Jean Michel Claverie

Summary

Affiliation: University of Nebraska
Country: USA

Publications

  1. pmc The genome of the polar eukaryotic microalga Coccomyxa subellipsoidea reveals traits of cold adaptation
    Guillaume Blanc
    Structural and Genomic Information Laboratory, UMR7256 CNRS, Aix Marseille University, Mediterranean Institute of Microbiology FR3479, Marseille, FR 13385, France
    Genome Biol 13:R39. 2012
  2. pmc Chloroviruses: not your everyday plant virus
    James L Van Etten
    Department of Plant Pathology and Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68583 0900, USA
    Trends Plant Sci 17:1-8. 2012
  3. ncbi request reprint Giant viruses infecting algae
    J L Van Etten
    Department of Plant Pathology, University of Nebraska, Lincoln 68583 0722, USA
    Annu Rev Microbiol 53:447-94. 1999
  4. ncbi request reprint Unusual life style of giant chlorella viruses
    James L Van Etten
    Nebraska Center for Virology and Department of Plant Pathology, University of Nebraska, Lincoln, Nebraska 68583 0722, USA
    Annu Rev Genet 37:153-95. 2003
  5. pmc DNA viruses: the really big ones (giruses)
    James L Van Etten
    Department of Plant Pathology, University of Nebraska, Lincoln, Nebraska 68583, USA
    Annu Rev Microbiol 64:83-99. 2010
  6. pmc Another really, really big virus
    James L Van Etten
    Department of Plant Pathology, Nebraska Center for Virology, 205 Morrison Hall, University of Nebraska, Lincoln, NE 68583, USA
    Viruses 3:32-46. 2011
  7. pmc Sequence and annotation of the 288-kb ATCV-1 virus that infects an endosymbiotic chlorella strain of the heliozoon Acanthocystis turfacea
    Lisa A Fitzgerald
    Department of Chemistry, University of Nebraska Lincoln, Lincoln, NE 68588 0304, USA
    Virology 362:350-61. 2007
  8. ncbi request reprint Are chlorella viruses a rich source of ion channel genes?
    Ming Kang
    Department of Plant Pathology, University of Nebraska, Lincoln, NE 68583 0722, USA
    FEBS Lett 552:2-6. 2003
  9. ncbi request reprint Phycodnaviruses: a peek at genetic diversity
    David D Dunigan
    Department of Plant Pathology, University of Nebraska Lincoln, Lincoln, NE 68583 0722, USA
    Virus Res 117:119-32. 2006
  10. pmc Sequence and annotation of the 369-kb NY-2A and the 345-kb AR158 viruses that infect Chlorella NC64A
    Lisa A Fitzgerald
    Department of Chemistry, University of Nebraska Lincoln, Lincoln, NE 68588 0304, USA
    Virology 358:472-84. 2007

Collaborators

  • David D Dunigan
  • WILLIAM CHARLES NIERMAN
  • Karsten Suhre
  • Dario DiFrancesco
  • Tae Jin Choi
  • D T Dryden
  • Noreen E Murray
  • Michela Tonetti
  • Nick Grishin
  • Nicolas Delaroque
  • Takashi Yamada
  • R J Roberts
  • James Van Etten
  • James L Van Etten
  • Lisa A Fitzgerald
  • Anna Moroni
  • Gerhard Thiel
  • Ming Kang
  • Sabrina Gazzarrini
  • James R Gurnon
  • Yuanzheng Zhang
  • Michael V Graves
  • Giane M Yanai-Balser
  • Mario Mehmel
  • Jennifer S Dickey
  • Xiao Li
  • Irina Agarkova
  • Irina V Agarkova
  • Florian Frohns
  • Guillaume Blanc
  • Neil Osheroff
  • James Gurnon
  • Alan A Simpson
  • Narayanasamy Nandhagopal
  • Jörg Balss
  • Floriana Fruscione
  • Monika Neupärtl
  • Brigitte Hertel
  • Garry Duncan
  • Detlef Kramer
  • Tamara Feldblyum
  • James Hartigan
  • Sascha Baumann
  • Paola Valbuzzi
  • Yu G Kuznetsov
  • Siu Hong Chan
  • Sébastien Graziani
  • Nicolas Markine-Goriaynoff
  • Rahul Shah
  • Christen Brownlee
  • Maria Severino
  • Tobias Meckel
  • Byron Adams
  • Michael G Rossmann
  • Tiara A Morehead
  • John M Fortune
  • Jasmyn Pangilinan
  • Thomas Pröschold
  • Asaf Salamov
  • Mark Borodovsky
  • Igor V Grigoriev
  • Alexandre Lomsadze
  • Alan Kuo
  • Erika Lindquist
  • Andrew Brueggeman
  • Istvan Ladunga
  • Donald Weeks
  • Jane Grimwood
  • Susan Lucas
  • Jeremy Schmutz
  • Dong Wang
  • James D Eudy
  • Leslie C Lane
  • Garry A Duncan
  • Gentry Lewis
  • Christine Meyer
  • Dirk Baumeister
  • Panagiotis Papatheodorou
  • Joachim Rassow
  • Franck C Chatelain
  • Isabell Woll
  • Julia Barres
  • Daniel L Minor
  • J L Van Etten
  • Eleonora Di Zanni
  • Laura Sturla
  • Timo Greiner
  • Antonio De Flora
  • Philip T Boucher
  • Adrianne Sander

Detail Information

Publications46

  1. pmc The genome of the polar eukaryotic microalga Coccomyxa subellipsoidea reveals traits of cold adaptation
    Guillaume Blanc
    Structural and Genomic Information Laboratory, UMR7256 CNRS, Aix Marseille University, Mediterranean Institute of Microbiology FR3479, Marseille, FR 13385, France
    Genome Biol 13:R39. 2012
    ..This is the first eukaryotic microorganism from a polar environment to have its genome sequenced...
  2. pmc Chloroviruses: not your everyday plant virus
    James L Van Etten
    Department of Plant Pathology and Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68583 0900, USA
    Trends Plant Sci 17:1-8. 2012
    ..About 40% of the PBCV-1 encoded proteins resemble proteins of known function including many that are completely unexpected for a virus. In many respects, chlorovirus infection resembles bacterial infection by tailed bacteriophages...
  3. ncbi request reprint Giant viruses infecting algae
    J L Van Etten
    Department of Plant Pathology, University of Nebraska, Lincoln 68583 0722, USA
    Annu Rev Microbiol 53:447-94. 1999
    ..Unlike the chlorella viruses, large double-stranded-DNA-containing viruses that infect marine, filamentous brown algae have a circular genome and a lysogenic phase in their life cycle...
  4. ncbi request reprint Unusual life style of giant chlorella viruses
    James L Van Etten
    Nebraska Center for Virology and Department of Plant Pathology, University of Nebraska, Lincoln, Nebraska 68583 0722, USA
    Annu Rev Genet 37:153-95. 2003
    ..d) Many chlorella virus-encoded proteins are either the smallest or among the smallest proteins of their class. (e) Accumulating evidence indicates that the chlorella viruses have a very long evolutionary history...
  5. pmc DNA viruses: the really big ones (giruses)
    James L Van Etten
    Department of Plant Pathology, University of Nebraska, Lincoln, Nebraska 68583, USA
    Annu Rev Microbiol 64:83-99. 2010
    ..This review focuses on some of these differences than on extensive details about individual viruses...
  6. pmc Another really, really big virus
    James L Van Etten
    Department of Plant Pathology, Nebraska Center for Virology, 205 Morrison Hall, University of Nebraska, Lincoln, NE 68583, USA
    Viruses 3:32-46. 2011
    ..Proc. Natl. Acad. Sci. USA 2010, 107, 19508-19513). CroV has a 730 kb genome (with ∼544 protein-encoding genes) and infects the marine microzooplankton Cafeteria roenbergensis producing a lytic infection...
  7. pmc Sequence and annotation of the 288-kb ATCV-1 virus that infects an endosymbiotic chlorella strain of the heliozoon Acanthocystis turfacea
    Lisa A Fitzgerald
    Department of Chemistry, University of Nebraska Lincoln, Lincoln, NE 68588 0304, USA
    Virology 362:350-61. 2007
    ..Comparison of ATCV-1 protein-encoding genes with the prototype chlorella virus PBCV-1 indicates that about 80% of the ATCV-1 genes are present in PBCV-1...
  8. ncbi request reprint Are chlorella viruses a rich source of ion channel genes?
    Ming Kang
    Department of Plant Pathology, University of Nebraska, Lincoln, NE 68583 0722, USA
    FEBS Lett 552:2-6. 2003
    ..The viruses also encode other proteins that could be involved in the assembly and/or function of ion channels, including protein kinases and a phosphatase, polyamine biosynthetic enzymes and histamine decarboxylase...
  9. ncbi request reprint Phycodnaviruses: a peek at genetic diversity
    David D Dunigan
    Department of Plant Pathology, University of Nebraska Lincoln, Lincoln, NE 68583 0722, USA
    Virus Res 117:119-32. 2006
    ..Little is known about the replication of these viruses, but the consequences of these infections of the phytoplankton have global affects, including altered geochemical cycling and weather patterns...
  10. pmc Sequence and annotation of the 369-kb NY-2A and the 345-kb AR158 viruses that infect Chlorella NC64A
    Lisa A Fitzgerald
    Department of Chemistry, University of Nebraska Lincoln, Lincoln, NE 68588 0304, USA
    Virology 358:472-84. 2007
    ..Comparison of NY-2A and AR158 protein-encoding genes with the prototype chlorella virus PBCV-1 indicates that 85% of the genes are present in all three viruses...
  11. pmc Characterization of a monothiol glutaredoxin encoded by Chlorella virus PBCV-1
    Lisa A Fitzgerald
    Department of Plant Pathology, University of Nebraska, Lincoln, NE 68583, USA
    Virus Genes 39:418-26. 2009
    ..The grx gene is common in the Chlorella viruses. Molecular phylogenetic analyses of the PBCV-1 enzyme support its relatedness to those from other Chlorella viruses and yet demonstrate the divergence of the Grx molecule...
  12. pmc Virion-associated restriction endonucleases of chloroviruses
    Irina V Agarkova
    Department of Plant Pathology and Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68583 0722, USA
    J Virol 80:8114-23. 2006
    ..These immediate-early events associated with chlorovirus infections may facilitate rapid switching of the host transcriptional apparatus to viral transcription, which begins within 5 to 10 min p.i...
  13. pmc Sequence and annotation of the 314-kb MT325 and the 321-kb FR483 viruses that infect Chlorella Pbi
    Lisa A Fitzgerald
    Deparment of Chemistry, University of Nebraska Lincoln, Lincoln, NE 68588 0304, USA
    Virology 358:459-71. 2007
    ..Comparison of MT325 and FR483 protein-encoding genes with the prototype chlorella virus PBCV-1 indicates that approximately 82% of the genes are present in all three viruses...
  14. pmc Microarray analysis of Paramecium bursaria chlorella virus 1 transcription
    Giane M Yanai-Balser
    Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68583 0900, USA
    J Virol 84:532-42. 2010
    ..This study provides the first comprehensive evaluation of virus gene expression during the PBCV-1 life cycle...
  15. pmc Putative gene promoter sequences in the chlorella viruses
    Lisa A Fitzgerald
    Department of Plant Pathology, University of Nebraska Lincoln, Lincoln, NE 68583 0722, USA
    Virology 380:388-93. 2008
    ..The sequence and location of the motifs were often conserved among homologous ORFs within the Chlorovirus family. One of these conserved sequences (AATGACA) is predominately associated with genes expressed early in virus replication...
  16. ncbi request reprint Genetic diversity in chlorella viruses flanking kcv, a gene that encodes a potassium ion channel protein
    Ming Kang
    Department of Plant Pathology, University of Nebraska, Lincoln, NE 68583 0722, USA
    Virology 326:150-9. 2004
    ..iv) A comparison of the kcv 5' upstream sequences from the 16 viruses identified a highly conserved 10-nucleotide sequence that is present in the promoter region of all of the viruses...
  17. pmc Chloroviruses encode a bifunctional dCMP-dCTP deaminase that produces two key intermediates in dTTP formation
    Yuanzheng Zhang
    Department of Plant Pathology, University of Nebraska Lincoln, Lincoln, NE 68583 0722, USA
    J Virol 81:7662-71. 2007
    ..Zhang, H. Moriyama, K. Homma, and J. L. Van Etten, J. Virol. 79:9945-9953, 2005), means that PBCV-1 is the first virus to encode enzymes involved in all three known pathways to form dUMP...
  18. ncbi request reprint Characterization of a chlorella virus PBCV-1 encoded ribonuclease III
    Yuanzheng Zhang
    Department of Plant Pathology, University of Nebraska, Lincoln, NE 68583 0722, USA
    Virology 317:73-83. 2003
    ..i. and disappears by 120 min p.i. The a464r gene is highly conserved among the chlorella viruses. Phylogenetic analyses indicate that the PBCV enzyme is most closely related to Mycoplasma pneumoniae RNase III...
  19. pmc Chlorovirus-mediated membrane depolarization of Chlorella alters secondary active transport of solutes
    Irina Agarkova
    Department of Plant Pathology, University of Nebraska Lincoln, Lincoln, NE 68583 0900, USA
    J Virol 82:12181-90. 2008
    ....
  20. pmc Small potassium ion channel proteins encoded by chlorella viruses
    Ming Kang
    Department of Plant Pathology, University of Nebraska, Lincoln, NE 68583 0722, USA
    Proc Natl Acad Sci U S A 101:5318-24. 2004
    ....
  21. doi request reprint Chlorella viruses encode most, if not all, of the machinery to glycosylate their glycoproteins independent of the endoplasmic reticulum and Golgi
    James L Van Etten
    Department of Plant Pathology and Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68583 0900, USA
    Biochim Biophys Acta 1800:152-9. 2010
    ..Furthermore, all experimental results indicate that glycosylation occurs independent of the endoplasmic reticulum and Golgi...
  22. pmc Chlorella virus-encoded deoxyuridine triphosphatases exhibit different temperature optima
    Yuanzheng Zhang
    Department of Plant Pathology, University of Nebraska Lincoln, 68583 0722, USA
    J Virol 79:9945-53. 2005
    ..We postulate that the change in temperature optimum is due to reduction in charge and balkiness in the active cavity that allows more movement of the ligand and protein before the enzyme and substrate complex is formed...
  23. ncbi request reprint Ornithine decarboxylase encoded by chlorella virus PBCV-1
    Tiara A Morehead
    Department of Plant Pathology, University of Nebraska, Lincoln, Nebraska 68583 0722, USA
    Virology 301:165-75. 2002
    ..The 42-kDa PBCV-1 ODC (372 amino acids) is the smallest ODC in the databases and, to our knowledge, is the first virus-encoded ODC...
  24. pmc Chlorella viruses
    Takashi Yamada
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi, Japan
    Adv Virus Res 66:293-336. 2006
    ..This review mainly deals with research on the virion structure, genome rearrangements, gene expression, cell wall degradation, polysaccharide synthesis, and evolution of PBCV-1 as well as other related viruses...
  25. pmc The structure and evolution of the major capsid protein of a large, lipid-containing DNA virus
    Narayanasamy Nandhagopal
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 99:14758-63. 2002
    ....
  26. ncbi request reprint Differential role of NADP+ and NADPH in the activity and structure of GDP-D-mannose 4,6-dehydratase from two chlorella viruses
    Floriana Fruscione
    Department of Experimental Medicine, University of Genoa and Center of Excellence for Biomedical Research, Viale Benedetto XV 1, 16132 Genoa, Italy
    J Biol Chem 283:184-93. 2008
    ....
  27. ncbi request reprint Possible function for virus encoded K+ channel Kcv in the replication of chlorella virus PBCV-1
    Mario Mehmel
    Membrane Biophysics, Botany Institute, Darmstadt University of Technology, Schnittspahnstrasse 3, 64287 Darmstadt, Germany
    FEBS Lett 552:7-11. 2003
    ..Together these data are consistent with the idea that the virus carries functional K+ channels in the virion and inserts them into the host cell plasma membrane during infection...
  28. pmc Transmembrane domain length of viral K+ channels is a signal for mitochondria targeting
    Jörg Balss
    Institute of Botany, Technische Universitat Darmstadt, D 64287 Darmstadt, Germany
    Proc Natl Acad Sci U S A 105:12313-8. 2008
    ..Hence only minor structural alterations in a transmembrane domain are sufficient to switch sorting of a K(+) channel between the plasma membrane and mitochondria...
  29. ncbi request reprint Paramecium bursaria Chlorella virus 1 encodes two enzymes involved in the biosynthesis of GDP-L-fucose and GDP-D-rhamnose
    Michela Tonetti
    Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV 1, 16132 Genoa, Italy
    J Biol Chem 278:21559-65. 2003
    ..Because fucose and rhamnose are components of the glycans attached to Vp54, the pathway could circumvent a limited supply of GDP sugars by the algal host...
  30. ncbi request reprint Site-specific DNA cleavage by Chlorella virus topoisomerase II
    John M Fortune
    Departments of Biochemistry and Medicine Hematology Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Biochemistry 41:11761-9. 2002
    ..These findings suggest that PBCV-1 topoisomerase II represents a unique model with which to dissect the DNA cleavage reaction of eukaryotic type II topoisomerases...
  31. ncbi request reprint The short N-terminus is required for functional expression of the virus-encoded miniature K(+) channel Kcv
    Anna Moroni
    Department of Biology and Istituto di Biofisica del CNR, Universita degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy
    FEBS Lett 530:65-9. 2002
    ..We conclude that the N-terminus controls functional properties of the Kcv channel, but does not influence protein expression...
  32. ncbi request reprint DNA methylation impacts the cleavage activity of Chlorella virus topoisomerase II
    Jennifer S Dickey
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 44:15378-86. 2005
    ..These findings suggest that the high DNA cleavage activity of chlorella virus topoisomerase II on unmodified nucleic acid substrates may reflect, at least in part, an adaptation to act on methylated genomic DNA...
  33. ncbi request reprint Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases
    Rahul Shah
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Biol Chem 279:35760-7. 2004
    ..This residue was found to be an important determinant of substrate binding for both l-arginine and l-ornithine, but it is not sufficient to encode the change in substrate preference...
  34. ncbi request reprint The viral potassium channel Kcv: structural and functional features
    Sabrina Gazzarrini
    Department of Biology, CNR IBF Unità di Milano, Universita degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
    FEBS Lett 552:12-6. 2003
    ..Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels...
  35. ncbi request reprint Glycosyltransferases encoded by viruses
    Nicolas Markine-Goriaynoff
    Immunology Vaccinology B43b, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, B 4000 Liege, Belgium
    J Gen Virol 85:2741-54. 2004
    ..The description of these enzymes illustrates several intriguing aspects of virology and provides further support for the importance of glycomics in biological processes...
  36. pmc Cloning of CviPII nicking and modification system from chlorella virus NYs-1 and application of Nt.CviPII in random DNA amplification
    Siu Hong Chan
    New England Biolabs, Inc, 32 Tozer Road, Beverly, MA 01915, USA
    Nucleic Acids Res 32:6187-99. 2004
    ..Nt.CviPII was used in combination with Bst DNA polymerase I large fragment to rapidly amplify anonymous DNA from genomic DNA or from a single bacterial colony...
  37. ncbi request reprint Atomic force microscopy investigation of a chlorella virus, PBCV-1
    Yu G Kuznetsov
    Department of Molecular Biology and Biochemistry, University of California Irvine, 560 Steinhaus Hall, Irvine, CA 92697 3900, USA
    J Struct Biol 149:256-63. 2005
    ..Also observed upon disintegration are strands of linear dsDNA. Fibers of unknown function are also occasionally seen associated with some virions...
  38. ncbi request reprint Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes
    Jennifer S Dickey
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 44:3899-908. 2005
    ..These findings suggest that robust DNA cleavage is intrinsic to the viral enzyme and imply that chlorella virus topoisomerase II plays a physiological role beyond the control of DNA topology...
  39. pmc Biography of James L. Van Etten
    Christen Brownlee
    Proc Natl Acad Sci U S A 101:5315-7. 2004
  40. pmc Potassium ion channels of Chlorella viruses cause rapid depolarization of host cells during infection
    Florian Frohns
    Institute of Botany, Department of Biology, Darmstadt University of Technology, Germany
    J Virol 80:2437-44. 2006
    ..We hypothesize that fusion of the virus internal membrane with the host plasma membrane results in an increase in K(+) conductance and membrane depolarization; this depolarization lowers the energy barrier for DNA release into the host...
  41. pmc Chlorella virus MT325 encodes water and potassium channels that interact synergistically
    Sabrina Gazzarrini
    Dipartimento di Biologia and Istituto di Biofisica Consiglio Nazionale delle Ricerche, Universita degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 103:5355-60. 2006
    ..Considering the universal role of osmosis, this mechanism is relevant to any cell coexpressing water and potassium channels and could have pathological as well as basic physiological relevance...
  42. ncbi request reprint Functional analysis of FAD-dependent thymidylate synthase ThyX from Paramecium bursaria Chlorella virus-1
    Sébastien Graziani
    Laboratory of Optics and Biosciences, INSERM U451 CNRS UMR 7645, Ecole Polytechnique, 91128 Palaiseau Cedex, France
    J Biol Chem 279:54340-7. 2004
    ..This oxidation activity is directly linked to FAD reduction. Our results indicate that ThyX-specific inhibitors can be designed that do not affect ThyA enzymes. Finally, a model is proposed for the early stages of ThyX catalysis...
  43. ncbi request reprint Structural analyses of Phycodnaviridae and Iridoviridae
    Alan A Simpson
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Acta Crystallogr D Biol Crystallogr 59:2053-9. 2003
    ..The adoption of pseudo-hexagonal capsomers places these viruses into a subset of the Caspar and Klug surface lattices...
  44. pmc A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes
    Richard J Roberts
    New England Biolabs, Beverly, MA 01915, USA
    Nucleic Acids Res 31:1805-12. 2003
    ..It provides explicit categories for the many different Type II enzymes now identified and provides a system for naming the putative genes found by sequence analysis of microbial genomes...
  45. pmc Chlorella viruses contain genes encoding a complete polyamine biosynthetic pathway
    Sascha Baumann
    Department of Plant Physiology, Ruhr Universitat Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Virology 360:209-17. 2007
    ..The aih and cpa genes are widespread in the chlorella viruses...
  46. ncbi request reprint Chlorella viruses evoke a rapid release of K+ from host cells during the early phase of infection
    Monika Neupärtl
    Institute of Botany, Technische Universitat Darmstadt, Schnittspahnstrasse 3, D 64287 Darmstadt, Germany
    Virology 372:340-8. 2008
    ..Therefore, it is reasonable to postulate that loss of K(+) and associated water fluxes from the host lower the pressure barrier to aid ejection of DNA from the virus particles into the host...

Research Grants25

  1. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 2000
    ..Such mutants could be important in structure-function analyses and in providing an assay for new inhibitors of these proteins, which would bear on treatments for heart disease and cancer. ..
  2. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 2004
    ..We propose to initiate studies on the role of Kcv in PBCV-1 replication. ..
  3. DNA REPLICATION & GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 1991
    ..v) Isolate and characterize virus DNA and RNA polymerases from different virus-host combinations and compare the ability of the enzymes to function with different methylated DNA templates...
  4. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 1993
    ..v) To determine by genetic, molecular genetic, immunological, and biochemical methods those genes and gene products encoded by the prototype virus, PBCV-1, which glycosylate the virus major capsid protein...
  5. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 2009
    ..Thus, chlorella viruses are an important model for studying large nucleocytoplasmic dsDNA viruses because they have evolutionary ties to important mammalian viruses, such as the pox viruses and the quarantined African swine fever virus. ..