Pawel S Ciborowski

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi Immunoreactivity of anti-gelsolin antibodies: implications for biomarker validation
    Nicole Haverland
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Transl Med 8:137. 2010
  2. ncbi Biomarkers of HIV-1-associated neurocognitive disorders: challenges of proteomic approaches
    Pawel Ciborowski
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Biomark Med 3:771-85. 2009
  3. ncbi Biomarkers of HIV-1 associated dementia: proteomic investigation of sera
    Jayme Wiederin
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Proteome Sci 7:8. 2009
  4. ncbi Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome
    Pawel Ciborowski
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Virology 363:198-209. 2007
  5. ncbi Human immunodeficiency virus-mononuclear phagocyte interactions: emerging avenues of biomarker discovery, modes of viral persistence and disease pathogenesis
    Pawel Ciborowski
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Curr HIV Res 4:279-91. 2006
  6. ncbi Genomic and proteomic microglial profiling: pathways for neuroprotective inflammatory responses following nerve fragment clearance and activation
    Jason G Glanzer
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 102:627-45. 2007
  7. ncbi Plasma proteomic analysis of simian immunodeficiency virus infection of rhesus macaques
    Jayme L Wiederin
    University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Proteome Res 9:4721-31. 2010
  8. ncbi HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: new insights into blood-brain barrier dysfunction for HIV-1-associated dementia
    Mary Ricardo-Dukelow
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 185:37-46. 2007
  9. ncbi Diminished matrix metalloproteinase 9 secretion in human immunodeficiency virus-infected mononuclear phagocytes: modulation of innate immunity and implications for neurological disease
    Pawel Ciborowski
    Center for Neurovirology and Neurodegenerative Disorders, 985215 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5215, U SA
    J Neuroimmunol 157:11-6. 2004
  10. ncbi Proteomic fingerprints distinguish microglia, bone marrow, and spleen macrophage populations
    Yoshimi Enose
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198-5880, USA
    Glia 51:161-72. 2005

Research Grants

  1. Macrophage Protein Fingerprints in HIV-1 Dementia
    Pawel Ciborowski; Fiscal Year: 2006

Collaborators

Detail Information

Publications19

  1. ncbi Immunoreactivity of anti-gelsolin antibodies: implications for biomarker validation
    Nicole Haverland
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Transl Med 8:137. 2010
    ..Gelsolin is one such biomarker candidate in HIV-associated neurocognitive disorders...
  2. ncbi Biomarkers of HIV-1-associated neurocognitive disorders: challenges of proteomic approaches
    Pawel Ciborowski
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Biomark Med 3:771-85. 2009
    ....
  3. ncbi Biomarkers of HIV-1 associated dementia: proteomic investigation of sera
    Jayme Wiederin
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Proteome Sci 7:8. 2009
    ....
  4. ncbi Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome
    Pawel Ciborowski
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Virology 363:198-209. 2007
    ..This study, using a unique proteomics platform, provides novel insights into virus-host cell interactions that likely affect the functional role of macrophages in HIV disease...
  5. ncbi Human immunodeficiency virus-mononuclear phagocyte interactions: emerging avenues of biomarker discovery, modes of viral persistence and disease pathogenesis
    Pawel Ciborowski
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Curr HIV Res 4:279-91. 2006
    ....
  6. ncbi Genomic and proteomic microglial profiling: pathways for neuroprotective inflammatory responses following nerve fragment clearance and activation
    Jason G Glanzer
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 102:627-45. 2007
    ..Most importantly, this molecular and biochemical signature supports a broad range of microglial functions for debris clearance and promotion of neural repair after injury...
  7. ncbi Plasma proteomic analysis of simian immunodeficiency virus infection of rhesus macaques
    Jayme L Wiederin
    University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Proteome Res 9:4721-31. 2010
    ..Observed changes in plasma proteins expression likely represent a compensatory host response to persistent viral infection...
  8. ncbi HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: new insights into blood-brain barrier dysfunction for HIV-1-associated dementia
    Mary Ricardo-Dukelow
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 185:37-46. 2007
    ..Results were validated by Western blot analysis. We conclude that HIV-1-infected MDM affect the HBMEC proteome and, in this way, affect BBB dysfunction and the development of HIV-1 CNS disease...
  9. ncbi Diminished matrix metalloproteinase 9 secretion in human immunodeficiency virus-infected mononuclear phagocytes: modulation of innate immunity and implications for neurological disease
    Pawel Ciborowski
    Center for Neurovirology and Neurodegenerative Disorders, 985215 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5215, U SA
    J Neuroimmunol 157:11-6. 2004
    ..These data further demonstrate immunoregulatory activities of HIV-1-infected MDM providing unique insights into cellular function in disease...
  10. ncbi Proteomic fingerprints distinguish microglia, bone marrow, and spleen macrophage populations
    Yoshimi Enose
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198-5880, USA
    Glia 51:161-72. 2005
    ..The results provide a unique means to distinguish microglia from other MP subtypes...
  11. ncbi Cytoskeletal protein transformation in HIV-1-infected macrophage giant cells
    Irena Kadiu
    Laboratory of Neuroregeneration, Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha 68198, USA
    J Immunol 178:6404-15. 2007
    ..Such events favor the virus over the host cell and provide insights into macrophage defense mechanisms used to contain viral growth and how they may be affected during progressive HIV-1 infection...
  12. ncbi Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment
    Wojciech Rozek
    Center for Neurovirology and Neurodegenerative Disorders, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
    J Proteome Res 6:4189-99. 2007
    ..We posit that these proteins, alone or together, are potential HAD biomarkers...
  13. ncbi Proteomic fingerprinting of HIV-1-infected human monocyte-derived macrophages: a preliminary report
    Kimberly A Carlson
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5215, USA
    J Neuroimmunol 147:35-42. 2004
    ..Moreover, this evolving technology can be utilized to unravel changes in immune activities initiated by interactions between virus, environmental cues and drugs of abuse...
  14. ncbi HIV-1-infected astrocytes and the microglial proteome
    Tong Wang
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 3:173-86. 2008
    ..The observations confirmed the potential of astrocytes to influence the neuropathogenesis of HIV-1 infection by specifically altering the neurotoxic potential of infected microglia and regulating viral maturation...
  15. ncbi Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET
    Lindsey B Martinez
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 4:116-28. 2009
    ..These data suggest that calpain and proteasome are involved in OTK18 endoproteolysis and degradation. Additionally, intramolecular FRET has proven to be a useful tool for monitoring the processing in live cells...
  16. ncbi Proteomic modeling for HIV-1 infected microglia-astrocyte crosstalk
    Tong Wang
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, Omaha, Nebraska, United States of America
    PLoS ONE 3:e2507. 2008
    ..In contrast, astrocytes can affect disease by modulating the nervous system's microenvironment. Interestingly, little is known how astrocytes communicate with MP to influence disease...
  17. ncbi HIV-1 transforms the monocyte plasma membrane proteome
    Irena Kadiu
    Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Immunol 258:44-58. 2009
    ..These results demonstrate that HIV-1 uniquely affects monocyte activation and oxidative stress. These do not affect viral infection dynamics but are linked to stress-induced cell death...
  18. ncbi Nitrated alpha-synuclein and microglial neuroregulatory activities
    Ashley D Reynolds
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroimmune Pharmacol 3:59-74. 2008
    ..Inhibition of cathepsin B attenuated, in part, N-alpha-syn microglial neurotoxicity. These data support multifaceted microglia functions in PD-associated neurodegeneration...
  19. ncbi Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease
    Ashley D Reynolds
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 104:1504-25. 2008
    ..Taken together, the transcriptome and proteome of nitrated alpha-syn activated microglia, shown herein, provide new potential insights into disease mechanisms...

Research Grants1

  1. Macrophage Protein Fingerprints in HIV-1 Dementia
    Pawel Ciborowski; Fiscal Year: 2006
    ..The long-term goal of this aim is to uncover biomarkers specific for HAD and to see if they are based on products of immune competent virus-infected MDM as demonstrated in aim 1. ..