Helena Chui

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Different associations of white matter lesions with depression and cognition
    Jun Young Lee
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    BMC Neurol 12:83. 2012
  2. pmc Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review
    Helena C Chui
    Department of Neurology, University of Southern California, 1520 San Pablo Street, Los Angeles, CA 90033, USA
    Alzheimers Res Ther 4:1. 2012
  3. pmc Validation of multi-stage telephone-based identification of cognitive impairment and dementia
    Valerie C Crooks
    Department of Research and Evaluation, Kaiser Permanente Southern California, 100 S Los Robles, Pasadena, CA91101, USA
    BMC Neurol 5:8. 2005
  4. ncbi request reprint Neuropathology lessons in vascular dementia
    Helena Chui
    Department of Neurology, University of Southern California, Los Angeles, California 90033, USA
    Alzheimer Dis Assoc Disord 19:45-52. 2005
  5. pmc Cognitive impact of subcortical vascular and Alzheimer's disease pathology
    Helena C Chui
    Department of Neurology, University of Southern California, Los Angeles, USA
    Ann Neurol 60:677-87. 2006
  6. ncbi request reprint Cultural diversity in Alzheimer disease: the interface between biology, belief, and behavior
    Helena C Chui
    Department of Neurology, University of Southern California Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 19:250-5. 2005
  7. pmc Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study
    Helen Lavretsky
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Psychiatry 167:589-97. 2010
  8. pmc The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia
    Helen Lavretsky
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Int J Geriatr Psychiatry 23:1040-50. 2008
  9. pmc Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults
    Sarah Tomaszewski Farias
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Clin Neuropsychol 23:446-61. 2009
  10. pmc Diagnosing depression in Alzheimer disease with the national institute of mental health provisional criteria
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Am J Geriatr Psychiatry 16:469-77. 2008

Research Grants

  1. CORE--CENTRAL COORDINATING CORE
    Helena Chui; Fiscal Year: 2007

Detail Information

Publications37

  1. pmc Different associations of white matter lesions with depression and cognition
    Jun Young Lee
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    BMC Neurol 12:83. 2012
    ....
  2. pmc Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review
    Helena C Chui
    Department of Neurology, University of Southern California, 1520 San Pablo Street, Los Angeles, CA 90033, USA
    Alzheimers Res Ther 4:1. 2012
    ..We conclude that, at the present time, there is no consistent body of evidence to show that vascular risk factors increase AD pathology...
  3. pmc Validation of multi-stage telephone-based identification of cognitive impairment and dementia
    Valerie C Crooks
    Department of Research and Evaluation, Kaiser Permanente Southern California, 100 S Los Robles, Pasadena, CA91101, USA
    BMC Neurol 5:8. 2005
    ..This study evaluates whether a brief telephone cognitive assessment strategy can reliably classify cognitive status when compared to an in-person "gold-standard" clinical assessment...
  4. ncbi request reprint Neuropathology lessons in vascular dementia
    Helena Chui
    Department of Neurology, University of Southern California, Los Angeles, California 90033, USA
    Alzheimer Dis Assoc Disord 19:45-52. 2005
  5. pmc Cognitive impact of subcortical vascular and Alzheimer's disease pathology
    Helena C Chui
    Department of Neurology, University of Southern California, Los Angeles, USA
    Ann Neurol 60:677-87. 2006
    ..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype...
  6. ncbi request reprint Cultural diversity in Alzheimer disease: the interface between biology, belief, and behavior
    Helena C Chui
    Department of Neurology, University of Southern California Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 19:250-5. 2005
  7. pmc Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study
    Helen Lavretsky
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Psychiatry 167:589-97. 2010
    ....
  8. pmc The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia
    Helen Lavretsky
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Int J Geriatr Psychiatry 23:1040-50. 2008
    ..We examined the magnetic resonance imaging (MRI) correlates of depressed mood, apathy, anhedonia, and anergia in older adults with and without cognitive impairment or dementia...
  9. pmc Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults
    Sarah Tomaszewski Farias
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Clin Neuropsychol 23:446-61. 2009
    ..Findings indicate that declines in MEM and EXEC over time make unique and independent contributions to declines in older adults' ability to function in daily life...
  10. pmc Diagnosing depression in Alzheimer disease with the national institute of mental health provisional criteria
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Am J Geriatr Psychiatry 16:469-77. 2008
    ....
  11. pmc Cognitive and neuroimaging predictors of instrumental activities of daily living
    Deborah A Cahn-Weiner
    Department of Neurology, University of California, San Francisco, California 94143 0138, USA
    J Int Neuropsychol Soc 13:747-57. 2007
    ..Perhaps executive function is particularly important with respect to maintaining IADLs. Alternatively, executive dysfunction may be a sentinel event indicating widespread cortical involvement and poor prognosis...
  12. pmc Longitudinal MRI and cognitive change in healthy elderly
    Joel H Kramer
    Department of Neurology, San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
    Neuropsychology 21:412-8. 2007
    ..The association between WMSH and EXEC further highlights the cognitive sequealae associated with cerebrovascular disease in normal elderly...
  13. ncbi request reprint Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issues
    Chris Zarow
    University of Southern California, Rancho Los Amigos National Rehabilitation Center, 7601 E Imperial Highway, Medical Science Building, Room 26, Downey, CA 90242, USA
    Curr Neurol Neurosci Rep 8:363-70. 2008
    ..Little is known about the prevention and treatment of late-life HS, although circumstantial evidence suggests the importance of identifying and treating vascular risk factors...
  14. ncbi request reprint Performance of Spanish speakers on the Mattis dementia rating scale (MDRS)
    Scott A Lyness
    Department of Neurology, Keck School of Medicine, University of Southern California, CA, USA
    Arch Clin Neuropsychol 21:827-36. 2006
    ....
  15. pmc Subcortical ischemic vascular dementia
    Helena C Chui
    Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA
    Neurol Clin 25:717-40, vi. 2007
    ..Lacunes and deep white matter changes are associated with dysexecutive syndrome. Hypertension, the leading risk factor for sporadic SIVD, is treatable. High priority must be given to reducing vascular risk profiles...
  16. ncbi request reprint Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis
    Scott A Lyness
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Neurobiol Aging 24:1-23. 2003
    ..Symptomatic drug treatment for AD might be beneficially directed toward ameliorating multiple neurotransmitter deficiencies, particularly cholinergic and noradrenergic...
  17. pmc Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia
    Chris Zarow
    University of Southern California, Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA
    Ann Neurol 57:896-903. 2005
    ..Reductions in magnetic resonance imaging-derived hippocampal volume reflect loss, rather than shrinkage, of CA1 neurons...
  18. ncbi request reprint Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
    Chris Zarow
    Department of Neurology, University of Southern California, Los Angeles, CA, USA
    Arch Neurol 60:337-41. 2003
    ..Alzheimer disease (AD) and Parkinson disease (PD) are associated with neuronal degeneration in major subcortical nuclei, but few studies have examined the neuronal degeneration in these nuclei concurrently...
  19. ncbi request reprint A randomized controlled comparison of upper-extremity rehabilitation strategies in acute stroke: A pilot study of immediate and long-term outcomes
    Carolee J Winstein
    Dept of Biokinesiology and Physical Therapy, University of Southern California, Health Sciences Campus, 1540 E Alcazar St, CHP 155, Los Angeles, CA 90089 9006, USA
    Arch Phys Med Rehabil 85:620-8. 2004
    ..To evaluate the immediate and long-term effects of 2 upper-extremity rehabilitation approaches for stroke compared with standard care in participants stratified by stroke severity...
  20. ncbi request reprint Category fluency in a latino sample: associations with age, education, gender, and language
    Wendy J Mack
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    J Clin Exp Neuropsychol 27:591-8. 2005
    ....
  21. ncbi request reprint Advances in vascular cognitive impairment 2005
    Helena Chui
    The University of Southern California, Los Angeles, USA
    Stroke 37:323-5. 2006
  22. pmc Hippocampal volume and retention in Alzheimer's disease
    Joel H Kramer
    Department of Neurology, University of California at San Francisco, 94143, USA
    J Int Neuropsychol Soc 10:639-43. 2004
    ..Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories...
  23. pmc Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunes
    Yuan Yu Hsu
    Department of Veterans Affairs Medical Center, Magnetic Resonance Unit, San Francisco, California, USA
    Alzheimer Dis Assoc Disord 16:58-64. 2002
    ..In conclusion, the presence of subcortical lacunes in those with AD is associated with more WM lesions and ventriculomegaly but not with cortical atrophy...
  24. ncbi request reprint Depression as a risk factor for Alzheimer disease: the MIRAGE Study
    Robert C Green
    Department of Neurology, Genetics Program, Boston University School of Medicine, MA 02118, USA
    Arch Neurol 60:753-9. 2003
    ..Depression symptoms may be associated with the development of Alzheimer disease (AD)...
  25. ncbi request reprint Clinical and neuropsychological features in autopsy-defined vascular dementia
    Bruce R Reed
    Alzheimer s Disease Center, University of California, Davis 94553, USA
    Clin Neuropsychol 18:63-74. 2004
    ..A illustrative case example is included. We conclude that the profile of cognitive impairment in IVD is highly variable, but that in clinical settings neuropsychological readings may contribute to the differential diagnosis of dementia...
  26. pmc Age effects on atrophy rates of entorhinal cortex and hippocampus
    An Tao Du
    Magnetic Resonance Unit 114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurobiol Aging 27:733-40. 2006
    ..In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials...
  27. ncbi request reprint Subcortical ischaemic vascular dementia
    Gustavo C Roman
    University of Texas at San Antonio and the Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas 78284 7883, USA
    Lancet Neurol 1:426-36. 2002
    ..Treatment is symptomatic and prevention requires control of treatable risk factors...
  28. pmc Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular disease
    Beth Kuczynski
    Helen Wills Neuroscience Institute and the Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Arch Neurol 65:650-5. 2008
    ..Understanding how each disease contributes to dementia is essential from both a pathophysiologic and diagnostic perspective...
  29. ncbi request reprint Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease
    Bruce R Reed
    University of California, Davis, CA, USA
    Brain 130:731-9. 2007
    ....
  30. doi request reprint Incidence of dementia in long-term hormone users
    Diana B Petitti
    Department of Clinical Analysis, Kaiser Permanente Southern California, Pasadena, CA
    Am J Epidemiol 167:692-700. 2008
    ..95, 1.89) in estrogen/progestin users and 1.23 (95% confidence interval: 0.94, 1.59) in estrogen users. These findings do not provide support for an effect of estrogen or estrogen/progestin use in preventing dementia...
  31. pmc Neuropathological basis of magnetic resonance images in aging and dementia
    William J Jagust
    School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
    Ann Neurol 63:72-80. 2008
    ..Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present...
  32. ncbi request reprint White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy
    An Tao Du
    Magnetic Resonance Unit 114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurobiol Aging 26:553-9. 2005
    ..Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy...
  33. pmc Forgetting in dementia with and without subcortical lacunes
    Joel H Kramer
    San Francisco Medical Center, University of California, CA 94143, USA
    Clin Neuropsychol 18:32-40. 2004
    ..Three SIVD patients with rapid forgetting followed to autopsy all had AD pathology, further supporting the link between memory patterns and AD...
  34. pmc Memory in the aging brain: doubly dissociating the contribution of the hippocampus and entorhinal cortex
    Andrew P Yonelinas
    Department of Psychology, University of California, Davis, California 95616, USA
    Hippocampus 17:1134-40. 2007
    ....
  35. pmc Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly
    Catherine L Carey
    Department of Psychiatry, University of California, San Diego, 150 W Washington, 2nd Floor San Diego, CA 92103, USA
    Stroke 39:397-402. 2008
    ..We therefore hypothesized that MRI markers of SIVD would be selectively associated with worse executive functioning...
  36. pmc Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience
    Nathan A Johnson
    MR Research Unit, VA Medical Center, 4150 Clement St 114M San Francisco, CA 94107, USA
    Radiology 234:851-9. 2005
    ....
  37. ncbi request reprint The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers
    John C Morris
    Washington University, St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 20:210-6. 2006
    ..Data obtained with the UDS are submitted to the National Alzheimer's Coordinating Center and represent a unique and valuable source of data to support and stimulate collaborative research...

Research Grants3

  1. CORE--CENTRAL COORDINATING CORE
    Helena Chui; Fiscal Year: 2007
    ..Consultants and an external advisory group provide invaluable feedback and guidance. The PPG functions as a vital and cohesive whole. ..