Research Topics
| D B ClarkSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Health problems in adolescents with alcohol use disorders: self-report, liver injury, and physical examination findings and correlatesD B Clark
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Alcohol Clin Exp Res 25:1350-9. 2001..The relevance of negative emotionality to understanding these health problems was also investigated...- Physical and sexual abuse, depression and alcohol use disorders in adolescents: onsets and outcomesDuncan B Clark
Department of Psychiatry and Pharmaceutical Sciences, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 69:51-60. 2003..These results indicate that MDD among adolescents with AUD may be partly attributable to PS Abuse... - Childhood psychopathology and adolescent cigarette smoking: a prospective survival analysis in children at high risk for substance use disordersDuncan B Clark
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Addict Behav 29:837-41. 2004..Through the identification of childhood characteristics predicting daily cigarette smoking in adolescence, these results may facilitate targeting of early childhood preventive interventions... 
Psychopathology risk transmission in children of parents with substance use disordersDuncan B Clark
Center for Education and Drug Abuse Research, University of Pittsburgh, PA 15213, USA
Am J Psychiatry 161:685-91. 2004..This study examined the distinct influences of parent substance use disorder and other psychopathology in the transmission of the risk for psychopathology to their children...- Clinical practices in the pharmacological treatment of comorbid psychopathology in adolescents with alcohol use disordersDuncan B Clark
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Subst Abuse Treat 25:293-5. 2003..The treatment setting did not significantly influence antidepressant prescribing practices. The common and increasing use of psychiatric medications in this population emphasizes the urgent need for empirically based clinical guidelines... - Serum tryptophan ratio and suicidal behavior in adolescents: a prospective studyDuncan B Clark
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychiatry Res 119:199-204. 2003..This finding suggests that the tryptophan ratio may improve the identification of adolescents at high risk for suicidal behavior... - Measuring risks and outcomes in substance use disorders prevention researchDuncan B Clark
J Consult Clin Psychol 70:1207-23. 2002..Comprehensive diachronic evaluation over critical developmental periods provides the technical foundation for etiology and intervention research... - Alcohol use disorders in adolescents: epidemiology, diagnosis, psychosocial interventions, and pharmacological treatmentDuncan B Clark
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Paediatr Drugs 4:493-502. 2002..In this population, pharmacological interventions require further investigation and, where indicated, are generally considered to be supplementary to psychosocial approaches... - Alcohol use disorders and risk factor interactions for adolescent suicidal ideation and attemptsT M Kelly
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213-2593, USA
Suicide Life Threat Behav 31:181-93. 2001.... - Clinical correlates of heavy tobacco use among adolescentsJ R Cornelius
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
Addict Behav 26:273-7. 2001..Also, depressive disorders were associated with smoking at any level in our sample, but depressive disorders were not associated with heavy smoking... - Gender differences and similarities in the personality correlates of adolescent alcohol problemsC S Martin
Pittsburgh Adolescent Research Center, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213 2593, USA
Psychol Addict Behav 14:121-33. 2000..Although there are gender differences in levels of BU and NE, mechanisms of alcohol involvement related to these 2 personality traits may operate similarly in adolescent males and females... - Hippocampal volume in adolescent-onset alcohol use disordersM D De Bellis
University of Pittsburgh Medical Center, Developmental Traumatology Neuroimaging Laboratory, Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Am J Psychiatry 157:737-44. 2000..This study compared the hippocampal volumes of adolescents and young adults with adolescent-onset alcohol use disorders to those of healthy matched comparison subjects... - Correlates of mental health service utilization and unmet need among a sample of male adolescentsJ R Cornelius
Center for Education and Drug Abuse Research, USA
Addict Behav 26:11-9. 2001.... - Psychopathology and substance-related problems during early adolescence: a survival analysisD B Clark
Center for Education and Drug Abuse Research, University of Pittsburgh, PA 15213, USA
J Clin Child Psychol 28:333-41. 1999..Results support a model in which paternal SUD predisposes to increased antisocial and negative affect disorders in boys, and antisocial disorders lead to substance-related problems in early adolescence... - Treating the substance-abusing suicidal patientJ R Cornelius
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Ann N Y Acad Sci 932:78-90; discussion 91-3. 2001..Further studies are clearly warranted to evaluate the efficacy of various pharmacotherapeutic agents and various psychotherapies in the treatment of substance-abusing suicidal patients... - Systematic assessment of social phobia in clinical practiceD B Clark
Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
Depress Anxiety 6:47-61. 1997..Guidelines for selecting appropriate social phobia measures for varying clinical and research situations will be proposed that take into consideration the strengths and weaknesses of these methods... - Supervisory neglect and adolescent alcohol use disorders: effects on AUD onset and treatment outcomeDuncan B Clark
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Addict Behav 30:1737-50. 2005..Utilizing a four-item supervision scale, this study identified adolescents with inadequate supervision, and examined effects on AUD development and treatment outcome... - Alcohol use frequency as a screen for alcohol use disorders in adolescentsDuncan B Clark
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Int J Adolesc Med Health 18:181-7. 2006..These results indicate that an assessment of the frequency of alcohol use in the prior month provides an initial screen with acceptable sensitivity and specificity for use with adolescents... - Cardiovascular risk factors in adolescents with alcohol use disordersDawn L Thatcher
Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
Int J Adolesc Med Health 18:151-7. 2006..Interventions focusing on health behaviors in conjunction with addiction treatment might help improve long-term health outcomes in adolescents with AUDs... - Alcohol and drug use and related disorders: An underrecognized health issue among adolescents and young adults attending sexually transmitted disease clinicsRobert L Cook
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Sex Transm Dis 33:565-70. 2006.... - Diary study of substance use and unsafe sex among adolescents with substance use disordersSusan L Bailey
Division of Epidemiology and Biostatistics, University of Illinois, Chicago, Illinois 60612, USA
J Adolesc Health 38:297.e13-20. 2006..This study tested event-level associations between substance use and condom use, as well as potential covariates, among adolescents with substance use disorders (SUDs)... - Predicting risky drinking outcomes longitudinally: what kind of advance notice can we get?Robert A Zucker
Department of Psychiatry, University of Michigan Addiction Research Center, Ann Arbor, Michigan 48105, USA
Alcohol Clin Exp Res 30:243-52. 2006..Finally, Robert Zucker examines the degree to which the core symposium questions are answered and comments on next step research and clinical practice changes that are called for by these findings... - Fluoxetine for the treatment of childhood anxiety disorders: open-label, long-term extension to a controlled trialDuncan B Clark
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 44:1263-70. 2005..To assess the efficacy of fluoxetine for the long-term treatment of children and adolescents with anxiety disorders, including generalized anxiety disorder, separation anxiety disorder, and/or social phobia... - Prefrontal cortex, thalamus, and cerebellar volumes in adolescents and young adults with adolescent-onset alcohol use disorders and comorbid mental disordersMichael D De Bellis
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Alcohol Clin Exp Res 29:1590-600. 2005.... - Substance use disorder trajectory classes: diachronic integration of onset age, severity, and courseDuncan B Clark
Center for Education and Drug Abuse Research, University of Pittsburgh, and Western Psychiatric Institute and Clinic, PA 15213, USA
Addict Behav 31:995-1009. 2006..This article illustrates the utilization of SAS-TRAJ mixture modeling to characterize variations in SUD symptom trajectories to define phenotypes... - Different lengths of times for progressions in adolescent substance involvementTy A Ridenour
The Pennsylvania State University, Prevention Research Center, State College 16801, United States
Addict Behav 31:962-83. 2006..Females had shorter transition times, though gender differences were small. Some evidence was found for a familial influence on transition times above what was accounted for by differences between substances... - Early age of first sexual intercourse and affiliation with deviant peers predict development of SUD: a prospective longitudinal studyJack R Cornelius
Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh, 3811 O Hara Street, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 32:850-4. 2007..The objective of this study was to assess whether early onset of sexual intercourse and affiliation with deviant peers serve as predictors of the development of SUD, using a prospective longitudinal study design... - Parental supervision and alcohol use in adolescence: developmentally specific interactionsDuncan B Clark
Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Dev Behav Pediatr 29:285-92. 2008..This study examined the interaction of parental supervision and adolescent alcohol use from late childhood through middle adolescence... - Adolescent-onset substance use disorders predict young adult mortalityDuncan B Clark
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Adolesc Health 42:637-9. 2008..Adolescent SUDs, as well as gender, ethnic group, hazardous substance use, and drug trafficking, predicted these deaths. Among African American males with SUDs, 23% died by age 25... - Concurrent change in alcohol and drug problems among treated adolescents over three yearsTammy Chung
Western Psychiatric Institute and Clinic Pittsburgh Adolescent Alcohol Research Center, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
J Stud Alcohol Drugs 69:420-9. 2008.... 
Cannabis withdrawal predicts severity of cannabis involvement at 1-year follow-up among treated adolescentsTammy Chung
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Addiction 103:787-99. 2008..This study contrasted the concurrent and predictive validity of three operational definitions of cannabis withdrawal in a sample of treated adolescents...- Introduction to alcohol and adolescent brain developmentDuncan B Clark
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Alcohol Clin Exp Res 32:373-4. 2008 - Alcohol, psychological dysregulation, and adolescent brain developmentDuncan B Clark
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Alcohol Clin Exp Res 32:375-85. 2008..This article will describe some of the opportunities contemporary neuroimaging techniques offer for advancing understanding of adolescent neurodevelopment and alcohol involvement... - Premature mortality among males with substance use disordersJack R Cornelius
Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh, 3811 O Hara Street, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 33:156-60. 2008..The objective of this study was to assess whether the presence of SUD or ASP is associated with early mortality among males (fathers) in a predominantly community sample, using a 15-year prospective longitudinal study design... - Predictors of marijuana use in adolescents before and after licit drug use: examination of the gateway hypothesisRalph E Tarter
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA
Am J Psychiatry 163:2134-40. 2006..They also evaluated the accuracy of the "gateway sequence" (illicit drug use following licit drugs) for predicting a diagnosis of substance use disorder... - The drinking situations of adolescents treated for alcohol use disorders: a psychometric and alcohol-related outcomes investigationGilbert R Parra
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Addict Behav 30:1725-36. 2005..These results indicate that the IDS is a reliable and valid measure for use with adolescents receiving treatment for alcohol-related problems... - Acute phase and five-year follow-up study of fluoxetine in adolescents with major depression and a comorbid substance use disorder: a reviewJack R Cornelius
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 30:1824-33. 2005..However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor... - Adolescent alcohol use disorders predict adult borderline personalityDawn L Thatcher
Pittsburgh Adolescent Alcohol Research Center PAARC, Department of Psychiatry, University of Pittsburgh Medical Center, USA
Addict Behav 30:1709-24. 2005..This study investigated adolescent alcohol use disorders (AUDs) and other characteristics as predictors of adult borderline personality disorder (BPD) symptoms... - Rapid relapse generally follows treatment for substance use disorders among adolescentsJack R Cornelius
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Addict Behav 28:381-6. 2003..1993). In J. S. Baer, G. A. Marlatt, & R. J. McMahon (Eds.), Addictive behaviors across the life span (pp. 160-183). London: SAGE.] in showing that most adolescents relapse quickly following treatment for substance use disorders... - Fluoxetine for the treatment of childhood anxiety disordersBoris Birmaher
Department of Child Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 42:415-23. 2003..To assess the efficacy and tolerability of fluoxetine for the acute treatment of children and adolescents with generalized anxiety disorder, separation anxiety disorder, and/or social phobia... - Psychiatric disorders among older adolescents treated in emergency departments on weekends: a comparison with a matched community sampleThomas M Kelly
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
J Stud Alcohol 64:616-22. 2003.... - Liability to substance use disorders: 1. Common mechanisms and manifestationsMichael M Vanyukov
Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
Neurosci Biobehav Rev 27:507-15. 2003..An accompanying paper describes an approach to the quantitative estimation of this trait... - Psychiatric disorders and attempted suicide among adolescents with substance use disordersThomas M Kelly
Pittsburgh Adolescent Alcohol Research Center, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 73:87-97. 2004..To determine the effects of psychiatric disorders on attempted suicide among adolescents with substance use disorders (SUD)... - Fluoxetine in depressed AUD adolescents: a 1-year follow-up evaluationJack R Cornelius
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Child Adolesc Psychopharmacol 14:33-8. 2004..1998) and the significant levels of drinking of our comorbid adolescents suggest that longer term treatment may be needed for at least some adolescents with major depressive disorder and alcohol use disorder... - Dental abnormalities in children of fathers with substance use disordersJack R Cornelius
School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Addict Behav 29:979-82. 2004..The data from this study provide evidence that paternal SUDs (HAR vs. LAR status) is associated with poor dental condition, poor oral hygiene, a greater need for dental treatment, and inadequate levels of dental treatment utilization... - Major depression associated with earlier alcohol relapse in treated teens with AUDJack R Cornelius
Department of Psychiatry, Western Psychiatric Institute, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Addict Behav 29:1035-8. 2004..27, df=1, P=.039). These results suggest that the comorbid presence of MDD is associated with an earlier relapse to alcohol use among adolescents with an AUD... - Increased prevalence of herpes simplex virus type 2 among adolescent women with alcohol use disordersRobert L Cook
Department of Medicine and the Center for Research on Health Care, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Adolesc Health 30:169-74. 2002..To determine the relationship between alcohol use disorders (AUDs) and herpes simplex virus type 2 (HSV-2), hepatitis B virus (HBV), and human immunodeficiency virus (HIV) infections among a sample of sexually active adolescents... - The natural history of adolescent alcohol use disordersDuncan B Clark
University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Addiction 99:5-22. 2004..To examine clinically relevant research on the development, course and outcomes of adolescence alcohol use disorders (AUDs)... - Adolescent neglect and alcohol use disorders in two-parent familiesDuncan B Clark
University of Pittsburgh, USA
Child Maltreat 9:357-70. 2004..Among adolescents receiving treatment for AUDs, those in the Neglect group showed more improvement during a 1-year follow-up period. The results indicate that inadequate parent involvement may be a form of neglect... - Fluoxetine in adolescents with comorbid major depression and an alcohol use disorder: a 3-year follow-up studyJack R Cornelius
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 30:807-14. 2005..The high rate of MDD at follow-up suggests that longer term antidepressant medication treatment may be needed for at least some comorbid adolescents... - Treatment of co-occurring alcohol, drug, and psychiatric disordersJack R Cornelius
School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2593, USA
Recent Dev Alcohol 17:349-65. 2005..This chapter also identifies gaps in knowledge regarding the treatment of comorbid adolescents, and outlines directions for future research in this field... - Childhood risk categories for adolescent substance involvement: a general liability typologyDuncan B Clark
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 77:13-21. 2005..The findings indicate that these five risk categories constitute general liability classes for adolescent substance involvement, and may identify homogeneous groups of children requiring distinct preventive interventions... - Alcohol screening in young persons attending a sexually transmitted disease clinic. Comparison of AUDIT, CRAFFT, and CAGE instrumentsRobert L Cook
Division of General Internal Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Gen Intern Med 20:1-6. 2005.... - Multidimensional assessment of nicotine dependence in adolescentsDuncan B Clark
Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 77:235-42. 2005..The findings suggest that the NDSS has acceptable psychometric properties when applied to adolescents, complementing smoking rate and FTND in a multidimensional smoking assessment... - Is there an association between alcohol consumption and sexually transmitted diseases? A systematic reviewRobert L Cook
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Sex Transm Dis 32:156-64. 2005..The objective of this study was to conduct a systematic review of published literature on the association between problematic alcohol consumption and sexually transmitted diseases (STDs)... - Brain activation, response inhibition, and increased risk for substance use disorderREBECCA L MCNAMEE
Department of Pharmaceutical Sciences, University of Pittsburgh, Pennsylvania 15261, USA
Alcohol Clin Exp Res 32:405-13. 2008..Youth at high risk for developing substance use disorders (SUDs) often exhibit differences which suggest inhibitory impairments when compared to average risk youth... - Liability to substance use disorders: 2. A measurement approachMichael M Vanyukov
Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
Neurosci Biobehav Rev 27:517-26. 2003..This method is also applicable to measuring liabilities to other complex disorders, especially those with relatively late onset... - Testosterone levels and sexual maturation predict substance use disorders in adolescent boys: a prospective studyMaureen D Reynolds
Center for Education and Drug Abuse Research, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15261, USA
Biol Psychiatry 61:1223-7. 2007..This investigation determined whether testosterone level and sexual maturation in boys biased development of socially nonnormative behavior culminating in a substance use disorder (SUD)... - Interventions in suicidal alcoholicsJack R Cornelius
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Alcohol Clin Exp Res 28:89S-96S. 2004..Appropriate hospitalization, discharge, and family involvement are discussed. Finally, gaps in knowledge are identified with a focus on priorities and directions for future research... - Analyzing milestones in smoking cessation: illustration in a nicotine patch trial in adult smokersSaul Shiffman
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Consult Clin Psychol 74:276-85. 2006..6). The biggest effect of treatment was to prevent progression to relapse among those who had lapsed (HR = 7.1). Analysis of effects by milestones may enhance understanding of cessation treatments and their mechanisms of action...