Deborah J Clegg

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Charles River Sprague Dawley rats lack early age-dependent susceptibility to DMBA-induced mammary carcinogenesis
    R B Gear
    Department of Psychiatry, University of Cincinnati, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Int J Biol Sci 3:408-16. 2007
  2. ncbi request reprint Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, Ohio 45267, USA
    Am J Physiol Regul Integr Comp Physiol 284:R494-9. 2003
  3. ncbi request reprint Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Diabetes 56:1051-8. 2007
  4. ncbi request reprint Gonadal hormones determine sensitivity to central leptin and insulin
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, PO Box 670559, Cincinatti, OH 45267 0559, USA
    Diabetes 55:978-87. 2006
  5. ncbi request reprint Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Endocrinology 144:2941-6. 2003
  6. ncbi request reprint Eating elicited by orexin-a, but not melanin-concentrating hormone, is opioid mediated
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559 Cincinnati, OH 45267 0559, USA
    Endocrinology 143:2995-3000. 2002
  7. ncbi request reprint Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 51:3196-201. 2002
  8. ncbi request reprint Consumption of a high-fat diet alters the homeostatic regulation of energy balance
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Physiol Behav 83:573-8. 2004
  9. ncbi request reprint Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
    Lynda M Brown
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Physiol Behav 89:687-91. 2006
  10. ncbi request reprint The catabolic action of insulin in the brain is mediated by melanocortins
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Neurosci 22:9048-52. 2002

Research Grants

Detail Information

Publications50

  1. pmc Charles River Sprague Dawley rats lack early age-dependent susceptibility to DMBA-induced mammary carcinogenesis
    R B Gear
    Department of Psychiatry, University of Cincinnati, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Int J Biol Sci 3:408-16. 2007
    ..We conclude this strain of Charles River Sprague Dawley rats has prolactin-induced pituitary stimulation, and therefore, the window of susceptibility for mammary tumorigenesis is absent...
  2. ncbi request reprint Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, Ohio 45267, USA
    Am J Physiol Regul Integr Comp Physiol 284:R494-9. 2003
    ..Hence, in contrast to AgRP, MCH elicits increased water intake independent of food intake. These results are consistent with historical data linking activity of the LH with water as well as food intake...
  3. ncbi request reprint Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Diabetes 56:1051-8. 2007
    ....
  4. ncbi request reprint Gonadal hormones determine sensitivity to central leptin and insulin
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, PO Box 670559, Cincinatti, OH 45267 0559, USA
    Diabetes 55:978-87. 2006
    ..These data indicate that estrogen acts within the brain to increase leptin sensitivity, decrease insulin sensitivity, and favor subcutaneous over visceral fat...
  5. ncbi request reprint Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Endocrinology 144:2941-6. 2003
    ..These results indicate that consumption of a HF diet decreases signaling through the melanocortin system, an abnormality that could contribute to diet-induced obesity...
  6. ncbi request reprint Eating elicited by orexin-a, but not melanin-concentrating hormone, is opioid mediated
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559 Cincinnati, OH 45267 0559, USA
    Endocrinology 143:2995-3000. 2002
    ..These data indicate that despite several similarities between MCH and orexin-A, these two lateral hypothalamic area peptides stimulate food intake by recruiting different neural circuits and exert different effects on food choice...
  7. ncbi request reprint Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 51:3196-201. 2002
    ..Understanding the mechanisms by which FAS inhibition in the CNS reduces food intake could lead to specific targets for the manipulation of energy balance and the treatment of obesity...
  8. ncbi request reprint Consumption of a high-fat diet alters the homeostatic regulation of energy balance
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Physiol Behav 83:573-8. 2004
    ..HF-fed animals, independent of whether they become obese or not, also have central insulin and MTII insensitivity. Finally, HF rats have a down-regulated hypothalamic apo A-IV system that could contribute to their hyperphagia...
  9. ncbi request reprint Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
    Lynda M Brown
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Physiol Behav 89:687-91. 2006
    ..Hence, genetic manipulations that influence brain insulin sensitivity in mice can now more easily be integrated with the broader literature on energy homeostasis...
  10. ncbi request reprint The catabolic action of insulin in the brain is mediated by melanocortins
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Neurosci 22:9048-52. 2002
    ..These data suggest that the hypothalamic melanocortin system mediates the anorexic effects of central insulin, as well as of leptin...
  11. pmc Brain apolipoprotein E: an important regulator of food intake in rats
    Ling Shen
    Cincinnati Obesity Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Diabetes 57:2092-8. 2008
    ....
  12. ncbi request reprint Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake
    Koro Gotoh
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 290:R202-7. 2006
    ..In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate...
  13. pmc Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat
    Jon F Davis
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Behav Neurosci 122:1257-63. 2008
    ....
  14. pmc Tetrahydroindenoindole inhibits the progression of diabetes in mice
    Howard G Shertzer
    Department of Environmental Health and Center for Environmental Genetics University of Cincinnati Medical Center, Cincinnati, OH, 45267, USA
    Chem Biol Interact 177:71-80. 2009
    ..We conclude that THII may retard the progression of diabetes via multiple pathways, including the inhibition of oxidative and inflammatory pathways...
  15. ncbi request reprint Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet
    Deborah J Clegg
    University of Cincinnati, Department of Psychiatry, Cincinnati, Ohio, USA
    Am J Physiol Regul Integr Comp Physiol 288:R981-6. 2005
    ....
  16. pmc Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats
    Jon F Davis
    University of Cincinnati, Department of Psychiatry, ML 0506, Reading, OH 45237, United States
    Physiol Behav 92:924-30. 2007
    ..These results suggest that binge-intake behavior occurs on a nutritionally complete high-fat diet and that this regimen is capable of altering both body composition and endocrine profile...
  17. ncbi request reprint Adrenalectomy alters the sensitivity of the central nervous system melanocortin system
    Deborah L Drazen
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Diabetes 52:2928-34. 2003
    ..We conclude that the potent weight-reducing effects of ADX likely involve heightened responsiveness to melanocortin receptor stimulation...
  18. ncbi request reprint Differential sensitivity to central leptin and insulin in male and female rats
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH 45267 0559, USA
    Diabetes 52:682-7. 2003
    ..Because insulin and leptin reflect different fat beds and are differentially distributed in the male and female sexes, the implication is that the male and female sexes regulate adiposity-relevant parameters differently...
  19. ncbi request reprint The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides
    Stephen C Benoit
    University of Cincinnati, Department of Psychiatry North, 2170 East Galbraith Rd, Cincinnati, OH 45243, USA
    Peptides 26:751-7. 2005
    ....
  20. ncbi request reprint Insulin and leptin combine additively to reduce food intake and body weight in rats
    Ellen L Air
    Department of Biomedical Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0555, USA
    Endocrinology 143:2449-52. 2002
    ....
  21. ncbi request reprint Intraventricular (i3vt) ghrelin increases food intake in fatty Zucker rats
    Lynda M Brown
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, United States
    Peptides 28:612-6. 2007
    ..Fatty Zucker rats had 4.5 times more ghrelin receptor mRNA in the hypothalamus than lean Zucker rats, suggesting a possible mechanism for the increased sensitivity...
  22. ncbi request reprint Learned meal initiation attenuates the anorexic effects of the melanocortin agonist MTII
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0559, USA
    Diabetes 52:2684-8. 2003
    ..These results support the hypothesis that meal-feeding schedules can lead to anticipatory physiological responses that attenuate the anorexic effects of exogenous melanocortin agonists...
  23. pmc Novel functions of orexigenic hypothalamic peptides: from genes to behavior
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Nutrition 24:843-7. 2008
    ....
  24. pmc Voluntary consumption of ethyl oleate reduces food intake and body weight in rats
    Christopher J Kemp
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237 USA
    Physiol Behav 93:912-8. 2008
    ..These data indicate that voluntary access to EO promoted short-term satiety, compared to SO diet, and that these effects contributed to an important and novel attenuated weight gain in EO-fed animals...
  25. doi request reprint Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet
    Eric L Kendig
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Biochem Pharmacol 76:216-24. 2008
    ..We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition...
  26. pmc Leptin regulates energy balance and motivation through action at distinct neural circuits
    Jon F Davis
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio 45237 0506, USA
    Biol Psychiatry 69:668-74. 2011
    ..The current study asked whether leptin signaling within the lateral hypothalamus (LH) and midbrain is involved in effort-based responding for food rewards and/or the modulation of mesolimbic dopamine...
  27. pmc GM-CSF action in the CNS decreases food intake and body weight
    Jacquelyn A Reed
    University of Cincinnati, Cincinnati, Ohio, USA
    J Clin Invest 115:3035-44. 2005
    ..Energy expenditure in GM-/- mice was decreased compared with that in GM+/+ mice. Taken together, these findings demonstrate that GM-CSF signaling in the CNS can regulate energy homeostasis...
  28. ncbi request reprint Chronic food restriction and reduced dietary fat: risk factors for bouts of overeating
    Ryuichi Ogawa
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237 1625, USA
    Physiol Behav 86:578-85. 2005
    ..Chronic food restriction accompanied by reduced dietary fat may increase risk for bouts of overeating...
  29. ncbi request reprint Clinical endocrinology and metabolism. Regulation of energy homeostasis by peripheral signals
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Best Pract Res Clin Endocrinol Metab 18:497-515. 2004
    ..Considerable effort is being directed towards finding ways to intervene in specific circuits to help accomplish weight loss...
  30. ncbi request reprint Insulin and leptin as adiposity signals
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    Recent Prog Horm Res 59:267-85. 2004
    ..Hence, insulin and leptin provide important negative feedback signals to the central nervous system, proportional to peripheral energy stores and coupled with catabolic circuits...
  31. pmc Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    J Clin Invest 119:2577-89. 2009
    ..These results suggest that many of the deleterious effects of high-fat diets, specifically those enriched with palmitic acid, are CNS mediated via PKC-theta activation, resulting in reduced insulin activity...
  32. ncbi request reprint Acetaminophen normalizes glucose homeostasis in mouse models for diabetes
    Howard G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Biochem Pharmacol 75:1402-10. 2008
    ....
  33. ncbi request reprint Acute third ventricular administration of insulin decreases food intake in two paradigms
    Ellen L Air
    Department of Biomedical Sciences, University of Cincinnati, Cincinnati, OH 45267, USA
    Pharmacol Biochem Behav 72:423-9. 2002
    ..These data suggest that insulin can reduce food intake in acute delivery paradigms and provide another means by which to assess the roles of other central systems in the mediation of insulin's effects on energy homeostasis...
  34. ncbi request reprint Gender differences in the control of energy homeostasis
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Exp Biol Med (Maywood) 228:1175-80. 2003
    ..The implications of this are discussed...
  35. ncbi request reprint Altered feeding responses in mice with targeted disruption of the dopamine-3 receptor gene
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Ohio 45267 0559, USA
    Behav Neurosci 117:46-54. 2003
    ..These results support the hypothesis that D3Rs chronically inhibit the effects of adiposity hormones, thereby contributing to a net anabolic state...
  36. ncbi request reprint The critical role of the melanocortin system in the control of energy balance
    Randy J Seeley
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267 0559, USA
    Annu Rev Nutr 24:133-49. 2004
    ..Reviewed here is the wide range of evidence that points to the melanocortin system as a critical node in the diverse neurocircuitry that regulates food intake and body weight...
  37. pmc Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice
    Jon F Davis
    University of Cincinnati, Department of Psychiatry, Cincinnati, OH, USA
    Physiol Behav 103:39-43. 2011
    ..Collectively, these results suggest that ghrelin receptor signaling is necessary for adaptations in the anticipatory responses that accompany restricted feeding...
  38. pmc The regulation of alcohol intake by melanin-concentrating hormone in rats
    Elizabeth A Duncan
    Department of Psychiatry, University of Cincinnati, USA
    Pharmacol Biochem Behav 85:728-35. 2006
    ..Further, endogenous MCH does not seem to regulate alcohol drinking, however because the antagonist failed to attenuate MCH-induced alcohol intake this conclusion is tentative...
  39. ncbi request reprint Sexual differences in the control of energy homeostasis
    Haifei Shi
    Obesity Research Center, University of Cincinnati, Cincinnati, OH, USA
    Front Neuroendocrinol 30:396-404. 2009
    ..Sexual dimorphisms in energy balance, body fat distribution, and the role sex hormones have in mediating these differences are the focus of this review...
  40. ncbi request reprint Central insulin potentiates eating elicited by 2-deoxy-D-glucose
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Physiol Behav 78:331-6. 2003
    ....
  41. pmc The melanocortin antagonist AgRP (83-132) increases appetitive responding for a fat, but not a carbohydrate, reinforcer
    Andrea L Tracy
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
    Pharmacol Biochem Behav 89:263-71. 2008
    ..These results suggest a possible role for AgRP in the increased fat intake associated with obesity...
  42. ncbi request reprint The physiology of obesity
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0559, USA
    Clin Obstet Gynecol 47:967-79; discussion 980-1. 2004
  43. pmc Dietary ketosis enhances memory in mild cognitive impairment
    Robert Krikorian
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Neurobiol Aging 33:425.e19-27. 2012
    ..Further investigation of this intervention is warranted to evaluate its preventive potential and mechanisms of action in the context of early neurodegeneration...
  44. ncbi request reprint C75 inhibits food intake by increasing CNS glucose metabolism
    Matthew D Wortman
    Nat Med 9:483-5. 2003
  45. ncbi request reprint Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway
    Ofer Reizes
    Procter Gamble Pharmaceuticals, Inc, Health Care Research Center, Mason, Ohio 45040, USA
    Ann N Y Acad Sci 994:66-73. 2003
    ..Collectively, the data suggest that the modulation of melanocortin regulation of energy balance by syndecan-3 is modulated by the action of a TIMP-3-sensitive metalloprotease...
  46. pmc A potential role for the hippocampus in energy intake and body weight regulation
    Terry L Davidson
    Department of Psychological Sciences, Ingestive Behavior Research Center, Purdue University, West Lafayette, IN, USA
    Curr Opin Pharmacol 7:613-6. 2007
    ..The present paper summarizes these findings and ideas and considers the hypothesis that excessive caloric intake and obesity may be produced by dietary and other factors that are known to alter hippocampal functioning...
  47. ncbi request reprint Small-molecule melanin-concentrating hormone-1 receptor antagonists require brain penetration for inhibition of food intake and reduction in body weight
    X Eric Hu
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, OH 44195, USA
    J Pharmacol Exp Ther 324:206-13. 2008
    ..The effect is dose-dependent and appears to be partially driven by a reduction in food intake. Finally, these studies show the utility of a medicinal chemistry approach to address an important biological and pharmacological question...
  48. ncbi request reprint Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
    Kevin D Niswender
    Division of Metabolism, Endocrinology and Nutrition, University of Washington School of Medicine and Harborview Medical Center, Seattle 98104, USA
    Diabetes 52:227-31. 2003
    ....
  49. ncbi request reprint A role for syndecan-3 in the melanocortin regulation of energy balance
    Ofer Reizes
    Procter and Gamble Pharmaceuticals Inc Health Care Research Center, Mason, OH 45040, USA
    Peptides 27:274-80. 2006
    ..In this review, we present an overview of the biology and potential functions of syndecan-3 and describe a novel hypothesis for its regulation of energy balance...
  50. pmc Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome
    Sergei Musatov
    Neurologix, Inc, Fort Lee, NJ 07024, USA
    Proc Natl Acad Sci U S A 104:2501-6. 2007
    ..Together, these findings indicate that ERalpha in the ventromedial nucleus of the hypothalamus neurons plays an essential role in the control of energy balance and the maintenance of normal body weight...

Research Grants2