Affiliation: University of Southern California
- Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based reviewHelena C Chui
Department of Neurology, University of Southern California, 1520 San Pablo Street, Los Angeles, CA 90033, USA
Alzheimers Res Ther 4:1. 2012..We conclude that, at the present time, there is no consistent body of evidence to show that vascular risk factors increase AD pathology...
- Validation of multi-stage telephone-based identification of cognitive impairment and dementiaValerie C Crooks
Department of Research and Evaluation, Kaiser Permanente Southern California, 100 S Los Robles, Pasadena, CA91101, USA
BMC Neurol 5:8. 2005..This study evaluates whether a brief telephone cognitive assessment strategy can reliably classify cognitive status when compared to an in-person "gold-standard" clinical assessment...
- Neuropathology lessons in vascular dementiaHelena Chui
Department of Neurology, University of Southern California, Los Angeles, California 90033, USA
Alzheimer Dis Assoc Disord 19:45-52. 2005
- Cognitive impact of subcortical vascular and Alzheimer's disease pathologyHelena C Chui
Department of Neurology, University of Southern California, Los Angeles, USA
Ann Neurol 60:677-87. 2006..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype...
- Cultural diversity in Alzheimer disease: the interface between biology, belief, and behaviorHelena C Chui
Department of Neurology, University of Southern California Los Angeles, California, USA
Alzheimer Dis Assoc Disord 19:250-5. 2005
- Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic studyHelen Lavretsky
Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Am J Psychiatry 167:589-97. 2010....
- The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementiaHelen Lavretsky
Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Int J Geriatr Psychiatry 23:1040-50. 2008..We examined the magnetic resonance imaging (MRI) correlates of depressed mood, apathy, anhedonia, and anergia in older adults with and without cognitive impairment or dementia...
- Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adultsSarah Tomaszewski Farias
Department of Neurology, School of Medicine, University of California, Davis, CA, USA
Clin Neuropsychol 23:446-61. 2009..Findings indicate that declines in MEM and EXEC over time make unique and independent contributions to declines in older adults' ability to function in daily life...
- Diagnosing depression in Alzheimer disease with the national institute of mental health provisional criteriaEdmond Teng
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Am J Geriatr Psychiatry 16:469-77. 2008....
- Cognitive and neuroimaging predictors of instrumental activities of daily livingDeborah A Cahn-Weiner
Department of Neurology, University of California, San Francisco, California 94143 0138, USA
J Int Neuropsychol Soc 13:747-57. 2007..Perhaps executive function is particularly important with respect to maintaining IADLs. Alternatively, executive dysfunction may be a sentinel event indicating widespread cortical involvement and poor prognosis...
- Subcortical ischemic vascular dementiaHelena C Chui
Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA
Neurol Clin 25:717-40, vi. 2007..Lacunes and deep white matter changes are associated with dysexecutive syndrome. Hypertension, the leading risk factor for sporadic SIVD, is treatable. High priority must be given to reducing vascular risk profiles...
- Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issuesChris Zarow
University of Southern California, Rancho Los Amigos National Rehabilitation Center, 7601 E Imperial Highway, Medical Science Building, Room 26, Downey, CA 90242, USA
Curr Neurol Neurosci Rep 8:363-70. 2008..Little is known about the prevention and treatment of late-life HS, although circumstantial evidence suggests the importance of identifying and treating vascular risk factors...
- Performance of Spanish speakers on the Mattis dementia rating scale (MDRS)Scott A Lyness
Department of Neurology, Keck School of Medicine, University of Southern California, CA, USA
Arch Clin Neuropsychol 21:827-36. 2006....
- Longitudinal MRI and cognitive change in healthy elderlyJoel H Kramer
Department of Neurology, San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
Neuropsychology 21:412-8. 2007..The association between WMSH and EXEC further highlights the cognitive sequealae associated with cerebrovascular disease in normal elderly...
- Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementiaChris Zarow
University of Southern California, Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA
Ann Neurol 57:896-903. 2005..Reductions in magnetic resonance imaging-derived hippocampal volume reflect loss, rather than shrinkage, of CA1 neurons...
- Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysisScott A Lyness
Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
Neurobiol Aging 24:1-23. 2003..Symptomatic drug treatment for AD might be beneficially directed toward ameliorating multiple neurotransmitter deficiencies, particularly cholinergic and noradrenergic...
- Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseasesChris Zarow
Department of Neurology, University of Southern California, Los Angeles, CA, USA
Arch Neurol 60:337-41. 2003..Alzheimer disease (AD) and Parkinson disease (PD) are associated with neuronal degeneration in major subcortical nuclei, but few studies have examined the neuronal degeneration in these nuclei concurrently...
- A randomized controlled comparison of upper-extremity rehabilitation strategies in acute stroke: A pilot study of immediate and long-term outcomesCarolee J Winstein
Dept of Biokinesiology and Physical Therapy, University of Southern California, Health Sciences Campus, 1540 E Alcazar St, CHP 155, Los Angeles, CA 90089 9006, USA
Arch Phys Med Rehabil 85:620-8. 2004..To evaluate the immediate and long-term effects of 2 upper-extremity rehabilitation approaches for stroke compared with standard care in participants stratified by stroke severity...
- Category fluency in a latino sample: associations with age, education, gender, and languageWendy J Mack
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
J Clin Exp Neuropsychol 27:591-8. 2005....
- Advances in vascular cognitive impairment 2005Helena Chui
The University of Southern California, Los Angeles, USA
Stroke 37:323-5. 2006
- Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunesYuan-Yu Hsu
Department of Veterans Affairs Medical Center, Magnetic Resonance Unit, San Francisco, California, USA
Alzheimer Dis Assoc Disord 16:58-64. 2002..In conclusion, the presence of subcortical lacunes in those with AD is associated with more WM lesions and ventriculomegaly but not with cortical atrophy...
- Hippocampal volume and retention in Alzheimer's diseaseJoel H Kramer
Department of Neurology, University of California at San Francisco, 94143, USA
J Int Neuropsychol Soc 10:639-43. 2004..Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories...
- Depression as a risk factor for Alzheimer disease: the MIRAGE StudyRobert C Green
Department of Neurology, Genetics Program, Boston University School of Medicine, MA 02118, USA
Arch Neurol 60:753-9. 2003..Depression symptoms may be associated with the development of Alzheimer disease (AD)...
- Clinical and neuropsychological features in autopsy-defined vascular dementiaBruce R Reed
Alzheimer s Disease Center, University of California, Davis 94553, USA
Clin Neuropsychol 18:63-74. 2004..A illustrative case example is included. We conclude that the profile of cognitive impairment in IVD is highly variable, but that in clinical settings neuropsychological readings may contribute to the differential diagnosis of dementia...
- Subcortical ischaemic vascular dementiaGustavo C Roman
University of Texas at San Antonio and the Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas 78284 7883, USA
Lancet Neurol 1:426-36. 2002..Treatment is symptomatic and prevention requires control of treatable risk factors...
- Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular diseaseBeth Kuczynski
Helen Wills Neuroscience Institute and the Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
Arch Neurol 65:650-5. 2008..Understanding how each disease contributes to dementia is essential from both a pathophysiologic and diagnostic perspective...
- White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophyAn-Tao Du
Magnetic Resonance Unit (114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Neurobiol Aging 26:553-9. 2005..Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy...
- Incidence of dementia in long-term hormone usersDiana B Petitti
Department of Clinical Analysis, Kaiser Permanente Southern California, Pasadena, CA
Am J Epidemiol 167:692-700. 2008..95, 1.89) in estrogen/progestin users and 1.23 (95% confidence interval: 0.94, 1.59) in estrogen users. These findings do not provide support for an effect of estrogen or estrogen/progestin use in preventing dementia...
- Neuropathological basis of magnetic resonance images in aging and dementiaWilliam J Jagust
School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
Ann Neurol 63:72-80. 2008..Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present...
- Subcortical lacunes are associated with executive dysfunction in cognitively normal elderlyCatherine L Carey
Department of Psychiatry, University of California, San Diego, 150 W Washington, 2nd Floor San Diego, CA 92103, USA
Stroke 39:397-402. 2008..We therefore hypothesized that MRI markers of SIVD would be selectively associated with worse executive functioning...
- Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular diseaseBruce R Reed
University of California, Davis, CA, USA
Brain 130:731-9. 2007....
- Memory in the aging brain: doubly dissociating the contribution of the hippocampus and entorhinal cortexAndrew P Yonelinas
Department of Psychology, University of California, Davis, California 95616, USA
Hippocampus 17:1134-40. 2007....
- Forgetting in dementia with and without subcortical lacunesJoel H Kramer
San Francisco Medical Center, University of California, CA 94143, USA
Clin Neuropsychol 18:32-40. 2004..Three SIVD patients with rapid forgetting followed to autopsy all had AD pathology, further supporting the link between memory patterns and AD...
- Age effects on atrophy rates of entorhinal cortex and hippocampusAn-Tao Du
Magnetic Resonance Unit (114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Neurobiol Aging 27:733-40. 2006..In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials...
- The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease CentersJohn C Morris
Washington University, St Louis, MO 63108, USA
Alzheimer Dis Assoc Disord 20:210-6. 2006..Data obtained with the UDS are submitted to the National Alzheimer's Coordinating Center and represent a unique and valuable source of data to support and stimulate collaborative research...
- Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experienceNathan A Johnson
MR Research Unit, VA Medical Center, 4150 Clement St 114M San Francisco, CA 94107, USA
Radiology 234:851-9. 2005....
- CORE--CENTRAL COORDINATING COREHelena Chui; Fiscal Year: 2007..Consultants and an external advisory group provide invaluable feedback and guidance. The PPG functions as a vital and cohesive whole. ..