Chaira Cirelli

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Sleep and waking modulate spine turnover in the adolescent mouse cortex
    Stephanie Maret
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA
    Nat Neurosci 14:1418-20. 2011
  2. doi request reprint Sleep and synaptic changes
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA Electronic address
    Curr Opin Neurobiol 23:841-6. 2013
  3. ncbi request reprint Brain plasticity, sleep and aging
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Gerontology 58:441-5. 2012
  4. pmc Sleep, aging, and lifespan in Drosophila
    Daniel Bushey
    Dept of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    BMC Neurosci 11:56. 2010
  5. pmc Homeostatic regulation of sleep in the white-crowned sparrow (Zonotrichia leucophrys gambelii)
    Stephany G Jones
    Neuroscience Training Program, University of Wisconsin Madison, USA
    BMC Neurosci 9:47. 2008
  6. pmc Sleep in Kcna2 knockout mice
    Christopher L Douglas
    Department of Psychiatry, University of Wisconsin, Madison, WI, 53719, USA
    BMC Biol 5:42. 2007
  7. pmc Sleep and wakefulness in Drosophila melanogaster
    Chaira Cirelli
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
    Ann N Y Acad Sci 1129:323-9. 2008
  8. pmc Is sleep essential?
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Biol 6:e216. 2008
  9. pmc Sleep disruption, oxidative stress, and aging: new insights from fruit flies
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Proc Natl Acad Sci U S A 103:13901-2. 2006
  10. ncbi request reprint Changes in brain gene expression after long-term sleep deprivation
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    J Neurochem 98:1632-45. 2006

Research Grants

  1. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2005
  2. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2006
  3. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2007
  4. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2009
  5. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2009

Collaborators

Detail Information

Publications44

  1. pmc Sleep and waking modulate spine turnover in the adolescent mouse cortex
    Stephanie Maret
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA
    Nat Neurosci 14:1418-20. 2011
    ..Using two-photon microscopy in adolescent mice, we found that waking results in a net increase in cortical spines, whereas sleep is associated with net spine loss...
  2. doi request reprint Sleep and synaptic changes
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA Electronic address
    Curr Opin Neurobiol 23:841-6. 2013
    ..Moreover, partial and total loss of sleep affect the ability of synapses to undergo long-term potentiation, an effect that may underlie some of the negative consequences of sleep deprivation on memory and other cognitive functions. ..
  3. ncbi request reprint Brain plasticity, sleep and aging
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Gerontology 58:441-5. 2012
    ..This distinction has obvious practical implications. However, very little research has been done on this topic...
  4. pmc Sleep, aging, and lifespan in Drosophila
    Daniel Bushey
    Dept of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    BMC Neurosci 11:56. 2010
    ..Also, sleep quality has been shown to decrease in old flies, but it remains unclear whether aging-related sleep fragmentation is a generalized phenomenon...
  5. pmc Homeostatic regulation of sleep in the white-crowned sparrow (Zonotrichia leucophrys gambelii)
    Stephany G Jones
    Neuroscience Training Program, University of Wisconsin Madison, USA
    BMC Neurosci 9:47. 2008
    ..To accomplish this goal, we investigated amount of sleep, sleep time course, and measures of sleep intensity in 6 birds during baseline sleep and during recovery sleep following 6 hours of sleep deprivation...
  6. pmc Sleep in Kcna2 knockout mice
    Christopher L Douglas
    Department of Psychiatry, University of Wisconsin, Madison, WI, 53719, USA
    BMC Biol 5:42. 2007
    ..To address this issue, we studied sleep in Kcna2 knockout (KO) mice. Kcna2 codes for Kv1.2, the alpha subunit of a Shaker-like voltage-dependent potassium channel with high expression in the mammalian thalamocortical system...
  7. pmc Sleep and wakefulness in Drosophila melanogaster
    Chaira Cirelli
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
    Ann N Y Acad Sci 1129:323-9. 2008
    ..Over the last few years, mutagenesis screens have isolated several short sleeping mutants, a demonstration that single genes can have a powerful effect on a complex trait like sleep...
  8. pmc Is sleep essential?
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Biol 6:e216. 2008
  9. pmc Sleep disruption, oxidative stress, and aging: new insights from fruit flies
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Proc Natl Acad Sci U S A 103:13901-2. 2006
  10. ncbi request reprint Changes in brain gene expression after long-term sleep deprivation
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    J Neurochem 98:1632-45. 2006
    ..These findings suggest that sustained sleep loss may trigger a generalized inflammatory and stress response in the brain...
  11. ncbi request reprint Cellular consequences of sleep deprivation in the brain
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
    Sleep Med Rev 10:307-21. 2006
    ..However, it is too early to draw firm conclusions relative to the molecular consequences of sleep deprivation, and more extensive studies using DNA and protein arrays are needed in different species and in different brain regions...
  12. ncbi request reprint Sleep and wakefulness modulate gene expression in Drosophila
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    J Neurochem 94:1411-9. 2005
    ....
  13. ncbi request reprint Locus ceruleus control of slow-wave homeostasis
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719, USA
    J Neurosci 25:4503-11. 2005
    ....
  14. ncbi request reprint Searching for sleep mutants of Drosophila melanogaster
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison WI 53719, USA
    Bioessays 25:940-9. 2003
    ..Ultimately, the characterization of these lines should help identifying crucial cellular pathways involved in the regulatory mechanisms of sleep and its functional consequences...
  15. ncbi request reprint Extensive and divergent effects of sleep and wakefulness on brain gene expression
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, 53719, USA
    Neuron 41:35-43. 2004
    ....
  16. pmc Proteomic profiling of the rat cerebral cortex in sleep and waking
    C Cirelli
    Dept of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd Madison, WI 53719, USA
    Arch Ital Biol 147:59-68. 2009
    ..The upregulation of hemoglobins and cytochrome C may be part of a cellular stress response triggered by even short periods of sleep loss...
  17. ncbi request reprint Uncoupling proteins and sleep deprivation
    C Cirelli
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison WI 53719, USA
    Arch Ital Biol 142:541-9. 2004
    ..Since the skeletal muscle is the largest tissue in the body, an elevated muscular expression of UCP2 is likely to affect the overall resting EE and may thus contribute to its increase after SD...
  18. ncbi request reprint A molecular window on sleep: changes in gene expression between sleep and wakefulness
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Neuroscientist 11:63-74. 2005
    ..Sleep-related transcripts are involved in brain protein synthesis, synaptic consolidation/depression, and membrane trafficking and maintenance, including cholesterol metabolism, myelin formation, and synaptic vesicle turnover...
  19. pmc The genetic and molecular regulation of sleep: from fruit flies to humans
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Nat Rev Neurosci 10:549-60. 2009
    ..These findings have given valuable insights into the molecular underpinnings of sleep regulation and function that might lead the way to more efficient treatments for sleep disorders...
  20. ncbi request reprint Locus ceruleus control of state-dependent gene expression
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719, USA
    J Neurosci 24:5410-9. 2004
    ....
  21. pmc Cortical firing and sleep homeostasis
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Neuron 63:865-78. 2009
    ..Changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Thus, the systematic increase of firing during wakefulness is counterbalanced by staying asleep...
  22. ncbi request reprint Exploratory behavior, cortical BDNF expression, and sleep homeostasis
    Reto Huber
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 30:129-39. 2007
    ..The aim of the study was to determine whether neuronal plasticity underlies the link between waking activities and the SWA response...
  23. doi request reprint Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    Nat Neurosci 11:200-8. 2008
    ..Thus, wakefulness appears to be associated with net synaptic potentiation, whereas sleep may favor global synaptic depression, thereby preserving an overall balance of synaptic strength...
  24. ncbi request reprint Molecular correlates of sleep and wakefulness in the brain of the white-crowned sparrow
    Stephany Jones
    Neuroscience Training Program, and Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    J Neurochem 105:46-62. 2008
    ....
  25. ncbi request reprint Reduced sleep in Drosophila Shaker mutants
    Chiara Cirelli
    Department of Psychiatry, 6001 Research Park Blvd, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    Nature 434:1087-92. 2005
    ..Shaker, which encodes a voltage-dependent potassium channel controlling membrane repolarization and transmitter release, may thus regulate sleep need or efficiency...
  26. pmc Sleep homeostasis and cortical synchronization: II. A local field potential study of sleep slow waves in the rat
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Sleep 30:1631-42. 2007
    ..Here we tested the model predictions by obtaining LFP recordings from the rat cerebral cortex and comparing conditions of high homeostatic sleep pressure (early sleep) and low homeostatic sleep pressure (late sleep)...
  27. pmc Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila
    Giorgio F Gilestro
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Science 324:109-12. 2009
    ..The decrease of synaptic markers during sleep was progressive, and sleep was necessary for their decline. Thus, sleep may be involved in maintaining synaptic homeostasis altered by waking activities...
  28. pmc The Drosophila fragile X mental retardation gene regulates sleep need
    Daniel Bushey
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 29:1948-61. 2009
    ..Thus, dFmr1 expression dose-dependently affects both sleep and synapses, suggesting that changes in sleep time in dFmr1 mutants may derive from changes in synaptic physiology...
  29. ncbi request reprint Sleep homeostasis in Drosophila melanogaster
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison 53719, USA
    Sleep 27:628-39. 2004
    ....
  30. pmc Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states
    Michael B Dash
    Department of Psychiatry, and Neuroscience Training Program, University of Wisconsin Madison, Madison, WI 53719, USA
    J Neurosci 29:620-9. 2009
    ..These results provide evidence for a long-term homeostasis of extracellular glutamate across sleep-waking states...
  31. pmc Changes in brain gene expression during migration in the white-crowned sparrow
    Stephany Jones
    Neuroscience Training Program, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Brain Res Bull 76:536-44. 2008
    ..These data suggest that migration is associated with brain cellular stress and enhanced energetic demands...
  32. ncbi request reprint Sleep deprivation and cellular responses to oxidative stress
    Anupama Gopalakrishnan
    Department of Psychiatry, University of Wisconsin, Madison 53719, USA
    Sleep 27:27-35. 2004
    ....
  33. pmc Effects of skilled training on sleep slow wave activity and cortical gene expression in the rat
    Erin C Hanlon
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 32:719-29. 2009
    ....
  34. ncbi request reprint Sleep and synaptic homeostasis: a hypothesis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Brain Res Bull 62:143-50. 2003
    ..Synaptic downscaling is tied to the beneficial effects of sleep on performance. The hypothesized link between sleep and synaptic homeostasis is supported by several lines of evidence and leads to testable predictions...
  35. ncbi request reprint How sleep deprivation affects gene expression in the brain: a review of recent findings
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Appl Physiol (1985) 92:394-400. 2002
    ....
  36. ncbi request reprint Sleep function and synaptic homeostasis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Sleep Med Rev 10:49-62. 2006
    ..The hypothesis accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders...
  37. pmc Staying awake puts pressure on brain arousal systems
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Clin Invest 117:3648-50. 2007
    ..This increase in synaptic strength may be one of the mechanisms that help us to stay awake when we are sleep deprived, but it may also represent one of the signals telling the brain that it is time to sleep...
  38. pmc pySolo: a complete suite for sleep analysis in Drosophila
    Giorgio F Gilestro
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Bioinformatics 25:1466-7. 2009
    ..Support for development of additional plug-ins is provided through a community website...
  39. pmc Triggering slow waves during NREM sleep in the rat by intracortical electrical stimulation: effects of sleep/wake history and background activity
    Vladyslav V Vyazovskiy
    Dept of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
    J Neurophysiol 101:1921-31. 2009
    ..These results show that in the rat a volley of electrical activity that is sufficiently strong to excite and recruit a large cortical neuronal population is capable of inducing slow waves during natural sleep...
  40. pmc Sleep-dependent improvement in visuomotor learning: a causal role for slow waves
    ERIC C LANDSNESS
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 32:1273-84. 2009
    ..Here, we tested this hypothesis by studying the effects of slow wave deprivation (SWD)...
  41. pmc Sleep homeostasis in the rat is preserved during chronic sleep restriction
    Susan Leemburg
    Department of Psychiatry, University of Wisconsin, Madison, 53719, USA
    Proc Natl Acad Sci U S A 107:15939-44. 2010
    ..Analysis of cumulative slow wave energy demonstrated that the loss of SWA during SR was compensated by the end of the second recovery day. Thus, the homeostatic regulation of sleep is preserved under conditions of chronic SR...
  42. pmc A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep
    Ugo Faraguna
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 28:4088-95. 2008
    ..These effects were also reversible and specific for NREM sleep. These results show a causal link between BDNF expression during wakefulness and subsequent sleep regulation...
  43. ncbi request reprint Drosophila Hyperkinetic mutants have reduced sleep and impaired memory
    Daniel Bushey
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 27:5384-93. 2007
    ..These data identify a gene, Hk, which is necessary to maintain normal sleep, and provide genetic evidence that short sleep and poor memory are linked...
  44. ncbi request reprint Chlorotoxin-mediated disinhibition of noradrenergic locus coeruleus neurons using a conditional transgenic approach
    J Michael Salbaum
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Brain Res 1016:20-32. 2004
    ..This method represents a powerful new tool to assess the long-term effects of LC activation and is potentially applicable to other neuronal systems...

Research Grants6

  1. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2005
    ..This research will help to identify the molecular mechanisms regulating the need for sleep and provide novel clues to its functions. ..
  2. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2006
    ..This research will help to identify the molecular mechanisms regulating the need for sleep and provide novel clues to its functions. ..
  3. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2007
    ..This research will help to identify the molecular mechanisms regulating the need for sleep and provide novel clues to its functions. ..
  4. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2009
    ..This research will help to identify the molecular mechanisms regulating the need for sleep and provide novel clues to its functions. ..
  5. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2009
    ..This research will help to identify the molecular mechanisms regulating the need for sleep and provide novel clues to its functions. ..