Research Topics
| M P ClearySummaryAffiliation: University of Minnesota Country: USA Publications
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Detail Information
Publications
Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-alpha miceSoner Dogan
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Breast Cancer Res 9:R91. 2007..One link between obesity and breast cancer is the adipokine, leptin. Here, the focus is on diet-induced obesity and MT and mammary fat pad (MFP) leptin and apoptotic signaling proteins...
Serum insulin-like growth factor-I and mammary tumor development in ad libitum-fed, chronic calorie-restricted, and intermittent calorie-restricted MMTV-TGF-alpha miceOlga P Rogozina
The Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
Cancer Prev Res (Phila) 2:712-9. 2009..However, the specific role of IGF-I in the protective effect of calorie restriction remains to be determined. These results confirm that ICR prevents MT development to a greater extent than CCR...- Effect of obesity on breast cancer developmentM P Cleary
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Vet Pathol 47:202-13. 2010..This review explores the relationship between these factors and the development of mammary cancer in humans and mouse models... 
Prevention of mammary tumorigenesis by intermittent caloric restriction: does caloric intake during refeeding modulate the response?Margot P Cleary
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Exp Biol Med (Maywood) 232:70-80. 2007..001), but there was no effect on MTs. These results confirm that ICR prevents development of MTs to a greater extent than does CCR, although "overeating" during refeeding may compromise this protection...- Leptin as a potential therapeutic target for breast cancer prevention and treatmentAmitbha Ray
University of Minnesota, The Hormel Institute, 801 16th Avenue NE, Austin, MN 55912, USA
Expert Opin Ther Targets 14:443-51. 2010..Leptin is one of the adipokines that is measured in serum/plasma in increasing amounts as body weight/body fat increases... - Diet-induced obesity and mammary tumor development in MMTV-neu female miceMargot P Cleary
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Nutr Cancer 50:174-80. 2004..0001). MT latency, incidence, metastasis, and burden were similar for all groups. These findings support that obesity is not a risk factor for development of estrogen-negative breast cancer... - Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-alpha miceM P Cleary
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Int J Obes Relat Metab Disord 28:956-62. 2004..Body weight at 34 weeks of age was used to assign high fat diet mice to obesity-prone>overweight>obesity-resistant groups (n=17) (P<0.0001). Mice were euthanized when MTs developed or at 85 weeks of age... - Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumorsMargot P Cleary
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Exp Biol Med (Maywood) 229:182-93. 2004..This study provides additional evidence that leptin and its cognate receptor may be involved in mammary tumorigenesis... - Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumorsMargot P Cleary
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Breast Cancer Res Treat 77:205-15. 2003..However, the finding that increased body weight is associated with increased oncogene-induced MT development within the normal weight range provides experimental support for the role of body weight in breast cancer... - Weight-cycling decreases incidence and increases latency of mammary tumors to a greater extent than does chronic caloric restriction in mouse mammary tumor virus-transforming growth factor-alpha female miceMargot P Cleary
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Cancer Epidemiol Biomarkers Prev 11:836-43. 2002..Future studies should address the application of this intervention to additional transgenic mice as well as other MT models... - Genotype and diet effects in lean and obese Zucker rats fed either safflower or coconut oil dietsM P Cleary
Hormel Institute, University of Minnesota, Austin 55912, USA
Proc Soc Exp Biol Med 220:153-61. 1999..However, high-fat feeding did not result in a heterozygous effect in young adult lean male rats. We will next evaluate the role of sex on this effect... - The presence of the "fa" gene in heterozygous (FA/fa) lean female rats, effects on body weight, body fat and serum leptinM P Cleary
Hormel Institute, University of Minnesota, Austin 55912, USA
Obes Res 7:293-8. 1999..In the present study, the effect of the "fa" gene on body weight and body fat in lean female rats was investigated... - Effect of moderate caloric restriction and/or weight cycling on mammary tumor incidence and latency in MMTV-Neu female miceKristin A Pape-Ansorge
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Nutr Cancer 44:162-8. 2002..These results indicate that intermittent caloric restriction-refeeding provides a moderate protective effect, whereas chronic caloric restriction provides no significant protection against MT development in transgenic Neu mice... - Cross-sectional analysis of intermittent versus chronic caloric restriction in the TRAMP mouseMelissa J L Bonorden
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Prostate 69:317-26. 2009..Previously we found that intermittent calorie restriction (ICR) delayed the age of prostate tumor detection and death in TRAMP mice in comparison to chronic calorie restricted (CCR) and ad libitum fed (AL) TRAMP mice... - Obesity is associated with a decreased leptin transport across the blood-brain barrier in ratsB Burguera
Endocrine Research Unit, University of Minnesota, Austin, USA
Diabetes 49:1219-23. 2000..These findings strongly suggest that the leptin receptor (OB-R) in the BBB can be easily saturated. Saturation of the BBB OB-R in obese individuals would explain the defect in leptin transport into the brain described in this study... - Restoration of fertility in young obese (Lep(ob) Lep(ob)) male mice with low dose recombinant mouse leptin treatmentM P Cleary
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Int J Obes Relat Metab Disord 25:95-7. 2001..We investigated the effects of low-dose leptin treatment on restoration of fertility in young adult male leptin deficient obese mice... - Effects of adiponectin on breast cancer cell growth and signalingM E Grossmann
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Br J Cancer 98:370-9. 2008..This inhibition appeared to be due to blockage of JNK2 signalling. These results provide information on how obesity may influence breast cancer cell proliferation and establish a new model to examine interactions between ER and Acrp30... - Diet-induced obesity and mammary tumor development in relation to estrogen receptor statusAmitabha Ray
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Cancer Lett 253:291-300. 2007..In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism... - Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland developmentXin Hu
The Hormel Institute, University of Minnesota, Austin 55912, USA
J Natl Cancer Inst 94:1704-11. 2002..Consequently, the leptin pathway should be further studied as a target for interventions to treat or prevent breast cancer... - Intermittent calorie restriction delays prostate tumor detection and increases survival time in TRAMP miceMelissa J L Bonorden
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Nutr Cancer 61:265-75. 2009..These results indicate that the way in which calories are restricted impacts both time to tumor detection and survival in TRAMP mice, with ICR providing greater protective effect compared to CCR... - Mammary tumor development from T47-D human breast cancer cells in obese ovariectomized mice with and without estradiol supplementsKatai J Nkhata
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Breast Cancer Res Treat 114:71-83. 2009..These findings suggest that in vivo estrogen suppressed proliferation of T47-D cells but without supplemental estrogen obesity enhanced tumor development. The exact reason for this is not presently clear... - No effect of long-term DHEA treatment on either hepatocyte and adipocyte pentose pathway activity or adipocyte glycerol releaseD A Diersen-Schade
Hormel Institute, University of Minnesota, Austin
Horm Metab Res 21:356-8. 1989..No significant effects could be attributed to this treatment. There was also no effect on basal or epinephrine-stimulated glycerol release from adipocytes... - Minireview: Obesity and breast cancer: the estrogen connectionMargot P Cleary
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Endocrinology 150:2537-42. 2009..Human and relevant preclinical studies are cited. In addition, other growth factors that may be involved in this relationship are considered... - Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefitLei Wang
Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
Cancer Prev Res (Phila) 2:484-95. 2009..Therefore, these selenium compounds may effectively inhibit this model of prostate cancer carcinogenesis... - Effects of adiponectin and leptin co-treatment on human breast cancer cell growthKatai J Nkhata
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Oncol Rep 21:1611-9. 2009..This may explain previous inconsistencies for the relationship of serum leptin with BC. More studies are needed to better understand the complex interactions that exist between these two adipokines... - Enhancement of mammary carcinogenesis in two rodent models by silymarin dietary supplementsBarbara Malewicz
The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Carcinogenesis 27:1739-47. 2006..Because silymarin is being used in the treatment of liver cirrhosis and a variety of other human ailments, and is sold as a dietary supplement, our findings add a cautionary note to its application in breast cancer prevention... - Role of the adiponectin leptin ratio in prostate cancerMichael E Grossmann
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Oncol Res 18:269-77. 2009..Overall, this work suggests that adiponectin, leptin, and their receptors may play an important role in prostate cancer... - Punicic acid is an omega-5 fatty acid capable of inhibiting breast cancer proliferationMichael E Grossmann
University of Minnesota, Hormel Institute, Austin, MN 55912 3679, USA
Int J Oncol 36:421-6. 2010..These results suggest that punicic acid has breast cancer inhibitor properties that are dependent on lipid peroxidation and the PKC pathway... - Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 statusAmitabha Ray
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Int J Oncol 30:1499-509. 2007..Continued study on leptin may be helpful for a better understanding of breast cancer development in obese women... - Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanismMichael E Grossmann
University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Cancer Prev Res (Phila) 2:879-86. 2009..These results illustrate that alpha-ESA can block breast cancer cell proliferation and induce apoptosis through a mechanism that may be oxidation dependent... - Targeting the adiponectin:leptin ratio for postmenopausal breast cancer preventionMargot P Cleary
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Front Biosci (Schol Ed) 1:329-57. 2009..Additionally, we propose strategies to alter this ratio and thus provide protection against the development of breast cancer... - Effect of chronic and intermittent calorie restriction on serum adiponectin and leptin and mammary tumorigenesisOlga P Rogozina
1The Hormel Institute, University of Minnesota, Austin and 2Mayo Clinic, Rochester, Minnesota 55912, USA
Cancer Prev Res (Phila) 4:568-81. 2011....