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Genomes and GenesSpecies | Orlo H ClarkSummaryAffiliation: University of California Country: USA Publications
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Thyroid cancer and lymph node metastasesOrlo H Clark
Department of Surgery, Mt Zion Medical Center, University of California San Francisco, San Francisco, California 94115, USA
J Surg Oncol 103:615-8. 2011..Until more information is available we recommend preoperative ultrasonography and a selective ipsilateral neck dissection for patients with papillary thyroid cancer...- Are additional localization studies and referral indicated for patients with primary hyperparathyroidism who have negative sestamibi scan results?Dina M Elaraj
Department of Surgery, Feinberg School of Medicine, Northwestern University, 676 N St Clair St, Ste 650, Chicago, IL 60611, USA
Arch Surg 145:578-81. 2010..Additional imaging studies are useful to select patients who are candidates for minimally invasive parathyroidectomy, and referral is not indicated when results from a preoperative sestamibi scan are negative... 
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase AMichael W Yeh
Endocrine Surgery Laboratory, UCSF Mt Zion Medical Center, San Francisco, California 94115, USA
Endocr Relat Cancer 13:1173-83. 2006..MMP inhibitors and growth factor antagonists may be effective tumoristatic agents for the treatment of aggressive thyroid carcinomas...
Nonfunctioning parathyroid carcinoma: case report and review of literatureGustavo G Fernandez Ranvier
Department of Surgery, University of California, San Francisco, California, USA
Endocr Pract 13:750-7. 2007..To report a case of nonfunctioning parathyroid carcinoma that was incidentally found during a thyroidectomy for multinodular goiter...- Diagnostic and prognostic value of cell-cycle regulatory genes in malignant thyroid neoplasmsElectron Kebebew
San Francisco Comprehensive Cancer Center, University of California, San Francisco, CA 94143 1674, USA
World J Surg 30:767-74. 2006..We hypothesized that genes that regulate cell-cycle progression would be differentially expressed in malignant versus benign thyroid nodules and could serve as diagnostic markers and markers of disease aggressiveness... - Troglitazone, the peroxisome proliferator-activated receptor-gamma agonist, induces antiproliferation and redifferentiation in human thyroid cancer cell linesJin Woo Park
Department of Surgery University of California, San Francisco, UCSF Mount Zion Medical Center, San Francisco, CA 94143, USA
Thyroid 15:222-31. 2005..PPARgamma agonists may therefore be effective therapeutic agents for the treatment of patients with thyroid cancer that fails to respond to traditional treatments... - Multiple genetic alterations in papillary thyroid cancer are associated with younger age at presentationWillieford Moses
Department of Surgery, University of California, San Francisco, California 94143, USA
J Surg Res 160:179-83. 2010..There is a significant gender and age disparity in thyroid cancer incidence and outcome. The molecular basis for these divergent clinical presentations and outcome are essentially unknown... - Serum thyroglobulin is a poor diagnostic biomarker of malignancy in follicular and Hurthle-cell neoplasms of the thyroidInsoo Suh
Department of Surgery, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0470, USA
Am J Surg 200:41-6. 2010..However, some clinicians measure preoperative Tg as a diagnostic cancer marker despite lack of supporting evidence. We examined whether Tg accurately predicts malignancy in follicular or Hürthle-cell neoplasms... - Is adrenal venous sampling necessary in all patients with hyperaldosteronism before adrenalectomy?Rasa Zarnegar
Department of Surgery, University of California San Francisco Medical Center, San Francisco, CA, USA
J Vasc Interv Radiol 19:66-71. 2008..To evaluate whether selective rather than universal use of adrenal vein sampling (AVS) may be warranted in patients with hyperaldosteronism to characterize and lateralize disease before adrenalectomy... - A phase II trial of rosiglitazone in patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancerElectron Kebebew
Department of Surgery, University of California, San Francisco, CA 94143, USA
Surgery 140:960-6; discussion 966-7. 2006..Rosiglitazone is a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist that has been shown to induce differentiation, cell cycle arrest, and apoptosis in a variety of human cancers including thyroid cancer... - Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancersDaniel T Ruan
Department of Surgery, University of California, San Francisco, San Francisco, Calif, USA
Surgery 144:908-13; discussion 913-4. 2008..The purpose of this study was to determine if Mig-6 expression is associated with EGFR expression or surgical outcomes in PTC... - Identification of biomarkers of adrenocortical carcinoma using genomewide gene expression profilingGustavo G Fernandez-Ranvier
Department of Surgery, J David Gladstone Institutes Genomics Core Laboratory, University of California, San Francisco, CA 94143 1674, USA
Arch Surg 143:841-6; discussion 846. 2008..The gene expression profiles of benign and malignant adrenocortical tumors are different... - Id1 gene expression is up-regulated in hyperplastic and neoplastic thyroid tissue and regulates growth and differentiation in thyroid cancer cellsElectron Kebebew
San Francisco Comprehensive Cancer Center, University of California, San Francisco, California 94143 1674, USA
J Clin Endocrinol Metab 89:6105-11. 2004.... - Does the presence of additional thyroid nodules on ultrasound alter the risk of malignancy in patients with a follicular neoplasm of the thyroid?Rebecca S Sippel
Department of Surgery, University of California San Francisco, and the UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, CA 94143 1674, USA
Surgery 142:851-7; discussion 857.e1-2. 2007..We sought to determine whether the presence of additional thyroid nodules on preoperative ultrasound decreased the risk of malignancy in a patient with a follicular neoplasm... - Tumor size predicts malignant potential in Hürthle cell neoplasms of the thyroidRebecca S Sippel
Department of Surgery, University of California San Francisco and the UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, CA 94143, USA
World J Surg 32:702-7. 2008..We sought to determine if the primary tumor size correlated with the risk of malignancy in patients with a preoperative FNA diagnosis of a Hürthle cell neoplasm... - Prospective evaluation of the rate and impact of hemolysis on intraoperative parathyroid hormone (IOPTH) assay resultsJacob Moalem
Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
Ann Surg Oncol 17:2963-9. 2010..Retrospective evidence suggested that hemolysis may artificially lower IOPTH results. Falsely decreased IOPTH measurements could result in either failed parathyroidectomy or unnecessary bilateral neck exploration... - Results of rosiglitazone therapy in patients with thyroglobulin-positive and radioiodine-negative advanced differentiated thyroid cancerElectron Kebebew
Department of Surgery, University of California San Francisco UCSF, San Francisco, California 94143, USA
Thyroid 19:953-6. 2009..We investigated the efficacy and side effects of rosiglitazone therapy in patients with differentiated thyroid cancer of follicular cell origin that fails to take up radioiodine or is unresectable... - Expression of vascular endothelial growth factor-C in benign and malignant thyroid tumorsChung J Hung
Endocrine Surgical Oncology Fellows, University of California San Francisco, California 94143, USA
J Clin Endocrinol Metab 88:3694-9. 2003..The lymphangiogenic role of VEGF-C in thyroid cancers therefore appears to be complex and other factors are likely to be also involved... - Molecular testing for somatic mutations improves the accuracy of thyroid fine-needle aspiration biopsyWillieford Moses
Department of Surgery, University of California, San Francisco, CA 94143, USA
World J Surg 34:2589-94. 2010..To determine the clinical utility of genetic testing in thyroid FNA biopsy, we conducted a prospective clinical trial... - Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis?Gustavo G Fernandez-Ranvier
Department of Surgery, University of California at San Francisco, San Francisco, California 94143 1674, USA
Cancer 110:255-64. 2007..Parathyroid carcinoma, atypical parathyroid adenoma, and parathyromatosis can be differentiated relatively easily from typical parathyroid adenomas, but distinguishing them from each other is more difficult... - Extent of disease at presentation and outcome for adrenocortical carcinoma: have we made progress?Electron Kebebew
Department of Surgery, University of California, San Francisco, Box 1674, San Francisco, CA 94143 1674, USA
World J Surg 30:872-8. 2006..Recent studies suggest that this has led to earlier stage of ACC at diagnosis, more curative operations, and better survival... - Comparison of clinical characteristics at diagnosis and during follow-up in 118 patients with Hurthle cell or follicular thyroid cancerYevgeniya Kushchayeva
Department of Surgery, University of California San Francisco, UCSF Mt Zion Medical Center, 1600 Divisadero Street C347, San Francisco, CA 94143 1674, USA
Am J Surg 195:457-62. 2008..Hurthle cell cancer (HCC) is considered by some to be a variant of follicular cancer (FC), but many think it is a distinct histologic tumor with a more aggressive behavior... - Central neck lymph node dissection for papillary thyroid cancer: the reliability of surgeon judgment in predicting which patients will benefitWen T Shen
Department of Surgery, University of California, San Francisco Mt Zion Medical Center, San Francisco, CA 94115, USA
Surgery 148:398-403. 2010..We perform CLND for PTC only in patients with enlarged nodes as determined by preoperative ultrasound and intraoperative inspection and palpation... - GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidismElectron Kebebew
Department of Surgery, University of California San Francisco, Box 1674, San Francisco, CA 94143, USA
Surgery 136:1261-6. 2004..The glial cell missing gene, GCMB , encodes a transcription factor, which is a master regulator of parathyroid development. We postulated that the GCMB gene might play a role in parathyroid tumorigenesis in hyperparathyroidism... - Accuracy of preoperative localization studies and intraoperative parathyroid hormone assay in patients with primary hyperparathyroidism and double adenomaMehmet Haciyanli
Department of Surgery, University of California San Francisco/Mount Zion Medical Center, San Francisco, CA, USA
J Am Coll Surg 197:739-46. 2003..The combined accuracy of US, sestamibi, and IOPTH assay predicted a double adenoma in 80% of the patients... - Distinct loci on chromosome 1q21 and 6q22 predispose to familial nonmedullary thyroid cancer: a SNP array-based linkage analysis of 38 familiesInsoo Suh
Department of Surgery, University of California, San Francisco, CA, USA
Surgery 146:1073-80. 2009..We aimed to identify loci linked to FNMTC susceptibility using single-nucleotide polymorphism (SNP) array-based linkage analysis in a broad sampling of affected families... - Does routine consultation of thyroid fine-needle aspiration cytology change surgical management?Yah Y Tan
Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 1674, USA
J Am Coll Surg 205:8-12. 2007..We sought to determine the concordance rates between FNA interpretations at referring institutions and our center to determine if they alter surgical management... - Metastatic papillary thyroid cancer misdiagnosed as non-small [corrected] cell lung cancerJacob Moalem
Division of Surgical Oncology, Department of Surgery, University of Rochester, Rochester, New York 14642, USA
Thyroid 21:319-23. 2011..As thyroid cancers commonly spread to the lungs, metastatic thyroid cancer should be included in the differential diagnosis of a pulmonary lesion or lesions... - Risk assessment in 457 adrenal cortical carcinomas: how much does tumor size predict the likelihood of malignancy?Cord Sturgeon
Department of Surgery, University of California, San Francisco, USA
J Am Coll Surg 202:423-30. 2006..The recent NIH consensus conference did not make a definitive recommendation about management of 4- to 6-cm nonfunctioning incidentalomas... - Should pheochromocytoma size influence surgical approach? A comparison of 90 malignant and 60 benign pheochromocytomasWen T Shen
Department of Surgery, University of California San Francisco, Hellman Building C3 47, 1600 Divisadero Street, San Francisco, CA 94143, USA
Surgery 136:1129-37. 2004..The aim of this study was to determine if pheochromocytoma size should affect the choice of surgical approach... - The number of needle passes affects the accuracy of parathyroid hormone assay with intraoperative parathyroid aspirationMarlon A Guerrero
Department of Surgery, University of Arizona, Tucson, AZ 85724, USA
Am J Surg 200:701-5; discussion 705-6. 2010..However, the reported aspiration technique varies in the literature. We sought to determine if the number of passes affected the accuracy of PTH analysis... - Predictors of single-gland vs multigland parathyroid disease in primary hyperparathyroidism: a simple and accurate scoring modelElectron Kebebew
Comprehensive Cancer Center and Department of Surgery, University of California, San Francisco, USA
Arch Surg 141:777-82; discussion 782. 2006.... - Candidate genes associated with malignant pheochromocytomas by genome-wide expression profilingInsoo Suh
Department of Surgery, University of California, San Francisco, CA 94143 1674, USA
Ann Surg 250:983-90. 2009..To improve our understanding of the molecular mechanisms involved in malignant pheochromocytoma by examining differences in the gene expression profile between benign and malignant tumors... - Localization of recurrent thyroid cancer using intraoperative ultrasound-guided dye injectionRebecca S Sippel
Department of Surgery, University of Wisconsin Madison, Madison, WI, USA
World J Surg 33:434-9. 2009..The goal of this study was to evaluate the utility of preincision ultrasound-guided injection of blue dye into the abnormal lymph nodes to facilitate their safe and efficient removal... - Malignant pheochromocytomaRasa Zarnegar
Department of Surgery, University California San Francisco, Comprehensive Cancer Center at Mount Zion, Medical Center, 1600 Divisadero Street, Hellman Building, Room C347, San Francisco, CA 94143 1764, USA
Surg Oncol Clin N Am 15:555-71. 2006.... - Adrenal incidentaloma: does an adequate workup rule out surprises?Raymon H Grogan
Department of Endocrine Surgery, University of California San Francisco, San Francisco, CA 94143, USA
Surgery 148:392-7. 2010..We sought to determine how accurately these guidelines identify functioning incidentalomas and how often these guidelines result in adrenalectomy for benign tumors... - Patterns of antibiotic prophylaxis use for thyroidectomy and parathyroidectomy: results of an international survey of endocrine surgeonsJacob Moalem
Department of Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Am Coll Surg 210:949-56. 2010..Although cervical endocrine operations are classified as clean cases, and prophylactic antibiotics (pABX) are generally not indicated, practice patterns vary... - Central neck lymph node dissection for papillary thyroid cancer: comparison of complication and recurrence rates in 295 initial dissections and reoperationsWen T Shen
Department of Surgery, University of California, San Francisco Mt Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94115, USA
Arch Surg 145:272-5. 2010..Critics of this approach argue that reoperative CLND has higher complication and recurrence rates than initial CLND. We sought to test this argument, using it as our hypothesis... - Observation or laparoscopic adrenalectomy for adrenal incidentaloma? A surgical decision analysisLaurent Brunaud
Department of Surgery, University California San Francisco and Mount Zion Medical Center, Mount Zion Medical Center, San Francisco, CA, USA
Med Sci Monit 12:CR355-62. 2006..A decision analysis model was used to identify relevant variables for selecting the optimal management (observation versus adrenalectomy)... - Defining a molecular phenotype for benign and malignant parathyroid tumorsGustavo G Fernandez-Ranvier
Department of Surgery, University of California at San Francisco, San Francisco, California 94143 1674, USA
Cancer 115:334-44. 2009.... - Does the 3-gene diagnostic assay accurately distinguish benign from malignant thyroid neoplasms?Daniel Shibru
Department of Surgery, University of California at San Francisco, San Francisco, California 94143 1674, USA
Cancer 113:930-5. 2008..The aim of the current study was to determine the diagnostic accuracy of the 3-gene assay in thyroid tissue and in FNA biopsy for distinguishing benign from malignant thyroid neoplasms... - Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancerChi Iou Lin
Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 96:E554-65. 2011..Low tumoral expression of mitogen-inducible gene-6 (Mig-6) is associated with papillary thyroid cancer (PTC) recurrence after thyroidectomy... - A population-based prospective cohort study of complications after thyroidectomy in the elderlyRaymon H Grogan
Endocrine Surgery Research Program, Department of Surgery, Section of Endocrine Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA
J Clin Endocrinol Metab 97:1645-53. 2012..Data on the risk of postthyroidectomy complications in elderly patients are sparse, unclear, and conflicting... - Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cellsWen T Shen
Department of Surgery, Endocrine Surgery Laboratory, UCSF/Mt. Zion Medical Center, San Francisco, CA 94143-1674, USA
Surgery 138:979-84; discussion 984-5. 2005..These findings suggest that VA may be useful clinically for patients with thyroid cancers of follicular cell origin... - The prevalence and prognostic value of BRAF mutation in thyroid cancerElectron Kebebew
Department of Surgery, University of California, San Francisco, San Francisco, California 94143 1674, USA
Ann Surg 246:466-70; discussion 470-1. 2007..To examine the prevalence of BRAF mutation among thyroid cancer histologic subtypes and determine the association of BRAF mutation with indicators of poor prognosis for papillary thyroid cancer and patient outcome... - The aldosteronoma resolution score: predicting complete resolution of hypertension after adrenalectomy for aldosteronomaRasa Zarnegar
Department of Surgery, Weill Cornell Medical College, New York, NY 10021, USA
Ann Surg 247:511-8. 2008..To develop a prediction model using information readily available, at clinical presentation, which could determine whether patients with aldosterone-producing adenomas would have complete resolution of hypertension after adrenalectomy... - Anaplastic thyroid cancer: cytogenetic patterns by comparative genomic hybridizationDaishu Miura
Department of Surgery, University of California, San Francisco/Mount Zion Medical Center, San Francisco, California 94143-1674, USA
Thyroid 13:283-90. 2003..These findings support the concept that PTC and FTC have different genetic backgrounds and, even after the transformation to ATC, they may retain some of their cytogenetic characteristics... - Modulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by chemotherapy in thyroid cancer cell linesJin Woo Park
Department of Surgery, University of California, San Francisco, UCSF Mount Zion Medical Center, San Francisco, California 94143 1674, USA
Thyroid 13:1103-10. 2003..In conclusion, TRAIL in combination with troglitazone, paclitaxel, and cycloheximide induces apoptosis in thyroid cancer cells at suboptimal concentrations that cannot be achieved using TRAIL alone... - The management of aldosterone-producing adrenal adenomas--does adrenalectomy increase costs?Bethann Reimel
Department of Surgery, Columbia University Medical Center, New York, NY, USA
Surgery 148:1178-85; discussion 1185. 2010..We sought to compare the current guideline-based (surgical) strategy with universal pharmacologic management to determine the optimal strategy from a cost perspective... - Diagnostic and prognostic value of fas and telomeric-repeat binding factor-1 genes in adrenal tumorsHajime Kanauchi
Endocrine Surgical Oncology Fellows, Department of Surgery, University of California San Francisco UCSF, San Francisco, California 94143, USA
J Clin Endocrinol Metab 88:3690-3. 2003..This lack of expression of fas in adrenal cortical cancer may help to distinguish it from benign adrenal tumors. The level of TRF-1 expression may be helpful prognostically for patients with adrenal cortical cancers... - Clinical spectrum of pheochromocytomaMarlon A Guerrero
Department of Surgery, University of California, 1600 Divisadero St, San Francisco, CA 94115, USA
J Am Coll Surg 209:727-32. 2009..The goal of this study was to determine if tumor size and hormone level correlate according to the clinical presentation at diagnosis... - Incision length for standard thyroidectomy and parathyroidectomy: when is it minimally invasive?Laurent Brunaud
Department of Surgery, University of California, San Francisco, USA
Arch Surg 138:1140-3. 2003..Current techniques for open conventional thyroidectomy or parathyroidectomy have evolved to enable a shorter incision (main proposition), and the length of the incision is influenced by objective factors... - Should total thyroidectomy become the preferred procedure for surgical management of Graves' disease?Geeta Lal
Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Thyroid 15:569-74. 2005..Total or near-total thyroidectomy obviates these disadvantages and can be performed without increased complication rates, thus appearing to be the preferred extent of thyroidectomy for Graves' disease... - Primary hyperparathyroidism: controversies in surgical managementGeeta Lal
UCSF Mt Zion Medical Center, University of California, San Francisco, CA 94115, USA
Trends Endocrinol Metab 14:417-22. 2003.... - Chromosomal aberrations by comparative genomic hybridization in thyroid tumors in patients with familial nonmedullary thyroid cancerLaurent Brunaud
Endocrine Surgical Oncology Fellow, University of California San Francisco UCSF/Mount Zion Medical Center, San Francisco, California 94143, USA
Thyroid 13:621-9. 2003..CONCLUSIONS: Our findings suggest that chromosomal aberrations in thyroid tumors in patients with FNMTC are not related to inheritance pattern but rather to tumorigenesis... - Hemolysis falsely decreases intraoperative parathyroid hormone levelsJacob Moalem
University of California, San Francisco, CA, USA
Am J Surg 197:222-6. 2009..Falsely decreased IOPTH measurements could result in false-negative or false-positive results and lead to failed parathyroidectomy or unnecessary additional exploration... - Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13Gustavo G Fernandez-Ranvier
Department of Surgery, University of California, San Francisco, School of Medicine, UCSF Mt Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94143 1674, USA
World J Surg 32:873-81. 2008..As genes on this chromosome may be important in the pathogenesis of adrenocortical carcinoma, we compared their expression profile between benign and malignant adrenocortical tissue... - Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitorsElliot J Mitmaker
Department of Surgery, University of California, San Francisco, CA, USA
Surgery 149:504-11. 2011.... - False-negative fine-needle aspiration cytology results delay treatment and adversely affect outcome in patients with thyroid carcinomaMichael W Yeh
Endocrine Surgery Laboratory, UCSF/Mt. Zion Medical Center, San Francisco, California 94115, USA
Thyroid 14:207-15. 2004..28). False-negative results remain a concern in the cytologic diagnosis of thyroid cancer. Although FNA is a useful test, clinical findings should overrule cytologic data in order for timely treatment to occur... - Extent of disease and practice patterns for medullary thyroid cancerElectron Kebebew
Department of Surgery, University of California, San Francisco, San Francisco, CA 94143-1674, USA
J Am Coll Surg 200:890-6. 2005..A high proportion of patients continue to receive less than optimal initial surgical treatment... - Tertiary hyperparathyroidism: histologic patterns of disease and results of parathyroidectomyElectron Kebebew
Department of Surgery, University of California, San Francisco 94143 1674, USA
Arch Surg 139:974-7. 2004..Patients with tertiary hyperparathyroidism (THPT) commonly have parathyroid hyperplasia and should have a bilateral neck exploration with subtotal or total parathyroidectomy with autotransplantation to obtain long-term cure... - Prognostic indications for Hürthle cell cancerYevgeniya Kushchayeva
Endocrine Surgical Oncology, Department of Surgery, University of California-San Francisco/Mount Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94143-1674, USA
World J Surg 28:1266-70. 2004..Disease-free survivals were 65.0% and 40.5% at 5 and 10 years, respectively. Our findings show that gender and stage of disease influence the prognosis of patients with HCC... - ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsyElectron Kebebew
Endocrine Surgery and Oncology Program, Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
Ann Surg 242:353-61; discussion 361-3. 2005..The objective of this study was to determine whether genes that regulate cellular invasion and metastasis are differentially expressed and could serve as diagnostic markers of malignant thyroid nodules... - An evidence-based approach to familial nonmedullary thyroid cancer: screening, clinical management, and follow-upRebecca S Sippel
University of California San Francisco Department of Surgery, UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, California, USA
World J Surg 31:924-33. 2007..Conclusions: To date, the optimal clinical approach is yet to be established, but improved awareness and screening will permit earlier detection, more timely intervention, and hopefully improved outcomes for patients and their families... - Papillary thyroid cancerNadine R Caron
Mount Zion Medical Center, University of California, San Francisco, Room C 347, 1600 Divisadero Street, 94143, USA
Curr Treat Options Oncol 7:309-19. 2006..The treatment options that are chosen depend on patient factors, disease factors, and the decisions of the patient and treatment team... - Complications of neck dissection for thyroid cancerW Keat Cheah
Department of Surgery, University of California, San Francisco/Mt. Zion Medical Center, 1600 Divisadero Street, 94143-1674, USA
World J Surg 26:1013-6. 2002..Therapeutic neck dissection or repeated neck dissection can be performed relatively safely in patients with thyroid cancer. Hypocalcemia occurs most frequently when neck dissection is combined with total thyroidectomy... - Two hundred and two consecutive operations for secondary hyperparathyroidism: has medical management changed the profiles of patients requiring parathyroidectomy?Wen T Shen
Department of Surgery, University of California, San Francisco, CA 94115, USA
Surgery 146:296-9. 2009..Because of improvements in the medical management of end-stage renal disease, some surgeons perceive that they now perform fewer operations for secondary hyperparathyroidism, and that current patients have more advanced disease... - One hundred two patients with pheochromocytoma treated at a single institution since the introduction of laparoscopic adrenalectomyWen T Shen
University of California San Francisco Mount Zion Medical Center, 1600 Divisadero Street, San Francisco, CA 94115, USA
Arch Surg 145:893-7. 2010..Pheochromocytoma can be safely treated laparoscopically; "subclinical" pheochromocytoma is increasingly common... - Papillary thyroid cancer: surgical management of lymph node metastasesNadine R Caron
University of California, San Francisco and UCSF Comprehensive Cancer Center at Mt. Zion Hospital, 1600 Divisadero Street, Hellman Bldg. Room C347, San Francisco, California 94143, USA
Curr Treat Options Oncol 6:311-22. 2005..While the extent of lymphadenectomy is debated, most physicians treating patients with PTC agree that clinical evidence of lymphatic metastases should be surgically exercised and there is no role for prophylactic LND... - The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell linesJin-Woo Park
Department of Surgery, University of California, Mount Zion Medical Center, San Francisco, California 94143-1674, USA
J Clin Endocrinol Metab 88:3346-53. 2003..In conclusion, geldanamycin inhibited cancer cell proliferation, down-regulated oncoproteins, and inhibited EGF-induced invasion in thyroid cancer cell lines... - Reasons for conversion from laparoscopic to open or hand-assisted adrenalectomy: review of 261 laparoscopic adrenalectomies from 1993 to 2003Wen T Shen
Department of Surgery, University of California, San Francisco/Mt Zion Medical Center, San Francisco, California 94143-1674, USA
World J Surg 28:1176-9. 2004..All eight of the tumors removed were at least 5 cm in size (range 5-16 cm). The mean length of hospitalization was 4.4 days (range 3-8 days)... - Laparoscopic adrenalectomy for pheochromocytomaW Keat Cheah
Department of Surgery, University of California San Francisco, Veterans Affairs Medical Center, 4150 Clement Street, 94121, USA
World J Surg 26:1048-51. 2002..Laparoscopic adrenalectomy is the preferred surgical approach for patients with pheochromocytoma because it is safe and efficacious... - Prevention, evaluation, and management of complications following thyroidectomy for thyroid carcinomaReza Zarnegar
Department of Surgery, UCSF-Mount Zion Medical Center, University of California at San Francisco, 1600 Divisadero Street, Box 1674, San Francisco, CA 94143, USA
Endocrinol Metab Clin North Am 32:483-502. 2003..Experience in performing thyroid operations is essential for the best outcome with the fewest complications... - The helix-loop-helix protein, Id-1, is overexpressed and regulates growth in papillary thyroid cancerElectron Kebebew
Department of Surgery Department of Pathology, University of California, San Francisco, CA 94143, USA
Surgery 134:235-41. 2003..Furthermore, deregulated expression of Id proteins has been observed in some human malignancies. Therefore we hypothesized that the Id-1 gene may play a role in papillary thyroid carcinogenesis... - Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitorRasa Zarnegar
Department of Surgery, Division of General Surgery, and Cancer Center, University of California San Francisco/Mount Zion Medical Center, 1600 Divisadero Street, Room 437, San Francisco, CA 94143-1674, USA
Surgery 132:984-90; discussion 990. 2002..The increased NIS expression and reduced PDS expression may make radioiodine therapy more effective in patients with thyroid cancer, especially when the tumors have no or low uptake of radioiodine... - Intraoperative parathyroid hormone assay and parathyroid reoperationsFrederic Sebag
Department of Endocrine Surgery, Mount Zion Hospital, 1600 Divisidero Street, San Francisco, CA 94143-1674, USA
Surgery 134:1049-55; discussion 1056. 2003..CONCLUSIONS: IOPTH testing was relatively reliable in patients with persistent or recurrent sporadic primary hyperparathyroidism, but the test unfortunately failed to improve the overall success rate at reoperation... - Chromosomal aberrations by comparative genomic hybridization in hürthle cell thyroid carcinomas are associated with tumor recurrenceNobuyuki Wada
Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA
J Clin Endocrinol Metab 87:4595-601. 2002..Such chromosomal aberrations may be predictive for recurrent disease in patients with Hürthle cell thyroid carcinoma... - Results of laparoscopic adrenalectomy for suspected and unsuspected malignant adrenal neoplasmsElectron Kebebew
Department of Surgery, University of California, San Francisco 94121, USA
Arch Surg 137:948-51; discussion 952-3. 2002..Furthermore, preoperative fine-needle aspiration cytology for the evaluation of suspected malignant adrenal tumors is unreliable... - Anaplastic thyroid carcinoma. Treatment outcome and prognostic factorsElectron Kebebew
Department of Surgery, University of California San Francisco, San Francisco, CA 94143 1674, USA
Cancer 103:1330-5. 2005..The authors analyzed prognostic factors and treatment outcomes in patients with ATC reported in the National Cancer Institute's Surveillance, Epidemiology, and End Results data base... - Changing management in patients with papillary thyroid cancerDina M Elaraj
Department of Surgery, UCSF Mt Zion Medical Center, 1600 Diviadero Street, San Francisco, CA 94115, USA
Curr Treat Options Oncol 8:305-13. 2007..For those patients whose tumor has become radioactive iodine resistant, emerging therapies include redifferentiation agents, antiangiogenic agents, and multi-tyrosine kinase inhibitors... - Locally advanced differentiated thyroid cancerElectron Kebebew
Department of Surgery, University of California, San Francisco, UCSF Mount Zion Medical Center, 513 Parnassus, S 343, San Francisco, CA 94143 1674, USA
Surg Oncol 12:91-9. 2003..Patients with microscopic or small gross residual disease, after surgical resection, may benefit from postoperative external radiotherapy for local control of disease... - Selective use of adrenal venous sampling in the lateralization of aldosterone-producing adenomasYah Yuen Tan
Department of Surgery, University of California San Francisco, 4150 Clement Street, San Francisco, California 94121, USA
World J Surg 30:879-85; discussion 886-7. 2006..This practice in our center has resulted in high cure rates. During the era of improved imaging resolution and experience, mandatory routine AVS is not necessary to achieve high cure rates for aldosteronomas... - Parathyroid surgery: separating promise from realityNancy D Perrier
Department of Surgery, University of California, San Francisco Mount Zion Medical Center, San Francisco, California 94143 1674, USA
J Clin Endocrinol Metab 87:1024-9. 2002..The combination of a solitary hot spot on sestamibi scan and a fall in IOPTH allows the surgeon to make the correct decision regarding the need to convert to a bilateral approach in 93% of these selected patients... - Persistent and recurrent hyperparathyroidismNadine R Caron
Department of Surgery, University of California San Francisco and UCSF Comprehensive Cancer Center at Mount Zion, 1600 Divisadero Street, Hellman Building, Room C3-47, San Francisco, CA 94143, USA
Curr Treat Options Oncol 5:335-45. 2004..Surgery should be considered first-line treatment in most circumstances... - Retrocardiac parathyroid tumor: a rare mediastinal siteCarlos U Corvera
Department of Surgery, University of California, San Francisco, Calif 94143, USA
Surgery 135:104-7. 2004 - Follicular thyroid carcinoma: histology and prognosisPatrick Treseler
Department of Surgery, University of California-San Francisco/Mount Zion Medical Center, San Francisco, California 94143-1674, USA
Cancer 100:1123-9. 2004.... - Surgical approaches to thyroid tumorsJessica E Gosnell
University of California, San Francisco, Mt Zion Medical Center, San Francisco, CA 94143 1674, USA
Endocrinol Metab Clin North Am 37:437-55, x. 2008..A description of the authors' surgical technique for thyroidectomy is detailed. Finally, several emerging technologies are introduced... - HER2 expression in thyroid tumorsMatthew M Mondi
Department of Surgery, Wake Forest University Medical Center, Winston-Salem, North Carolina 27158, USA
Am Surg 69:1100-3. 2003..No significant expression of HER2 was noted in benign or malignant thyroid tissue. These results cast doubt on the value of HER2 as a prognostic factor or possible target for specific antitumor therapy for thyroid cancer... - Predictors of airway complications after thyroidectomy for substernal goiterWen T Shen
Department of Surgery, University of California, San Francisco, USA
Arch Surg 139:656-9; discussion 659-60. 2004..The few patients who developed postoperative airway complications were older, had larger goiters, and were more likely to have tracheal compression on preoperative imaging than those without airway complications... - Medullary thyroid carcinoma manifesting as an ovarian mass: case report and review of literatureJessica E Gosnell
Department of General Surgery, San Mateo Medical Center, San Francisco, California, USA
Endocr Pract 14:351-7. 2008..To report the uncommon case of a woman with abdominal pain and a complex adnexal mass, who was subsequently found to have medullary thyroid carcinoma (MTC) metastatic to the ovary... - The optimal treatment for pediatric Graves' disease is surgeryJames A Lee
Department of Surgery, University California, San Francisco, Comprehensive Cancer Center at Mount Zion, Medical Center, 1600 Divisadero Street, Hellman Building, Room C347, San Francisco, California 94143-1764, USA
J Clin Endocrinol Metab 92:801-3. 2007 - Report of a hürthle cell neoplasm in a peripubertal girlAndrew A Bremer
Department of Pediatrics, University of California, San Francisco, California, USA
Thyroid 17:175-8. 2007..To our knowledge, she represents the youngest patient with a Hürthle cell neoplasm... - Apoptosis regulating genes, bcl-2 and bax, and human telomerase reverse transcriptase messenger RNA expression in adrenal tumors: possible diagnostic and prognostic importanceHajime Kanauchi
Department of Surgery, University of California San Francisco/Mount Zion Medical Center, 1600 Divisadero Street, Room 437, San Francisco, CA 94143-1674, USA
Surgery 132:1021-6; discussion 1026-7. 2002..CONCLUSIONS: Expression of bax gene appears to distinguish adrenal cancer from benign adrenal tumors. Gene expression of hTERT should be investigated as a prognostic marker in adrenal cortical cancers... - Hyperparathyroidism after radioactive iodine therapyShanthi M Colaco
Department of Surgery, University of California San Francisco and UCSF Mt Zion Medical Center, 1600 Divisadero Street, C347, San Francisco, CA 94143 1674, USA
Am J Surg 194:323-7. 2007..Radioactive iodine (RAI) treatment has been suggested to cause primary hyperparathyroidism (HPT). We describe a series of patients with HPT and a history of RAI exposure... - Intraoperative diagnostic strategy to distinguish parathyroid adenomas from metastatic thyroid cancerMarlon A Guerrero
Department of Surgery, University of California at San Francisco, San Francisco, California 94143, USA
Endocr Pract 15:454-7. 2009..To report the limitations of frozen section examination and the value of intraoperative tissue aspiration for parathyroid hormone assay to distinguish parathyroid adenomas from metastatic thyroid carcinoma... - Coagulopathy, marantic endocarditis, and cerebrovascular accidents as paraneoplastic features in medullary thyroid cancer--case report and review of the literatureGeeta Lal
Department of Surgery, University of California, San Francisco, UCSF/Mt. Zion Medical Center, San Francisco, California 94143, USA
Thyroid 13:601-5. 2003..The literature pertaining to the diagnosis and management of hypercoagulability states in patients with cancer, in general, and thyroid cancer, in particular, is reviewed... - Parathyroidectomy for primary hyperparathyroidism in octogenarians and nonagenarians: a plea for early surgical referralElectron Kebebew
Department of Surgery, University of California, San Francisco, CA 94143 1674, USA
Arch Surg 138:867-71. 2003....