Gilles Clermont

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Modeling longitudinal data in acute illness
    Gilles Clermont
    Crit Care 11:152. 2007
  2. pmc Artificial neural networks as prediction tools in the critically ill
    Gilles Clermont
    The CRISMA Laboratory, Department of Critical Care Medicine, The Center for Inflammatory and Regenerative Modeling, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 9:153-4. 2005
  3. pmc The effect of pulmonary artery catheter use on costs and long-term outcomes of acute lung injury
    Gilles Clermont
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e22512. 2011
  4. pmc Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated?
    Hernando Gomez
    Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA
    J Surg Res 178:358-69. 2012
  5. pmc In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice
    Jose M Prince
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Med 12:88-96. 2006
  6. doi request reprint Clinical and economic effects of iNO in premature newborns with respiratory failure at 1 year
    R Scott Watson
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 124:1333-43. 2009
  7. doi request reprint Growth of intensive care unit resource use and its estimated cost in Medicare
    Eric B Milbrandt
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:2504-10. 2008
  8. ncbi request reprint The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis
    Claudio E Lagoa
    Department of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Shock 26:592-600. 2006
  9. pmc Intensive care unit safety culture and outcomes: a US multicenter study
    David T Huang
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Int J Qual Health Care 22:151-61. 2010
  10. ncbi request reprint Dynamic microsimulation to model multiple outcomes in cohorts of critically ill patients
    Gilles Clermont
    Room 606B, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 30:2237-44. 2004

Research Grants

  1. Modeling the acute inflammatory response
    Gilles Clermont; Fiscal Year: 2005
  2. International Conference on Complexity in Acute Illness
    Gilles Clermont; Fiscal Year: 2007
  3. Biological Models of Influenza A Virus
    Gilles Clermont; Fiscal Year: 2007
  4. Biological Models of Influenza A Virus
    Gilles Clermont; Fiscal Year: 2010

Detail Information

Publications62

  1. pmc Modeling longitudinal data in acute illness
    Gilles Clermont
    Crit Care 11:152. 2007
    ....
  2. pmc Artificial neural networks as prediction tools in the critically ill
    Gilles Clermont
    The CRISMA Laboratory, Department of Critical Care Medicine, The Center for Inflammatory and Regenerative Modeling, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Crit Care 9:153-4. 2005
    ..However, these newer methods have yet to demonstrate their practicality and usefulness within the context of predicting outcomes in the critically ill...
  3. pmc The effect of pulmonary artery catheter use on costs and long-term outcomes of acute lung injury
    Gilles Clermont
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e22512. 2011
    ..central venous catheter (CVC). We explored if use of the PAC in ALI is justified by a beneficial cost-effectiveness profile...
  4. pmc Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated?
    Hernando Gomez
    Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA
    J Surg Res 178:358-69. 2012
    ..We hypothesized that vascular tone loss characterizes CC, and that arterial pulse pressure/stroke volume index ratio or vascular tone index (VTI) would identify CC...
  5. pmc In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice
    Jose M Prince
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Med 12:88-96. 2006
    ....
  6. doi request reprint Clinical and economic effects of iNO in premature newborns with respiratory failure at 1 year
    R Scott Watson
    Department of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 124:1333-43. 2009
    ..We therefore studied the clinical and economic outcomes to 1 year of corrected age after a randomized controlled trial of prophylactic iNO...
  7. doi request reprint Growth of intensive care unit resource use and its estimated cost in Medicare
    Eric B Milbrandt
    Department of Critical Care Medicine, CRISMA Laboratory, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:2504-10. 2008
    ..We sought to determine contemporary Medicare intensive care unit resource use, costs, and R values; whether these vary by patient and hospital characteristics; and the impact of updated values on estimated intensive care unit costs...
  8. ncbi request reprint The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis
    Claudio E Lagoa
    Department of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Shock 26:592-600. 2006
    ..Mathematical simulations and DNA microarrays, both systems biology tools, may provide valuable insight into the complex global physiological interactions that occur in response to trauma and hemorrhagic shock...
  9. pmc Intensive care unit safety culture and outcomes: a US multicenter study
    David T Huang
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Int J Qual Health Care 22:151-61. 2010
    ..Safety culture may influence patient outcomes, but evidence is limited. We sought to determine if intensive care unit (ICU) safety culture is independently associated with outcomes...
  10. ncbi request reprint Dynamic microsimulation to model multiple outcomes in cohorts of critically ill patients
    Gilles Clermont
    Room 606B, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 30:2237-44. 2004
    ..Existing intensive care unit (ICU) prediction tools forecast single outcomes, (e.g., risk of death) and do not provide information on timing...
  11. ncbi request reprint Pneumonia: still the old man's friend?
    Vladimir Kaplan
    Room 604, Scaife Hall, Critical Care Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Arch Intern Med 163:317-23. 2003
    ..However, the long-term survival of those discharged alive is less clear. We sought to determine long-term survival of patients hospitalized with CAP and compare the outcome with controls hospitalized for reasons other than CAP...
  12. ncbi request reprint Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States
    Derek C Angus
    Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pediatrics 112:1351-60. 2003
    ..Our objective was to estimate the cost-effectiveness ratio of iNO in this population...
  13. ncbi request reprint Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria
    Derek C Angus
    Department of Critical Care Medicine, and Division of General Internal Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Respir Crit Care Med 166:717-23. 2002
    ..In conclusion, ICU use for CAP is common and expensive but admission rates are variable. Clinical prediction rules for severe CAP do not appear adequately robust to guide clinical care at the current time...
  14. ncbi request reprint Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients
    Eric B Milbrandt
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 33:226-9; discussion 263-5. 2005
    ..To determine whether haloperidol use is associated with lower mortality in mechanically ventilated patients...
  15. ncbi request reprint In silico models of acute inflammation in animals
    Yoram Vodovotz
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Shock 26:235-44. 2006
    ..Mathematical modeling may provide insights into the complex dynamics of acute inflammation in a manner that can be tested in vivo using many fewer animals than has been possible previously...
  16. ncbi request reprint Healthcare costs and long-term outcomes after acute respiratory distress syndrome: A phase III trial of inhaled nitric oxide
    Derek C Angus
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 34:2883-90. 2006
    ..To determine the costs and long-term outcomes of acute respiratory distress syndrome (ARDS) in previously healthy adults. To determine whether treatment with inhaled nitric oxide affects these costs and outcomes...
  17. ncbi request reprint A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration
    Judy Day
    Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Theor Biol 242:237-56. 2006
    ....
  18. ncbi request reprint Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?
    Tony Dremsizov
    606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
    Chest 129:968-78. 2006
    ....
  19. doi request reprint Intensive care unit renal support therapy volume is not associated with patient outcome
    Yên Lan Nguyen
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Crit Care Med 39:2470-7. 2011
    ..Our objective was to determine whether there is a volume-outcome relationship among intensive care unit patients receiving renal support therapy in two different healthcare systems (France and the United States)...
  20. pmc An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage
    Rajaie Namas
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 4:e8406. 2009
    ..Trauma/hemorrhagic shock (T/HS) results in cytokine-mediated acute inflammation that is generally considered detrimental...
  21. ncbi request reprint Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modeling
    Gilles Clermont
    Department of Critical Care Medicine, University of Pittsburgh, PA, USA
    Crit Care Med 31:2627-33. 2003
    ..This may be partly due to the use of insensitive mortality end points. We explored whether modeling survival was more sensitive than traditional end points in detecting mortality differences in cohorts of patients with sepsis...
  22. ncbi request reprint The acute inflammatory response in diverse shock states
    Carson C Chow
    Department of Mathematics, University of Pittsburgh, Pittsburgh, Pensylvania 15261, USA
    Shock 24:74-84. 2005
    ....
  23. doi request reprint Blood purification in sepsis: a new paradigm
    Zhiyong Peng
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Contrib Nephrol 165:322-8. 2010
    ..Finally, the emerging paradigm of sepsis-induced immune suppression provides additional rationale for the development of extracorporeal blood purification therapy for sepsis...
  24. pmc RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis
    Eric A J Hoste
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 10:R73. 2006
    ..RIFLE, a newly developed international consensus classification for acute kidney injury, defines three grades of severity--risk (class R), injury (class I) and failure (class F)--but has not yet been evaluated in a clinical series...
  25. ncbi request reprint Comparison of Cox and Gray's survival models in severe sepsis
    Jan Kasal
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:700-7. 2004
    ..Newer, more flexible models, such as Gray's model, may be more appropriate...
  26. ncbi request reprint The epidemiology of severe sepsis in children in the United States
    R Scott Watson
    Department of Critical Care Medicine, Center for Research on Health Care, and the CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 167:695-701. 2003
    ..97 billion US dollars nationally. Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources. Infants are at highest risk, especially those with a low birth weight...
  27. doi request reprint An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: results from parameter space reduction
    Silvia Daun
    Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Scaife 606B, 3550 Terrace St, Pittsburgh, PA 15261, USA
    J Theor Biol 253:843-53. 2008
    ....
  28. pmc Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis
    Zhi Yong Peng
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 81:363-9. 2012
    ..These results may have important implications for the design and conduct of future trials in sepsis including defining alternative targets for extracorporeal blood purification and other therapies...
  29. ncbi request reprint Implementation of early goal-directed therapy for severe sepsis and septic shock: A decision analysis
    David T Huang
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory CRISMA, Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:2090-100. 2007
    ..However, implementation of EGDT faces several barriers, including perceived costs and logistic difficulties. We conducted a decision analysis to explore the potential costs and consequences of EGDT implementation...
  30. doi request reprint Recovery from acute kidney injury: determinants and predictors
    Nattachai Srisawat
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Contrib Nephrol 165:284-91. 2010
    ..This review will describe the current understanding of the renal recovery process, and the role of clinical severity scores and novel biomarkers such as NGAL, HGF, and cystatin C in predicting renal recovery...
  31. ncbi request reprint Risk and markers of severe acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Gastroenterol Clin North Am 36:277-96, viii. 2007
    ....
  32. pmc Predicting late anemia in critical illness
    Eric B Milbrandt
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 10:R39. 2006
    ..We sought to determine whether a predictive model could be constructed that would serve as a useful decision support tool for the pre-emptive management of intensive care unit (ICU)-related anemia...
  33. pmc Ensemble models of neutrophil trafficking in severe sepsis
    Sang Ok Song
    CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Comput Biol 8:e1002422. 2012
    ....
  34. pmc A mathematical simulation of the inflammatory response to anthrax infection
    Rukmini Kumar
    Department of Physics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Shock 29:104-11. 2008
    ..Rather, our simulations suggest that an optimal strategy would require both vaccination and antibiotic administration...
  35. pmc A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury
    Nicole Y K Li
    Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 3:e2789. 2008
    ..We propose that this translational application of computational modeling could be used to design patient-specific therapies for the larynx, and will serve as a paradigm for future extension to other clinical domains...
  36. ncbi request reprint Thresholded area over the curve of spectrometric tissue oxygen saturation as an indicator of volume resuscitability in porcine hemorrhagic shock
    Sven Zenker
    Center for Inflammation and Regenerative Modeling CIRM, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Trauma 63:573-8; discussion 578-80. 2007
    ..We therefore explored the value of peripheral muscle Sto2 in predicting systemic responsiveness to colloid volume resuscitation in a porcine model of hemorrhagic shock...
  37. ncbi request reprint Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, Clinical Research, Investigation and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, PA 15213, USA
    Crit Care Med 31:1-11. 2003
    ..To assess the cost-effectiveness of drotrecogin alfa (activated) therapy, which was recently shown to reduce mortality in severe sepsis...
  38. ncbi request reprint Perceptions of safety culture vary across the intensive care units of a single institution
    David T Huang
    CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:165-76. 2007
    ..To determine whether safety culture factors varied across the intensive care units (ICUs) of a single hospital, between nurses and physicians, and to explore ICU nursing directors' perceptions of their personnel's attitudes...
  39. doi request reprint Angiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and Germany
    David C Whitcomb
    Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Am J Gastroenterol 105:2287-92. 2010
    ..The aim of this study was to determine whether Ang-1 and/or Ang-2 levels are predictive biomarkers of persistent organ failure (>48 h) and prolonged hospital course...
  40. pmc Evidence-based modeling of critical illness: an initial consensus from the Society for Complexity in Acute Illness
    Yoram Vodovotz
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Crit Care 22:77-84. 2007
    ..Accordingly, SCAI identified a need for and carried out a critical appraisal of DMM as currently used in the setting of acute illness...
  41. ncbi request reprint In silico design of clinical trials: a method coming of age
    Gilles Clermont
    Department of Critical Care Medicine and Clinical Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 32:2061-70. 2004
    ..To determine the feasibility and potential usefulness of mathematical models in evaluating immunomodulatory strategies in clinical trials of severe sepsis...
  42. ncbi request reprint Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes
    Gilles Clermont
    Department of Critical Care Medicine and Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Kidney Int 62:986-96. 2002
    ..We sought to determine the impact of renal dysfunction and/or loss of organ function on outcome...
  43. pmc Robust model-based quantification of global ventricular torsion from spatially sparse three-dimensional time series data by orthogonal distance regression: evaluation in a canine animal model under different pacing regimes
    Sven Zenker
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Pacing Clin Electrophysiol 36:13-23. 2013
    ..Current methods require specific positioning and numbers of myocardial markers and assumptions about temporal positional evolution that may be violated during dyssynchronous contraction...
  44. doi request reprint A comparison of three methods to estimate baseline creatinine for RIFLE classification
    Jakub Zavada
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, USA
    Nephrol Dial Transplant 25:3911-8. 2010
    ..Estimation of baseline creatinine by solving the Modification of Diet in Renal Disease (MDRD) equation assuming a glomerular filtration rate of 75 ml/min/1.73 m(2) has been widely used but never validated...
  45. ncbi request reprint Evaluating disorders with a complex genetics basis. the future roles of meta-analysis and systems biology
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 50:2195-202. 2005
    ..Instead, systems biology-based approaches should be developed to integrate multiple, focused, and mechanistic association studies with the goal of assisting in the risk assessment of patients on a person-by-person basis...
  46. pmc Systems engineering medicine: engineering the inflammation response to infectious and traumatic challenges
    Robert S Parker
    Department of Chemical and Petroleum Engineering, Swanson School of Engineering, University of Pittsburgh, 1249 Benedum Hall, Pittsburgh, PA 15261, USA
    J R Soc Interface 7:989-1013. 2010
    ..In this review we introduce acute inflammation and sepsis as an example of just one area that is currently underserved by the systems medicine community, and, therefore, an area in which contributions of all types can be made...
  47. pmc A mathematical model of pulmonary gas exchange under inflammatory stress
    Angela Reynolds
    Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Theor Biol 264:161-73. 2010
    ....
  48. ncbi request reprint A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation
    Angela Reynolds
    Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Theor Biol 242:220-36. 2006
    ..Further, we offer a clinical correlation between model predictions and potential therapeutic interventions based on modulation of immunity by anti-inflammatory agents...
  49. doi request reprint Equation-based models of dynamic biological systems
    Silvia Daun
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Crit Care 23:585-94. 2008
    ..Equation-based modeling, although potentially an integrative approach, is complementary to and extends the potential of traditional statistically based approaches to inference...
  50. pmc From inverse problems in mathematical physiology to quantitative differential diagnoses
    Sven Zenker
    Center for Inflammation and Regenerative Modeling, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS Comput Biol 3:e204. 2007
    ....
  51. ncbi request reprint Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1
    Qi Mi
    Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Wound Repair Regen 15:671-82. 2007
    ..reduced TGF-beta1). In silico methods may elucidate mechanisms of and suggest therapies for aberrant skin healing...
  52. ncbi request reprint Does acute organ dysfunction predict patient-centered outcomes?
    Gilles Clermont
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Chest 121:1963-71. 2002
    ..Long-term patient-centered outcomes after acute illness may be associated with baseline health status, the development of acute organ dysfunction (AOD), or both...
  53. ncbi request reprint A dynamical model of human immune response to influenza A virus infection
    Baris Hancioglu
    Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Theor Biol 246:70-86. 2007
    ..This behavior is robust to a wide range of parameter values. The absence of antibody response leads to recurrence of disease and appearance of a chronic state with nontrivial constant viral load...
  54. ncbi request reprint Mathematical models of the acute inflammatory response
    Yoram Vodovotz
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Crit Care 10:383-90. 2004
    ..There is a growing recognition that the complexity of the acute inflammatory response precludes the efficient development of therapies for sepsis and multiple organ failure until systems approaches are brought to bear on this problem...
  55. ncbi request reprint The dynamics of acute inflammation
    Rukmini Kumar
    Departments of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Theor Biol 230:145-55. 2004
    ..We suggest that the clinical condition of sepsis can arise from several distinct physiological states, each of which requires a different treatment approach...
  56. ncbi request reprint Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States
    Vladimir Kaplan
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 165:766-72. 2002
    ..The sex differences are of concern and require further investigation...
  57. pmc A three-dimensional mathematical and computational model of necrotizing enterocolitis
    Jared Barber
    Department of Mathematics, 301 Thackeray Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Theor Biol 322:17-32. 2013
    ....
  58. ncbi request reprint Medical emergency teams: a strategy for improving patient care and nursing work environments
    Sanjay Galhotra
    Department of Critical Care Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Adv Nurs 55:180-7. 2006
    ..This paper reports a study of nurses' perceptions about medical emergency teams and their impact on patient care and the nursing work environment...
  59. ncbi request reprint Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial
    Pierre Francois Laterre
    Department of Critical Care, St Luc University Hospital, UCL, Brussels, Belgium
    Crit Care Med 32:2207-18. 2004
    ..To compare differences in hospital mortality and resource use in adult severe sepsis subjects randomized to receive drotrecogin alfa (activated) (DrotAA) or placebo in the PROWESS trial...
  60. ncbi request reprint Systems biology and translational research
    Gilles Clermont
    J Crit Care 20:381-2. 2005
  61. pmc Challenges and rewards on the road to translational systems biology in acute illness: four case reports from interdisciplinary teams
    Gary An
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Crit Care 22:169-75. 2007
    ..However, the development of these groups must overcome domain-specific barriers to communication and understanding...
  62. ncbi request reprint Preventing "bored-lung disease" when treating patients with ventilatory failure
    John R Hotchkiss
    Crit Care Med 35:1797-9. 2007

Research Grants9

  1. Modeling the acute inflammatory response
    Gilles Clermont; Fiscal Year: 2005
    ..The long-term goal of this study is to provide a rational basis for the design of therapies to combat SIRS as well as to aid in patient management. ..
  2. International Conference on Complexity in Acute Illness
    Gilles Clermont; Fiscal Year: 2007
    ..Scientific abstracts will be solicited and meritorious ones selected for presentations, and published in the December 2006 issue of the Journal of Critical Care. ..
  3. Biological Models of Influenza A Virus
    Gilles Clermont; Fiscal Year: 2007
    ....
  4. Biological Models of Influenza A Virus
    Gilles Clermont; Fiscal Year: 2010
    ....