Marilyn Cipolla

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Pregnant serum induces neuroinflammation and seizure activity via TNFα
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Exp Neurol 234:398-404. 2012
  2. ncbi request reprint Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arteries: role of ion channels and calcium sensitivity
    Marilyn J Cipolla
    Department of Neurological Sciences, University of Vermont, Burlington, Vermont Department of Pharmacology, University of Vermont, Burlington, Vermont and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, Vermont
    J Appl Physiol (1985) 117:53-9. 2014
  3. pmc Effect of PPARγ inhibition during pregnancy on posterior cerebral artery function and structure
    Siu Lung Chan
    Department of Neurology, University of Vermont Burlington, VT, USA
    Front Physiol 1:130. 2010
  4. pmc The adaptation of the cerebral circulation to pregnancy: mechanisms and consequences
    Marilyn J Cipolla
    Departments of Neurological Sciences, Obstetrics, Gynecology and Reproductive Sciences, Pharmacology, University of Vermont College of Medicine, Burlington, VT, USA
    J Cereb Blood Flow Metab 33:465-78. 2013
  5. pmc Increased oxidized low-density lipoprotein causes blood-brain barrier disruption in early-onset preeclampsia through LOX-1
    Malou P H Schreurs
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    FASEB J 27:1254-63. 2013
  6. pmc Effect of pregnancy on autoregulation of cerebral blood flow in anterior versus posterior cerebrum
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, 149 Beaumont Ave, HSRF 416, Burlington, VT 05405, USA
    Hypertension 60:705-11. 2012
  7. pmc Differential effects of low-dose endotoxin on the cerebral circulation during pregnancy
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Reprod Sci 18:1211-21. 2011
  8. pmc PPAR{gamma} activation prevents hypertensive remodeling of cerebral arteries and improves vascular function in female rats
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, 89 Beaumont Avenue, Given C454, Burlington, VT 05405, USA
    Stroke 41:1266-70. 2010
  9. ncbi request reprint Cerebrovascular function in pregnancy and eclampsia
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Hypertension 50:14-24. 2007
  10. doi request reprint Pregnancy reverses hypertensive remodeling of cerebral arteries
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
    Hypertension 51:1052-7. 2008

Research Grants

Collaborators

Detail Information

Publications42

  1. pmc Pregnant serum induces neuroinflammation and seizure activity via TNFα
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Exp Neurol 234:398-404. 2012
    ..These studies provide novel insight into the underlying cause of eclampsia without elevated blood pressure and the protective role of the BBB that prevents exposure of the brain to hyperexcitable factors...
  2. ncbi request reprint Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arteries: role of ion channels and calcium sensitivity
    Marilyn J Cipolla
    Department of Neurological Sciences, University of Vermont, Burlington, Vermont Department of Pharmacology, University of Vermont, Burlington, Vermont and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, Vermont
    J Appl Physiol (1985) 117:53-9. 2014
    ..Thus increased myogenic tone in PAs appears related to differences in ion channel activity that promotes VSM membrane depolarization but not to a direct sensitization of the contractile apparatus to calcium. ..
  3. pmc Effect of PPARγ inhibition during pregnancy on posterior cerebral artery function and structure
    Siu Lung Chan
    Department of Neurology, University of Vermont Burlington, VT, USA
    Front Physiol 1:130. 2010
    ..Down-regulation of PPARγ and AT1R in cerebral arteries may be responsible for the lack of effect of PPARγ in cerebral vasculature and may be part of the vascular adaptation to pregnancy...
  4. pmc The adaptation of the cerebral circulation to pregnancy: mechanisms and consequences
    Marilyn J Cipolla
    Departments of Neurological Sciences, Obstetrics, Gynecology and Reproductive Sciences, Pharmacology, University of Vermont College of Medicine, Burlington, VT, USA
    J Cereb Blood Flow Metab 33:465-78. 2013
    ....
  5. pmc Increased oxidized low-density lipoprotein causes blood-brain barrier disruption in early-onset preeclampsia through LOX-1
    Malou P H Schreurs
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    FASEB J 27:1254-63. 2013
    ..As increased BBB permeability is a primary means by which seizure and other neurological symptoms ensue, our findings highlight oxLDL, LOX-1, and peroxynitrite as important therapeutic targets in EPE...
  6. pmc Effect of pregnancy on autoregulation of cerebral blood flow in anterior versus posterior cerebrum
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, 149 Beaumont Ave, HSRF 416, Burlington, VT 05405, USA
    Hypertension 60:705-11. 2012
    ..These findings suggest that, although pregnancy shifted the cerebral blood flow autoregulatory curve to higher pressures in both the anterior and posterior cortices, it did not protect from edema during acute hypertension...
  7. pmc Differential effects of low-dose endotoxin on the cerebral circulation during pregnancy
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Reprod Sci 18:1211-21. 2011
    ..These results demonstrate that pregnancy enhances sensitivity to the effects of LPS in the cerebral circulation, which may be due to an enhanced inflammatory state during pregnancy...
  8. pmc PPAR{gamma} activation prevents hypertensive remodeling of cerebral arteries and improves vascular function in female rats
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, 89 Beaumont Avenue, Given C454, Burlington, VT 05405, USA
    Stroke 41:1266-70. 2010
    ..We hypothesized that activation of PPARgamma could prevent hypertensive remodeling of cerebral arteries and improve vascular function...
  9. ncbi request reprint Cerebrovascular function in pregnancy and eclampsia
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Hypertension 50:14-24. 2007
  10. doi request reprint Pregnancy reverses hypertensive remodeling of cerebral arteries
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
    Hypertension 51:1052-7. 2008
    ..This reversal of protective remodeling during hypertension in pregnancy may be detrimental by lowering the upper limit of autoregulation, whereas blood pressure remains elevated...
  11. pmc SKCa and IKCa Channels, myogenic tone, and vasodilator responses in middle cerebral arteries and parenchymal arterioles: effect of ischemia and reperfusion
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Stroke 40:1451-7. 2009
    ....
  12. ncbi request reprint Pregnancy prevents hypertensive remodeling of cerebral arteries: a potential role in the development of eclampsia
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Hypertension 47:619-26. 2006
    ....
  13. pmc Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia
    Marilyn J Cipolla
    Department of Neurology, Univ of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
    J Appl Physiol (1985) 110:329-39. 2011
    ....
  14. ncbi request reprint Cerebral artery reactivity changes during pregnancy and the postpartum period: a role in eclampsia?
    Marilyn J Cipolla
    Dept of Neurology, University of Vermont, Given Bldg, Rm C454, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 286:H2127-32. 2004
    ....
  15. pmc The adaptation of the blood-brain barrier to vascular endothelial growth factor and placental growth factor during pregnancy
    Malou P H Schreurs
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    FASEB J 26:355-62. 2012
    ..Our findings suggest that VEGF and PLGF enhance BBB permeability through different VEGFR pathways and that circulating sFlt1 prevents VEGF- and PLGF-induced BBB permeability during pregnancy...
  16. ncbi request reprint Perivascular innervation of penetrating brain parenchymal arterioles
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    J Cardiovasc Pharmacol 44:1-8. 2004
    ..It appears that in PA, the dominant vasoconstricting stimulus is intrinsic myogenic tone and that the role of neurotransmitter and intrinsic innervation is beyond that of controlling CBF...
  17. pmc Reactivity of brain parenchymal arterioles after ischemia and reperfusion
    Marilyn J Cipolla
    Department of Neurology, Ob Gyn and Pharmacology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Microcirculation 15:495-501. 2008
    ..We investigated the effect of ischemia and reperfusion on the vasoactive function of penetrating brain parenchymal arterioles under pressurized conditions...
  18. ncbi request reprint Resistance artery vasodilation to magnesium sulfate during pregnancy and the postpartum state
    Anna G Euser
    Dept of Neurology, University of Vermont, 89 Beaumont Ave, Given Bldg, Rm C454, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 288:H1521-5. 2005
    ....
  19. pmc Inhibition of protein kinase Cβ reverses increased blood-brain barrier permeability during hyperglycemic stroke and prevents edema formation in vivo
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Stroke 42:3252-7. 2011
    ..We investigated the effect of circulating factors and protein kinase Cβ on blood-brain barrier permeability and edema during hyperglycemic stroke...
  20. ncbi request reprint Effect of estrogen therapy on cerebral arteries during stroke in female rats
    Gwen J Goodrow
    Department of Obstetrics and Gynecology, University of Vermont, Burlington, VT 05405, USA
    Menopause 12:99-109. 2005
    ..To investigate the effect of estrogen therapy on the structural and functional properties of the middle cerebral artery during ischemia and reperfusion...
  21. pmc Resistance artery adaptation to pregnancy counteracts the vasoconstricting influence of plasma from normal pregnant women
    Odul A Amburgey
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Reprod Sci 17:29-39. 2010
    ..The increased reactivity and tone noted in NP vessels was abolished when pregnant plasma was perfused through LP arteries, suggesting these vessels adapt during pregnancy to the vasoconstricting influence of pregnant plasma...
  22. ncbi request reprint Cerebral blood flow autoregulation and edema formation during pregnancy in anesthetized rats
    Anna G Euser
    Department of Neurology, University of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
    Hypertension 49:334-40. 2007
    ....
  23. pmc PPAR-gamma agonist rosiglitazone reverses increased cerebral venous hydraulic conductivity during hypertension
    Tim J M Roberts
    1Departments of Neurology, Obstetrics, Gynecology and Reproductive Sciences, and Pharmacology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Physiol Heart Circ Physiol 297:H1347-53. 2009
    ..Our findings suggest that PPAR-gamma may be a key regulator of blood-brain barrier permeability and a potential therapeutic target during hypertension...
  24. ncbi request reprint Pregnancy prevents hypertensive remodeling and decreases myogenic reactivity in posterior cerebral arteries from Dahl salt-sensitive rats: a role in eclampsia?
    Annet M Aukes
    Department of Neurology, University of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 292:H1071-6. 2007
    ..This effect may predispose the brain to autoregulatory breakthrough, hyperperfusion, and eclampsia when MAP is elevated...
  25. ncbi request reprint Peroxynitrite diminishes myogenic activity and is associated with decreased vascular smooth muscle F-actin in rat posterior cerebral arteries
    Matthew J Maneen
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Stroke 37:894-9. 2006
    ..This study investigated the effect of peroxynitrite (ONOO-) on pressure-induced myogenic activity and vascular smooth muscle (VSM) actin of isolated posterior cerebral arteries (PCAs)...
  26. ncbi request reprint Pressure-induced actin polymerization in vascular smooth muscle as a mechanism underlying myogenic behavior
    Marilyn J Cipolla
    Department of Ob Gyn, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    FASEB J 16:72-6. 2002
    ..g., PKC activation, Rho A, and tyrosine phosphorylation)...
  27. ncbi request reprint Middle cerebral artery function after stroke: the threshold duration of reperfusion for myogenic activity
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Stroke 33:2094-9. 2002
    ..We measured both the amount of spontaneous myogenic tone that developed at 75 mm Hg and the contractile response to increased transmural pressure (TMP), ie, myogenic reactivity...
  28. ncbi request reprint Transcellular transport as a mechanism of blood-brain barrier disruption during stroke
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Front Biosci 9:777-85. 2004
    ....
  29. ncbi request reprint Mechanical properties of rat middle cerebral arteries with and without myogenic tone
    Rebecca J Coulson
    Mechanical Engineering Department, University of Vermont, Burlington, VT 05405, USA
    J Biomech Eng 126:76-81. 2004
    ..Einc-a (10(6) dynes/cm2) increased significantly with pressure (from 15.1 +/- 2.3 at 75 mmHg to 49.4 +/- 12.6 at 125 mmHg, p < 0.001), indicating a greater contribution of SMC activity to vessel wall stiffness at higher pressures...
  30. ncbi request reprint The cerebral endothelium during pregnancy: a potential role in the development of eclampsia
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Endothelium 12:5-9. 2005
    ..These results suggest a pregnancy-specific effect on the cerebral endothelium that may promote enhanced vascular permeability during acute hypertension and may contribute to the edema formation and neurologic complications of eclampsia...
  31. ncbi request reprint Fibroblast spreading induced by connective tissue stretch involves intracellular redistribution of alpha- and beta-actin
    Helene M Langevin
    Department of Neurology, Given C423, University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT 05405, USA
    Histochem Cell Biol 125:487-95. 2006
    ..This dual response pattern of alpha- and beta-actin may be an important component of cellular mechanotransduction mechanisms relevant to physiologic and therapeutic mechanical forces applied to connective tissue...
  32. ncbi request reprint Magnesium sulphate treatment decreases blood-brain barrier permeability during acute hypertension in pregnant rats
    Anna G Euser
    University of Vermont, Department of Neurology, 89 Beaumont Avenue, Given C454, Burlington, VT 05405, USA
    Exp Physiol 93:254-61. 2008
    ..The greatest effect on BBB permeability to EB was in the posterior cerebrum, an area particularly susceptible to oedema formation during eclampsia...
  33. doi request reprint The influence of pregnancy and gender on perivascular innervation of rat posterior cerebral arteries
    Annet M Aukes
    University of Vermont, Department of Neurology, Burlington, VT 05405, USA
    Reprod Sci 15:411-9. 2008
    ..Together, these results suggest that the increase in trigeminal innervation during pregnancy is more related to nociception than in controlling resting cerebral blood flow...
  34. pmc The effect of ovariectomy and estrogen on penetrating brain arterioles and blood-brain barrier permeability
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, Burlington, Vermont, USA marilyn
    Microcirculation 16:685-93. 2009
    ..We investigated the effect of estrogen replacement on the structure and function of penetrating brain arterioles (PA) and blood-brain barrier (BBB) permeability...
  35. pmc Magnesium sulfate for the treatment of eclampsia: a brief review
    Anna G Euser
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Stroke 40:1169-75. 2009
    ..This review summarizes current evidence supporting the possible mechanisms of action and several controversies for magnesium sulfate treatment...
  36. pmc Plasma from preeclamptic women increases blood-brain barrier permeability: role of vascular endothelial growth factor signaling
    Odul A Amburgey
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA
    Hypertension 56:1003-8. 2010
    ....
  37. ncbi request reprint Pregnancy-induced up-regulation of aquaporin-4 protein in brain and its role in eclampsia
    Allison M Quick
    Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    FASEB J 19:170-5. 2005
    ..Quick, A. M., Cipolla, M. J. Pregnancy-induced up-regulation of aquaporin-4 protein in brain and its role in eclampsia...
  38. ncbi request reprint Peroxynitrite diminishes myogenic tone in cerebral arteries: role of nitrotyrosine and F-actin
    Matthew J Maneen
    Department of Neurology, University of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 292:H1042-50. 2007
    ....
  39. doi request reprint Regional expression of aquaporin 1, 4, and 9 in the brain during pregnancy
    Marchien J Wiegman
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Reprod Sci 15:506-16. 2008
    ..The expression levels of AQP1, 4, and 9 in the brainstem did not change with gestation, whereas changes were found in the anterior cerebrum for AQP4 and in the posterior cerebrum and cerebellum for all AQPs...
  40. pmc Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-γ
    Siu Lung Chan
    Department of Neurology, University of Vermont, Burlington, VT 05401 USA
    FASEB J 25:3229-39. 2011
    ..These results suggest that relaxin produced during pregnancy may be partly responsible for selective remodeling of PAs during pregnancy through a mechanism involving PPARγ..
  41. ncbi request reprint Arterial wall hyperplasia is increased in placental compared with myoendometrial radial uterine arteries from late-pregnant rats
    Erica S Hammer
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Obstet Gynecol 192:302-8. 2005
    ..This study compared myoendometrial versus placental radial uterine arteries from late-pregnant rats to evaluate differences in passive mechanical properties and arterial wall hyperplasia...
  42. ncbi request reprint Effects of ischemia and myogenic activity on active and passive mechanical properties of rat cerebral arteries
    Rebecca J Coulson
    Department of Mechanical Engineering and Department of Neurology, The University of Vermont, Burlington 05405, USA
    Am J Physiol Heart Circ Physiol 283:H2268-75. 2002
    ..E(inc,a) increased with pressure for all conditions, signifying that changes in stiffness are influenced by SMC activity and vascular tone...

Research Grants18

  1. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2006
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
  2. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2005
    ....
  3. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2004
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
  4. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  5. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2003
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
  6. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn J Cipolla; Fiscal Year: 2010
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  7. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2009
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  8. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2007
    ....
  9. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2009
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  10. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....
  11. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2006
    ....
  12. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 1999
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  13. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2005
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
  14. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2002
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  15. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2001
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  16. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2000
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  17. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn J Cipolla; Fiscal Year: 2010
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..