M P Cleary

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Effects of adiponectin on breast cancer cell growth and signaling
    M E Grossmann
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Br J Cancer 98:370-9. 2008
  2. pmc The manner in which calories are restricted impacts mammary tumor cancer prevention
    Margot P Cleary
    University of Minnesota Hormel Institute, 801 16th Ave NE Austin, MN 55912 3679, USA
    J Carcinog 10:21. 2011
  3. pmc Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity
    Melissa J L Bonorden
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Prostate Cancer 2012:543970. 2012
  4. pmc Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-alpha mice
    Soner Dogan
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Breast Cancer Res 9:R91. 2007
  5. doi request reprint Serum insulin-like growth factor-I and mammary tumor development in ad libitum-fed, chronic calorie-restricted, and intermittent calorie-restricted MMTV-TGF-alpha mice
    Olga P Rogozina
    The Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 2:712-9. 2009
  6. ncbi request reprint Diet-induced obesity and mammary tumor development in MMTV-neu female mice
    Margot P Cleary
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Nutr Cancer 50:174-80. 2004
  7. ncbi request reprint Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-alpha mice
    M P Cleary
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Int J Obes Relat Metab Disord 28:956-62. 2004
  8. ncbi request reprint Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors
    Margot P Cleary
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Exp Biol Med (Maywood) 229:182-93. 2004
  9. doi request reprint Leptin as a potential therapeutic target for breast cancer prevention and treatment
    Amitbha Ray
    University of Minnesota, The Hormel Institute, 801 16th Avenue NE, Austin, MN 55912, USA
    Expert Opin Ther Targets 14:443-51. 2010
  10. ncbi request reprint Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Breast Cancer Res Treat 77:205-15. 2003

Collaborators

Detail Information

Publications34

  1. pmc Effects of adiponectin on breast cancer cell growth and signaling
    M E Grossmann
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Br J Cancer 98:370-9. 2008
    ..This inhibition appeared to be due to blockage of JNK2 signalling. These results provide information on how obesity may influence breast cancer cell proliferation and establish a new model to examine interactions between ER and Acrp30...
  2. pmc The manner in which calories are restricted impacts mammary tumor cancer prevention
    Margot P Cleary
    University of Minnesota Hormel Institute, 801 16th Ave NE Austin, MN 55912 3679, USA
    J Carcinog 10:21. 2011
    ..Application of this approach to at-risk women may provide an approach to lower the risk of breast cancer in overweight/obese women...
  3. pmc Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity
    Melissa J L Bonorden
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Prostate Cancer 2012:543970. 2012
    ..In summary, TRAMP-C2 cells grew faster when the mice were fed a high-fat diet. Further synaptophysin may be a marker of poor prognosis independent of weight and diet...
  4. pmc Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-alpha mice
    Soner Dogan
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Breast Cancer Res 9:R91. 2007
    ..One link between obesity and breast cancer is the adipokine, leptin. Here, the focus is on diet-induced obesity and MT and mammary fat pad (MFP) leptin and apoptotic signaling proteins...
  5. doi request reprint Serum insulin-like growth factor-I and mammary tumor development in ad libitum-fed, chronic calorie-restricted, and intermittent calorie-restricted MMTV-TGF-alpha mice
    Olga P Rogozina
    The Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 2:712-9. 2009
    ..However, the specific role of IGF-I in the protective effect of calorie restriction remains to be determined. These results confirm that ICR prevents MT development to a greater extent than CCR...
  6. ncbi request reprint Diet-induced obesity and mammary tumor development in MMTV-neu female mice
    Margot P Cleary
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Nutr Cancer 50:174-80. 2004
    ..0001). MT latency, incidence, metastasis, and burden were similar for all groups. These findings support that obesity is not a risk factor for development of estrogen-negative breast cancer...
  7. ncbi request reprint Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-alpha mice
    M P Cleary
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Int J Obes Relat Metab Disord 28:956-62. 2004
    ..This provided the opportunity to compare mice fed the high fat diet exhibiting different body weights and mice of similar weight consuming high vs low fat diets...
  8. ncbi request reprint Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors
    Margot P Cleary
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Exp Biol Med (Maywood) 229:182-93. 2004
    ..This study provides additional evidence that leptin and its cognate receptor may be involved in mammary tumorigenesis...
  9. doi request reprint Leptin as a potential therapeutic target for breast cancer prevention and treatment
    Amitbha Ray
    University of Minnesota, The Hormel Institute, 801 16th Avenue NE, Austin, MN 55912, USA
    Expert Opin Ther Targets 14:443-51. 2010
    ..Leptin is one of the adipokines that is measured in serum/plasma in increasing amounts as body weight/body fat increases...
  10. ncbi request reprint Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Breast Cancer Res Treat 77:205-15. 2003
    ..However, the finding that increased body weight is associated with increased oncogene-induced MT development within the normal weight range provides experimental support for the role of body weight in breast cancer...
  11. ncbi request reprint Weight-cycling decreases incidence and increases latency of mammary tumors to a greater extent than does chronic caloric restriction in mouse mammary tumor virus-transforming growth factor-alpha female mice
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Epidemiol Biomarkers Prev 11:836-43. 2002
    ..Future studies should address the application of this intervention to additional transgenic mice as well as other MT models...
  12. doi request reprint Effect of obesity on breast cancer development
    M P Cleary
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Vet Pathol 47:202-13. 2010
    ..This review explores the relationship between these factors and the development of mammary cancer in humans and mouse models...
  13. ncbi request reprint Prevention of mammary tumorigenesis by intermittent caloric restriction: does caloric intake during refeeding modulate the response?
    Margot P Cleary
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Exp Biol Med (Maywood) 232:70-80. 2007
    ..001), but there was no effect on MTs. These results confirm that ICR prevents development of MTs to a greater extent than does CCR, although "overeating" during refeeding may compromise this protection...
  14. ncbi request reprint Genotype and diet effects in lean and obese Zucker rats fed either safflower or coconut oil diets
    M P Cleary
    Hormel Institute, University of Minnesota, Austin 55912, USA
    Proc Soc Exp Biol Med 220:153-61. 1999
    ..The heterozygous effect of the "fa" gene in suckling Zucker rats was confirmed. However, high-fat feeding did not result in a heterozygous effect in young adult lean male rats. We will next evaluate the role of sex on this effect...
  15. ncbi request reprint The presence of the "fa" gene in heterozygous (FA/fa) lean female rats, effects on body weight, body fat and serum leptin
    M P Cleary
    Hormel Institute, University of Minnesota, Austin 55912, USA
    Obes Res 7:293-8. 1999
    ..In the present study, the effect of the "fa" gene on body weight and body fat in lean female rats was investigated...
  16. ncbi request reprint Effect of moderate caloric restriction and/or weight cycling on mammary tumor incidence and latency in MMTV-Neu female mice
    Kristin A Pape-Ansorge
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Nutr Cancer 44:162-8. 2002
    ..These results indicate that intermittent caloric restriction-refeeding provides a moderate protective effect, whereas chronic caloric restriction provides no significant protection against MT development in transgenic Neu mice...
  17. doi request reprint Cross-sectional analysis of intermittent versus chronic caloric restriction in the TRAMP mouse
    Melissa J L Bonorden
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Prostate 69:317-26. 2009
    ..Previously we found that intermittent calorie restriction (ICR) delayed the age of prostate tumor detection and death in TRAMP mice in comparison to chronic calorie restricted (CCR) and ad libitum fed (AL) TRAMP mice...
  18. ncbi request reprint Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats
    B Burguera
    Endocrine Research Unit, University of Minnesota, Austin, USA
    Diabetes 49:1219-23. 2000
    ..These findings strongly suggest that the leptin receptor (OB-R) in the BBB can be easily saturated. Saturation of the BBB OB-R in obese individuals would explain the defect in leptin transport into the brain described in this study...
  19. ncbi request reprint Restoration of fertility in young obese (Lep(ob) Lep(ob)) male mice with low dose recombinant mouse leptin treatment
    M P Cleary
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Int J Obes Relat Metab Disord 25:95-7. 2001
    ..We investigated the effects of low-dose leptin treatment on restoration of fertility in young adult male leptin deficient obese mice...
  20. ncbi request reprint Diet-induced obesity and mammary tumor development in relation to estrogen receptor status
    Amitabha Ray
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Cancer Lett 253:291-300. 2007
    ..In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism...
  21. ncbi request reprint Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development
    Xin Hu
    The Hormel Institute, University of Minnesota, Austin 55912, USA
    J Natl Cancer Inst 94:1704-11. 2002
    ....
  22. doi request reprint Intermittent calorie restriction delays prostate tumor detection and increases survival time in TRAMP mice
    Melissa J L Bonorden
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Nutr Cancer 61:265-75. 2009
    ..These results indicate that the way in which calories are restricted impacts both time to tumor detection and survival in TRAMP mice, with ICR providing greater protective effect compared to CCR...
  23. doi request reprint Mammary tumor development from T47-D human breast cancer cells in obese ovariectomized mice with and without estradiol supplements
    Katai J Nkhata
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Breast Cancer Res Treat 114:71-83. 2009
    ..These findings suggest that in vivo estrogen suppressed proliferation of T47-D cells but without supplemental estrogen obesity enhanced tumor development. The exact reason for this is not presently clear...
  24. ncbi request reprint No effect of long-term DHEA treatment on either hepatocyte and adipocyte pentose pathway activity or adipocyte glycerol release
    D A Diersen-Schade
    Hormel Institute, University of Minnesota, Austin
    Horm Metab Res 21:356-8. 1989
    ..No significant effects could be attributed to this treatment. There was also no effect on basal or epinephrine-stimulated glycerol release from adipocytes...
  25. pmc Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit
    Lei Wang
    Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 2:484-95. 2009
    ..Therefore, these selenium compounds may effectively inhibit this model of prostate cancer carcinogenesis...
  26. ncbi request reprint Enhancement of mammary carcinogenesis in two rodent models by silymarin dietary supplements
    Barbara Malewicz
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 27:1739-47. 2006
    ..Because silymarin is being used in the treatment of liver cirrhosis and a variety of other human ailments, and is sold as a dietary supplement, our findings add a cautionary note to its application in breast cancer prevention...
  27. ncbi request reprint Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status
    Amitabha Ray
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Int J Oncol 30:1499-509. 2007
    ..Continued study on leptin may be helpful for a better understanding of breast cancer development in obese women...
  28. ncbi request reprint Role of the adiponectin leptin ratio in prostate cancer
    Michael E Grossmann
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Oncol Res 18:269-77. 2009
    ..Overall, this work suggests that adiponectin, leptin, and their receptors may play an important role in prostate cancer...
  29. ncbi request reprint Effects of adiponectin and leptin co-treatment on human breast cancer cell growth
    Katai J Nkhata
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Oncol Rep 21:1611-9. 2009
    ..This may explain previous inconsistencies for the relationship of serum leptin with BC. More studies are needed to better understand the complex interactions that exist between these two adipokines...
  30. ncbi request reprint Punicic acid is an omega-5 fatty acid capable of inhibiting breast cancer proliferation
    Michael E Grossmann
    University of Minnesota, Hormel Institute, Austin, MN 55912 3679, USA
    Int J Oncol 36:421-6. 2010
    ..These results suggest that punicic acid has breast cancer inhibitor properties that are dependent on lipid peroxidation and the PKC pathway...
  31. pmc Minireview: Obesity and breast cancer: the estrogen connection
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Endocrinology 150:2537-42. 2009
    ..Human and relevant preclinical studies are cited. In addition, other growth factors that may be involved in this relationship are considered...
  32. doi request reprint Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism
    Michael E Grossmann
    University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 2:879-86. 2009
    ..These results illustrate that alpha-ESA can block breast cancer cell proliferation and induce apoptosis through a mechanism that may be oxidation dependent...
  33. ncbi request reprint Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Front Biosci (Schol Ed) 1:329-57. 2009
    ..Additionally, we propose strategies to alter this ratio and thus provide protection against the development of breast cancer...
  34. pmc Effect of chronic and intermittent calorie restriction on serum adiponectin and leptin and mammary tumorigenesis
    Olga P Rogozina
    1The Hormel Institute, University of Minnesota, Austin and 2Mayo Clinic, Rochester, Minnesota 55912, USA
    Cancer Prev Res (Phila) 4:568-81. 2011
    ....