A H Clayton

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..They also show that specific types of sexual problems may be related more to nonshared environmental factors. Overall, the results suggest FSD is multifactorial...

..The symptoms of major depressive disorder (MDD) include sexual dysfunction, but antidepressant pharmacotherapies are also associated with treatment-emergent sexual dysfunction...

..The sensitivity of the decreased sexual desire screener was 0.946 in a North American trial and 0.960 in a European trial...

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..Depression is particularly prevalent among women in the reproductive years. This article reviews research on the risk of depression during the transition to menopause and discusses screening methods and management options...

..Thus, a separate section on medications that impair sexual functioning is presented. A table of common medications as a quick reference to their effects on each stage of the sexual cycle is also provided...

..g., with oral contraceptives). Treatment with oral contraceptives (OCs), particularly extended or continuous use, may significantly reduce the incidence of menstrual cycle-related symptoms...

..Sexual dysfunction is a disturbance in sexual functioning involving one or multiple phases of the sexual response cycle or pain associated with sexual activity, while a sexual disorder includes both dysfunction and marked distress...

..Thus, bupropion has proven effective across a broad spectrum of depressive conditions, subtypes and comorbidities...

..The addition of antidotal therapy has been proven to be among the effective management strategies for sexual dysfunction. However, due to a lack of systematic data, additional studies are warranted to further investigate these findings...

..The purpose of this investigation was to characterize the safety and tolerability of desvenlafaxine (administered as desvenlafaxine succinate) in treating depression...

..Sexual dysfunction (SD) occurs frequently in patients with psychiatric illness...

..This study suggests that supplemental testosterone may improve sexual desire in women with hypoactive sexual desire without hypoandrogenism...

..A variety of treatment modalities exist, though current research has not yet provided Food and Drug Administration approved therapies for sexual disorders in women...

..Clinical trial design in female sexual dysfunction (FSD) is an evolving science, with some areas of controversy...

..A variety of treatment modalities exist, though current research has not yet provided Food and Drug Administration-approved therapies for sexual disorders in women...

..A greater understanding of the complex pathophysiology of HSDD would improve the identification and management of women for whom low sexual desire is a concern...

..The Sexual Interest and Desire Inventory-Female (SIDI-F) is a 13-item scale developed as a clinician-administered assessment tool to measure hypoactive sexual desire disorder (HSDD) severity in women...

..The aim of this article is to present an overview of the pharmacology, clinical efficacy and safety of flibanserin. Flibanserin is an investigational drug that is not licensed for any indication in any country...

..To compare the effects on sexual functioning and the antidepressant efficacy of once-daily bupropion extended release (XL) and escitalopram in adults with major depressive disorder (MDD)...

..The 24 women who returned for the second and third visits reported less frequent orgasms and less satisfaction from their orgasms premenstrually than during midcycle...

..Gender differences in clinical presentation and response to sertraline treatment were examined for patients diagnosed with DSM-III-R panic disorder with or without agoraphobia...

..The three groups exhibited potentially significant differences in several biological markers. This study's results are consistent with a hypothesis implicating serotonin in the generation of premenstrual symptomology...

..Exploratory analyses of the association of testosterone and sexual functioning in women in the study were also performed...

..Interventions may also be multifaceted, ranging from sex education to psychotherapy to medical treatment. Restoration of sexual functioning is the goal of treatment, but more research is needed for true success to be realized...

..Taken together, the results of the present investigation indicate that the SIDI-F is a reliable and valid measure of HSDD severity, independent of relationship issues...

..These results suggest that reboxetine may be of particular benefit for patients at risk for sexual dysfunction with SSRIs...

..Emerging data on the pathophysiology of sexual function and dysfunction, and new treatment options may lead to improved quality of life for women diagnosed with depression...

..This study examines phase-specific sexual dysfunction among patients who are being treated for major depression and who do not meet criteria for global sexual dysfunction...

..Treatment should therefore be tailored accordingly. Thus, it is often necessary to combine different options in order to achieve the maximum benefit in patients suffering from fibromyalgia...

..Results show that sexual functioning improves after the addition of bupropion SR to SSRI treatment and continues to improve, after discontinuation of the SSRI, with bupropion SR treatment alone...

..Appropriate evaluation of sexual functioning associated with depression could help reduce the enormous societal costs of this disorder...

..In conclusion, in this patient population (ie, relatively young, sexually active outpatients), bupropion XL was at least as effective as venlafaxine XR and had a significantly more favorable sexual side effect profile...

..To identify putative demographic and clinical variables that correlate with antidepressant response to the SNRI duloxetine in major depression...

..Factor analysis confirms the construct validity of the CSFQ-14 as a global measure of sexual dysfunction. The CSFQ-14 and the individual scales exhibit strong internal reliability...

..This finding could, however, not be replicated when improvement in anxious/somatic symptoms was defined as a continuous measure...

..When reviewed in context with the efficacy trials, a compelling argument can be made for making sertraline a first choice among the serotonin reuptake inhibitors in the treatment of PD...

..A sample of Latino women from an ambulatory obstetrics and gynecology (Ob/Gyn) clinic were queried about their sexual functioning using the Changes in Sexual Functioning Questionnaire (CSFQ-14)...

..The objective of this study was to examine the impact of STS 6 mg/24 hours on various domains of sexual function in patients with major depressive disorder (MDD), using a patient-rated questionnaire...

..Thus, an increased understanding of the CED may result in improved treatment and functioning of many patients...

..Together, these data demonstrate a permissive role for serotonergic systems in the metabolic control of reproduction and are consistent with the hypothesis that serotonergic neurons convey leptin signals to GnRH neurons...

..6; p=0.046). Furthermore, the 5HT2A -1438 GG genotype was a significant predictor of lower arousal scores (p=0.022) after accounting for other measures. There was no significant relationship between any outcome measure and GNB3 genotype...

..In addition, the faculty discussed the importance of patient psychoeducation and self-management as well as the ways in which disease models of depression affect treatment...

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..The current study was designed to evaluate the validity of obtaining CSFQ data using interactive voice response (IVR) technology...

..Female sexual dysfunction (FSD), in particular, complaints of low desire, affects many American women. Despite the impact FSD may have on these women, many do not present their symptoms to their physicians...

..Sexual medicine education is an important and fundamental topic not adequately represented in most undergraduate and residency training programs...