Research Topics
| Chaira CirelliSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
Brain plasticity, sleep and agingChiara Cirelli
Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Gerontology 58:441-5. 2012..This distinction has obvious practical implications. However, very little research has been done on this topic...
Sleep, aging, and lifespan in DrosophilaDaniel Bushey
Dept of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
BMC Neurosci 11:56. 2010..Also, sleep quality has been shown to decrease in old flies, but it remains unclear whether aging-related sleep fragmentation is a generalized phenomenon...- Homeostatic regulation of sleep in the white-crowned sparrow (Zonotrichia leucophrys gambelii)Stephany G Jones
Neuroscience Training Program, University of Wisconsin Madison, USA
BMC Neurosci 9:47. 2008..To accomplish this goal, we investigated amount of sleep, sleep time course, and measures of sleep intensity in 6 birds during baseline sleep and during recovery sleep following 6 hours of sleep deprivation... 
Sleep in Kcna2 knockout miceChristopher L Douglas
Department of Psychiatry, University of Wisconsin, Madison, WI, 53719, USA
BMC Biol 5:42. 2007..To address this issue, we studied sleep in Kcna2 knockout (KO) mice. Kcna2 codes for Kv1.2, the alpha subunit of a Shaker-like voltage-dependent potassium channel with high expression in the mammalian thalamocortical system...
Locus ceruleus control of state-dependent gene expressionChiara Cirelli
Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719, USA
J Neurosci 24:5410-9. 2004....- Sleep and wakefulness modulate gene expression in DrosophilaChiara Cirelli
Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
J Neurochem 94:1411-9. 2005.... - Sleep and wakefulness in Drosophila melanogasterChaira Cirelli
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
Ann N Y Acad Sci 1129:323-9. 2008..Over the last few years, mutagenesis screens have isolated several short sleeping mutants, a demonstration that single genes can have a powerful effect on a complex trait like sleep... - Cellular consequences of sleep deprivation in the brainChiara Cirelli
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
Sleep Med Rev 10:307-21. 2006..However, it is too early to draw firm conclusions relative to the molecular consequences of sleep deprivation, and more extensive studies using DNA and protein arrays are needed in different species and in different brain regions... - Changes in brain gene expression after long-term sleep deprivationChiara Cirelli
Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
J Neurochem 98:1632-45. 2006..These findings suggest that sustained sleep loss may trigger a generalized inflammatory and stress response in the brain... - Sleep disruption, oxidative stress, and aging: new insights from fruit fliesChiara Cirelli
Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
Proc Natl Acad Sci U S A 103:13901-2. 2006 - Locus ceruleus control of slow-wave homeostasisChiara Cirelli
Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719, USA
J Neurosci 25:4503-11. 2005.... - Is sleep essential?Chiara Cirelli
Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, United States of America
PLoS Biol 6:e216. 2008 - Searching for sleep mutants of Drosophila melanogasterChiara Cirelli
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison WI 53719, USA
Bioessays 25:940-9. 2003..Ultimately, the characterization of these lines should help identifying crucial cellular pathways involved in the regulatory mechanisms of sleep and its functional consequences... - Extensive and divergent effects of sleep and wakefulness on brain gene expressionChiara Cirelli
Department of Psychiatry, University of Wisconsin, Madison, 53719, USA
Neuron 41:35-43. 2004.... - Proteomic profiling of the rat cerebral cortex in sleep and wakingC Cirelli
Dept of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd Madison, WI 53719, USA
Arch Ital Biol 147:59-68. 2009..The upregulation of hemoglobins and cytochrome C may be part of a cellular stress response triggered by even short periods of sleep loss... - The genetic and molecular regulation of sleep: from fruit flies to humansChiara Cirelli
Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
Nat Rev Neurosci 10:549-60. 2009..These findings have given valuable insights into the molecular underpinnings of sleep regulation and function that might lead the way to more efficient treatments for sleep disorders... - Uncoupling proteins and sleep deprivationC Cirelli
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison WI 53719, USA
Arch Ital Biol 142:541-9. 2004..Since the skeletal muscle is the largest tissue in the body, an elevated muscular expression of UCP2 is likely to affect the overall resting EE and may thus contribute to its increase after SD... - A molecular window on sleep: changes in gene expression between sleep and wakefulnessChiara Cirelli
Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Neuroscientist 11:63-74. 2005..Sleep-related transcripts are involved in brain protein synthesis, synaptic consolidation/depression, and membrane trafficking and maintenance, including cholesterol metabolism, myelin formation, and synaptic vesicle turnover... - Cortical firing and sleep homeostasisVladyslav V Vyazovskiy
Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Neuron 63:865-78. 2009..Changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Thus, the systematic increase of firing during wakefulness is counterbalanced by staying asleep... - Exploratory behavior, cortical BDNF expression, and sleep homeostasisReto Huber
Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Sleep 30:129-39. 2007..The aim of the study was to determine whether neuronal plasticity underlies the link between waking activities and the SWA response... - Molecular correlates of sleep and wakefulness in the brain of the white-crowned sparrowStephany Jones
Neuroscience Training Program, and Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
J Neurochem 105:46-62. 2008.... - Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleepVladyslav V Vyazovskiy
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
Nat Neurosci 11:200-8. 2008..Thus, wakefulness appears to be associated with net synaptic potentiation, whereas sleep may favor global synaptic depression, thereby preserving an overall balance of synaptic strength... - Reduced sleep in Drosophila Shaker mutantsChiara Cirelli
Department of Psychiatry, 6001 Research Park Blvd, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
Nature 434:1087-92. 2005..Shaker, which encodes a voltage-dependent potassium channel controlling membrane repolarization and transmitter release, may thus regulate sleep need or efficiency... - Widespread changes in synaptic markers as a function of sleep and wakefulness in DrosophilaGiorgio F Gilestro
Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
Science 324:109-12. 2009..The decrease of synaptic markers during sleep was progressive, and sleep was necessary for their decline. Thus, sleep may be involved in maintaining synaptic homeostasis altered by waking activities... - The Drosophila fragile X mental retardation gene regulates sleep needDaniel Bushey
Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
J Neurosci 29:1948-61. 2009..Thus, dFmr1 expression dose-dependently affects both sleep and synapses, suggesting that changes in sleep time in dFmr1 mutants may derive from changes in synaptic physiology... - Sleep homeostasis and cortical synchronization: II. A local field potential study of sleep slow waves in the ratVladyslav V Vyazovskiy
Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
Sleep 30:1631-42. 2007..Here we tested the model predictions by obtaining LFP recordings from the rat cerebral cortex and comparing conditions of high homeostatic sleep pressure (early sleep) and low homeostatic sleep pressure (late sleep)... - Changes in brain gene expression during migration in the white-crowned sparrowStephany Jones
Neuroscience Training Program, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
Brain Res Bull 76:536-44. 2008..These data suggest that migration is associated with brain cellular stress and enhanced energetic demands... - Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking statesMichael B Dash
Department of Psychiatry, and Neuroscience Training Program, University of Wisconsin Madison, Madison, WI 53719, USA
J Neurosci 29:620-9. 2009..These results provide evidence for a long-term homeostasis of extracellular glutamate across sleep-waking states... - Sleep homeostasis in Drosophila melanogasterReto Huber
Department of Psychiatry, University of Wisconsin, Madison 53719, USA
Sleep 27:628-39. 2004.... - Sleep deprivation and cellular responses to oxidative stressAnupama Gopalakrishnan
Department of Psychiatry, University of Wisconsin, Madison 53719, USA
Sleep 27:27-35. 2004..CONCLUSION: The available data do not support the assumption that prolonged wakefulness may cause oxidative damage, nor that it can represent an oxidative stress for the brain or for peripheral tissue such as liver and skeletal muscle... - Effects of skilled training on sleep slow wave activity and cortical gene expression in the ratErin C Hanlon
Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Sleep 32:719-29. 2009.... - Sleep and synaptic homeostasis: a hypothesisGiulio Tononi
Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
Brain Res Bull 62:143-50. 2003..Synaptic downscaling is tied to the beneficial effects of sleep on performance. The hypothesized link between sleep and synaptic homeostasis is supported by several lines of evidence and leads to testable predictions... - pySolo: a complete suite for sleep analysis in DrosophilaGiorgio F Gilestro
Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Bioinformatics 25:1466-7. 2009..AVAILABILITY: Software and documentation are located at (http://www.pysolo.net). pySolo is a free software released under the GNU General Public License... - How sleep deprivation affects gene expression in the brain: a review of recent findingsChiara Cirelli
Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
J Appl Physiol 92:394-400. 2002.... - Sleep function and synaptic homeostasisGiulio Tononi
Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
Sleep Med Rev 10:49-62. 2006..The hypothesis accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders... - Staying awake puts pressure on brain arousal systemsGiulio Tononi
Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
J Clin Invest 117:3648-50. 2007..This increase in synaptic strength may be one of the mechanisms that help us to stay awake when we are sleep deprived, but it may also represent one of the signals telling the brain that it is time to sleep... - Triggering slow waves during NREM sleep in the rat by intracortical electrical stimulation: effects of sleep/wake history and background activityVladyslav V Vyazovskiy
Dept of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
J Neurophysiol 101:1921-31. 2009..These results show that in the rat a volley of electrical activity that is sufficiently strong to excite and recruit a large cortical neuronal population is capable of inducing slow waves during natural sleep... - Sleep-dependent improvement in visuomotor learning: a causal role for slow wavesERIC C LANDSNESS
Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Sleep 32:1273-84. 2009..Here, we tested this hypothesis by studying the effects of slow wave deprivation (SWD)... - Sleep homeostasis in the rat is preserved during chronic sleep restrictionSusan Leemburg
Department of Psychiatry, University of Wisconsin, Madison, 53719, USA
Proc Natl Acad Sci U S A 107:15939-44. 2010..Analysis of cumulative slow wave energy demonstrated that the loss of SWA during SR was compensated by the end of the second recovery day. Thus, the homeostatic regulation of sleep is preserved under conditions of chronic SR... - A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleepUgo Faraguna
Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
J Neurosci 28:4088-95. 2008..These effects were also reversible and specific for NREM sleep. These results show a causal link between BDNF expression during wakefulness and subsequent sleep regulation... - Drosophila Hyperkinetic mutants have reduced sleep and impaired memoryDaniel Bushey
Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
J Neurosci 27:5384-93. 2007..These data identify a gene, Hk, which is necessary to maintain normal sleep, and provide genetic evidence that short sleep and poor memory are linked... - Chlorotoxin-mediated disinhibition of noradrenergic locus coeruleus neurons using a conditional transgenic approachJ Michael Salbaum
The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
Brain Res 1016:20-32. 2004..This method represents a powerful new tool to assess the long-term effects of LC activation and is potentially applicable to other neuronal systems...
Research Grants
- Characterization of Sleep Mutants of DrososphilaChiara Cirelli; Fiscal Year: 2009..This research will help to identify the molecular mechanisms regulating the need for sleep and provide novel clues to its functions. ..