers the penile implant surgeon a decreased probability of auto-inflation with ectopic reservoir placement... - A survey of patients with inflatable penile prostheses for satisfactionMary Jo Brinkman
University of Arkansas, Fayetteville, USA
J Urol 174:253-7. 2005..We assessed patient satisfaction with 3 types of penile prostheses, namely the AMS 700 Series(R), Mentor Alpha 1(R) and Mentor Alpha NB(R)... - Management of hypoplastic left heart syndromeJohn M Tilford
Pediatrics 112:1210-1; author reply 1210-1. 2003