Steven D Clarke

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. ncbi request reprint Fatty acid regulation of gene expression: a genomic explanation for the benefits of the mediterranean diet
    Steven D Clarke
    Institute for Cellular and Molecular Biology and Division of Nutritional Sciences, University of Texas, Austin 78712, USA
    Ann N Y Acad Sci 967:283-98. 2002
  2. ncbi request reprint Nutrient regulation of gene expression: a methodological strategy
    S D Clarke
    Department of Human Ecology, University of Texas, Austin 78712, USA
    Miner Electrolyte Metab 23:130-4. 1997
  3. ncbi request reprint Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription
    S D Clarke
    Graduate Program of Nutrition and Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA
    Am J Physiol Gastrointest Liver Physiol 281:G865-9. 2001
  4. ncbi request reprint Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome
    S D Clarke
    Graduate Program of Nutrition and the Institute of Cell and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA
    J Nutr 131:1129-32. 2001
  5. ncbi request reprint Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance
    S D Clarke
    Graduate Program of Nutritional Sciences, University of Texas at Austin 78712, USA
    Br J Nutr 83:S59-66. 2000
  6. ncbi request reprint Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors
    S D Clarke
    Division of Nutritional Sciences and the Institute for Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA
    Am J Clin Nutr 70:566-71. 1999
  7. ncbi request reprint Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay
    J Xu
    Division of Nutritional Sciences, and the Institute for Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA
    J Biol Chem 276:9800-7. 2001
  8. ncbi request reprint Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms
    Jing Xu
    The Division of Nutritional Sciences and the Institute for Cellular and Molecular Biology, The University of Texas, Austin, TX 78712, USA
    J Nutr 132:3333-9. 2002
  9. ncbi request reprint NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription
    Margarita Teran-Garcia
    Division of Nutritional Sciences, University of Texas, Austin 78712, USA
    Biochem Biophys Res Commun 290:1295-9. 2002
  10. ncbi request reprint Omega-3 polyunsaturated fatty acid regulation of gene expression
    P T Price
    Division of Nutritional Sciences, and the Institute for Cellular and Molecular Biology, University of Texas at Austin, 78712 1097, USA
    Curr Opin Lipidol 11:3-7. 2000

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Fatty acid regulation of gene expression: a genomic explanation for the benefits of the mediterranean diet
    Steven D Clarke
    Institute for Cellular and Molecular Biology and Division of Nutritional Sciences, University of Texas, Austin 78712, USA
    Ann N Y Acad Sci 967:283-98. 2002
    ..In this review, we discuss the influence that (n-9), (n-6), and (n-3) fatty acids exert on gene expression in the liver and skeletal muscle and the impact this has on intra- and interorgan partitioning of metabolic fuels...
  2. ncbi request reprint Nutrient regulation of gene expression: a methodological strategy
    S D Clarke
    Department of Human Ecology, University of Texas, Austin 78712, USA
    Miner Electrolyte Metab 23:130-4. 1997
    ..More importantly, studies of this nature provide a basis for screening genetically susceptible populations and information that will allow the nutritionists of the 21st century to customize a diet for patients at risk...
  3. ncbi request reprint Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription
    S D Clarke
    Graduate Program of Nutrition and Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA
    Am J Physiol Gastrointest Liver Physiol 281:G865-9. 2001
    ....
  4. ncbi request reprint Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome
    S D Clarke
    Graduate Program of Nutrition and the Institute of Cell and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA
    J Nutr 131:1129-32. 2001
    ....
  5. ncbi request reprint Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance
    S D Clarke
    Graduate Program of Nutritional Sciences, University of Texas at Austin 78712, USA
    Br J Nutr 83:S59-66. 2000
    ....
  6. ncbi request reprint Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors
    S D Clarke
    Division of Nutritional Sciences and the Institute for Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA
    Am J Clin Nutr 70:566-71. 1999
    ....
  7. ncbi request reprint Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay
    J Xu
    Division of Nutritional Sciences, and the Institute for Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA
    J Biol Chem 276:9800-7. 2001
    ....
  8. ncbi request reprint Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms
    Jing Xu
    The Division of Nutritional Sciences and the Institute for Cellular and Molecular Biology, The University of Texas, Austin, TX 78712, USA
    J Nutr 132:3333-9. 2002
    ..These data indicate that PUFA suppress the in vivo proteolytic release of SREBP-1 and -2, but the effect on SREBP-2 is transitory, possibly reflecting the ability of PUFA to enhance cholesterol losses via bile acid synthesis...
  9. ncbi request reprint NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription
    Margarita Teran-Garcia
    Division of Nutritional Sciences, University of Texas, Austin 78712, USA
    Biochem Biophys Res Commun 290:1295-9. 2002
    ..Interestingly, the distal PUFA-RR(FAS) has many similarities to the PUFA-RR of l-pyruvate kinase gene while the proximal PUFA-RR(FAS) is comparable to the PUFA-RR of the S14 and stearoyl-CoA desaturase genes...
  10. ncbi request reprint Omega-3 polyunsaturated fatty acid regulation of gene expression
    P T Price
    Division of Nutritional Sciences, and the Institute for Cellular and Molecular Biology, University of Texas at Austin, 78712 1097, USA
    Curr Opin Lipidol 11:3-7. 2000
    ....
  11. ncbi request reprint A novel 3T3-L1 preadipocyte variant that expresses PPARgamma2 and RXRalpha but does not undergo differentiation
    R A Baillie
    Institute for Cellular and Molecular Biology, and the Division of Nutritional Sciences, The University of Texas, Austin 78712, USA
    J Lipid Res 39:2048-53. 1998
    ..These data suggest that the 3T3-L1/RB1 variant contains a mutation that may prevent ligand activation of PPARgamma2, and the subsequent conversion of 3T3-L1/RB1 cells to mature fat cells...
  12. ncbi request reprint Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription
    C Rufo
    Division of Nutritional Sciences and the Institute for Cellular and Molecular Biology, The University of Texas, Austin, Texas, 78712, USA
    J Biol Chem 276:21969-75. 2001
    ..More importantly, a unique hepatic ChoRF has now been shown to recognize glucose responsive sequences that are common to three different genes: fatty-acid synthase, l-type pyruvate kinase, and S(14)...
  13. ncbi request reprint Cloning, expression, and fatty acid regulation of the human delta-5 desaturase
    H P Cho
    Program of Nutritional Sciences and the Institute for Cellular and Molecular Biology, The University of Texas Austin, Austin, Texas 78712, USA
    J Biol Chem 274:37335-9. 1999
    ..Finally, a BLAST and Genemap search of the human genome revealed that the Delta-5 and Delta-6 desaturase genes reside in reverse orientation on chromosome 11 and that they are separated by <11,000 base pairs...
  14. ncbi request reprint Polyunsaturated fatty acids and gene expression
    Alexandre Lapillonne
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2600, USA
    Curr Opin Clin Nutr Metab Care 7:151-6. 2004
    ....
  15. ncbi request reprint The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors
    Steven D Clarke
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Curr Opin Lipidol 15:13-8. 2004
    ..Although the intracellular signaling mechanisms employed by highly unsaturated fatty acids are unknown, this review presents a summary of the emerging knowledge regarding highly unsaturated fatty acids as kinase cascade activators...
  16. ncbi request reprint Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats
    Gabriela Suchankova
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Biochem Biophys Res Commun 326:851-8. 2005
    ....