Charles V Clevenger

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Prolactin as an autocrine/paracrine factor in breast tissue
    C V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Mammary Gland Biol Neoplasia 2:59-68. 1997
  2. pmc Roles and regulation of stat family transcription factors in human breast cancer
    Charles V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 513 SC Labs, 422 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Pathol 165:1449-60. 2004
  3. pmc Nuclear localization and function of polypeptide ligands and their receptors: a new paradigm for hormone specificity within the mammary gland?
    Charles V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Breast Cancer Res 5:181-7. 2003
  4. pmc The role of prolactin in mammary carcinoma
    Charles V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocr Rev 24:1-27. 2003
  5. ncbi Prolactin receptor signal transduction
    C V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19066, USA
    Lupus 10:706-18. 2001
  6. ncbi A novel and functional interaction between cyclophilin A and prolactin receptor
    Farhat Syed
    Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Endocrine 20:83-90. 2003
  7. ncbi Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor
    Sommer L Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 19:939-49. 2005
  8. ncbi Characterization of a novel and functional human prolactin receptor isoform (deltaS1PRLr) containing only one extracellular fibronectin-like domain
    J Bradford Kline
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 16:2310-22. 2002
  9. doi Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2
    Gayathri Swaminathan
    Department of Animal Biology and Mari Lowe Center for Comparative Oncology Research Cell, University of Pennsylvania, 380 S University Avenue, Philadelphia, Pennsylvania 19104, USA
    J Endocrinol 196:R1-7. 2008
  10. pmc The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer
    Michael A Rycyzyn
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:6790-5. 2002

Collaborators

  • Vincent Goffin
  • Susan E Hankinson
  • Serge Y Fuchs
  • Virginia A LiVolsi
  • Farhat Syed
  • Feng Fang
  • Linda Schuler
  • A D Everett
  • Gayathri Swaminathan
  • Michael A Rycyzyn
  • Kevin McHale
  • Siang Yo Lin
  • Elizabeth M Jablonski
  • Camille Keeler
  • Samantha L Gadd
  • Sommer L Miller
  • J Bradford Kline
  • Christopher J Carbone
  • K G Suresh Kumar
  • Ragunath Puthiyaveettil
  • Pravin J Mishra
  • John Glod
  • Jun Yang
  • Barton Kamen
  • Debabrata Banerjee
  • Chellappagounder Thangavel
  • Mythili Koneru
  • Alexander Plotnikov
  • Stuart J Frank
  • Bentley Varghese
  • John E Tomaszewski
  • Luqin Deng
  • Michael E Hodsdon
  • David G Myszka
  • Branden D Taylor
  • Yvonne B Albert
  • David O Freier
  • Jamie E DeMaria
  • Angela M Riegel

Detail Information

Publications15

  1. ncbi Prolactin as an autocrine/paracrine factor in breast tissue
    C V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Mammary Gland Biol Neoplasia 2:59-68. 1997
    ..These findings provide the precedent for novel therapeutic strategies aimed at interrupting the stimulation of breast cancer growth by PRL at both endocrine and autocrine/paracrine levels...
  2. pmc Roles and regulation of stat family transcription factors in human breast cancer
    Charles V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 513 SC Labs, 422 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Pathol 165:1449-60. 2004
    ..Given this, the future utilization of Stats as prognostic markers and therapeutic targets in human breast cancer appears likely...
  3. pmc Nuclear localization and function of polypeptide ligands and their receptors: a new paradigm for hormone specificity within the mammary gland?
    Charles V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Breast Cancer Res 5:181-7. 2003
    ..The intranuclear function of these complexes may contribute to the explicit functions associated with a given ligand, and may serve as new targets for pharmacologic intervention...
  4. pmc The role of prolactin in mammary carcinoma
    Charles V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocr Rev 24:1-27. 2003
    ..These findings indicate that antagonists of PRL/PRL receptor interaction or PRL receptor-associated signal transduction may be of considerable utility in the treatment of human breast cancer...
  5. ncbi Prolactin receptor signal transduction
    C V Clevenger
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19066, USA
    Lupus 10:706-18. 2001
    ..Differential activation of these pathways may contribute to the pleiotropism of PRL action in tissues of the immune system...
  6. ncbi A novel and functional interaction between cyclophilin A and prolactin receptor
    Farhat Syed
    Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Endocrine 20:83-90. 2003
    ..Hence, the interaction between CypA and the PRLR plays a differential regulatory role in the various signaling pathways leading from the PRLR...
  7. ncbi Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor
    Sommer L Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 19:939-49. 2005
    ....
  8. ncbi Characterization of a novel and functional human prolactin receptor isoform (deltaS1PRLr) containing only one extracellular fibronectin-like domain
    J Bradford Kline
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 16:2310-22. 2002
    ..Furthermore, the functionality of this receptor raises interesting questions regarding the minimal extracellular domain necessary for ligand-induced receptor signaling...
  9. doi Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2
    Gayathri Swaminathan
    Department of Animal Biology and Mari Lowe Center for Comparative Oncology Research Cell, University of Pennsylvania, 380 S University Avenue, Philadelphia, Pennsylvania 19104, USA
    J Endocrinol 196:R1-7. 2008
    ..We discuss how Jak2-mediated signaling might be transduced into Ser349 phosphorylation of PRLr as well as its ubiquitination and endocytosis...
  10. pmc The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer
    Michael A Rycyzyn
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:6790-5. 2002
    ....
  11. doi Altered expression of prolactin receptor-associated signaling proteins in human breast carcinoma
    Kevin McHale
    Thomas Jefferson University, Philadelphia, PA, USA
    Mod Pathol 21:565-71. 2008
    ..Since these species are known to regulate prolactin-mediated actions, these results suggest multiple targets for modulating prolactin receptor-mediated growth and differentiation in breast cancer...
  12. pmc Quantification of PRL/Stat5 signaling with a novel pGL4-CISH reporter
    Feng Fang
    Department of Pathology, Northwestern University, Chicago, Illinois 60611 USA
    BMC Biotechnol 8:11. 2008
    ..Luciferase-based reporter assays have been widely used to evaluate the activity of this pathway. However, the existing reporters are often not sensitive enough to monitor the effect of PRL in this pathway...
  13. ncbi Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications
    Samantha L Gadd
    Department of Pathology, Northwestern University, Lurie 4 107, 303 East Superior Street, Chicago, Illinois 60611, USA
    Mol Endocrinol 20:2734-46. 2006
    ..We also demonstrated an endogenous TM-ICD in T47D cells, suggesting that these findings are relevant to PRL-signaling pathways in breast cancer...
  14. ncbi The kinetics of binding human prolactin, but not growth hormone, to the prolactin receptor vary over a physiologic pH range
    Camille Keeler
    Department of Laboratory Medicine, Yale University, New Haven, Connecticut 06520, USA
    Biochemistry 46:2398-410. 2007
    ..The potential implications of this variation in hPRL's structural stability and receptor-binding kinetics over this physiologic range of pH are discussed...
  15. pmc The isolation of novel mesenchymal stromal cell chemotactic factors from the conditioned medium of tumor cells
    Siang Yo Lin
    Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Exp Cell Res 314:3107-17. 2008
    ..Two proteins, cyclophilin B and hepatoma-derived growth factor were then further characterized and shown to promote MSC chemotaxis...