Constance Chu

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Early diagnosis to enable early treatment of pre-osteoarthritis
    Constance R Chu
    Cartilage Restoration Center, Department of Orthopaedic Surgery, University of Pittsburgh, Biomedical Science Tower E1640, 200 Lothrop Street, PA 15261, USA
    Arthritis Res Ther 14:212. 2012
  2. pmc Animal models for cartilage regeneration and repair
    Constance R Chu
    Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Tissue Eng Part B Rev 16:105-15. 2010
  3. doi request reprint The in vitro effects of bupivacaine on articular chondrocytes
    C R Chu
    Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, School of Medicine, 3471 Fifth Ave, Suite 911, Pittsburgh, Pennsylvania 15213, USA
    J Bone Joint Surg Br 90:814-20. 2008
  4. doi request reprint The 2007 ABC Traveling Fellowship: building international orthopaedic bridges
    Constance R Chu
    University of Pittsburgh, 3471 Fifth Avenue, Suite 911, Pittsburgh, PA 15213, USA
    J Bone Joint Surg Am 90:672-4. 2008
  5. doi request reprint In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage
    Constance R Chu
    Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, BST E1640, Pittsburgh, PA 15261, USA
    J Bone Joint Surg Am 92:599-608. 2010
  6. ncbi request reprint Clinical diagnosis of potentially treatable early articular cartilage degeneration using optical coherence tomography
    Constance R Chu
    University of Pittsburgh, Department of Orthopaedic Surgery, 3471 Fifth Avenue, Suite 1010, Pittsburgh, Pennsylvania 15213, USA
    J Biomed Opt 12:051703. 2007
  7. ncbi request reprint In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes
    Constance R Chu
    Cartilage Restoration Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    Arthroscopy 22:693-9. 2006
  8. pmc Closing the gap between bench and bedside research for early arthritis therapies (EARTH): report from the AOSSM/NIH U-13 Post-Joint Injury Osteoarthritis Conference II
    Constance R Chu
    University of Pittsburgh, Department of Orthopaedic Surgery, Cartilage Restoration Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Sports Med 39:1569-78. 2011
  9. pmc Clinical optical coherence tomography of early articular cartilage degeneration in patients with degenerative meniscal tears
    Constance R Chu
    Cartilage Restoration Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Arthritis Rheum 62:1412-20. 2010
  10. ncbi request reprint Arthroscopic microscopy of articular cartilage using optical coherence tomography
    Constance R Chu
    Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    Am J Sports Med 32:699-709. 2004

Research Grants

  1. CHONDROPROTECTIVE EFFECTS OF SUPEROXIDE DISMUTASE
    Constance Chu; Fiscal Year: 2002
  2. Chondrogenesis In Situ
    Constance R Chu; Fiscal Year: 2010
  3. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance R Chu; Fiscal Year: 2010
  4. Chondrogenesis In Situ
    Constance Chu; Fiscal Year: 2009
  5. Chondrogenesis In Situ
    Constance Chu; Fiscal Year: 2007
  6. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance Chu; Fiscal Year: 2007
  7. Chondrogenesis In Situ
    Constance R Chu; Fiscal Year: 2010

Collaborators

  • Freddie H Fu
  • Lee D Kaplan
  • William M Ricci
  • Joseph A Buckwalter
  • Jack Farr
  • Bruce D Beynnon
  • Yingtian Pan
  • Lyle Micheli
  • Rebecca K Studer
  • Michael Nevitt
  • J Antoniou
  • James P Bradley
  • Yongxian Qian
  • A S Hilibrand
  • Alastair Se Younger
  • Tuqiang Xie
  • Christian H Coyle
  • David M Bear
  • Michal Szczodry
  • Nicholas J Izzo
  • John C Karpie
  • Patrick Smolinski
  • Kenneth Zaslav
  • Venkat Seshadri
  • Huaping Tan
  • Laura R Thompson
  • Kristin E Wescoe
  • Brian N Dontchos
  • Kacey G Marra
  • Alicia J DeFail
  • Peter U Brucker
  • Ashley Williams
  • Scott Kramer
  • Anne B Newman
  • Christian Christensen
  • Steven Svoboda
  • Peter Fowler
  • Karin A Payne
  • Robert McCormack
  • Robert Arciero
  • C Kent Kwoh
  • Douglas Vermillion
  • Michael Malek
  • Robert Boudreau
  • Brian Cole
  • Robert LaPrade
  • David Teuscher
  • Darryl Thomas
  • David Oster
  • Mary Jansen
  • Michael Gibbons
  • Scott Gillogly
  • Noah Weiss
  • Jeff Headrick
  • Kenneth DeHaven
  • Daniel Unger
  • Timothy Mologne
  • Arnold Scheller
  • Matthew Provencher
  • Edward Arrington
  • Thomas DeBerardino
  • Frank Burke
  • Robert Brewster
  • Alexandra Kirkley
  • Carl Nissen
  • Kevin Bonner
  • Scott J Kramer
  • James Hall
  • Michael J Hannon
  • Bert Mandelbaum
  • Ralph Gambardella
  • David Tearse
  • Francis McGuigan
  • Schuyler Dejong
  • David Sitler
  • Patrick St Pierre
  • Peter Macdonald
  • Dean Taylor
  • Rebecca C Schugar
  • Bridget M Deasy
  • Deanna M Didiano
  • Alison Logar
  • Nicholas Izzo

Detail Information

Publications28

  1. pmc Early diagnosis to enable early treatment of pre-osteoarthritis
    Constance R Chu
    Cartilage Restoration Center, Department of Orthopaedic Surgery, University of Pittsburgh, Biomedical Science Tower E1640, 200 Lothrop Street, PA 15261, USA
    Arthritis Res Ther 14:212. 2012
    ..This review focuses on recent advances in imaging and biochemical biomarkers suitable for characterization of the pre-osteoarthritic joint as well as implications for development of effective early treatment strategies...
  2. pmc Animal models for cartilage regeneration and repair
    Constance R Chu
    Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Tissue Eng Part B Rev 16:105-15. 2010
    ..A multifactorial analysis of each animal model should be carried out when planning in vivo studies. Ultimately, the scientific goals of the study will be critical in determining the appropriate animal model...
  3. doi request reprint The in vitro effects of bupivacaine on articular chondrocytes
    C R Chu
    Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, School of Medicine, 3471 Fifth Ave, Suite 911, Pittsburgh, Pennsylvania 15213, USA
    J Bone Joint Surg Br 90:814-20. 2008
    ..125% bupivacaine for up to 60 minutes, the viability of both bovine and human chondrocytes was similar to that of control groups. These data show that prolonged exposure 0.5% and 0.25% bupivacaine solutions are potentially chondrotoxic...
  4. doi request reprint The 2007 ABC Traveling Fellowship: building international orthopaedic bridges
    Constance R Chu
    University of Pittsburgh, 3471 Fifth Avenue, Suite 911, Pittsburgh, PA 15213, USA
    J Bone Joint Surg Am 90:672-4. 2008
  5. doi request reprint In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage
    Constance R Chu
    Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, BST E1640, Pittsburgh, PA 15261, USA
    J Bone Joint Surg Am 92:599-608. 2010
    ..This in vivo study was conducted to determine whether a single intra-articular injection of 0.5% bupivacaine results in chondrocyte morbidity and rapid chondrolysis...
  6. ncbi request reprint Clinical diagnosis of potentially treatable early articular cartilage degeneration using optical coherence tomography
    Constance R Chu
    University of Pittsburgh, Department of Orthopaedic Surgery, 3471 Fifth Avenue, Suite 1010, Pittsburgh, Pennsylvania 15213, USA
    J Biomed Opt 12:051703. 2007
    ....
  7. ncbi request reprint In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes
    Constance R Chu
    Cartilage Restoration Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    Arthroscopy 22:693-9. 2006
    ..This study was conducted to test the hypotheses that (1) 0.5% bupivacaine is toxic to articular chondrocytes, and (2) the intact articular surface protects chondrocytes from the effects of short-term exposure to 0.5% bupivacaine...
  8. pmc Closing the gap between bench and bedside research for early arthritis therapies (EARTH): report from the AOSSM/NIH U-13 Post-Joint Injury Osteoarthritis Conference II
    Constance R Chu
    University of Pittsburgh, Department of Orthopaedic Surgery, Cartilage Restoration Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Sports Med 39:1569-78. 2011
    ..Systematic study of posttraumatic osteoarthritis is anticipated to advance understanding and treatment of all forms of osteoarthritis...
  9. pmc Clinical optical coherence tomography of early articular cartilage degeneration in patients with degenerative meniscal tears
    Constance R Chu
    Cartilage Restoration Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Arthritis Rheum 62:1412-20. 2010
    ..This study tested the hypotheses that OCT can be used clinically to identify early cartilage degeneration and that OCT findings correlate with magnetic resonance imaging (MRI) T2 values and arthroscopy results...
  10. ncbi request reprint Arthroscopic microscopy of articular cartilage using optical coherence tomography
    Constance R Chu
    Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    Am J Sports Med 32:699-709. 2004
    ..Optical coherence tomography is an echograph of infrared light that can yield microscopic cross-sectional images of articular cartilage without removing or damaging the tissue...
  11. doi request reprint Sustained hypoxia enhances chondrocyte matrix synthesis
    Christian H Coyle
    Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Orthop Res 27:793-9. 2009
    ..These studies show that sustained hypoxia enhances articular chondrocyte matrix synthesis and viability in three-dimensional alginate culture...
  12. doi request reprint Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content
    David M Bear
    Cartilage Restoration Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Biomedical Science Tower E1640, Pittsburgh, PA 15261, USA
    J Orthop Res 28:546-52. 2010
    ..Our results demonstrate the ability of OCT and T2 mapping to detect early cartilage degeneration in clinically normal appearing cartilage...
  13. ncbi request reprint Tonic activation of hypoxia-inducible factor 1alpha in avascular articular cartilage and implications for metabolic homeostasis
    Peter U Brucker
    Cartilage Restoration Laboratory, Pittsburgh, Pennsylvania 15232, USA
    Arthritis Rheum 52:3181-91. 2005
    ....
  14. pmc Multicomponent T2* mapping of knee cartilage: technical feasibility ex vivo
    Yongxian Qian
    MR Research Center, Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Magn Reson Med 64:1426-31. 2010
    ..A map of decay types presented spatial distribution of these T2* decays. These results showed the technical feasibility of multicomponent T2* mapping on human knee cartilage explants...
  15. pmc Optical coherence tomography detection of subclinical traumatic cartilage injury
    David M Bear
    Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Orthop Trauma 24:577-82. 2010
    ..This study tests the hypothesis that OCT detects acute articular cartilage injury after impact at energy levels resulting in chondrocyte death and microstructural changes, but insufficient to produce macroscopic surface damage...
  16. ncbi request reprint Lidocaine exhibits dose- and time-dependent cytotoxic effects on bovine articular chondrocytes in vitro
    John C Karpie
    Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Sports Med 35:1621-7. 2007
    ..Intra-articular lidocaine is commonly used...
  17. doi request reprint Lidocaine potentiates the chondrotoxicity of methylprednisolone
    Venkat Seshadri
    Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Arthroscopy 25:337-47. 2009
    ..This study examined the viability of bovine articular chondrocytes after exposure to methylprednisolone, methylprednisolone with lidocaine, and methylprednisolone in a simulated inflammatory environment...
  18. pmc Progressive chondrocyte death after impact injury indicates a need for chondroprotective therapy
    Michal Szczodry
    Cartilage Restoration Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Sports Med 37:2318-22. 2009
    ..Impact injury to articular cartilage can lead to posttraumatic osteoarthritis...
  19. doi request reprint A prospective study of autologous chondrocyte implantation in patients with failed prior treatment for articular cartilage defect of the knee: results of the Study of the Treatment of Articular Repair (STAR) clinical trial
    Kenneth Zaslav
    Department of Orthopedic Surgery, Advanced Orthopedic Centers, Virginia Commonwealth University, Richmond, VA 23294, USA
    Am J Sports Med 37:42-55. 2009
    ..This is a prospective clinical study to assess the effectiveness of autologous chondrocyte implantation in patients who failed prior treatments for articular cartilage defects of the knee...
  20. ncbi request reprint Optimizing CO2 normalizes pH and enhances chondrocyte viability during cold storage
    Brian N Dontchos
    Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, BST E 1640, Pittsburgh, Pennsylvania 15621, USA
    J Orthop Res 26:643-50. 2008
    ..This data shows that an increase in pH decreased bovine chondrocyte viability when refrigerated at 4 degrees C in DMEM, and that optimization of CO(2) normalized pH and improved chondrocyte viability during cold storage in DMEM...
  21. pmc The knee pain map: reliability of a method to identify knee pain location and pattern
    Laura R Thompson
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Arthritis Rheum 61:725-31. 2009
    ..To describe the location and pattern of knee pain in patients with chronic, frequent knee pain using the Knee Pain Map, and to evaluate the inter- and intrarater reliability of the map...
  22. ncbi request reprint Recovery of articular cartilage metabolism following thermal stress is facilitated by IGF-1 and JNK inhibitor
    Constance R Chu
    Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    Am J Sports Med 32:191-6. 2004
    ..The safety of intra-articular use of thermal probes is related to whether chondrocytes can tolerate exposure to high temperatures and whether cytoprotective agents may improve chondrocyte survival after thermal injury...
  23. ncbi request reprint Controlled release of bioactive TGF-beta 1 from microspheres embedded within biodegradable hydrogels
    Alicia J DeFail
    Department of Bioengineering, University of Pittsburgh, 200 Lothrop Street, BST 1555W, Pittsburgh, PA 15261, USA
    Biomaterials 27:1579-85. 2006
    ..Based on these in vitro observations, we predict that we can develop a microsphere-loaded hydrogel for controlled release of TGF-beta1 to a cartilage wound site...
  24. doi request reprint The role of the biochemical and biophysical environment in chondrogenic stem cell differentiation assays and cartilage tissue engineering
    Kristin E Wescoe
    Department of Bioengineering, University of Pittsburgh, 3460 Fifth Avenue, 5113 Rangos Research Center, Pittsburgh, PA 15213, USA
    Cell Biochem Biophys 52:85-102. 2008
    ..g., spatial and temporal application of the stimuli, and time of transplantation of an engineered construct. Understanding the necessary microenvironmental signals for cell differentiation will advance cell therapy for cartilage repair...
  25. ncbi request reprint Recovery of chondrocyte metabolic activity after thermal exposure
    Lee D Kaplan
    University of Pittsburgh School of Medicine, Department of Orthopaedic Surgery, Pittsburgh, Pennsylvania 15213, USA
    Am J Sports Med 31:392-8. 2003
    ..The relationship between temperature elevation and thermal exposure time during thermal chondroplasty has implications for cell viability and subsequent articular cartilage function...
  26. ncbi request reprint p38 MAPK and COX2 inhibition modulate human chondrocyte response to TGF-beta
    Rebecca K Studer
    VA Pittsburgh Healthcare System, University of Pittsburgh Medical School, Pittsburgh, PA 15240, USA
    J Orthop Res 23:454-61. 2005
    ..Use of these inhibitors to minimize cartilage damage in arthritic and mechanically stressed joints should reflect these characteristics...
  27. pmc Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering
    Huaping Tan
    Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Biomaterials 30:2499-506. 2009
    ..These characteristics provide a potential opportunity to use the injectable, composite hydrogels in tissue engineering applications...
  28. ncbi request reprint Hand-held arthroscopic optical coherence tomography for in vivo high-resolution imaging of articular cartilage
    Yingtian Pan
    State University of New York, Stony Brook, Department of Biomedical Engineering, Stony Brook, New York 11794 8181, USA
    J Biomed Opt 8:648-54. 2003
    ..Successful application of in vivo arthroscopy to porcine articular cartilage demonstrates sufficient resolution and practicality for use in human joints...

Research Grants14

  1. CHONDROPROTECTIVE EFFECTS OF SUPEROXIDE DISMUTASE
    Constance Chu; Fiscal Year: 2002
    ..These studies will also serve to improve understanding of the relative roles of NO and peroxynitrite on the pathophysiology of arthritis. ..
  2. Chondrogenesis In Situ
    Constance R Chu; Fiscal Year: 2010
    ....
  3. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance R Chu; Fiscal Year: 2010
    ..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. ..
  4. Chondrogenesis In Situ
    Constance Chu; Fiscal Year: 2009
    ....
  5. Chondrogenesis In Situ
    Constance Chu; Fiscal Year: 2007
    ....
  6. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance Chu; Fiscal Year: 2007
    ..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. ..
  7. Chondrogenesis In Situ
    Constance R Chu; Fiscal Year: 2010
    ....