Research Topics
Genomes and Genes | Gilles ClermontSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Predicting late anemia in critical illnessEric B Milbrandt
The CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Crit Care 10:R39. 2006..CONCLUSION: A rule-based decision support tool using information available within six hours of ICU admission may lead to earlier and more appropriate use of blood-sparing strategies...- Modeling longitudinal data in acute illnessGilles Clermont
Crit Care 11:152. 2007.... - Artificial neural networks as prediction tools in the critically illGilles Clermont
The CRISMA Laboratory, Department of Critical Care Medicine, The Center for Inflammatory and Regenerative Modeling, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Crit Care 9:153-4. 2005..However, these newer methods have yet to demonstrate their practicality and usefulness within the context of predicting outcomes in the critically ill... - The effect of pulmonary artery catheter use on costs and long-term outcomes of acute lung injuryGilles Clermont
Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 6:e22512. 2011..central venous catheter (CVC). We explored if use of the PAC in ALI is justified by a beneficial cost-effectiveness profile... - Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated?Hernando Gomez
Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA
J Surg Res 178:358-69. 2012..We hypothesized that vascular tone loss characterizes CC, and that arterial pulse pressure/stroke volume index ratio or vascular tone index (VTI) would identify CC... - In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient miceJose M Prince
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Mol Med 12:88-96. 2006.... 
Clinical and economic effects of iNO in premature newborns with respiratory failure at 1 yearR Scott Watson
Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Pediatrics 124:1333-43. 2009..We therefore studied the clinical and economic outcomes to 1 year of corrected age after a randomized controlled trial of prophylactic iNO...
The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysisClaudio E Lagoa
Department of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Shock 26:592-600. 2006..Mathematical simulations and DNA microarrays, both systems biology tools, may provide valuable insight into the complex global physiological interactions that occur in response to trauma and hemorrhagic shock...- Intensive care unit safety culture and outcomes: a US multicenter studyDavid T Huang
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Int J Qual Health Care 22:151-61. 2010..Safety culture may influence patient outcomes, but evidence is limited. We sought to determine if intensive care unit (ICU) safety culture is independently associated with outcomes... - Growth of intensive care unit resource use and its estimated cost in MedicareEric B Milbrandt
Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 36:2504-10. 2008..We sought to determine contemporary Medicare intensive care unit resource use, costs, and R values; whether these vary by patient and hospital characteristics; and the impact of updated values on estimated intensive care unit costs... - Dynamic microsimulation to model multiple outcomes in cohorts of critically ill patientsGilles Clermont
Room 606B, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Intensive Care Med 30:2237-44. 2004..Existing intensive care unit (ICU) prediction tools forecast single outcomes, (e.g., risk of death) and do not provide information on timing... - Haloperidol use is associated with lower hospital mortality in mechanically ventilated patientsEric B Milbrandt
CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 33:226-9; discussion 263-5. 2005..Because of their observational nature and the potential risks associated with haloperidol use, they require confirmation in a randomized, controlled trial before being applied to routine patient care... - Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United StatesDerek C Angus
Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Pediatrics 112:1351-60. 2003..Our objective was to estimate the cost-effectiveness ratio of iNO in this population... - Pneumonia: still the old man's friend?Vladimir Kaplan
Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
Arch Intern Med 163:317-23. 2003..However, the long-term survival of those discharged alive is less clear. We sought to determine long-term survival of patients hospitalized with CAP and compare the outcome with controls hospitalized for reasons other than CAP... - Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteriaDerek C Angus
Department of Critical Care Medicine, and Division of General Internal Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
Am J Respir Crit Care Med 166:717-23. 2002..In conclusion, ICU use for CAP is common and expensive but admission rates are variable. Clinical prediction rules for severe CAP do not appear adequately robust to guide clinical care at the current time... - Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?Tony Dremsizov
606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
Chest 129:968-78. 2006.... - In silico models of acute inflammation in animalsYoram Vodovotz
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Shock 26:235-44. 2006..Mathematical modeling may provide insights into the complex dynamics of acute inflammation in a manner that can be tested in vivo using many fewer animals than has been possible previously... - A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administrationJudy Day
Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Theor Biol 242:237-56. 2006.... - Healthcare costs and long-term outcomes after acute respiratory distress syndrome: A phase III trial of inhaled nitric oxideDerek C Angus
CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 34:2883-90. 2006..Inhaled nitric oxide at 5 ppm had no effect on these outcomes... - The acute inflammatory response in diverse shock statesCarson C Chow
Department of Mathematics, University of Pittsburgh, Pittsburgh, Pensylvania 15261, USA
Shock 24:74-84. 2005.... - An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhageRajaie Namas
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
PLoS ONE 4:e8406. 2009..Trauma/hemorrhagic shock (T/HS) results in cytokine-mediated acute inflammation that is generally considered detrimental... - Intensive care unit renal support therapy volume is not associated with patient outcomeYên Lan Nguyen
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Crit Care Med 39:2470-7. 2011..Our objective was to determine whether there is a volume-outcome relationship among intensive care unit patients receiving renal support therapy in two different healthcare systems (France and the United States)... - Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modelingGilles Clermont
Department of Critical Care Medicine, University of Pittsburgh, PA, USA
Crit Care Med 31:2627-33. 2003..We encourage further evaluation of modeling in the search for more sensitive mortality end points... - The epidemiology of severe sepsis in children in the United StatesR Scott Watson
Department of Critical Care Medicine, Center for Research on Health Care, and the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Respir Crit Care Med 167:695-701. 2003..97 billion US dollars nationally. Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources. Infants are at highest risk, especially those with a low birth weight... - Comparison of Cox and Gray's survival models in severe sepsisJan Kasal
CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 32:700-7. 2004..CONCLUSION: We confirm that many of the important predictors of mortality in severe sepsis are nonproportional and find that Gray's model seems best suited for modeling survival in this condition... - An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: results from parameter space reductionSilvia Daun
Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Scaife 606B, 3550 Terrace St, Pittsburgh, PA 15261, USA
J Theor Biol 253:843-53. 2008.... - Blood purification in sepsis: a new paradigmZhiyong Peng
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Contrib Nephrol 165:322-8. 2010..Finally, the emerging paradigm of sepsis-induced immune suppression provides additional rationale for the development of extracorporeal blood purification therapy for sepsis... - RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysisEric A J Hoste
The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Crit Care 10:R73. 2006.... - Recovery from acute kidney injury: determinants and predictorsNattachai Srisawat
The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Contrib Nephrol 165:284-91. 2010..This review will describe the current understanding of the renal recovery process, and the role of clinical severity scores and novel biomarkers such as NGAL, HGF, and cystatin C in predicting renal recovery... - Implementation of early goal-directed therapy for severe sepsis and septic shock: A decision analysisDavid T Huang
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory CRISMA, Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 35:2090-100. 2007..However, implementation of EGDT faces several barriers, including perceived costs and logistic difficulties. We conducted a decision analysis to explore the potential costs and consequences of EGDT implementation... - Ensemble models of neutrophil trafficking in severe sepsisSang Ok Song
CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS Comput Biol 8:e1002422. 2012.... - Risk and markers of severe acute pancreatitisGeorgios I Papachristou
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Gastroenterol Clin North Am 36:277-96, viii. 2007.... - A patient-specific in silico model of inflammation and healing tested in acute vocal fold injuryNicole Y K Li
Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 3:e2789. 2008..We propose that this translational application of computational modeling could be used to design patient-specific therapies for the larynx, and will serve as a paradigm for future extension to other clinical domains... - Thresholded area over the curve of spectrometric tissue oxygen saturation as an indicator of volume resuscitability in porcine hemorrhagic shockSven Zenker
Center for Inflammation and Regenerative Modeling CIRM, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Trauma 63:573-8; discussion 578-80. 2007..We therefore explored the value of peripheral muscle Sto2 in predicting systemic responsiveness to colloid volume resuscitation in a porcine model of hemorrhagic shock... - A mathematical simulation of the inflammatory response to anthrax infectionRukmini Kumar
Department of Physics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Shock 29:104-11. 2008..Rather, our simulations suggest that an optimal strategy would require both vaccination and antibiotic administration... - Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsisDerek C Angus
Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
Crit Care Med 31:1-11. 2003..To assess the cost-effectiveness of drotrecogin alfa (activated) therapy, which was recently shown to reduce mortality in severe sepsis... - Perceptions of safety culture vary across the intensive care units of a single institutionDavid T Huang
CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 35:165-76. 2007..To determine whether safety culture factors varied across the intensive care units (ICUs) of a single hospital, between nurses and physicians, and to explore ICU nursing directors' perceptions of their personnel's attitudes... - Angiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and GermanyDavid C Whitcomb
Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
Am J Gastroenterol 105:2287-92. 2010..The aim of this study was to determine whether Ang-1 and/or Ang-2 levels are predictive biomarkers of persistent organ failure (>48 h) and prolonged hospital course... - Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomesGilles Clermont
Department of Critical Care Medicine and Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15213, USA
Kidney Int 62:986-96. 2002..We were unable to identify a unique mortality associated with ARF, but the presence of measurable renal insufficiency continues to be a sensitive marker for poor outcome... - Evidence-based modeling of critical illness: an initial consensus from the Society for Complexity in Acute IllnessYoram Vodovotz
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Crit Care 22:77-84. 2007..Accordingly, SCAI identified a need for and carried out a critical appraisal of DMM as currently used in the setting of acute illness... - In silico design of clinical trials: a method coming of ageGilles Clermont
Department of Critical Care Medicine and Clinical Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Crit Care Med 32:2061-70. 2004.... - A comparison of three methods to estimate baseline creatinine for RIFLE classificationJakub Zavada
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, USA
Nephrol Dial Transplant 25:3911-8. 2010..Estimation of baseline creatinine by solving the Modification of Diet in Renal Disease (MDRD) equation assuming a glomerular filtration rate of 75 ml/min/1.73 m(2) has been widely used but never validated... - A mathematical model of pulmonary gas exchange under inflammatory stressAngela Reynolds
Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Theor Biol 264:161-73. 2010.... - Systems engineering medicine: engineering the inflammation response to infectious and traumatic challengesRobert S Parker
Department of Chemical and Petroleum Engineering, Swanson School of Engineering, University of Pittsburgh, 1249 Benedum Hall, Pittsburgh, PA 15261, USA
J R Soc Interface 7:989-1013. 2010..In this review we introduce acute inflammation and sepsis as an example of just one area that is currently underserved by the systems medicine community, and, therefore, an area in which contributions of all types can be made... - A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammationAngela Reynolds
Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Theor Biol 242:220-36. 2006..Further, we offer a clinical correlation between model predictions and potential therapeutic interventions based on modulation of immunity by anti-inflammatory agents... - Evaluating disorders with a complex genetics basis. the future roles of meta-analysis and systems biologyDavid C Whitcomb
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Dig Dis Sci 50:2195-202. 2005..Instead, systems biology-based approaches should be developed to integrate multiple, focused, and mechanistic association studies with the goal of assisting in the risk assessment of patients on a person-by-person basis... - Robust model-based quantification of global ventricular torsion from spatially sparse three-dimensional time series data by orthogonal distance regression: evaluation in a canine animal model under different pacing regimesSven Zenker
Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Pacing Clin Electrophysiol 36:13-23. 2013..Current methods require specific positioning and numbers of myocardial markers and assumptions about temporal positional evolution that may be violated during dyssynchronous contraction... - Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United StatesVladimir Kaplan
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 165:766-72. 2002..The sex differences are of concern and require further investigation... - Equation-based models of dynamic biological systemsSilvia Daun
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Crit Care 23:585-94. 2008..Equation-based modeling, although potentially an integrative approach, is complementary to and extends the potential of traditional statistically based approaches to inference... - Does acute organ dysfunction predict patient-centered outcomes?Gilles Clermont
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Chest 121:1963-71. 2002..Long-term patient-centered outcomes after acute illness may be associated with baseline health status, the development of acute organ dysfunction (AOD), or both... - Mathematical models of the acute inflammatory responseYoram Vodovotz
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Curr Opin Crit Care 10:383-90. 2004..There is a growing recognition that the complexity of the acute inflammatory response precludes the efficient development of therapies for sepsis and multiple organ failure until systems approaches are brought to bear on this problem... - A dynamical model of human immune response to influenza A virus infectionBaris Hancioglu
Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Theor Biol 246:70-86. 2007..This behavior is robust to a wide range of parameter values. The absence of antibody response leads to recurrence of disease and appearance of a chronic state with nontrivial constant viral load... - From inverse problems in mathematical physiology to quantitative differential diagnosesSven Zenker
Center for Inflammation and Regenerative Modeling, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
PLoS Comput Biol 3:e204. 2007.... - Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1Qi Mi
Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15213, USA
Wound Repair Regen 15:671-82. 2007..reduced TGF-beta1). In silico methods may elucidate mechanisms of and suggest therapies for aberrant skin healing... - The dynamics of acute inflammationRukmini Kumar
Departments of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Theor Biol 230:145-55. 2004..We suggest that the clinical condition of sepsis can arise from several distinct physiological states, each of which requires a different treatment approach... - A three-dimensional mathematical and computational model of necrotizing enterocolitisJared Barber
Department of Mathematics, 301 Thackeray Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Theor Biol 322:17-32. 2013.... - Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsisZhi Yong Peng
The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 81:363-9. 2012..These results may have important implications for the design and conduct of future trials in sepsis including defining alternative targets for extracorporeal blood purification and other therapies... - Medical emergency teams: a strategy for improving patient care and nursing work environmentsSanjay Galhotra
Department of Critical Care Medicine, University of Pittsburgh, Pennsylvania 15213, USA
J Adv Nurs 55:180-7. 2006..Our findings suggest that other institutions should consider implementing a medical emergency team programme as a strategy to improve patient care and nurse working environment... - Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trialPierre-Francois Laterre
Department of Critical Care, St Luc University Hospital, UCL, Brussels, Belgium
Crit Care Med 32:2207-18. 2004..Additional survivors created with DrotAA treatment did not increase per-patient resource use or intensive care unit or hospital length of stay... - Systems biology and translational researchGilles Clermont
J Crit Care 20:381-2. 2005 - Preventing "bored-lung disease" when treating patients with ventilatory failureJohn R Hotchkiss
Crit Care Med 35:1797-9. 2007 - Challenges and rewards on the road to translational systems biology in acute illness: four case reports from interdisciplinary teamsGary An
Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Crit Care 22:169-75. 2007..However, the development of these groups must overcome domain-specific barriers to communication and understanding...
Research Grants
- Modeling the acute inflammatory responseGilles Clermont; Fiscal Year: 2005..The long-term goal of this study is to provide a rational basis for the design of therapies to combat SIRS as well as to aid in patient management. ..
- International Conference on Complexity in Acute IllnessGilles Clermont; Fiscal Year: 2007..Scientific abstracts will be solicited and meritorious ones selected for presentations, and published in the December 2006 issue of the Journal of Critical Care. ..
- Biological Models of Influenza A VirusGilles Clermont; Fiscal Year: 2007....
- Biological Models of Influenza A VirusGilles Clermont; Fiscal Year: 2010....