Orlo H Clark

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Thyroid cancer and lymph node metastases
    Orlo H Clark
    Department of Surgery, Mt Zion Medical Center, University of California San Francisco, San Francisco, California 94115, USA
    J Surg Oncol 103:615-8. 2011
  2. doi request reprint Are additional localization studies and referral indicated for patients with primary hyperparathyroidism who have negative sestamibi scan results?
    Dina M Elaraj
    Department of Surgery, Feinberg School of Medicine, Northwestern University, 676 N St Clair St, Ste 650, Chicago, IL 60611, USA
    Arch Surg 145:578-81. 2010
  3. pmc Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A
    Michael W Yeh
    Endocrine Surgery Laboratory, UCSF Mt Zion Medical Center, San Francisco, California 94115, USA
    Endocr Relat Cancer 13:1173-83. 2006
  4. ncbi request reprint Troglitazone, the peroxisome proliferator-activated receptor-gamma agonist, induces antiproliferation and redifferentiation in human thyroid cancer cell lines
    Jin Woo Park
    Department of Surgery University of California, San Francisco, UCSF Mount Zion Medical Center, San Francisco, CA 94143, USA
    Thyroid 15:222-31. 2005
  5. doi request reprint Is adrenal venous sampling necessary in all patients with hyperaldosteronism before adrenalectomy?
    Rasa Zarnegar
    Department of Surgery, University of California San Francisco Medical Center, San Francisco, CA, USA
    J Vasc Interv Radiol 19:66-71. 2008
  6. doi request reprint Multiple genetic alterations in papillary thyroid cancer are associated with younger age at presentation
    Willieford Moses
    Department of Surgery, University of California, San Francisco, California 94143, USA
    J Surg Res 160:179-83. 2010
  7. doi request reprint Serum thyroglobulin is a poor diagnostic biomarker of malignancy in follicular and Hurthle-cell neoplasms of the thyroid
    Insoo Suh
    Department of Surgery, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0470, USA
    Am J Surg 200:41-6. 2010
  8. ncbi request reprint Nonfunctioning parathyroid carcinoma: case report and review of literature
    Gustavo G Fernandez-Ranvier
    Department of Surgery, University of California, San Francisco, California, USA
    Endocr Pract 13:750-7. 2007
  9. ncbi request reprint Diagnostic and prognostic value of cell-cycle regulatory genes in malignant thyroid neoplasms
    Electron Kebebew
    San Francisco Comprehensive Cancer Center, University of California, San Francisco, CA 94143 1674, USA
    World J Surg 30:767-74. 2006
  10. ncbi request reprint A phase II trial of rosiglitazone in patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancer
    Electron Kebebew
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    Surgery 140:960-6; discussion 966-7. 2006

Detail Information

Publications98

  1. doi request reprint Thyroid cancer and lymph node metastases
    Orlo H Clark
    Department of Surgery, Mt Zion Medical Center, University of California San Francisco, San Francisco, California 94115, USA
    J Surg Oncol 103:615-8. 2011
    ..Until more information is available we recommend preoperative ultrasonography and a selective ipsilateral neck dissection for patients with papillary thyroid cancer...
  2. doi request reprint Are additional localization studies and referral indicated for patients with primary hyperparathyroidism who have negative sestamibi scan results?
    Dina M Elaraj
    Department of Surgery, Feinberg School of Medicine, Northwestern University, 676 N St Clair St, Ste 650, Chicago, IL 60611, USA
    Arch Surg 145:578-81. 2010
    ..Additional imaging studies are useful to select patients who are candidates for minimally invasive parathyroidectomy, and referral is not indicated when results from a preoperative sestamibi scan are negative...
  3. pmc Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A
    Michael W Yeh
    Endocrine Surgery Laboratory, UCSF Mt Zion Medical Center, San Francisco, California 94115, USA
    Endocr Relat Cancer 13:1173-83. 2006
    ..MMP inhibitors and growth factor antagonists may be effective tumoristatic agents for the treatment of aggressive thyroid carcinomas...
  4. ncbi request reprint Troglitazone, the peroxisome proliferator-activated receptor-gamma agonist, induces antiproliferation and redifferentiation in human thyroid cancer cell lines
    Jin Woo Park
    Department of Surgery University of California, San Francisco, UCSF Mount Zion Medical Center, San Francisco, CA 94143, USA
    Thyroid 15:222-31. 2005
    ..PPARgamma agonists may therefore be effective therapeutic agents for the treatment of patients with thyroid cancer that fails to respond to traditional treatments...
  5. doi request reprint Is adrenal venous sampling necessary in all patients with hyperaldosteronism before adrenalectomy?
    Rasa Zarnegar
    Department of Surgery, University of California San Francisco Medical Center, San Francisco, CA, USA
    J Vasc Interv Radiol 19:66-71. 2008
    ..To evaluate whether selective rather than universal use of adrenal vein sampling (AVS) may be warranted in patients with hyperaldosteronism to characterize and lateralize disease before adrenalectomy...
  6. doi request reprint Multiple genetic alterations in papillary thyroid cancer are associated with younger age at presentation
    Willieford Moses
    Department of Surgery, University of California, San Francisco, California 94143, USA
    J Surg Res 160:179-83. 2010
    ..There is a significant gender and age disparity in thyroid cancer incidence and outcome. The molecular basis for these divergent clinical presentations and outcome are essentially unknown...
  7. doi request reprint Serum thyroglobulin is a poor diagnostic biomarker of malignancy in follicular and Hurthle-cell neoplasms of the thyroid
    Insoo Suh
    Department of Surgery, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0470, USA
    Am J Surg 200:41-6. 2010
    ..However, some clinicians measure preoperative Tg as a diagnostic cancer marker despite lack of supporting evidence. We examined whether Tg accurately predicts malignancy in follicular or Hürthle-cell neoplasms...
  8. ncbi request reprint Nonfunctioning parathyroid carcinoma: case report and review of literature
    Gustavo G Fernandez-Ranvier
    Department of Surgery, University of California, San Francisco, California, USA
    Endocr Pract 13:750-7. 2007
    ..To report a case of nonfunctioning parathyroid carcinoma that was incidentally found during a thyroidectomy for multinodular goiter...
  9. ncbi request reprint Diagnostic and prognostic value of cell-cycle regulatory genes in malignant thyroid neoplasms
    Electron Kebebew
    San Francisco Comprehensive Cancer Center, University of California, San Francisco, CA 94143 1674, USA
    World J Surg 30:767-74. 2006
    ..We hypothesized that genes that regulate cell-cycle progression would be differentially expressed in malignant versus benign thyroid nodules and could serve as diagnostic markers and markers of disease aggressiveness...
  10. ncbi request reprint A phase II trial of rosiglitazone in patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancer
    Electron Kebebew
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    Surgery 140:960-6; discussion 966-7. 2006
    ..Rosiglitazone is a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist that has been shown to induce differentiation, cell cycle arrest, and apoptosis in a variety of human cancers including thyroid cancer...
  11. doi request reprint Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancers
    Daniel T Ruan
    Department of Surgery, University of California, San Francisco, San Francisco, Calif, USA
    Surgery 144:908-13; discussion 913-4. 2008
    ..The purpose of this study was to determine if Mig-6 expression is associated with EGFR expression or surgical outcomes in PTC...
  12. doi request reprint Identification of biomarkers of adrenocortical carcinoma using genomewide gene expression profiling
    Gustavo G Fernandez-Ranvier
    Department of Surgery, J David Gladstone Institutes Genomics Core Laboratory, University of California, San Francisco, CA 94143 1674, USA
    Arch Surg 143:841-6; discussion 846. 2008
    ..The gene expression profiles of benign and malignant adrenocortical tumors are different...
  13. ncbi request reprint Does the presence of additional thyroid nodules on ultrasound alter the risk of malignancy in patients with a follicular neoplasm of the thyroid?
    Rebecca S Sippel
    Department of Surgery, University of California San Francisco, and the UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, CA 94143 1674, USA
    Surgery 142:851-7; discussion 857.e1-2. 2007
    ..We sought to determine whether the presence of additional thyroid nodules on preoperative ultrasound decreased the risk of malignancy in a patient with a follicular neoplasm...
  14. ncbi request reprint Id1 gene expression is up-regulated in hyperplastic and neoplastic thyroid tissue and regulates growth and differentiation in thyroid cancer cells
    Electron Kebebew
    San Francisco Comprehensive Cancer Center, University of California, San Francisco, California 94143 1674, USA
    J Clin Endocrinol Metab 89:6105-11. 2004
    ....
  15. doi request reprint Results of rosiglitazone therapy in patients with thyroglobulin-positive and radioiodine-negative advanced differentiated thyroid cancer
    Electron Kebebew
    Department of Surgery, University of California San Francisco UCSF, San Francisco, California 94143, USA
    Thyroid 19:953-6. 2009
    ..We investigated the efficacy and side effects of rosiglitazone therapy in patients with differentiated thyroid cancer of follicular cell origin that fails to take up radioiodine or is unresectable...
  16. doi request reprint Prospective evaluation of the rate and impact of hemolysis on intraoperative parathyroid hormone (IOPTH) assay results
    Jacob Moalem
    Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
    Ann Surg Oncol 17:2963-9. 2010
    ..Retrospective evidence suggested that hemolysis may artificially lower IOPTH results. Falsely decreased IOPTH measurements could result in either failed parathyroidectomy or unnecessary bilateral neck exploration...
  17. pmc Molecular testing for somatic mutations improves the accuracy of thyroid fine-needle aspiration biopsy
    Willieford Moses
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    World J Surg 34:2589-94. 2010
    ..To determine the clinical utility of genetic testing in thyroid FNA biopsy, we conducted a prospective clinical trial...
  18. doi request reprint Tumor size predicts malignant potential in Hürthle cell neoplasms of the thyroid
    Rebecca S Sippel
    Department of Surgery, University of California San Francisco and the UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, CA 94143, USA
    World J Surg 32:702-7. 2008
    ..We sought to determine if the primary tumor size correlated with the risk of malignancy in patients with a preoperative FNA diagnosis of a Hürthle cell neoplasm...
  19. ncbi request reprint Expression of vascular endothelial growth factor-C in benign and malignant thyroid tumors
    Chung J Hung
    Endocrine Surgical Oncology Fellows, University of California San Francisco, California 94143, USA
    J Clin Endocrinol Metab 88:3694-9. 2003
    ..The lymphangiogenic role of VEGF-C in thyroid cancers therefore appears to be complex and other factors are likely to be also involved...
  20. pmc Fluorodeoxyglucose-positron emission tomography scan-positive recurrent papillary thyroid cancer and the prognosis and implications for surgical management
    Jennifer M J Schreinemakers
    Department of Surgery, University of California, 1600 Divisadero Street, Box 1711, San Francisco, CA 94115, USA
    World J Surg Oncol 10:192. 2012
    ....
  21. doi request reprint Distinct loci on chromosome 1q21 and 6q22 predispose to familial nonmedullary thyroid cancer: a SNP array-based linkage analysis of 38 families
    Insoo Suh
    Department of Surgery, University of California, San Francisco, CA, USA
    Surgery 146:1073-80. 2009
    ..We aimed to identify loci linked to FNMTC susceptibility using single-nucleotide polymorphism (SNP) array-based linkage analysis in a broad sampling of affected families...
  22. ncbi request reprint Comparison of clinical characteristics at diagnosis and during follow-up in 118 patients with Hurthle cell or follicular thyroid cancer
    Yevgeniya Kushchayeva
    Department of Surgery, University of California San Francisco, UCSF Mt Zion Medical Center, 1600 Divisadero Street C347, San Francisco, CA 94143 1674, USA
    Am J Surg 195:457-62. 2008
    ..Hurthle cell cancer (HCC) is considered by some to be a variant of follicular cancer (FC), but many think it is a distinct histologic tumor with a more aggressive behavior...
  23. ncbi request reprint Accuracy of preoperative localization studies and intraoperative parathyroid hormone assay in patients with primary hyperparathyroidism and double adenoma
    Mehmet Haciyanli
    Department of Surgery, University of California San Francisco Mount Zion Medical Center, San Francisco, CA, USA
    J Am Coll Surg 197:739-46. 2003
    ..The purpose of this retrospective investigation was to evaluate the results of preoperative localization studies and intraoperative parathyroid hormone (IOPTH) assay in patients with primary hyperparathyroidism and double adenomas...
  24. doi request reprint Central neck lymph node dissection for papillary thyroid cancer: the reliability of surgeon judgment in predicting which patients will benefit
    Wen T Shen
    Department of Surgery, University of California, San Francisco Mt Zion Medical Center, San Francisco, CA 94115, USA
    Surgery 148:398-403. 2010
    ..We perform CLND for PTC only in patients with enlarged nodes as determined by preoperative ultrasound and intraoperative inspection and palpation...
  25. ncbi request reprint Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis?
    Gustavo G Fernandez-Ranvier
    Department of Surgery, University of California at San Francisco, San Francisco, California 94143 1674, USA
    Cancer 110:255-64. 2007
    ..Parathyroid carcinoma, atypical parathyroid adenoma, and parathyromatosis can be differentiated relatively easily from typical parathyroid adenomas, but distinguishing them from each other is more difficult...
  26. ncbi request reprint Extent of disease at presentation and outcome for adrenocortical carcinoma: have we made progress?
    Electron Kebebew
    Department of Surgery, University of California, San Francisco, Box 1674, San Francisco, CA 94143 1674, USA
    World J Surg 30:872-8. 2006
    ..Recent studies suggest that this has led to earlier stage of ACC at diagnosis, more curative operations, and better survival...
  27. ncbi request reprint GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism
    Electron Kebebew
    Department of Surgery, University of California San Francisco, Box 1674, San Francisco, CA 94143, USA
    Surgery 136:1261-6. 2004
    ..The glial cell missing gene, GCMB , encodes a transcription factor, which is a master regulator of parathyroid development. We postulated that the GCMB gene might play a role in parathyroid tumorigenesis in hyperparathyroidism...
  28. ncbi request reprint Does routine consultation of thyroid fine-needle aspiration cytology change surgical management?
    Yah Y Tan
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 1674, USA
    J Am Coll Surg 205:8-12. 2007
    ..We sought to determine the concordance rates between FNA interpretations at referring institutions and our center to determine if they alter surgical management...
  29. doi request reprint Metastatic papillary thyroid cancer misdiagnosed as non-small [corrected] cell lung cancer
    Jacob Moalem
    Division of Surgical Oncology, Department of Surgery, University of Rochester, Rochester, New York 14642, USA
    Thyroid 21:319-23. 2011
    ..As thyroid cancers commonly spread to the lungs, metastatic thyroid cancer should be included in the differential diagnosis of a pulmonary lesion or lesions...
  30. doi request reprint The number of needle passes affects the accuracy of parathyroid hormone assay with intraoperative parathyroid aspiration
    Marlon A Guerrero
    Department of Surgery, University of Arizona, Tucson, AZ 85724, USA
    Am J Surg 200:701-5; discussion 705-6. 2010
    ..However, the reported aspiration technique varies in the literature. We sought to determine if the number of passes affected the accuracy of PTH analysis...
  31. doi request reprint Candidate genes associated with malignant pheochromocytomas by genome-wide expression profiling
    Insoo Suh
    Department of Surgery, University of California, San Francisco, CA 94143 1674, USA
    Ann Surg 250:983-90. 2009
    ..To improve our understanding of the molecular mechanisms involved in malignant pheochromocytoma by examining differences in the gene expression profile between benign and malignant tumors...
  32. ncbi request reprint Risk assessment in 457 adrenal cortical carcinomas: how much does tumor size predict the likelihood of malignancy?
    Cord Sturgeon
    Department of Surgery, University of California, San Francisco, USA
    J Am Coll Surg 202:423-30. 2006
    ..The recent NIH consensus conference did not make a definitive recommendation about management of 4- to 6-cm nonfunctioning incidentalomas...
  33. ncbi request reprint Should pheochromocytoma size influence surgical approach? A comparison of 90 malignant and 60 benign pheochromocytomas
    Wen T Shen
    Department of Surgery, University of California San Francisco, Hellman Building C3 47, 1600 Divisadero Street, San Francisco, CA 94143, USA
    Surgery 136:1129-37. 2004
    ..The aim of this study was to determine if pheochromocytoma size should affect the choice of surgical approach...
  34. ncbi request reprint Predictors of single-gland vs multigland parathyroid disease in primary hyperparathyroidism: a simple and accurate scoring model
    Electron Kebebew
    Comprehensive Cancer Center and Department of Surgery, University of California, San Francisco, USA
    Arch Surg 141:777-82; discussion 782. 2006
    ....
  35. doi request reprint Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13
    Gustavo G Fernandez-Ranvier
    Department of Surgery, University of California, San Francisco, School of Medicine, UCSF Mt Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94143 1674, USA
    World J Surg 32:873-81. 2008
    ..As genes on this chromosome may be important in the pathogenesis of adrenocortical carcinoma, we compared their expression profile between benign and malignant adrenocortical tissue...
  36. doi request reprint Localization of recurrent thyroid cancer using intraoperative ultrasound-guided dye injection
    Rebecca S Sippel
    Department of Surgery, University of Wisconsin Madison, Madison, WI, USA
    World J Surg 33:434-9. 2009
    ..The goal of this study was to evaluate the utility of preincision ultrasound-guided injection of blue dye into the abnormal lymph nodes to facilitate their safe and efficient removal...
  37. doi request reprint Patterns of antibiotic prophylaxis use for thyroidectomy and parathyroidectomy: results of an international survey of endocrine surgeons
    Jacob Moalem
    Department of Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Am Coll Surg 210:949-56. 2010
    ..Although cervical endocrine operations are classified as clean cases, and prophylactic antibiotics (pABX) are generally not indicated, practice patterns vary...
  38. doi request reprint Adrenal incidentaloma: does an adequate workup rule out surprises?
    Raymon H Grogan
    Department of Endocrine Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Surgery 148:392-7. 2010
    ..We sought to determine how accurately these guidelines identify functioning incidentalomas and how often these guidelines result in adrenalectomy for benign tumors...
  39. doi request reprint Central neck lymph node dissection for papillary thyroid cancer: comparison of complication and recurrence rates in 295 initial dissections and reoperations
    Wen T Shen
    Department of Surgery, University of California, San Francisco Mt Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94115, USA
    Arch Surg 145:272-5. 2010
    ..Critics of this approach argue that reoperative CLND has higher complication and recurrence rates than initial CLND. We sought to test this argument, using it as our hypothesis...
  40. doi request reprint Defining a molecular phenotype for benign and malignant parathyroid tumors
    Gustavo G Fernandez-Ranvier
    Department of Surgery, University of California at San Francisco, San Francisco, California 94143 1674, USA
    Cancer 115:334-44. 2009
    ....
  41. ncbi request reprint Observation or laparoscopic adrenalectomy for adrenal incidentaloma? A surgical decision analysis
    Laurent Brunaud
    Department of Surgery, University California San Francisco and Mount Zion Medical Center, Mount Zion Medical Center, San Francisco, CA, USA
    Med Sci Monit 12:CR355-62. 2006
    ..A decision analysis model was used to identify relevant variables for selecting the optimal management (observation versus adrenalectomy)...
  42. ncbi request reprint Malignant pheochromocytoma
    Rasa Zarnegar
    Department of Surgery, University California San Francisco, Comprehensive Cancer Center at Mount Zion, Medical Center, 1600 Divisadero Street, Hellman Building, Room C347, San Francisco, CA 94143 1764, USA
    Surg Oncol Clin N Am 15:555-71. 2006
    ....
  43. doi request reprint Does the 3-gene diagnostic assay accurately distinguish benign from malignant thyroid neoplasms?
    Daniel Shibru
    Department of Surgery, University of California at San Francisco, San Francisco, California 94143 1674, USA
    Cancer 113:930-5. 2008
    ..The aim of the current study was to determine the diagnostic accuracy of the 3-gene assay in thyroid tissue and in FNA biopsy for distinguishing benign from malignant thyroid neoplasms...
  44. doi request reprint Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancer
    Chi Iou Lin
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 96:E554-65. 2011
    ..Low tumoral expression of mitogen-inducible gene-6 (Mig-6) is associated with papillary thyroid cancer (PTC) recurrence after thyroidectomy...
  45. doi request reprint A population-based prospective cohort study of complications after thyroidectomy in the elderly
    Raymon H Grogan
    Endocrine Surgery Research Program, Department of Surgery, Section of Endocrine Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 97:1645-53. 2012
    ..Data on the risk of postthyroidectomy complications in elderly patients are sparse, unclear, and conflicting...
  46. doi request reprint The aldosteronoma resolution score: predicting complete resolution of hypertension after adrenalectomy for aldosteronoma
    Rasa Zarnegar
    Department of Surgery, Weill Cornell Medical College, New York, NY 10021, USA
    Ann Surg 247:511-8. 2008
    ..To develop a prediction model using information readily available, at clinical presentation, which could determine whether patients with aldosterone-producing adenomas would have complete resolution of hypertension after adrenalectomy...
  47. doi request reprint The management of aldosterone-producing adrenal adenomas--does adrenalectomy increase costs?
    Bethann Reimel
    Department of Surgery, Columbia University Medical Center, New York, NY, USA
    Surgery 148:1178-85; discussion 1185. 2010
    ..We sought to compare the current guideline-based (surgical) strategy with universal pharmacologic management to determine the optimal strategy from a cost perspective...
  48. ncbi request reprint Anaplastic thyroid cancer: cytogenetic patterns by comparative genomic hybridization
    Daishu Miura
    Department of Surgery, University of California, San Francisco Mount Zion Medical Center, San Francisco, California 94143 1674, USA
    Thyroid 13:283-90. 2003
    ..These findings support the concept that PTC and FTC have different genetic backgrounds and, even after the transformation to ATC, they may retain some of their cytogenetic characteristics...
  49. ncbi request reprint Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells
    Wen T Shen
    Department of Surgery, Endocrine Surgery Laboratory, UCSF Mt Zion Medical Center, San Francisco, CA 94143 1674, USA
    Surgery 138:979-84; discussion 984-5. 2005
    ..Valproic acid (VA) is an anticonvulsant that inhibits histone deacetylase activity at nontoxic concentrations. We hypothesized that VA would have antineoplastic effects on human thyroid cancer cells...
  50. doi request reprint Clinical spectrum of pheochromocytoma
    Marlon A Guerrero
    Department of Surgery, University of California, 1600 Divisadero St, San Francisco, CA 94115, USA
    J Am Coll Surg 209:727-32. 2009
    ..The goal of this study was to determine if tumor size and hormone level correlate according to the clinical presentation at diagnosis...
  51. ncbi request reprint Modulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by chemotherapy in thyroid cancer cell lines
    Jin Woo Park
    Department of Surgery, University of California, San Francisco, UCSF Mount Zion Medical Center, San Francisco, California 94143 1674, USA
    Thyroid 13:1103-10. 2003
    ..In conclusion, TRAIL in combination with troglitazone, paclitaxel, and cycloheximide induces apoptosis in thyroid cancer cells at suboptimal concentrations that cannot be achieved using TRAIL alone...
  52. ncbi request reprint Diagnostic and prognostic value of fas and telomeric-repeat binding factor-1 genes in adrenal tumors
    Hajime Kanauchi
    Endocrine Surgical Oncology Fellows, Department of Surgery, University of California San Francisco UCSF, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 88:3690-3. 2003
    ..This lack of expression of fas in adrenal cortical cancer may help to distinguish it from benign adrenal tumors. The level of TRF-1 expression may be helpful prognostically for patients with adrenal cortical cancers...
  53. pmc The prevalence and prognostic value of BRAF mutation in thyroid cancer
    Electron Kebebew
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143 1674, USA
    Ann Surg 246:466-70; discussion 470-1. 2007
    ..To examine the prevalence of BRAF mutation among thyroid cancer histologic subtypes and determine the association of BRAF mutation with indicators of poor prognosis for papillary thyroid cancer and patient outcome...
  54. ncbi request reprint Should total thyroidectomy become the preferred procedure for surgical management of Graves' disease?
    Geeta Lal
    Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Thyroid 15:569-74. 2005
    ..Total or near-total thyroidectomy obviates these disadvantages and can be performed without increased complication rates, thus appearing to be the preferred extent of thyroidectomy for Graves' disease...
  55. ncbi request reprint Incision length for standard thyroidectomy and parathyroidectomy: when is it minimally invasive?
    Laurent Brunaud
    Department of Surgery, University of California, San Francisco, USA
    Arch Surg 138:1140-3. 2003
    ..Current techniques for open conventional thyroidectomy or parathyroidectomy have evolved to enable a shorter incision (main proposition), and the length of the incision is influenced by objective factors...
  56. doi request reprint Hemolysis falsely decreases intraoperative parathyroid hormone levels
    Jacob Moalem
    University of California, San Francisco, CA, USA
    Am J Surg 197:222-6. 2009
    ..Falsely decreased IOPTH measurements could result in false-negative or false-positive results and lead to failed parathyroidectomy or unnecessary additional exploration...
  57. ncbi request reprint False-negative fine-needle aspiration cytology results delay treatment and adversely affect outcome in patients with thyroid carcinoma
    Michael W Yeh
    Endocrine Surgery Laboratory, UCSF Mt Zion Medical Center, San Francisco, California 94115, USA
    Thyroid 14:207-15. 2004
    ..28). False-negative results remain a concern in the cytologic diagnosis of thyroid cancer. Although FNA is a useful test, clinical findings should overrule cytologic data in order for timely treatment to occur...
  58. doi request reprint Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors
    Elliot J Mitmaker
    Department of Surgery, University of California, San Francisco, CA, USA
    Surgery 149:504-11. 2011
    ....
  59. ncbi request reprint Tertiary hyperparathyroidism: histologic patterns of disease and results of parathyroidectomy
    Electron Kebebew
    Department of Surgery, University of California, San Francisco 94143 1674, USA
    Arch Surg 139:974-7. 2004
    ..Patients with tertiary hyperparathyroidism (THPT) commonly have parathyroid hyperplasia and should have a bilateral neck exploration with subtotal or total parathyroidectomy with autotransplantation to obtain long-term cure...
  60. ncbi request reprint Extent of disease and practice patterns for medullary thyroid cancer
    Electron Kebebew
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 1674, USA
    J Am Coll Surg 200:890-6. 2005
    ..It is unclear if the advances in diagnosis and treatment of MTC have led to earlier diagnosis and more complete initial treatment of patients with MTC...
  61. ncbi request reprint Chromosomal aberrations by comparative genomic hybridization in thyroid tumors in patients with familial nonmedullary thyroid cancer
    Laurent Brunaud
    Endocrine Surgical Oncology Fellow, University of California San Francisco UCSF Mount Zion Medical Center, San Francisco, California 94143, USA
    Thyroid 13:621-9. 2003
    ..However, the genetic background of FNMTC is still poorly understood and the causative gene(s) have not yet been identified...
  62. ncbi request reprint Prognostic indications for Hürthle cell cancer
    Yevgeniya Kushchayeva
    Endocrine Surgical Oncology, Department of Surgery, University of California San Francisco Mount Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94143 1674, USA
    World J Surg 28:1266-70. 2004
    ..Disease-free survivals were 65.0% and 40.5% at 5 and 10 years, respectively. Our findings show that gender and stage of disease influence the prognosis of patients with HCC...
  63. ncbi request reprint Primary hyperparathyroidism: controversies in surgical management
    Geeta Lal
    UCSF Mt Zion Medical Center, University of California, San Francisco, CA 94115, USA
    Trends Endocrinol Metab 14:417-22. 2003
    ....
  64. pmc ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy
    Electron Kebebew
    Endocrine Surgery and Oncology Program, Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Ann Surg 242:353-61; discussion 361-3. 2005
    ..The objective of this study was to determine whether genes that regulate cellular invasion and metastasis are differentially expressed and could serve as diagnostic markers of malignant thyroid nodules...
  65. ncbi request reprint Papillary thyroid cancer
    Nadine R Caron
    Mount Zion Medical Center, University of California, San Francisco, Room C 347, 1600 Divisadero Street, 94143, USA
    Curr Treat Options Oncol 7:309-19. 2006
    ..The treatment options that are chosen depend on patient factors, disease factors, and the decisions of the patient and treatment team...
  66. ncbi request reprint An evidence-based approach to familial nonmedullary thyroid cancer: screening, clinical management, and follow-up
    Rebecca S Sippel
    University of California San Francisco Department of Surgery, UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, California, USA
    World J Surg 31:924-33. 2007
    ..Conclusions: To date, the optimal clinical approach is yet to be established, but improved awareness and screening will permit earlier detection, more timely intervention, and hopefully improved outcomes for patients and their families...
  67. doi request reprint One hundred two patients with pheochromocytoma treated at a single institution since the introduction of laparoscopic adrenalectomy
    Wen T Shen
    University of California San Francisco Mount Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94115, USA
    Arch Surg 145:893-7. 2010
    ..Pheochromocytoma can be safely treated laparoscopically; "subclinical" pheochromocytoma is increasingly common...
  68. doi request reprint Two hundred and two consecutive operations for secondary hyperparathyroidism: has medical management changed the profiles of patients requiring parathyroidectomy?
    Wen T Shen
    Department of Surgery, University of California, San Francisco, CA 94115, USA
    Surgery 146:296-9. 2009
    ..Because of improvements in the medical management of end-stage renal disease, some surgeons perceive that they now perform fewer operations for secondary hyperparathyroidism, and that current patients have more advanced disease...
  69. ncbi request reprint Complications of neck dissection for thyroid cancer
    W Keat Cheah
    Department of Surgery, University of California, San Francisco Mt Zion Medical Center, 1600 Divisadero Street, 94143 1674, USA
    World J Surg 26:1013-6. 2002
    ..Therapeutic neck dissection or repeated neck dissection can be performed relatively safely in patients with thyroid cancer. Hypocalcemia occurs most frequently when neck dissection is combined with total thyroidectomy...
  70. ncbi request reprint Laparoscopic adrenalectomy for pheochromocytoma
    W Keat Cheah
    Department of Surgery, University of California San Francisco, Veterans Affairs Medical Center, 4150 Clement Street, 94121, USA
    World J Surg 26:1048-51. 2002
    ..Laparoscopic adrenalectomy is the preferred surgical approach for patients with pheochromocytoma because it is safe and efficacious...
  71. ncbi request reprint Prevention, evaluation, and management of complications following thyroidectomy for thyroid carcinoma
    Reza Zarnegar
    Department of Surgery, UCSF Mount Zion Medical Center, University of California at San Francisco, 1600 Divisadero Street, Box 1674, San Francisco, CA 94143, USA
    Endocrinol Metab Clin North Am 32:483-502. 2003
    ..Experience in performing thyroid operations is essential for the best outcome with the fewest complications...
  72. ncbi request reprint The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines
    Jin Woo Park
    Department of Surgery, University of California, Mount Zion Medical Center, San Francisco, California 94143 1674, USA
    J Clin Endocrinol Metab 88:3346-53. 2003
    ..In conclusion, geldanamycin inhibited cancer cell proliferation, down-regulated oncoproteins, and inhibited EGF-induced invasion in thyroid cancer cell lines...
  73. ncbi request reprint Papillary thyroid cancer: surgical management of lymph node metastases
    Nadine R Caron
    University of California, San Francisco and UCSF Comprehensive Cancer Center at Mt Zion Hospital, 1600 Divisadero Street, Hellman Bldg Room C347, San Francisco, California 94143, USA
    Curr Treat Options Oncol 6:311-22. 2005
    ..While the extent of lymphadenectomy is debated, most physicians treating patients with PTC agree that clinical evidence of lymphatic metastases should be surgically exercised and there is no role for prophylactic LND...
  74. ncbi request reprint Reasons for conversion from laparoscopic to open or hand-assisted adrenalectomy: review of 261 laparoscopic adrenalectomies from 1993 to 2003
    Wen T Shen
    Department of Surgery, University of California, San Francisco Mt Zion Medical Center, San Francisco, California 94143 1674, USA
    World J Surg 28:1176-9. 2004
    ..All eight of the tumors removed were at least 5 cm in size (range 5-16 cm). The mean length of hospitalization was 4.4 days (range 3-8 days)...
  75. ncbi request reprint The helix-loop-helix protein, Id-1, is overexpressed and regulates growth in papillary thyroid cancer
    Electron Kebebew
    Department of Surgery Department of Pathology, University of California, San Francisco, CA 94143, USA
    Surgery 134:235-41. 2003
    ..Furthermore, deregulated expression of Id proteins has been observed in some human malignancies. Therefore we hypothesized that the Id-1 gene may play a role in papillary thyroid carcinogenesis...
  76. ncbi request reprint Locally advanced differentiated thyroid cancer
    Electron Kebebew
    Department of Surgery, University of California, San Francisco, UCSF Mount Zion Medical Center, 513 Parnassus, S 343, San Francisco, CA 94143 1674, USA
    Surg Oncol 12:91-9. 2003
    ..Patients with microscopic or small gross residual disease, after surgical resection, may benefit from postoperative external radiotherapy for local control of disease...
  77. ncbi request reprint Intraoperative parathyroid hormone assay and parathyroid reoperations
    Frederic Sebag
    Department of Endocrine Surgery, Mount Zion Hospital, 1600 Divisidero Street, San Francisco, CA 94143 1674, USA
    Surgery 134:1049-55; discussion 1056. 2003
    ..The purpose of this study was to determine whether intraoperative parathyroid hormone (IOPTH) assay improved results of reoperations...
  78. ncbi request reprint Chromosomal aberrations by comparative genomic hybridization in hürthle cell thyroid carcinomas are associated with tumor recurrence
    Nobuyuki Wada
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 87:4595-601. 2002
    ..Such chromosomal aberrations may be predictive for recurrent disease in patients with Hürthle cell thyroid carcinoma...
  79. ncbi request reprint Changing management in patients with papillary thyroid cancer
    Dina M Elaraj
    Department of Surgery, UCSF Mt Zion Medical Center, 1600 Diviadero Street, San Francisco, CA 94115, USA
    Curr Treat Options Oncol 8:305-13. 2007
    ..For those patients whose tumor has become radioactive iodine resistant, emerging therapies include redifferentiation agents, antiangiogenic agents, and multi-tyrosine kinase inhibitors...
  80. ncbi request reprint Anaplastic thyroid carcinoma. Treatment outcome and prognostic factors
    Electron Kebebew
    Department of Surgery, University of California San Francisco, San Francisco, CA 94143 1674, USA
    Cancer 103:1330-5. 2005
    ..The authors analyzed prognostic factors and treatment outcomes in patients with ATC reported in the National Cancer Institute's Surveillance, Epidemiology, and End Results data base...
  81. ncbi request reprint Results of laparoscopic adrenalectomy for suspected and unsuspected malignant adrenal neoplasms
    Electron Kebebew
    Department of Surgery, University of California, San Francisco 94121, USA
    Arch Surg 137:948-51; discussion 952-3. 2002
    ..Laparoscopic resection for malignant adrenal tumors is controversial, because they are rare and limited data exist in the literature...
  82. ncbi request reprint Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor
    Rasa Zarnegar
    Department of Surgery, Division of General Surgery, and Cancer Center, University of California San Francisco Mount Zion Medical Center, 1600 Divisadero Street, Room 437, San Francisco, CA 94143 1674, USA
    Surgery 132:984-90; discussion 990. 2002
    ..In this investigation the effects of Trichostatin A (TSA), a histone deacetylating inhibitor, on human thyroid NIS and PDS gene expression was investigated...
  83. ncbi request reprint HER2 expression in thyroid tumors
    Matthew M Mondi
    Department of Surgery, Wake Forest University Medical Center, Winston Salem, North Carolina 27158, USA
    Am Surg 69:1100-3. 2003
    ..No significant expression of HER2 was noted in benign or malignant thyroid tissue. These results cast doubt on the value of HER2 as a prognostic factor or possible target for specific antitumor therapy for thyroid cancer...
  84. ncbi request reprint Follicular thyroid carcinoma: histology and prognosis
    Alessandra D'Avanzo
    Department of Surgery, University of California San Francisco Mount Zion Medical Center, San Francisco, California 94143 1674, USA
    Cancer 100:1123-9. 2004
    ..The authors studied the clinical course of 132 patients with FTC to determine whether there was a direct relation between the histologic degree of invasion, tumor recurrence, and patient survival...
  85. ncbi request reprint Persistent and recurrent hyperparathyroidism
    Nadine R Caron
    Department of Surgery, University of California San Francisco and UCSF Comprehensive Cancer Center at Mount Zion, 1600 Divisadero Street, Hellman Building, Room C3 47, San Francisco, CA 94143, USA
    Curr Treat Options Oncol 5:335-45. 2004
    ..Surgery should be considered first-line treatment in most circumstances...
  86. doi request reprint Surgical approaches to thyroid tumors
    Jessica E Gosnell
    University of California, San Francisco, Mt Zion Medical Center, San Francisco, CA 94143 1674, USA
    Endocrinol Metab Clin North Am 37:437-55, x. 2008
    ..A description of the authors' surgical technique for thyroidectomy is detailed. Finally, several emerging technologies are introduced...
  87. ncbi request reprint Selective use of adrenal venous sampling in the lateralization of aldosterone-producing adenomas
    Yah Yuen Tan
    Department of Surgery, University of California San Francisco, 4150 Clement Street, San Francisco, California 94121, USA
    World J Surg 30:879-85; discussion 886-7. 2006
    ..However, the success rate of AVS is variable, with potential risks. We review our experience at University of California San Francisco (UCSF), where AVS is used only selectively, to determine outcomes with this approach...
  88. ncbi request reprint Retrocardiac parathyroid tumor: a rare mediastinal site
    Carlos U Corvera
    Department of Surgery, University of California, San Francisco, Calif 94143, USA
    Surgery 135:104-7. 2004
  89. ncbi request reprint Parathyroid surgery: separating promise from reality
    Nancy D Perrier
    Department of Surgery, University of California, San Francisco Mount Zion Medical Center, San Francisco, California 94143 1674, USA
    J Clin Endocrinol Metab 87:1024-9. 2002
    ..The combination of a solitary hot spot on sestamibi scan and a fall in IOPTH allows the surgeon to make the correct decision regarding the need to convert to a bilateral approach in 93% of these selected patients...
  90. ncbi request reprint Medullary thyroid carcinoma manifesting as an ovarian mass: case report and review of literature
    Jessica E Gosnell
    Department of General Surgery, San Mateo Medical Center, San Francisco, California, USA
    Endocr Pract 14:351-7. 2008
    ..To report the uncommon case of a woman with abdominal pain and a complex adnexal mass, who was subsequently found to have medullary thyroid carcinoma (MTC) metastatic to the ovary...
  91. ncbi request reprint The optimal treatment for pediatric Graves' disease is surgery
    James A Lee
    Department of Surgery, University California, San Francisco, Comprehensive Cancer Center at Mount Zion, Medical Center, 1600 Divisadero Street, Hellman Building, Room C347, San Francisco, California 94143 1764, USA
    J Clin Endocrinol Metab 92:801-3. 2007
  92. ncbi request reprint Predictors of airway complications after thyroidectomy for substernal goiter
    Wen T Shen
    Department of Surgery, University of California, San Francisco, USA
    Arch Surg 139:656-9; discussion 659-60. 2004
    ..Airway complications after thyroidectomy for substernal goiter can be predicted by preoperative symptom profiles, radiologic findings, or other factors...
  93. ncbi request reprint Apoptosis regulating genes, bcl-2 and bax, and human telomerase reverse transcriptase messenger RNA expression in adrenal tumors: possible diagnostic and prognostic importance
    Hajime Kanauchi
    Department of Surgery, University of California San Francisco Mount Zion Medical Center, 1600 Divisadero Street, Room 437, San Francisco, CA 94143 1674, USA
    Surgery 132:1021-6; discussion 1026-7. 2002
    ..The purpose of this investigation was to determine whether bcl-2 or bax gene expression differs between benign and malignant adrenal tumors, and whether hTERT gene expression correlates with the prognosis of patients with adrenal cancer...
  94. ncbi request reprint Report of a hürthle cell neoplasm in a peripubertal girl
    Andrew A Bremer
    Department of Pediatrics, University of California, San Francisco, California, USA
    Thyroid 17:175-8. 2007
    ..To our knowledge, she represents the youngest patient with a Hürthle cell neoplasm...
  95. ncbi request reprint Coagulopathy, marantic endocarditis, and cerebrovascular accidents as paraneoplastic features in medullary thyroid cancer--case report and review of the literature
    Geeta Lal
    Department of Surgery, University of California, San Francisco, UCSF Mt Zion Medical Center, San Francisco, California 94143, USA
    Thyroid 13:601-5. 2003
    ..The literature pertaining to the diagnosis and management of hypercoagulability states in patients with cancer, in general, and thyroid cancer, in particular, is reviewed...
  96. ncbi request reprint Parathyroidectomy for primary hyperparathyroidism in octogenarians and nonagenarians: a plea for early surgical referral
    Electron Kebebew
    Department of Surgery, University of California, San Francisco, CA 94143 1674, USA
    Arch Surg 138:867-71. 2003
    ....
  97. ncbi request reprint Hyperparathyroidism after radioactive iodine therapy
    Shanthi M Colaco
    Department of Surgery, University of California San Francisco and UCSF Mt Zion Medical Center, 1600 Divisadero Street, C347, San Francisco, CA 94143 1674, USA
    Am J Surg 194:323-7. 2007
    ..Radioactive iodine (RAI) treatment has been suggested to cause primary hyperparathyroidism (HPT). We describe a series of patients with HPT and a history of RAI exposure...
  98. doi request reprint Intraoperative diagnostic strategy to distinguish parathyroid adenomas from metastatic thyroid cancer
    Marlon A Guerrero
    Department of Surgery, University of California at San Francisco, San Francisco, California 94143, USA
    Endocr Pract 15:454-7. 2009
    ..To report the limitations of frozen section examination and the value of intraoperative tissue aspiration for parathyroid hormone assay to distinguish parathyroid adenomas from metastatic thyroid carcinoma...