Research Topics
Genomes and GenesSpecies | Marilyn CipollaSummaryAffiliation: University of Vermont Country: USA Publications
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Publications
Pregnant serum induces neuroinflammation and seizure activity via TNFαMarilyn J Cipolla
Department of Neurology, University of Vermont, Burlington, VT 05405, USA
Exp Neurol 234:398-404. 2012..These studies provide novel insight into the underlying cause of eclampsia without elevated blood pressure and the protective role of the BBB that prevents exposure of the brain to hyperexcitable factors...- Effect of pregnancy on autoregulation of cerebral blood flow in anterior versus posterior cerebrumMarilyn J Cipolla
Department of Neurology, University of Vermont, 149 Beaumont Ave, HSRF 416, Burlington, VT 05405, USA
Hypertension 60:705-11. 2012..These findings suggest that, although pregnancy shifted the cerebral blood flow autoregulatory curve to higher pressures in both the anterior and posterior cortices, it did not protect from edema during acute hypertension... - Differential effects of low-dose endotoxin on the cerebral circulation during pregnancyMarilyn J Cipolla
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Reprod Sci 18:1211-21. 2011..These results demonstrate that pregnancy enhances sensitivity to the effects of LPS in the cerebral circulation, which may be due to an enhanced inflammatory state during pregnancy... 
Pregnancy reverses hypertensive remodeling of cerebral arteriesMarilyn J Cipolla
Department of Neurology, University of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
Hypertension 51:1052-7. 2008..This reversal of protective remodeling during hypertension in pregnancy may be detrimental by lowering the upper limit of autoregulation, whereas blood pressure remains elevated...- SKCa and IKCa Channels, myogenic tone, and vasodilator responses in middle cerebral arteries and parenchymal arterioles: effect of ischemia and reperfusionMarilyn J Cipolla
Department of Neurology, University of Vermont, Burlington, VT 05405, USA
Stroke 40:1451-7. 2009.... 
Cerebrovascular function in pregnancy and eclampsiaMarilyn J Cipolla
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Hypertension 50:14-24. 2007- Pregnancy prevents hypertensive remodeling of cerebral arteries: a potential role in the development of eclampsiaMarilyn J Cipolla
Department of Neurology, University of Vermont, Burlington, VT 05405, USA
Hypertension 47:619-26. 2006.... - Reactivity of brain parenchymal arterioles after ischemia and reperfusionMarilyn J Cipolla
Department of Neurology, Ob Gyn and Pharmacology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
Microcirculation 15:495-501. 2008..We investigated the effect of ischemia and reperfusion on the vasoactive function of penetrating brain parenchymal arterioles under pressurized conditions... - PPAR{gamma} activation prevents hypertensive remodeling of cerebral arteries and improves vascular function in female ratsMarilyn J Cipolla
Department of Neurology, University of Vermont, 89 Beaumont Avenue, Given C454, Burlington, VT 05405, USA
Stroke 41:1266-70. 2010..We hypothesized that activation of PPARgamma could prevent hypertensive remodeling of cerebral arteries and improve vascular function... - Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsiaMarilyn J Cipolla
Department of Neurology, Univ of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
J Appl Physiol 110:329-39. 2011.... - Resistance artery vasodilation to magnesium sulfate during pregnancy and the postpartum stateAnna G Euser
Dept of Neurology, University of Vermont, 89 Beaumont Ave, Given Bldg, Rm C454, Burlington, VT 05405, USA
Am J Physiol Heart Circ Physiol 288:H1521-5. 2005.... - Perivascular innervation of penetrating brain parenchymal arteriolesMarilyn J Cipolla
Department of Neurology, University of Vermont, Burlington, VT 05405, USA
J Cardiovasc Pharmacol 44:1-8. 2004..It appears that in PA, the dominant vasoconstricting stimulus is intrinsic myogenic tone and that the role of neurotransmitter and intrinsic innervation is beyond that of controlling CBF... - The adaptation of the blood-brain barrier to vascular endothelial growth factor and placental growth factor during pregnancyMalou P H Schreurs
Department of Neurology, University of Vermont, Burlington, VT 05405, USA
FASEB J 26:355-62. 2012..Our findings suggest that VEGF and PLGF enhance BBB permeability through different VEGFR pathways and that circulating sFlt1 prevents VEGF- and PLGF-induced BBB permeability during pregnancy... - Cerebral artery reactivity changes during pregnancy and the postpartum period: a role in eclampsia?Marilyn J Cipolla
Dept of Neurology, University of Vermont, Given Bldg, Rm C454, 89 Beaumont Avenue, Burlington, VT 05405, USA
Am J Physiol Heart Circ Physiol 286:H2127-32. 2004.... - Inhibition of protein kinase Cβ reverses increased blood-brain barrier permeability during hyperglycemic stroke and prevents edema formation in vivoMarilyn J Cipolla
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Stroke 42:3252-7. 2011..We investigated the effect of circulating factors and protein kinase Cβ on blood-brain barrier permeability and edema during hyperglycemic stroke... - Effect of estrogen therapy on cerebral arteries during stroke in female ratsGwen J Goodrow
Department of Obstetrics and Gynecology, University of Vermont, Burlington, VT 05405, USA
Menopause 12:99-109. 2005..CONCLUSIONS: The influence of ischemia and reperfusion on vessel function was more dominant than that of estrogen therapy. However, estrogen therapy seemed to partially restore vessel function to similar levels as nonischemic vessels... - Resistance artery adaptation to pregnancy counteracts the vasoconstricting influence of plasma from normal pregnant womenOdul A Amburgey
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
Reprod Sci 17:29-39. 2010..The increased reactivity and tone noted in NP vessels was abolished when pregnant plasma was perfused through LP arteries, suggesting these vessels adapt during pregnancy to the vasoconstricting influence of pregnant plasma... - Cerebral blood flow autoregulation and edema formation during pregnancy in anesthetized ratsAnna G Euser
Department of Neurology, University of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
Hypertension 49:334-40. 2007.... - PPAR-gamma agonist rosiglitazone reverses increased cerebral venous hydraulic conductivity during hypertensionTim J M Roberts
1Departments of Neurology, Obstetrics, Gynecology and Reproductive Sciences, and Pharmacology, University of Vermont, Burlington, Vermont 05405, USA
Am J Physiol Heart Circ Physiol 297:H1347-53. 2009..Our findings suggest that PPAR-gamma may be a key regulator of blood-brain barrier permeability and a potential therapeutic target during hypertension... - Pregnancy prevents hypertensive remodeling and decreases myogenic reactivity in posterior cerebral arteries from Dahl salt-sensitive rats: a role in eclampsia?Annet M Aukes
Department of Neurology, University of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
Am J Physiol Heart Circ Physiol 292:H1071-6. 2007..This effect may predispose the brain to autoregulatory breakthrough, hyperperfusion, and eclampsia when MAP is elevated... - Peroxynitrite diminishes myogenic activity and is associated with decreased vascular smooth muscle F-actin in rat posterior cerebral arteriesMatthew J Maneen
Department of Neurology, University of Vermont, Burlington, VT 05405, USA
Stroke 37:894-9. 2006.... - The effect of ovariectomy and estrogen on penetrating brain arterioles and blood-brain barrier permeabilityMarilyn J Cipolla
Department of Neurology, University of Vermont, Burlington, Vermont, USA marilyn
Microcirculation 16:685-93. 2009..We investigated the effect of estrogen replacement on the structure and function of penetrating brain arterioles (PA) and blood-brain barrier (BBB) permeability... - Pressure-induced actin polymerization in vascular smooth muscle as a mechanism underlying myogenic behaviorMarilyn J Cipolla
Department of Ob Gyn, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
FASEB J 16:72-6. 2002..g., PKC activation, Rho A, and tyrosine phosphorylation)... - The influence of pregnancy and gender on perivascular innervation of rat posterior cerebral arteriesAnnet M Aukes
University of Vermont, Department of Neurology, Burlington, VT 05405, USA
Reprod Sci 15:411-9. 2008..Together, these results suggest that the increase in trigeminal innervation during pregnancy is more related to nociception than in controlling resting cerebral blood flow... - Middle cerebral artery function after stroke: the threshold duration of reperfusion for myogenic activityMarilyn J Cipolla
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Stroke 33:2094-9. 2002..We measured both the amount of spontaneous myogenic tone that developed at 75 mm Hg and the contractile response to increased transmural pressure (TMP), ie, myogenic reactivity... - Magnesium sulphate treatment decreases blood-brain barrier permeability during acute hypertension in pregnant ratsAnna G Euser
University of Vermont, Department of Neurology, 89 Beaumont Avenue, Given C454, Burlington, VT 05405, USA
Exp Physiol 93:254-61. 2008..The greatest effect on BBB permeability to EB was in the posterior cerebrum, an area particularly susceptible to oedema formation during eclampsia... - Transcellular transport as a mechanism of blood-brain barrier disruption during strokeMarilyn J Cipolla
Department of Neurology, University of Vermont, Burlington, VT 05405, USA
Front Biosci 9:777-85. 2004.... - Fibroblast spreading induced by connective tissue stretch involves intracellular redistribution of alpha- and beta-actinHelene M Langevin
Department of Neurology, Given C423, University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT 05405, USA
Histochem Cell Biol 125:487-95. 2006..This dual response pattern of alpha- and beta-actin may be an important component of cellular mechanotransduction mechanisms relevant to physiologic and therapeutic mechanical forces applied to connective tissue... - The cerebral endothelium during pregnancy: a potential role in the development of eclampsiaMarilyn J Cipolla
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Endothelium 12:5-9. 2005..These results suggest a pregnancy-specific effect on the cerebral endothelium that may promote enhanced vascular permeability during acute hypertension and may contribute to the edema formation and neurologic complications of eclampsia... - Mechanical properties of rat middle cerebral arteries with and without myogenic toneRebecca J Coulson
Mechanical Engineering Department, University of Vermont, Burlington, VT 05405, USA
J Biomech Eng 126:76-81. 2004..Einc-a (10(6) dynes/cm2) increased significantly with pressure (from 15.1 +/- 2.3 at 75 mmHg to 49.4 +/- 12.6 at 125 mmHg, p < 0.001), indicating a greater contribution of SMC activity to vessel wall stiffness at higher pressures... - Plasma from preeclamptic women increases blood-brain barrier permeability: role of vascular endothelial growth factor signalingOdul A Amburgey
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA
Hypertension 56:1003-8. 2010.... - Magnesium sulfate for the treatment of eclampsia: a brief reviewAnna G Euser
Department of Neurology, University of Vermont, Burlington, VT 05405, USA
Stroke 40:1169-75. 2009..This review summarizes current evidence supporting the possible mechanisms of action and several controversies for magnesium sulfate treatment... - Pregnancy-induced up-regulation of aquaporin-4 protein in brain and its role in eclampsiaAllison M Quick
Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
FASEB J 19:170-5. 2005..Quick, A. M., Cipolla, M. J. Pregnancy-induced up-regulation of aquaporin-4 protein in brain and its role in eclampsia... - Peroxynitrite diminishes myogenic tone in cerebral arteries: role of nitrotyrosine and F-actinMatthew J Maneen
Department of Neurology, University of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
Am J Physiol Heart Circ Physiol 292:H1042-50. 2007.... - Regional expression of aquaporin 1, 4, and 9 in the brain during pregnancyMarchien J Wiegman
Department of Neurology, University of Vermont, Burlington, VT 05405, USA
Reprod Sci 15:506-16. 2008..The expression levels of AQP1, 4, and 9 in the brainstem did not change with gestation, whereas changes were found in the anterior cerebrum for AQP4 and in the posterior cerebrum and cerebellum for all AQPs... - Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-γSiu Lung Chan
Department of Neurology, University of Vermont, Burlington, VT 05401 USA
FASEB J 25:3229-39. 2011..These results suggest that relaxin produced during pregnancy may be partly responsible for selective remodeling of PAs during pregnancy through a mechanism involving PPARγ.. - Arterial wall hyperplasia is increased in placental compared with myoendometrial radial uterine arteries from late-pregnant ratsErica S Hammer
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Am J Obstet Gynecol 192:302-8. 2005..CONCLUSION: These data demonstrate differential growth and remodeling of uterine arteries that supply the placenta versus the myoendometrium, which likely is facilitated by enhanced arterial wall hyperplasia in placental arteries... - Effects of ischemia and myogenic activity on active and passive mechanical properties of rat cerebral arteriesRebecca J Coulson
Department of Mechanical Engineering and Department of Neurology, The University of Vermont, Burlington 05405, USA
Am J Physiol Heart Circ Physiol 283:H2268-75. 2002..E(inc,a) increased with pressure for all conditions, signifying that changes in stiffness are influenced by SMC activity and vascular tone...
Research Grants
- Cerebrovascular Changes in Pregnancy and HypertensionMarilyn J Cipolla; Fiscal Year: 2010..This understanding is crucial to effective management and treatment of this devastating condition. ..
- Cerebral Arteriole Function during Hyperglycemic StrokeMarilyn Cipolla; Fiscal Year: 2009....
- Cerebrovascular Changes in Pregnancy and HypertensionMarilyn Cipolla; Fiscal Year: 2006..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
- REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTIONMarilyn Cipolla; Fiscal Year: 2003..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
- Cerebrovascular Changes in Pregnancy and HypertensionMarilyn J Cipolla; Fiscal Year: 2010..This understanding is crucial to effective management and treatment of this devastating condition. ..